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The map label for this gene is phoR

Identifier: 41406690

GI number: 41406690

Start: 618028

End: 619464

Strand: Direct

Name: phoR

Synonym: MAP0592

Alternate gene names: 41406690

Gene position: 618028-619464 (Clockwise)

Preceding gene: 41406689

Following gene: 41406700

Centisome position: 12.8

GC content: 72.09

Gene sequence:

>1437_bases
ATGGTGGTGACAAGGCCTCGACGCGGACTACCCCTGCGGGTGGGGCTGGTCGCCGCCACCCTGGCCCTGGTCGCCTGCGG
TCTGGCCGTCTCCGGCATCGCGGTCACGTCGATCCTGCGGCACAGCCTGGTCAGCCGCATCGACTCCACCCTGCTCGACG
CCTCCCGCGGCTGGGCGCAGGCCCCGCGGCGCCAGTCGTCCTCGGCCTACGAGGGCCCGGACCCGGGCCGCCCGCCGTCG
AAGTTCTACGTGCGCGGCGTCAGCACCGACGGGACGCCGTTCACCGCCATCAACGACCGCAACGCCGAACCGGCGCTGCC
CGCCAACAACGACGTCGGACCCAACCCGACGACGTTGCCCTCGGTGAACGGTTCGGACATCCAGTGGCGCGCCGTGTCGG
TGCGCGGCCCGCACGGGCTGACCACGGTGGCCATCGACCTGTCCGACGTCCAGCACACCGTCAGCTCGCTGGTCTGGCTG
CAGATCGGCATCGGGGTCGCGGTGCTGGCCGTGGTGGGCATCGCCAGCTTCGCGGTGGTGCAGCGCAGCCTGCGGCCGCT
GGTCGAAGTCGAACAGACCGCCGCGGCGATCGCCGCTGGCCAGCTGGATCGCCGTGTGCCGGAACGTGATCCGCGCACCG
AGGTGGGCCGGCTGTCGCTCGCGCTCAACGGCATGCTCGCGCAGATCCAGCAGGCACTGGCGTCCTCGGAGTCCTCGGCT
GAAAAGGCCCGCGGCTCCGAGGACCGGATGCGGCGCTTCATCACCGACGCCAGCCACGAGCTGCGCACCCCGCTGACCAC
CATCCGGGGATTCGCCGAACTGTATCGCCAGGGCGCGGCCCGCGACGTCGCGATGTTGTTGTCGCGCATCGAAAGTGAGG
CCTCGCGGATGGGCCTGCTGGTCGACGACCTGCTGCTGCTGGCCCGGCTGGACGTGCAGCGGCCGCTGGAACACCACCGG
GTGGACCTGCTGGCGCTGGCCAGCGACGCCGTGCACGACGCGCAGGCGATGGACCCCAAGCGCACCATCACCCTGGAGGT
CCTCGACGGCCCCGGCACCCCGGAGGTGTTCGGCGACGAGCCCCGCATCCGGCAGGTGCTGGGCAACCTGATCGCCAACG
CCCTGCAGCACACCCCGGAAAGCGCCGACGTCACGGTGCGGGTGGGCACCGACGGCGACGACGCGGTCCTCGAGGTGGCC
GACCGGGGTCCCGGAATGAACGAGCAGGACGCGTCGCGGGTGTTCGAGCGGTTCTACCGCACCGACTCGTCAAGGGCGCG
GGCCAGCGGCGGTACCGGGCTGGGGCTGTCCATCGTCGAGTCGCTGGTGCGCGCGCACGGCGGCACCGTCGGCGTGACGA
CCGCGCCCGGCCAGGGTTGCTGCTTCCGGGTGACGTTGCCGCGGATCAGCGACGTGCCCGCGGTTCAGGCCAGCTGA

Upstream 100 bases:

>100_bases
GAGAAGCGGCTGCTGCACACGCTGCGCGGCGTCGGCTATGTGCTGCGGGAACCGCGCTGAGCGCGCGCTCGGCCACCGGC
GGTAGCGAGGAATCGGTCAG

Downstream 100 bases:

>100_bases
GCCAGGGCCGCCTTGATCTTGGCCTGGGCCTCGTCCAGGGACTCCGGGGACGGGTTGCGGTCCACGTTGGCGAAGCCGAA
GTCGCTGAGGCTGCGGGTGG

Product: PhoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MVVTRPRRGLPLRVGLVAATLALVACGLAVSGIAVTSILRHSLVSRIDSTLLDASRGWAQAPRRQSSSAYEGPDPGRPPS
KFYVRGVSTDGTPFTAINDRNAEPALPANNDVGPNPTTLPSVNGSDIQWRAVSVRGPHGLTTVAIDLSDVQHTVSSLVWL
QIGIGVAVLAVVGIASFAVVQRSLRPLVEVEQTAAAIAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQQALASSESSA
EKARGSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLSRIESEASRMGLLVDDLLLLARLDVQRPLEHHR
VDLLALASDAVHDAQAMDPKRTITLEVLDGPGTPEVFGDEPRIRQVLGNLIANALQHTPESADVTVRVGTDGDDAVLEVA
DRGPGMNEQDASRVFERFYRTDSSRARASGGTGLGLSIVESLVRAHGGTVGVTTAPGQGCCFRVTLPRISDVPAVQAS

Sequences:

>Translated_478_residues
MVVTRPRRGLPLRVGLVAATLALVACGLAVSGIAVTSILRHSLVSRIDSTLLDASRGWAQAPRRQSSSAYEGPDPGRPPS
KFYVRGVSTDGTPFTAINDRNAEPALPANNDVGPNPTTLPSVNGSDIQWRAVSVRGPHGLTTVAIDLSDVQHTVSSLVWL
QIGIGVAVLAVVGIASFAVVQRSLRPLVEVEQTAAAIAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQQALASSESSA
EKARGSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLSRIESEASRMGLLVDDLLLLARLDVQRPLEHHR
VDLLALASDAVHDAQAMDPKRTITLEVLDGPGTPEVFGDEPRIRQVLGNLIANALQHTPESADVTVRVGTDGDDAVLEVA
DRGPGMNEQDASRVFERFYRTDSSRARASGGTGLGLSIVESLVRAHGGTVGVTTAPGQGCCFRVTLPRISDVPAVQAS
>Mature_478_residues
MVVTRPRRGLPLRVGLVAATLALVACGLAVSGIAVTSILRHSLVSRIDSTLLDASRGWAQAPRRQSSSAYEGPDPGRPPS
KFYVRGVSTDGTPFTAINDRNAEPALPANNDVGPNPTTLPSVNGSDIQWRAVSVRGPHGLTTVAIDLSDVQHTVSSLVWL
QIGIGVAVLAVVGIASFAVVQRSLRPLVEVEQTAAAIAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQQALASSESSA
EKARGSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLSRIESEASRMGLLVDDLLLLARLDVQRPLEHHR
VDLLALASDAVHDAQAMDPKRTITLEVLDGPGTPEVFGDEPRIRQVLGNLIANALQHTPESADVTVRVGTDGDDAVLEVA
DRGPGMNEQDASRVFERFYRTDSSRARASGGTGLGLSIVESLVRAHGGTVGVTTAPGQGCCFRVTLPRISDVPAVQAS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=35.4260089686099, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788393, Length=251, Percent_Identity=34.2629482071713, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790346, Length=243, Percent_Identity=34.156378600823, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1786783, Length=358, Percent_Identity=30.4469273743017, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1787894, Length=325, Percent_Identity=30.1538461538462, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790861, Length=244, Percent_Identity=31.9672131147541, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789149, Length=371, Percent_Identity=26.9541778975741, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=31.25, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=31.8965517241379, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=29.7674418604651, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=27.1604938271605, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87081816, Length=380, Percent_Identity=27.8947368421053, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=27.7777777777778, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788713, Length=232, Percent_Identity=29.3103448275862, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788279, Length=227, Percent_Identity=27.7533039647577, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789808, Length=304, Percent_Identity=27.3026315789474, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=25.8620689655172, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788549, Length=213, Percent_Identity=27.6995305164319, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789403, Length=359, Percent_Identity=28.133704735376, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790300, Length=233, Percent_Identity=33.0472103004292, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50844; Mature: 50844

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVTRPRRGLPLRVGLVAATLALVACGLAVSGIAVTSILRHSLVSRIDSTLLDASRGWAQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
APRRQSSSAYEGPDPGRPPSKFYVRGVSTDGTPFTAINDRNAEPALPANNDVGPNPTTLP
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
SVNGSDIQWRAVSVRGPHGLTTVAIDLSDVQHTVSSLVWLQIGIGVAVLAVVGIASFAVV
CCCCCCEEEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRSLRPLVEVEQTAAAIAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQQALASSESSA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
EKARGSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLSRIESEASRMGLL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VDDLLLLARLDVQRPLEHHRVDLLALASDAVHDAQAMDPKRTITLEVLDGPGTPEVFGDE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC
PRIRQVLGNLIANALQHTPESADVTVRVGTDGDDAVLEVADRGPGMNEQDASRVFERFYR
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHEEEHHCCCCCCHHHHHHHHHHHHH
TDSSRARASGGTGLGLSIVESLVRAHGGTVGVTTAPGQGCCFRVTLPRISDVPAVQAS
CCCCHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MVVTRPRRGLPLRVGLVAATLALVACGLAVSGIAVTSILRHSLVSRIDSTLLDASRGWAQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
APRRQSSSAYEGPDPGRPPSKFYVRGVSTDGTPFTAINDRNAEPALPANNDVGPNPTTLP
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
SVNGSDIQWRAVSVRGPHGLTTVAIDLSDVQHTVSSLVWLQIGIGVAVLAVVGIASFAVV
CCCCCCEEEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRSLRPLVEVEQTAAAIAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQQALASSESSA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
EKARGSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLSRIESEASRMGLL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VDDLLLLARLDVQRPLEHHRVDLLALASDAVHDAQAMDPKRTITLEVLDGPGTPEVFGDE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC
PRIRQVLGNLIANALQHTPESADVTVRVGTDGDDAVLEVADRGPGMNEQDASRVFERFYR
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHEEEHHCCCCCCHHHHHHHHHHHHH
TDSSRARASGGTGLGLSIVESLVRAHGGTVGVTTAPGQGCCFRVTLPRISDVPAVQAS
CCCCHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]