The gene/protein map for NC_007794 is currently unavailable.
Definition Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession NC_002944
Length 4,829,781

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The map label for this gene is hdhA [H]

Identifier: 41406675

GI number: 41406675

Start: 601994

End: 602839

Strand: Direct

Name: hdhA [H]

Synonym: MAP0577

Alternate gene names: 41406675

Gene position: 601994-602839 (Clockwise)

Preceding gene: 41406674

Following gene: 41406676

Centisome position: 12.46

GC content: 69.98

Gene sequence:

>846_bases
GTGCAGCTTTCCTTCCAAGACCGGACCTATCTCATCACCGGCGGCGGCAGCGGGATCGGCAAGGGCGTGGCCGCGGGCCT
GGTCTCGGCCGGGGCGTCGGTGATGATCGTCGGCCGCAACCCGGACCGCCTGGCCGGCGCCGTCGAGGAGATCGCGCCGC
TGGCCGACCGCGCCGGGAACGGCGGGGCGATCCGCTACGAGCCCACGGACGTCACCAACGAGGACGAGGTGGCCCGCGCG
GTCGACGCCGCGACGGCATGGCACGGCCGGCTGCACGGGGCCGTGCACTGCGCCGGAGGCTCGTTGACGGTCGGGCCGAT
CACCCACACCGACTCGGAGGCATGGCGAAACACCGTCGACCTCAACGTCAACGGCACCATGTATGTGCTCAAGCACGTCG
GGCGCGAACTGGTGCGCGGGGGCGGCGGCTCGTTCATCGGGATCTCCTCGATCGCCGCCAGCAACACCCACCGCTGGTTC
GGGCCCTACGGCGTCACCAAGTCGGCCATCGACCACATGATGATGCTGGCCGCCGACGAACTCGGGGAGTCGTGGGTGCG
GGTCAACAGCATCCGCCCGGGCCTGATCCGCACGGATCTCGTTGACGCCAGCGTGATTCAGTCGCCGGAGATCAGCGCGG
ACTACGCCCAGTGCACGCCGCTGCCCCGCGTGGGCGAGGTCGAGGACGTCGCCAACCTGGCGATGTTTCTGCTCAGCGAC
GCCGCCGGCTGGATCACCGGCCAGTGCATCAACGTCGACGGCGGCCACATGTTGCGTCGCGGCCCCGACTACTCGTCGAT
GATGGTGCAGATGTTCGGCCAGGACGCGCTGCGCGGCGTGGTCTGA

Upstream 100 bases:

>100_bases
CACCCCGTAGCGAGCCCTAACGAGACCGGGGGTAGCGATATTCACCCCGAGGGGACATGCTTCTATAGCTAGAACCTGTT
CCAGTTCGAAAGGGCCTCGC

Downstream 100 bases:

>100_bases
GCCGGGAGAATCGCATGAAAAGGCTTGAGGGCAAACGGATTTTGGTGACCGGCGCCGCGTCGGGCATCGGCCAGGCGACC
GCGCTGCGGTTGCTGGACGA

Product: short chain dehydrogenase

Products: NA

Alternate protein names: 7-alpha-HSDH [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MQLSFQDRTYLITGGGSGIGKGVAAGLVSAGASVMIVGRNPDRLAGAVEEIAPLADRAGNGGAIRYEPTDVTNEDEVARA
VDAATAWHGRLHGAVHCAGGSLTVGPITHTDSEAWRNTVDLNVNGTMYVLKHVGRELVRGGGGSFIGISSIAASNTHRWF
GPYGVTKSAIDHMMMLAADELGESWVRVNSIRPGLIRTDLVDASVIQSPEISADYAQCTPLPRVGEVEDVANLAMFLLSD
AAGWITGQCINVDGGHMLRRGPDYSSMMVQMFGQDALRGVV

Sequences:

>Translated_281_residues
MQLSFQDRTYLITGGGSGIGKGVAAGLVSAGASVMIVGRNPDRLAGAVEEIAPLADRAGNGGAIRYEPTDVTNEDEVARA
VDAATAWHGRLHGAVHCAGGSLTVGPITHTDSEAWRNTVDLNVNGTMYVLKHVGRELVRGGGGSFIGISSIAASNTHRWF
GPYGVTKSAIDHMMMLAADELGESWVRVNSIRPGLIRTDLVDASVIQSPEISADYAQCTPLPRVGEVEDVANLAMFLLSD
AAGWITGQCINVDGGHMLRRGPDYSSMMVQMFGQDALRGVV
>Mature_281_residues
MQLSFQDRTYLITGGGSGIGKGVAAGLVSAGASVMIVGRNPDRLAGAVEEIAPLADRAGNGGAIRYEPTDVTNEDEVARA
VDAATAWHGRLHGAVHCAGGSLTVGPITHTDSEAWRNTVDLNVNGTMYVLKHVGRELVRGGGGSFIGISSIAASNTHRWF
GPYGVTKSAIDHMMMLAADELGESWVRVNSIRPGLIRTDLVDASVIQSPEISADYAQCTPLPRVGEVEDVANLAMFLLSD
AAGWITGQCINVDGGHMLRRGPDYSSMMVQMFGQDALRGVV

Specific function: 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=251, Percent_Identity=31.0756972111554, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4503301, Length=254, Percent_Identity=31.496062992126, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=29.3893129770992, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI7705925, Length=259, Percent_Identity=30.1158301158301, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI10190704, Length=276, Percent_Identity=27.536231884058, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=29.1666666666667, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI126723750, Length=258, Percent_Identity=28.2945736434109, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI5031737, Length=249, Percent_Identity=29.3172690763052, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI40254992, Length=253, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4758504, Length=258, Percent_Identity=29.8449612403101, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI59889578, Length=192, Percent_Identity=32.2916666666667, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI126723191, Length=193, Percent_Identity=28.4974093264249, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=36.2204724409449, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786812, Length=263, Percent_Identity=28.5171102661597, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=30.2325581395349, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=25.6809338521401, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=26.953125, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787526, Length=253, Percent_Identity=25.296442687747, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=27.2, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=28.3464566929134, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=27.9527559055118, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=25.6809338521401, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789208, Length=259, Percent_Identity=25.4826254826255, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787545, Length=251, Percent_Identity=25.0996015936255, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789057, Length=271, Percent_Identity=25.4612546125461, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=258, Percent_Identity=32.9457364341085, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17560150, Length=276, Percent_Identity=28.6231884057971, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562990, Length=276, Percent_Identity=30.0724637681159, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=28.6245353159851, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17538182, Length=258, Percent_Identity=32.5581395348837, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562904, Length=281, Percent_Identity=28.1138790035587, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=27.8195488721804, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=27.6923076923077, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=27.8195488721804, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560220, Length=277, Percent_Identity=28.158844765343, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17565030, Length=274, Percent_Identity=27.7372262773723, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=276, Percent_Identity=28.2608695652174, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=278, Percent_Identity=28.4172661870504, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=29.9212598425197, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=28, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17561402, Length=261, Percent_Identity=27.9693486590038, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17561272, Length=240, Percent_Identity=28.3333333333333, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=288, Percent_Identity=29.1666666666667, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=284, Percent_Identity=27.4647887323944, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=26.4591439688716, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=257, Percent_Identity=26.4591439688716, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=271, Percent_Identity=27.6752767527675, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=292, Percent_Identity=27.0547945205479, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=26.8, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=25.9398496240602, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=273, Percent_Identity=25.2747252747253, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=277, Percent_Identity=25.6317689530686, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=270, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324126, Length=256, Percent_Identity=26.953125, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322226, Length=193, Percent_Identity=26.4248704663212, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357041, Length=257, Percent_Identity=35.408560311284, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=33.203125, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=29.4117647058824, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI23397609, Length=257, Percent_Identity=28.7937743190661, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=29.1338582677165, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17737361, Length=271, Percent_Identity=26.1992619926199, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=26.8, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24644339, Length=263, Percent_Identity=26.9961977186312, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI116007236, Length=242, Percent_Identity=29.3388429752066, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24644337, Length=259, Percent_Identity=27.4131274131274, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.159 [H]

Molecular weight: Translated: 29576; Mature: 29576

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MQLSFQDRTYLITGGGSGIGKGVAAGLVSAGASVMIVGRNPDRLAGAVEEIAPLADRAGN
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC
GGAIRYEPTDVTNEDEVARAVDAATAWHGRLHGAVHCAGGSLTVGPITHTDSEAWRNTVD
CCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCHHHHCCEEE
LNVNGTMYVLKHVGRELVRGGGGSFIGISSIAASNTHRWFGPYGVTKSAIDHMMMLAADE
EECCCHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LGESWVRVNSIRPGLIRTDLVDASVIQSPEISADYAQCTPLPRVGEVEDVANLAMFLLSD
HCCHHEEECCCCCCCEEHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHH
AAGWITGQCINVDGGHMLRRGPDYSSMMVQMFGQDALRGVV
CCCCEEEEEEECCCCHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLSFQDRTYLITGGGSGIGKGVAAGLVSAGASVMIVGRNPDRLAGAVEEIAPLADRAGN
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC
GGAIRYEPTDVTNEDEVARAVDAATAWHGRLHGAVHCAGGSLTVGPITHTDSEAWRNTVD
CCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCHHHHCCEEE
LNVNGTMYVLKHVGRELVRGGGGSFIGISSIAASNTHRWFGPYGVTKSAIDHMMMLAADE
EECCCHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LGESWVRVNSIRPGLIRTDLVDASVIQSPEISADYAQCTPLPRVGEVEDVANLAMFLLSD
HCCHHEEECCCCCCCEEHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHH
AAGWITGQCINVDGGHMLRRGPDYSSMMVQMFGQDALRGVV
CCCCEEEEEEECCCCHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]