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The map label for this gene is echA13

Identifier: 41406674

GI number: 41406674

Start: 600959

End: 601903

Strand: Direct

Name: echA13

Synonym: MAP0576

Alternate gene names: 41406674

Gene position: 600959-601903 (Clockwise)

Preceding gene: 41406673

Following gene: 41406675

Centisome position: 12.44

GC content: 68.78

Gene sequence:

>945_bases
GTGGGCGCAATGACTCTCTCCGAGCAAGCGGGGGCGCAGCCCGGCGCCCGGCCGGCCGAGGAGCTGGTGACCTACGAAAC
CCTCGACGAGGGCCGCATCGCGCGCATCTGGCTCAACCGGCCCGACGCCCACAACGCGCAGAGCCGCGGGTTGCTCGTTC
AGCTCGACGAGGCGTTCGTGCGGGCCGAGGCCGATGACGCCGTTCGGGTGGTCATCCTGGCTGCGCGCGGCAAGAACTTC
TCCGCCGGTCACGACCTGGGCTCGGAGCTGGCGCTCGCCGAACGCCAGCCCGGGCCGGGCCAGCATCCGACCTTCCGGTT
CAACGGCGCCACCCGCGATCCCATCGCGGAGAAGACCTACCTGCAGGAGTGGCACTACTTCTTCCAAAACACTTGCCGCT
GGCGGGATCTGCGCAAGATCACCATCGCCCAGGTGCAGGGCAACGCGATCTCGGCCGGCCTGATGCTGATCTGGGCGTGC
GATCTGATCGTGGCCGCCGACAACGCCAAGTTCAGCGATGTGGTCGGCGTCCGGATGGGCATGCCGGGCGTCGAATACTA
CGCGCACCCTTGGGAATTCGGCCCCCGCAAGGCCAAAGAGCTGCTGCTGACCGGTGATGCGCTGGACGCCGACGAGGCCT
ACCGGCTGGGCATGGTGTCCAAGGTGTTCCCGGCCGACGAATTGGCCGACAAGACACTGGAATTCGCGCGCCGCATCGCC
GAGCGGCCGACCATGGCCGCCCTGCTGATCAAGGACTCGGTCAACGCCGCCTCGGACGCGATGGGCTTCACGGAGGCGCT
GCGGCACGCGTTCCACATCCACGAGCTGGGTCACGCGCACTGGGCGGCGCACAACGAGAACAGGTATCCGGTCGGCCTGC
CGCCCGACGTCGAGGACTGGCGCAACGCCAAGCCGACCAGGCTGGCCCGCCGCGACACCCCGTAG

Upstream 100 bases:

>100_bases
CCGCTGGATCAGCGGCCGCCGGATTGACCGTCAACCCCGGGGCGTTCCGGTTACACACTGGCCGTAATGTGTAAACAATC
CTGAGCCGACGACAAGCGAG

Downstream 100 bases:

>100_bases
CGAGCCCTAACGAGACCGGGGGTAGCGATATTCACCCCGAGGGGACATGCTTCTATAGCTAGAACCTGTTCCAGTTCGAA
AGGGCCTCGCGTGCAGCTTT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MGAMTLSEQAGAQPGARPAEELVTYETLDEGRIARIWLNRPDAHNAQSRGLLVQLDEAFVRAEADDAVRVVILAARGKNF
SAGHDLGSELALAERQPGPGQHPTFRFNGATRDPIAEKTYLQEWHYFFQNTCRWRDLRKITIAQVQGNAISAGLMLIWAC
DLIVAADNAKFSDVVGVRMGMPGVEYYAHPWEFGPRKAKELLLTGDALDADEAYRLGMVSKVFPADELADKTLEFARRIA
ERPTMAALLIKDSVNAASDAMGFTEALRHAFHIHELGHAHWAAHNENRYPVGLPPDVEDWRNAKPTRLARRDTP

Sequences:

>Translated_314_residues
MGAMTLSEQAGAQPGARPAEELVTYETLDEGRIARIWLNRPDAHNAQSRGLLVQLDEAFVRAEADDAVRVVILAARGKNF
SAGHDLGSELALAERQPGPGQHPTFRFNGATRDPIAEKTYLQEWHYFFQNTCRWRDLRKITIAQVQGNAISAGLMLIWAC
DLIVAADNAKFSDVVGVRMGMPGVEYYAHPWEFGPRKAKELLLTGDALDADEAYRLGMVSKVFPADELADKTLEFARRIA
ERPTMAALLIKDSVNAASDAMGFTEALRHAFHIHELGHAHWAAHNENRYPVGLPPDVEDWRNAKPTRLARRDTP
>Mature_313_residues
GAMTLSEQAGAQPGARPAEELVTYETLDEGRIARIWLNRPDAHNAQSRGLLVQLDEAFVRAEADDAVRVVILAARGKNFS
AGHDLGSELALAERQPGPGQHPTFRFNGATRDPIAEKTYLQEWHYFFQNTCRWRDLRKITIAQVQGNAISAGLMLIWACD
LIVAADNAKFSDVVGVRMGMPGVEYYAHPWEFGPRKAKELLLTGDALDADEAYRLGMVSKVFPADELADKTLEFARRIAE
RPTMAALLIKDSVNAASDAMGFTEALRHAFHIHELGHAHWAAHNENRYPVGLPPDVEDWRNAKPTRLARRDTP

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=236, Percent_Identity=31.3559322033898, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI31542718, Length=225, Percent_Identity=30.6666666666667, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788597, Length=278, Percent_Identity=28.7769784172662, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787659, Length=218, Percent_Identity=28.8990825688073, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787660, Length=231, Percent_Identity=29.4372294372294, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI87082183, Length=234, Percent_Identity=27.3504273504274, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=228, Percent_Identity=31.5789473684211, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17554946, Length=275, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17540714, Length=232, Percent_Identity=31.8965517241379, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540306, Length=264, Percent_Identity=29.1666666666667, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=230, Percent_Identity=24.7826086956522, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI20129971, Length=259, Percent_Identity=29.3436293436293, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653477, Length=259, Percent_Identity=29.3436293436293, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 34902; Mature: 34771

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAMTLSEQAGAQPGARPAEELVTYETLDEGRIARIWLNRPDAHNAQSRGLLVQLDEAFV
CCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEECHHHH
RAEADDAVRVVILAARGKNFSAGHDLGSELALAERQPGPGQHPTFRFNGATRDPIAEKTY
HCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEECCCCCCCCHHHHH
LQEWHYFFQNTCRWRDLRKITIAQVQGNAISAGLMLIWACDLIVAADNAKFSDVVGVRMG
HHHHHHHHHCCCCHHHHHEEEEEEECCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCC
MPGVEYYAHPWEFGPRKAKELLLTGDALDADEAYRLGMVSKVFPADELADKTLEFARRIA
CCCHHHCCCCCCCCCHHHHHEEEECCCCCCCHHHHHCCHHHHCCHHHHHHHHHHHHHHHH
ERPTMAALLIKDSVNAASDAMGFTEALRHAFHIHELGHAHWAAHNENRYPVGLPPDVEDW
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
RNAKPTRLARRDTP
CCCCCCHHHCCCCC
>Mature Secondary Structure 
GAMTLSEQAGAQPGARPAEELVTYETLDEGRIARIWLNRPDAHNAQSRGLLVQLDEAFV
CCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEECHHHH
RAEADDAVRVVILAARGKNFSAGHDLGSELALAERQPGPGQHPTFRFNGATRDPIAEKTY
HCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEECCCCCCCCHHHHH
LQEWHYFFQNTCRWRDLRKITIAQVQGNAISAGLMLIWACDLIVAADNAKFSDVVGVRMG
HHHHHHHHHCCCCHHHHHEEEEEEECCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCC
MPGVEYYAHPWEFGPRKAKELLLTGDALDADEAYRLGMVSKVFPADELADKTLEFARRIA
CCCHHHCCCCCCCCCHHHHHEEEECCCCCCCHHHHHCCHHHHCCHHHHHHHHHHHHHHHH
ERPTMAALLIKDSVNAASDAMGFTEALRHAFHIHELGHAHWAAHNENRYPVGLPPDVEDW
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
RNAKPTRLARRDTP
CCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA