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The map label for this gene is fadA6_1

Identifier: 41406608

GI number: 41406608

Start: 537668

End: 538828

Strand: Direct

Name: fadA6_1

Synonym: MAP0510

Alternate gene names: 41406608

Gene position: 537668-538828 (Clockwise)

Preceding gene: 41406607

Following gene: 41406615

Centisome position: 11.13

GC content: 69.16

Gene sequence:

>1161_bases
ATGCCTGAGGCGTACGTCATCGACGCTGTACGCACCGCGGTCGGCAAGCGCGGTGGATCGCTGGCCGGAATCCATCCGGT
CGACCTGGGCGCGCTGGGCTGGCGCGGGCTGCTGGACCGGGTCGACGTCGACCCCGCCGCCGTCGACGACGTGATCGCCG
GCTGCGTCGACGCCATCGGCGCCCAGGCCGGCAACATCGCCCGGCTCTCCTGGCTGGCCGCCGGCTATCCCGAAGAGGTG
CCCGGCGTCACCGTGGACCGGCAGTGCGGTTCCAGCCAGCAGGCGATTTCCTTTGGCGCGCAAGCGATCATGTCCGGGAC
CGCCGACCTCATCGTGGCCGGCGGCGTGCAGAACATGAGCCAGATCCCGATCTCGTCGGCGATGACGGTCGGCGAGCAGT
TCGGCTTCACCTCGCCCACCAACGAGTCCAAGCAGTGGCTGCACCGCTACGGCGATCAGGAGATCTCGCAATTCCGTGGC
TCGGAGCTGATCGCCGAGAAGTGGAACCTGTCCCGCGAGGAGATGGAACGCTACGCGCTGACCAGCCACGAGCGCGCCTT
CGCGGCCATCCGCGGCGGCCACTTCGACAACGAAATCATCACCGTGGAAACCGAATCCGGGCCGTTCCGGGTCGACGAGG
GTCCGCGCGAGTCGTCGCTGGAGAAGATGGCCGGCCTCAAGCCGCTGGTCGAGGGCGGCCGGCTGACCGCCGCGATGGCC
AGCCAGATCTCCGACGGCGCCAGCGCGGTGCTGCTGGCCTCCGAGCGGGCCGTCAACGACCACGGCCTGCAACCGCGCGC
CCGCATCCACCACATCAGCGCCCGCGCCGCCGACCCGGTGTTCATGCTCACCGGCCCCATTCCGGCCACCCGCTACGCGC
TGGACAAGACCGGGCTGTCCATCGACGACATCGACACCGTCGAGATCAACGAGGCCTTCGCGCCGGTGGTTTTGGCCTGG
CTCAAGGAGATCAAGGCCGACCCGGAGAAGGTCAACCCGAACGGCGGGGCGATCGCGCTCGGTCACCCGCTGGGCGCCAC
CGGCGCCAAGCTGTTCGCCACCATGCTCAACGAGCTGGAGCGCATCGGTGGCCGGTACGGTCTGCAGACCATGTGCGAGG
GCGGGGGCACCGCCAACGTCACCATCATCGAGCGGCTGTAA

Upstream 100 bases:

>100_bases
CGGACCGCTCACCGCCGAGCAAGTGGGTCAGCAGTACCTCGCCATCGTGTTGGGCGGGATCACGGTGGACGCGAAGAAAG
ACTAACGAAGGAGTCTGAAA

Downstream 100 bases:

>100_bases
CGGTTTTCCCGCGAGCTGCCCCTTCGCGACACTGCAACTACGCACCCGACACGCCGATCGGGATGTGCGTGGTTGCAATC
TCGTCGGGGCGCCTACCGGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MPEAYVIDAVRTAVGKRGGSLAGIHPVDLGALGWRGLLDRVDVDPAAVDDVIAGCVDAIGAQAGNIARLSWLAAGYPEEV
PGVTVDRQCGSSQQAISFGAQAIMSGTADLIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRG
SELIAEKWNLSREEMERYALTSHERAFAAIRGGHFDNEIITVETESGPFRVDEGPRESSLEKMAGLKPLVEGGRLTAAMA
SQISDGASAVLLASERAVNDHGLQPRARIHHISARAADPVFMLTGPIPATRYALDKTGLSIDDIDTVEINEAFAPVVLAW
LKEIKADPEKVNPNGGAIALGHPLGATGAKLFATMLNELERIGGRYGLQTMCEGGGTANVTIIERL

Sequences:

>Translated_386_residues
MPEAYVIDAVRTAVGKRGGSLAGIHPVDLGALGWRGLLDRVDVDPAAVDDVIAGCVDAIGAQAGNIARLSWLAAGYPEEV
PGVTVDRQCGSSQQAISFGAQAIMSGTADLIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRG
SELIAEKWNLSREEMERYALTSHERAFAAIRGGHFDNEIITVETESGPFRVDEGPRESSLEKMAGLKPLVEGGRLTAAMA
SQISDGASAVLLASERAVNDHGLQPRARIHHISARAADPVFMLTGPIPATRYALDKTGLSIDDIDTVEINEAFAPVVLAW
LKEIKADPEKVNPNGGAIALGHPLGATGAKLFATMLNELERIGGRYGLQTMCEGGGTANVTIIERL
>Mature_385_residues
PEAYVIDAVRTAVGKRGGSLAGIHPVDLGALGWRGLLDRVDVDPAAVDDVIAGCVDAIGAQAGNIARLSWLAAGYPEEVP
GVTVDRQCGSSQQAISFGAQAIMSGTADLIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRGS
ELIAEKWNLSREEMERYALTSHERAFAAIRGGHFDNEIITVETESGPFRVDEGPRESSLEKMAGLKPLVEGGRLTAAMAS
QISDGASAVLLASERAVNDHGLQPRARIHHISARAADPVFMLTGPIPATRYALDKTGLSIDDIDTVEINEAFAPVVLAWL
KEIKADPEKVNPNGGAIALGHPLGATGAKLFATMLNELERIGGRYGLQTMCEGGGTANVTIIERL

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=39.3316195372751, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=38.8324873096447, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=33.0788804071247, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI4501853, Length=401, Percent_Identity=36.6583541147132, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=33.953488372093, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=29.4871794871795, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=39.7058823529412, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=39.5989974937343, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI87082165, Length=395, Percent_Identity=37.2151898734177, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1788554, Length=401, Percent_Identity=38.6533665835411, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1788683, Length=406, Percent_Identity=28.5714285714286, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=394, Percent_Identity=37.8172588832487, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=32.8282828282828, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=30.5128205128205, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=30.4245283018868, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=28.2442748091603, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=35.264483627204, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6322031, Length=392, Percent_Identity=33.6734693877551, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24655093, Length=395, Percent_Identity=37.4683544303797, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=37.2750642673522, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=32.3232323232323, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=32.6291079812207, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24585051, Length=299, Percent_Identity=25.752508361204, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921506, Length=310, Percent_Identity=24.8387096774194, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 40910; Mature: 40779

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAYVIDAVRTAVGKRGGSLAGIHPVDLGALGWRGLLDRVDVDPAAVDDVIAGCVDAIG
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
AQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQAISFGAQAIMSGTADLIVAGGVQNMS
CCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHH
QIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRGSELIAEKWNLSREEMERYAL
HCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHCCCHHHHHHHCCCHHHHHHHHH
TSHERAFAAIRGGHFDNEIITVETESGPFRVDEGPRESSLEKMAGLKPLVEGGRLTAAMA
HHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHCCCHHHCCCCHHHHHH
SQISDGASAVLLASERAVNDHGLQPRARIHHISARAADPVFMLTGPIPATRYALDKTGLS
HHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCC
IDDIDTVEINEAFAPVVLAWLKEIKADPEKVNPNGGAIALGHPLGATGAKLFATMLNELE
CCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHH
RIGGRYGLQTMCEGGGTANVTIIERL
HHCCCCCHHHHHCCCCCEEEEEEECC
>Mature Secondary Structure 
PEAYVIDAVRTAVGKRGGSLAGIHPVDLGALGWRGLLDRVDVDPAAVDDVIAGCVDAIG
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
AQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQAISFGAQAIMSGTADLIVAGGVQNMS
CCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHH
QIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRGSELIAEKWNLSREEMERYAL
HCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHCCCHHHHHHHCCCHHHHHHHHH
TSHERAFAAIRGGHFDNEIITVETESGPFRVDEGPRESSLEKMAGLKPLVEGGRLTAAMA
HHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHCCCHHHCCCCHHHHHH
SQISDGASAVLLASERAVNDHGLQPRARIHHISARAADPVFMLTGPIPATRYALDKTGLS
HHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCC
IDDIDTVEINEAFAPVVLAWLKEIKADPEKVNPNGGAIALGHPLGATGAKLFATMLNELE
CCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHH
RIGGRYGLQTMCEGGGTANVTIIERL
HHCCCCCHHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]