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The map label for this gene is nhoA

Identifier: 41406599

GI number: 41406599

Start: 528543

End: 529373

Strand: Direct

Name: nhoA

Synonym: MAP0501

Alternate gene names: 41406599

Gene position: 528543-529373 (Clockwise)

Preceding gene: 41406598

Following gene: 41406605

Centisome position: 10.94

GC content: 71.48

Gene sequence:

>831_bases
ATGACGCTGGATCTGGGCGCGTATTTCGACCGCATCGGTTACGGCGGCAAGGCCGCGCCCAACCTCGAGGTGCTGCGGGC
CCTGATGGCCGCGCACACCGGCTCGATCCCGTTCGAGAACCTCGACCCGCTGATGGGGGTGCCGGTCGACGACCTGAGCC
CGGCGGCGCTGACCGACAAGCTGGTCCACCGGCGCCGCGGCGGCTACTGCTACGAGCAGAACGGCCTGCTGGGCTACGCG
CTGGCCGAAATCGGTTTCCGGGTGCGCCGATTGGCCGGCCGGGTGGTGTGGATGCAGCCGCCCGACACGCCGCCGCGCGC
CCAGACGCACACGGTCTTGGCGGTGACGTTCCCGGGCTCGCAGGGCGCCTACCTGGTCGACGTCGGCTTCGGTGGCCAGA
CGTTGCCCTCGCCCATCCGTTTCGAGACCGGCAACGCCCAGCAGACCACCCACGAGCCGTACCGGCTCGATGACCGCGGC
GAGGGCCTGGTGCTGCAGGCCCTGGTGCGCGATGAATGGCCGCCGCTGTACGTGTTCGGCACCCGCACCGTGCCGCAGAT
CGACCTGCTGGTGGGCAGCTGGTACGTCTCCACCCACCCGTCGTCGATGTTCGTCACCGGGCTGATGGTCGCGCGGACCA
CCGCCGACGCCCGGTGGAACCTGGCCGGGCGCGAGCTGACCGTGCACCGCGCGCAGAGCAGCGAGAAGATCCGCCTCGAC
GACGCGGACGCGGTGCTCGACGTGCTCGGGGAGCGGTTCGGCATCGACGTGGCCGGGATCGGCCAGCGCGGCGCGCTGCT
GGCGCGCATCGAGCAGGTGCTGGACGCCTGA

Upstream 100 bases:

>100_bases
AAGACGACCCCGGCGCAGTGGCGCGACGACCTGGAGGCGTTTTTGACCACCACAACCCAGGACACCTGGCTGTAACGCGC
CGGGCGCGGACAATGGTGGC

Downstream 100 bases:

>100_bases
GGGCGGGATTTGGCTAGCGGGCGCGCAGCCACGAGCCCAGCCGTCGCACCGCCTCCTCGATGTCGGTGGTGGGGCCGGCG
AAGGACAGCCGGACGAACGA

Product: NhoA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTLDLGAYFDRIGYGGKAAPNLEVLRALMAAHTGSIPFENLDPLMGVPVDDLSPAALTDKLVHRRRGGYCYEQNGLLGYA
LAEIGFRVRRLAGRVVWMQPPDTPPRAQTHTVLAVTFPGSQGAYLVDVGFGGQTLPSPIRFETGNAQQTTHEPYRLDDRG
EGLVLQALVRDEWPPLYVFGTRTVPQIDLLVGSWYVSTHPSSMFVTGLMVARTTADARWNLAGRELTVHRAQSSEKIRLD
DADAVLDVLGERFGIDVAGIGQRGALLARIEQVLDA

Sequences:

>Translated_276_residues
MTLDLGAYFDRIGYGGKAAPNLEVLRALMAAHTGSIPFENLDPLMGVPVDDLSPAALTDKLVHRRRGGYCYEQNGLLGYA
LAEIGFRVRRLAGRVVWMQPPDTPPRAQTHTVLAVTFPGSQGAYLVDVGFGGQTLPSPIRFETGNAQQTTHEPYRLDDRG
EGLVLQALVRDEWPPLYVFGTRTVPQIDLLVGSWYVSTHPSSMFVTGLMVARTTADARWNLAGRELTVHRAQSSEKIRLD
DADAVLDVLGERFGIDVAGIGQRGALLARIEQVLDA
>Mature_275_residues
TLDLGAYFDRIGYGGKAAPNLEVLRALMAAHTGSIPFENLDPLMGVPVDDLSPAALTDKLVHRRRGGYCYEQNGLLGYAL
AEIGFRVRRLAGRVVWMQPPDTPPRAQTHTVLAVTFPGSQGAYLVDVGFGGQTLPSPIRFETGNAQQTTHEPYRLDDRGE
GLVLQALVRDEWPPLYVFGTRTVPQIDLLVGSWYVSTHPSSMFVTGLMVARTTADARWNLAGRELTVHRAQSSEKIRLDD
ADAVLDVLGERFGIDVAGIGQRGALLARIEQVLDA

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649128, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI237649126, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI237649124, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI237649122, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI237649119, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI42741671, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI237649009, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI237649132, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI237649130, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI116295260, Length=256, Percent_Identity=27.734375, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787736, Length=261, Percent_Identity=39.8467432950192, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 30138; Mature: 30007

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDLGAYFDRIGYGGKAAPNLEVLRALMAAHTGSIPFENLDPLMGVPVDDLSPAALTDK
CEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHH
LVHRRRGGYCYEQNGLLGYALAEIGFRVRRLAGRVVWMQPPDTPPRAQTHTVLAVTFPGS
HHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCEEEEEEEECCC
QGAYLVDVGFGGQTLPSPIRFETGNAQQTTHEPYRLDDRGEGLVLQALVRDEWPPLYVFG
CCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCEECCCCCCCEEEEEEHHCCCCCEEEEE
TRTVPQIDLLVGSWYVSTHPSSMFVTGLMVARTTADARWNLAGRELTVHRAQSSEKIRLD
CCCCCEEEEEEEEEEEECCCCHHHHHHHHEEEECCCCEEECCCCEEEEEECCCCCEEEEC
DADAVLDVLGERFGIDVAGIGQRGALLARIEQVLDA
CHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TLDLGAYFDRIGYGGKAAPNLEVLRALMAAHTGSIPFENLDPLMGVPVDDLSPAALTDK
EECHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHH
LVHRRRGGYCYEQNGLLGYALAEIGFRVRRLAGRVVWMQPPDTPPRAQTHTVLAVTFPGS
HHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCEEEEEEEECCC
QGAYLVDVGFGGQTLPSPIRFETGNAQQTTHEPYRLDDRGEGLVLQALVRDEWPPLYVFG
CCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCEECCCCCCCEEEEEEHHCCCCCEEEEE
TRTVPQIDLLVGSWYVSTHPSSMFVTGLMVARTTADARWNLAGRELTVHRAQSSEKIRLD
CCCCCEEEEEEEEEEEECCCCHHHHHHHHEEEECCCCEEECCCCEEEEEECCCCCEEEEC
DADAVLDVLGERFGIDVAGIGQRGALLARIEQVLDA
CHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]