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The map label for this gene is hsaB [H]

Identifier: 41406598

GI number: 41406598

Start: 527954

End: 528517

Strand: Direct

Name: hsaB [H]

Synonym: MAP0500

Alternate gene names: 41406598

Gene position: 527954-528517 (Clockwise)

Preceding gene: 41406597

Following gene: 41406599

Centisome position: 10.93

GC content: 66.13

Gene sequence:

>564_bases
ATGGCTGCGCCGATCGATCCGCGGACCTTCCGGCAGGTGCTGGGCCAGTTCTGCACGGGCATCACCATCATCACCACGGT
GCACGACGAGGTGCCCGTCGGCTTCGCCTGCCAGTCCTTCGCGGCGCTGTCGCTGGACCCGCCGCTGGTGCTGTTCTGCC
CCACCAAGGTGTCGCGGTCCTGGAAGGCCATCGAGGCCACCGGCCGATTCTGCGTCAACGTGCTGACCGAGAAGCAGAAG
CACGTCTCGGCGCGGTTCGGGTCCAAGGAACCCGACAAGTTCGCCGGCATCGACTGGCATCCCTCCGAACTCGGCTCGCC
GATCATCGACGGGGCCCTGGCCCACATCGACTGCACCGTGGCCTCGGTGCACGAGGGGGGCGATCACTTCGTGGTGTTCG
GTGCGGTCCAATCCCTTTCGGAGGCACCGAAGATCAAGCCGCGGCCGCTGCTGTTCTATCGCGGGGAATACACCGGGATC
GAGCCGGACAAGACGACCCCGGCGCAGTGGCGCGACGACCTGGAGGCGTTTTTGACCACCACAACCCAGGACACCTGGCT
GTAA

Upstream 100 bases:

>100_bases
GCGAGGGAAGGCAAGTCGAAGACGACGACTGGGTCGCCCGGGAAAGCACCGCGGTCAGCCTGTGGGGCCACGACTTCACG
GTCGGCATGCGCGGCTGACC

Downstream 100 bases:

>100_bases
CGCGCCGGGCGCGGACAATGGTGGCATGACGCTGGATCTGGGCGCGTATTTCGACCGCATCGGTTACGGCGGCAAGGCCG
CGCCCAACCTCGAGGTGCTG

Product: hypothetical protein

Products: NAD(+); reduced flavin [C]

Alternate protein names: Flavin:NADH reductase [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MAAPIDPRTFRQVLGQFCTGITIITTVHDEVPVGFACQSFAALSLDPPLVLFCPTKVSRSWKAIEATGRFCVNVLTEKQK
HVSARFGSKEPDKFAGIDWHPSELGSPIIDGALAHIDCTVASVHEGGDHFVVFGAVQSLSEAPKIKPRPLLFYRGEYTGI
EPDKTTPAQWRDDLEAFLTTTTQDTWL

Sequences:

>Translated_187_residues
MAAPIDPRTFRQVLGQFCTGITIITTVHDEVPVGFACQSFAALSLDPPLVLFCPTKVSRSWKAIEATGRFCVNVLTEKQK
HVSARFGSKEPDKFAGIDWHPSELGSPIIDGALAHIDCTVASVHEGGDHFVVFGAVQSLSEAPKIKPRPLLFYRGEYTGI
EPDKTTPAQWRDDLEAFLTTTTQDTWL
>Mature_186_residues
AAPIDPRTFRQVLGQFCTGITIITTVHDEVPVGFACQSFAALSLDPPLVLFCPTKVSRSWKAIEATGRFCVNVLTEKQKH
VSARFGSKEPDKFAGIDWHPSELGSPIIDGALAHIDCTVASVHEGGDHFVVFGAVQSLSEAPKIKPRPLLFYRGEYTGIE
PDKTTPAQWRDDLEAFLTTTTQDTWL

Specific function: Catalyzes the reduction of free flavins (FMN or FAD) by NADH. Subsequently, the reduced flavins diffuse to the HsaA oxygenase subunit [H]

COG id: COG1853

COG function: function code R; Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the non-flavoprotein flavin reductase family [H]

Homologues:

Organism=Escherichia coli, GI87081819, Length=155, Percent_Identity=27.741935483871, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002563
- InterPro:   IPR012349
- InterPro:   IPR009002 [H]

Pfam domain/function: PF01613 Flavin_Reduct [H]

EC number: 1.6.8.- [C]

Molecular weight: Translated: 20544; Mature: 20412

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPIDPRTFRQVLGQFCTGITIITTVHDEVPVGFACQSFAALSLDPPLVLFCPTKVSRS
CCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHEEECCCCCEEEECCCCCCCC
WKAIEATGRFCVNVLTEKQKHVSARFGSKEPDKFAGIDWHPSELGSPIIDGALAHIDCTV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHCHHHHEEEEE
ASVHEGGDHFVVFGAVQSLSEAPKIKPRPLLFYRGEYTGIEPDKTTPAQWRDDLEAFLTT
EEEECCCCEEEEEHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHC
TTQDTWL
CCCCCCC
>Mature Secondary Structure 
AAPIDPRTFRQVLGQFCTGITIITTVHDEVPVGFACQSFAALSLDPPLVLFCPTKVSRS
CCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHEEECCCCCEEEECCCCCCCC
WKAIEATGRFCVNVLTEKQKHVSARFGSKEPDKFAGIDWHPSELGSPIIDGALAHIDCTV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHCHHHHEEEEE
ASVHEGGDHFVVFGAVQSLSEAPKIKPRPLLFYRGEYTGIEPDKTTPAQWRDDLEAFLTT
EEEECCCCEEEEEHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHC
TTQDTWL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; flavin [C]

Specific reaction: NADH + flavin = NAD(+) + reduced flavin [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]