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The map label for this gene is ispD

Identifier: 41406574

GI number: 41406574

Start: 503074

End: 503781

Strand: Direct

Name: ispD

Synonym: MAP0476

Alternate gene names: 41406574

Gene position: 503074-503781 (Clockwise)

Preceding gene: 41406573

Following gene: 41406575

Centisome position: 10.42

GC content: 74.44

Gene sequence:

>708_bases
TTGGTCCCGGAGACGGGGTTGGCCCCGGAGACGGGCAGCTCAGGCACCGTAGCCGCCGTCGTCCCGGCCGCCGGGTCGGG
GGAGCGACTGGCAGCGGGAATTCCCAAGGCATTCTGCGAGATCGACGGCGCCAGCATGCTGGCCCGCGCCGTCGCCGGTC
TGCTGGACTCCAAGGTGGTCGACCACGTGGTGGTGGCGGTACCCGCCGACCGCGTCGACGAGGCCAAACGACTGCTGCCC
GGGCAGGCCACCGTCGTCGCCGGCGGAGCCGACCGCACCGCATCCGTGCGCCTGGCCCTGGCCGCCGTCCCCGGCAACCC
CGCGTTCGTGCTGGTCCACGACGCCGCCCGCGCCCTGACGCCGCCGGCGCTGATCGCCCGGGTGGTGCAGGCGCTGCGCG
ACGGTCACCGCGCCGTGGTGCCGGCGCTGCCGCTGCACGACACCGTCAAGGCCGTGGACGCCAACGGGGTGGTGCTCGGC
ACGCCGGAACGCGACGGGCTGCGGGCGGTGCAGACACCGCAGGGTTTCGCCACCGACCTGCTGCTGCGCGCCTACGCCGC
CGGGGCCGGCACGGCGGGTTTCACCGACGACGCGTCGCTGGTCGAGCACGTCGGCGGCCAGGTCCAGGTGGTCGACGGCG
ACCCGCTGGCCTTCAAGATCACCACCCAGCTCGATCTGCTGCTGGCCGAGACCATCGTGCGCCGGTGA

Upstream 100 bases:

>100_bases
GTCGGTGAACTGGCGCTGGCCGAGAGCACCGACGACGCCAAGGCCGAGACCATCCTCGACGAGGTTCTGGCCGCCGCTTC
CTGAAGGTCCTGACACTTCA

Downstream 100 bases:

>100_bases
ACACCACCCCGCGGATCGGCCTGGGCGTCGACGTGCACCCGATCCAGCCCGGGCGGCCGTGCCGGCTGCTGGGCCTGCTT
TTCGACGACGCCGACGGCTG

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MVPETGLAPETGSSGTVAAVVPAAGSGERLAAGIPKAFCEIDGASMLARAVAGLLDSKVVDHVVVAVPADRVDEAKRLLP
GQATVVAGGADRTASVRLALAAVPGNPAFVLVHDAARALTPPALIARVVQALRDGHRAVVPALPLHDTVKAVDANGVVLG
TPERDGLRAVQTPQGFATDLLLRAYAAGAGTAGFTDDASLVEHVGGQVQVVDGDPLAFKITTQLDLLLAETIVRR

Sequences:

>Translated_235_residues
MVPETGLAPETGSSGTVAAVVPAAGSGERLAAGIPKAFCEIDGASMLARAVAGLLDSKVVDHVVVAVPADRVDEAKRLLP
GQATVVAGGADRTASVRLALAAVPGNPAFVLVHDAARALTPPALIARVVQALRDGHRAVVPALPLHDTVKAVDANGVVLG
TPERDGLRAVQTPQGFATDLLLRAYAAGAGTAGFTDDASLVEHVGGQVQVVDGDPLAFKITTQLDLLLAETIVRR
>Mature_235_residues
MVPETGLAPETGSSGTVAAVVPAAGSGERLAAGIPKAFCEIDGASMLARAVAGLLDSKVVDHVVVAVPADRVDEAKRLLP
GQATVVAGGADRTASVRLALAAVPGNPAFVLVHDAARALTPPALIARVVQALRDGHRAVVPALPLHDTVKAVDANGVVLG
TPERDGLRAVQTPQGFATDLLLRAYAAGAGTAGFTDDASLVEHVGGQVQVVDGDPLAFKITTQLDLLLAETIVRR

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family

Homologues:

Organism=Homo sapiens, GI157412259, Length=234, Percent_Identity=28.6324786324786, Blast_Score=85, Evalue=6e-17,
Organism=Escherichia coli, GI1789104, Length=226, Percent_Identity=36.283185840708, Blast_Score=95, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPD_MYCPA (Q743W5)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_959410.1
- ProteinModelPortal:   Q743W5
- SMR:   Q743W5
- EnsemblBacteria:   EBMYCT00000037572
- GeneID:   2719143
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP0476
- NMPDR:   fig|262316.1.peg.476
- GeneTree:   EBGT00050000016717
- HOGENOM:   HBG672839
- OMA:   SKVIVVC
- ProtClustDB:   PRK00155
- BRENDA:   2.7.7.60
- HAMAP:   MF_00108
- InterPro:   IPR001228
- InterPro:   IPR018294
- TIGRFAMs:   TIGR00453

Pfam domain/function: PF01128 IspD

EC number: =2.7.7.60

Molecular weight: Translated: 23798; Mature: 23798

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPETGLAPETGSSGTVAAVVPAAGSGERLAAGIPKAFCEIDGASMLARAVAGLLDSKVV
CCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHH
DHVVVAVPADRVDEAKRLLPGQATVVAGGADRTASVRLALAAVPGNPAFVLVHDAARALT
HHEEEEECCHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEECCCCCEEEEEECCHHHCC
PPALIARVVQALRDGHRAVVPALPLHDTVKAVDANGVVLGTPERDGLRAVQTPQGFATDL
CHHHHHHHHHHHHCCCEEEECCCCCCHHHHEECCCCEEEECCCCCCCEEECCCCCHHHHH
LLRAYAAGAGTAGFTDDASLVEHVGGQVQVVDGDPLAFKITTQLDLLLAETIVRR
HHHHHHCCCCCCCCCCCHHHHHHCCCEEEEEECCCEEEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MVPETGLAPETGSSGTVAAVVPAAGSGERLAAGIPKAFCEIDGASMLARAVAGLLDSKVV
CCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHH
DHVVVAVPADRVDEAKRLLPGQATVVAGGADRTASVRLALAAVPGNPAFVLVHDAARALT
HHEEEEECCHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEECCCCCEEEEEECCHHHCC
PPALIARVVQALRDGHRAVVPALPLHDTVKAVDANGVVLGTPERDGLRAVQTPQGFATDL
CHHHHHHHHHHHHCCCEEEECCCCCCHHHHEECCCCEEEECCCCCCCEEECCCCCHHHHH
LLRAYAAGAGTAGFTDDASLVEHVGGQVQVVDGDPLAFKITTQLDLLLAETIVRR
HHHHHHCCCCCCCCCCCHHHHHHCCCEEEEEECCCEEEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA