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The map label for this gene is fdxH [H]

Identifier: 41406467

GI number: 41406467

Start: 395593

End: 396567

Strand: Direct

Name: fdxH [H]

Synonym: MAP0369

Alternate gene names: 41406467

Gene position: 395593-396567 (Clockwise)

Preceding gene: 41406466

Following gene: 41406468

Centisome position: 8.19

GC content: 71.18

Gene sequence:

>975_bases
ATGGGCCAGCTGACCGGACCGACCGACCCGGCCGCCGACGCCGGCTGGGCGGATCGCAAGCCGCGCAAGGGTTTTTTCAC
CGACACCTCGATCTGCATCGGGTGCAAGGCCTGCGAGGTCGCCTGCAAGGAATGGAACCGCAACCCGCAGGACGGCGACC
TCGAGCTGCTGGGCTCGTCCTACGACAACACCGGCGCGCTGGGCGCCAGCACCTGGCGGCACGTGGCCTTCGTCGAACAG
GGTCGCGAACGCATCGAGCAGGCACGCGAATCCGGCAGGGCGCTCATCGATTTGGGCATGCCGACCCTCCCCGGCGCGGC
CTCCGAGCCGACCGAGCCGGCGGTGCCGCACACCCCGGAGTTCCGCTGGCTGATGTCCTCGGACGTCTGCAAGCACTGCA
CGCACGCCGGCTGCCTGGACGTCTGCCCCACCGGCGCGCTGTTTCGCACCGAATTCGGCACGGTGGTGGTGCAGCACGAC
GTCTGCAACGGATGCGGCACCTGCGTGGCGGGCTGCCCGTTCGGGGTCGTCGAGCGGCGCAACGACGGGACCTACGCGAC
ACCGGCGCAACGGCCGGACCGCCCCAGCGAGGAGATCGTCACCGGCGTCGCGCAGAAGTGCACGCTGTGTTACGACCGGC
TGCTCGAGGACGAGATCCCGGCGTGCGCCAAGACCTGCCCCACCACCTCGATCAAGTTCGGCGACCACGACGACCTGGTG
GCCATGGCGCGCCGGCGGGTGGCCGCCCTGCACGCCCAGGGGCTCACCGAGGCCCGGCTGTACGGGGCCAACGAGCACGA
CGGCGTCGGCGGCACCGGCTCCATCTTCTTGCTGCTCGACGAACCCGAGGTCTACGGTCTGCCGCCCGACCCGCGGGTGT
GCACCGCCGACCTGACGACCATGTTCAAGCGGGCCGGGCTGGCCGCGGCCGGCATGGTCGGGGCGGCCGTGCTGGCGTTT
TGGAGGAGCCGGTGA

Upstream 100 bases:

>100_bases
AGCTGCTCCGGCTGATCGCCGACTACCAGTCGCGCTCGGGCGTCACCGCCGAGACCGGCAACGTGCGGGTGGACGATGCC
GTGTGGGAAAGGGGGAGCTG

Downstream 100 bases:

>100_bases
GCACCTCGGAATTCGACAGTTTCCGGCCGCCTGAACCGGCGGGCGGCAAGCGCCGCAAAGACAAGCGCGGCGGCCGGCGC
GGGGCGGGCGACGGCTCCCG

Product: hypothetical protein

Products: CO2; NADH

Alternate protein names: Formate dehydrogenase subunit beta; FDH subunit beta [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MGQLTGPTDPAADAGWADRKPRKGFFTDTSICIGCKACEVACKEWNRNPQDGDLELLGSSYDNTGALGASTWRHVAFVEQ
GRERIEQARESGRALIDLGMPTLPGAASEPTEPAVPHTPEFRWLMSSDVCKHCTHAGCLDVCPTGALFRTEFGTVVVQHD
VCNGCGTCVAGCPFGVVERRNDGTYATPAQRPDRPSEEIVTGVAQKCTLCYDRLLEDEIPACAKTCPTTSIKFGDHDDLV
AMARRRVAALHAQGLTEARLYGANEHDGVGGTGSIFLLLDEPEVYGLPPDPRVCTADLTTMFKRAGLAAAGMVGAAVLAF
WRSR

Sequences:

>Translated_324_residues
MGQLTGPTDPAADAGWADRKPRKGFFTDTSICIGCKACEVACKEWNRNPQDGDLELLGSSYDNTGALGASTWRHVAFVEQ
GRERIEQARESGRALIDLGMPTLPGAASEPTEPAVPHTPEFRWLMSSDVCKHCTHAGCLDVCPTGALFRTEFGTVVVQHD
VCNGCGTCVAGCPFGVVERRNDGTYATPAQRPDRPSEEIVTGVAQKCTLCYDRLLEDEIPACAKTCPTTSIKFGDHDDLV
AMARRRVAALHAQGLTEARLYGANEHDGVGGTGSIFLLLDEPEVYGLPPDPRVCTADLTTMFKRAGLAAAGMVGAAVLAF
WRSR
>Mature_323_residues
GQLTGPTDPAADAGWADRKPRKGFFTDTSICIGCKACEVACKEWNRNPQDGDLELLGSSYDNTGALGASTWRHVAFVEQG
RERIEQARESGRALIDLGMPTLPGAASEPTEPAVPHTPEFRWLMSSDVCKHCTHAGCLDVCPTGALFRTEFGTVVVQHDV
CNGCGTCVAGCPFGVVERRNDGTYATPAQRPDRPSEEIVTGVAQKCTLCYDRLLEDEIPACAKTCPTTSIKFGDHDDLVA
MARRRVAALHAQGLTEARLYGANEHDGVGGTGSIFLLLDEPEVYGLPPDPRVCTADLTTMFKRAGLAAAGMVGAAVLAFW
RSR

Specific function: Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron- sulfur centers. Electrons are transferred from the gamma chain to the m

COG id: COG0437

COG function: function code C; Fe-S-cluster-containing hydrogenase components 1

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Escherichia coli, GI1787749, Length=304, Percent_Identity=34.5394736842105, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1790326, Length=272, Percent_Identity=34.1911764705882, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI2367345, Length=247, Percent_Identity=28.7449392712551, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787122, Length=218, Percent_Identity=28.4403669724771, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789370, Length=349, Percent_Identity=24.6418338108883, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1787872, Length=220, Percent_Identity=27.7272727272727, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI226510944, Length=127, Percent_Identity=34.6456692913386, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789067, Length=235, Percent_Identity=27.6595744680851, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082180, Length=123, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1789079, Length=171, Percent_Identity=26.9005847953216, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR006470
- InterPro:   IPR014603
- InterPro:   IPR015246 [H]

Pfam domain/function: PF09163 Form-deh_trans [H]

EC number: 1.2.1.2

Molecular weight: Translated: 34733; Mature: 34601

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQLTGPTDPAADAGWADRKPRKGFFTDTSICIGCKACEVACKEWNRNPQDGDLELLGSS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCC
YDNTGALGASTWRHVAFVEQGRERIEQARESGRALIDLGMPTLPGAASEPTEPAVPHTPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
FRWLMSSDVCKHCTHAGCLDVCPTGALFRTEFGTVVVQHDVCNGCGTCVAGCPFGVVERR
HHHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCEEEEEECCCCCHHHHHHCCCCCCEEEC
NDGTYATPAQRPDRPSEEIVTGVAQKCTLCYDRLLEDEIPACAKTCPTTSIKFGDHDDLV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEECCCCHHHH
AMARRRVAALHAQGLTEARLYGANEHDGVGGTGSIFLLLDEPEVYGLPPDPRVCTADLTT
HHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCEEEEEECCCCEECCCCCCCEEHHHHHH
MFKRAGLAAAGMVGAAVLAFWRSR
HHHHHCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GQLTGPTDPAADAGWADRKPRKGFFTDTSICIGCKACEVACKEWNRNPQDGDLELLGSS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCC
YDNTGALGASTWRHVAFVEQGRERIEQARESGRALIDLGMPTLPGAASEPTEPAVPHTPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
FRWLMSSDVCKHCTHAGCLDVCPTGALFRTEFGTVVVQHDVCNGCGTCVAGCPFGVVERR
HHHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCEEEEEECCCCCHHHHHHCCCCCCEEEC
NDGTYATPAQRPDRPSEEIVTGVAQKCTLCYDRLLEDEIPACAKTCPTTSIKFGDHDDLV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEECCCCHHHH
AMARRRVAALHAQGLTEARLYGANEHDGVGGTGSIFLLLDEPEVYGLPPDPRVCTADLTT
HHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCEEEEEECCCCEECCCCCCCEEHHHHHH
MFKRAGLAAAGMVGAAVLAFWRSR
HHHHHCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formate; NAD+

Specific reaction: formate + NAD+ = CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]