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The map label for this gene is fdhA [H]

Identifier: 41406466

GI number: 41406466

Start: 392969

End: 395593

Strand: Direct

Name: fdhA [H]

Synonym: MAP0368

Alternate gene names: 41406466

Gene position: 392969-395593 (Clockwise)

Preceding gene: 41406465

Following gene: 41406467

Centisome position: 8.14

GC content: 69.64

Gene sequence:

>2625_bases
ATGGCCGAGTGTCACCCGGTCGGCTTCCAATGGGTGGAAGAGGCCCGGGCCCGCGGCGCGCGGGTGATCCACGTCGACCC
GCGATTCACCCGCACCTCGGCGGTCTCCGACCGGCACATCCCGATCCGGGCCGGTTCGGACGTGGTGCTGCTCGGCGCGC
TGATCAACCACGTGCTCACCAACGACCTGTGGTTCTCCGAATACGTCGTCGCGTACACCAACGCCGCCACCATCATCAAC
GAAAACTTCCGCGACACCGAGGATCTCGGCGGCCTGTTCTCCGGGTTCGATCCCGAGACCGGGCAGTACGACACGTCGAG
TTGGGCCTACGAAGAGGAGGACGACGGCCGGTCCGGAGGCGAAATCGAGTCCCCCGGCGGCGGTCACACCCACGGCGCCA
CCGCCACCCACAGCGCCGCCGGTGACGAGCACGGCAGCGGCGGCCCGCCGCTGGCGCACGCCAGGGTGCGCCGCGACGAG
ACCCTGCAGCACCCGCGGACCGTCTTCCAGATCCTCAAGCGGCACTACGCCCGCTACACGCCGGAGATGGTCAAAGACGT
GTGCGGGATCAGCCGGGAGGACTTCGACTACCTGGCCCGCTCCATCGTGGAGAACTCCGGGCGCGAGCGCACCACCTGCT
TCGCCTACGCCGTCGGCTGGACGCAGCACACCCTGGGCGCCCAATTCATCCGCACCGCAACGATTTTGCAGCTGCTGATG
GGCAACGTCGGGCGCCCGGGCAGCGGCATCATGGCGCTGCGCGGCCACGCCACCATCCAGGGCTCCACCGACATCCCCAC
GCTGTTCAACCTGCTGCCCGGCTATCTGCCGATGCCCAAGGCGGGCGTGCACGACACCCTGGCCGACTACCTGGCCGCGG
TGGGATCCAAGAAACAGAAGGGCTTCTGGGCCAACGCCGACGCCTACACCGTCAGCCTGCTCAAGGCGTGGTGGGGCGAG
GCGGCCACCGCGGACAACGACTGGGCCTACGACTACCTGCCCCGACTGACCGGCCCGCACGGCACCTACCAGACCGTGAT
GGGCATGCTGGCCGACGAGGTCGAGGGCTACTTCCTGCTCGGCCAGAACCCCGCGGTCGGTTCGGCGCACGGCCGGATGC
AACGGCTGGGCATGTCGCATCTCAAGTGGCTGGTGGTGCGCGACTTCAACCTGATCGAATCGGCCACCTGGTGGAAGGAC
GGGCCCGAAATCGCCTCCGGGGAACTGAAAACCGAGGAGATCGAGACCGAGGTGTTCTTCCTGCCCGCCGCCACGCACGT
GGAGAAGGCCGGATCCTTCACGCAGACACAACGATTGGTGCAGTGGCGGCACCAGGCCGTCGAGCCGCCGGGACAGTGCC
AGAGCGAACTGCAGTTCTTCTACGAACTCGGCAAGCGGATCCGGCAACGGCTGGCTGGCTCGACCGACGAGCGGGACCGG
CCGCTGCTGGATCTGACCTGGGACTACCCCACCGACGAGCACGGCGACCCGGACGGGGAGGCGGTGCTGGCCGAGATCAA
CGGATACCGGGTCGGCGAGCCCGCGGACCCGTTGGCGTCCTACACCGAGCTGCGCGCCGACGGGTCGACCGCCGCCGGCT
GCTGGATCTACACCGGGGTGTACGCCAACGCCGTCAACCAGGCCGCGCGCCGGGTGCCCAACGGCGGTGCGTCACCGAGC
CAATCGGAGTGGGGCTGGGCGTGGCCCGCCGACCGGCGGGTGCTCTACAACCGCGCGTCGGCCGACCCGGACGGCAAACC
GTGGAGCGAACGCAAGCGCTACATCTGGTGGGATCCCGACCAGCGACGCTGGGTCGGCTACGACGTGCCGGACTTCGTGG
TCGACCGAGCCCCGGGCGCCCGGCCCGACCCCGAGCTGGGCGGCCCCGACGCGCTGGCCGGCGACGACCCGTTCATCATG
CAGGCCGACGGCAAGGGCTGGCTGTTCGCGCCCAAGGGTGTGGTCGACGGGCCGCTGCCCACGCACTACGAGCCGCAGGA
ATCGCCGGTGGCCAACGCGCTGTATCCCCAGCAGCGCAACCCGGCGCGAATCACCTTCGCGCGCAAGGACAATCTCAGCG
CACCCAGCGCCGGCGAGCCGGGCTCCGACGTCTACCCGTACGTGTTCACCACCTACCGGCTCACCGAGCATCACACCGCC
GGCGGCATGAGCCGGTGGCTGCCCTACCTCTCGGAGCTGCAACCGGAGATGTTCTGCGAGGTCTCGCCCGAGCTGGCCGC
CGAACGCGGCCTGCAGCCGTACGGGTGGGCCACCATCATCTCGCCGCGGGCCGCCATCGAGGCTCGGGTGCTGGTCACCA
AACGTGTTGCGCCGCTGGTCATCAACGGCCACACCGTGCACCAGATCGGGCTGCCCTACCACTGGGGTGTGGGCGGCGAC
GCGGTGGTCAGCGGGGACGCGGCCAACGACCTGCTCGGTGTCACACTGGATCCCAACGTGCAGATCCAGGAATCCAAGGC
CGGGTCGTGCGACATCCGCCCGGGCCGCCGCCCGCGCGGCGAGGAGCTGCTCCGGCTGATCGCCGACTACCAGTCGCGCT
CGGGCGTCACCGCCGAGACCGGCAACGTGCGGGTGGACGATGCCGTGTGGGAAAGGGGGAGCTGA

Upstream 100 bases:

>100_bases
CACGGTTCCCGGTCTGGGAGCCTCCTTCGGGCGCGGCGGCGCCACCCAATCACTGCAAGACATGGCCAATGCCGACTGCA
TCGTCATCCAGGGCTCCAAC

Downstream 100 bases:

>100_bases
TGGGCCAGCTGACCGGACCGACCGACCCGGCCGCCGACGCCGGCTGGGCGGATCGCAAGCCGCGCAAGGGTTTTTTCACC
GACACCTCGATCTGCATCGG

Product: hypothetical protein

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 874; Mature: 873

Protein sequence:

>874_residues
MAECHPVGFQWVEEARARGARVIHVDPRFTRTSAVSDRHIPIRAGSDVVLLGALINHVLTNDLWFSEYVVAYTNAATIIN
ENFRDTEDLGGLFSGFDPETGQYDTSSWAYEEEDDGRSGGEIESPGGGHTHGATATHSAAGDEHGSGGPPLAHARVRRDE
TLQHPRTVFQILKRHYARYTPEMVKDVCGISREDFDYLARSIVENSGRERTTCFAYAVGWTQHTLGAQFIRTATILQLLM
GNVGRPGSGIMALRGHATIQGSTDIPTLFNLLPGYLPMPKAGVHDTLADYLAAVGSKKQKGFWANADAYTVSLLKAWWGE
AATADNDWAYDYLPRLTGPHGTYQTVMGMLADEVEGYFLLGQNPAVGSAHGRMQRLGMSHLKWLVVRDFNLIESATWWKD
GPEIASGELKTEEIETEVFFLPAATHVEKAGSFTQTQRLVQWRHQAVEPPGQCQSELQFFYELGKRIRQRLAGSTDERDR
PLLDLTWDYPTDEHGDPDGEAVLAEINGYRVGEPADPLASYTELRADGSTAAGCWIYTGVYANAVNQAARRVPNGGASPS
QSEWGWAWPADRRVLYNRASADPDGKPWSERKRYIWWDPDQRRWVGYDVPDFVVDRAPGARPDPELGGPDALAGDDPFIM
QADGKGWLFAPKGVVDGPLPTHYEPQESPVANALYPQQRNPARITFARKDNLSAPSAGEPGSDVYPYVFTTYRLTEHHTA
GGMSRWLPYLSELQPEMFCEVSPELAAERGLQPYGWATIISPRAAIEARVLVTKRVAPLVINGHTVHQIGLPYHWGVGGD
AVVSGDAANDLLGVTLDPNVQIQESKAGSCDIRPGRRPRGEELLRLIADYQSRSGVTAETGNVRVDDAVWERGS

Sequences:

>Translated_874_residues
MAECHPVGFQWVEEARARGARVIHVDPRFTRTSAVSDRHIPIRAGSDVVLLGALINHVLTNDLWFSEYVVAYTNAATIIN
ENFRDTEDLGGLFSGFDPETGQYDTSSWAYEEEDDGRSGGEIESPGGGHTHGATATHSAAGDEHGSGGPPLAHARVRRDE
TLQHPRTVFQILKRHYARYTPEMVKDVCGISREDFDYLARSIVENSGRERTTCFAYAVGWTQHTLGAQFIRTATILQLLM
GNVGRPGSGIMALRGHATIQGSTDIPTLFNLLPGYLPMPKAGVHDTLADYLAAVGSKKQKGFWANADAYTVSLLKAWWGE
AATADNDWAYDYLPRLTGPHGTYQTVMGMLADEVEGYFLLGQNPAVGSAHGRMQRLGMSHLKWLVVRDFNLIESATWWKD
GPEIASGELKTEEIETEVFFLPAATHVEKAGSFTQTQRLVQWRHQAVEPPGQCQSELQFFYELGKRIRQRLAGSTDERDR
PLLDLTWDYPTDEHGDPDGEAVLAEINGYRVGEPADPLASYTELRADGSTAAGCWIYTGVYANAVNQAARRVPNGGASPS
QSEWGWAWPADRRVLYNRASADPDGKPWSERKRYIWWDPDQRRWVGYDVPDFVVDRAPGARPDPELGGPDALAGDDPFIM
QADGKGWLFAPKGVVDGPLPTHYEPQESPVANALYPQQRNPARITFARKDNLSAPSAGEPGSDVYPYVFTTYRLTEHHTA
GGMSRWLPYLSELQPEMFCEVSPELAAERGLQPYGWATIISPRAAIEARVLVTKRVAPLVINGHTVHQIGLPYHWGVGGD
AVVSGDAANDLLGVTLDPNVQIQESKAGSCDIRPGRRPRGEELLRLIADYQSRSGVTAETGNVRVDDAVWERGS
>Mature_873_residues
AECHPVGFQWVEEARARGARVIHVDPRFTRTSAVSDRHIPIRAGSDVVLLGALINHVLTNDLWFSEYVVAYTNAATIINE
NFRDTEDLGGLFSGFDPETGQYDTSSWAYEEEDDGRSGGEIESPGGGHTHGATATHSAAGDEHGSGGPPLAHARVRRDET
LQHPRTVFQILKRHYARYTPEMVKDVCGISREDFDYLARSIVENSGRERTTCFAYAVGWTQHTLGAQFIRTATILQLLMG
NVGRPGSGIMALRGHATIQGSTDIPTLFNLLPGYLPMPKAGVHDTLADYLAAVGSKKQKGFWANADAYTVSLLKAWWGEA
ATADNDWAYDYLPRLTGPHGTYQTVMGMLADEVEGYFLLGQNPAVGSAHGRMQRLGMSHLKWLVVRDFNLIESATWWKDG
PEIASGELKTEEIETEVFFLPAATHVEKAGSFTQTQRLVQWRHQAVEPPGQCQSELQFFYELGKRIRQRLAGSTDERDRP
LLDLTWDYPTDEHGDPDGEAVLAEINGYRVGEPADPLASYTELRADGSTAAGCWIYTGVYANAVNQAARRVPNGGASPSQ
SEWGWAWPADRRVLYNRASADPDGKPWSERKRYIWWDPDQRRWVGYDVPDFVVDRAPGARPDPELGGPDALAGDDPFIMQ
ADGKGWLFAPKGVVDGPLPTHYEPQESPVANALYPQQRNPARITFARKDNLSAPSAGEPGSDVYPYVFTTYRLTEHHTAG
GMSRWLPYLSELQPEMFCEVSPELAAERGLQPYGWATIISPRAAIEARVLVTKRVAPLVINGHTVHQIGLPYHWGVGGDA
VVSGDAANDLLGVTLDPNVQIQESKAGSCDIRPGRRPRGEELLRLIADYQSRSGVTAETGNVRVDDAVWERGS

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868720, Length=850, Percent_Identity=37.5294117647059, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI3868719, Length=852, Percent_Identity=37.0892018779343, Blast_Score=520, Evalue=1e-148,
Organism=Escherichia coli, GI3868721, Length=299, Percent_Identity=22.742474916388, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 96343; Mature: 96212

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAECHPVGFQWVEEARARGARVIHVDPRFTRTSAVSDRHIPIRAGSDVVLLGALINHVLT
CCCCCCCCHHHHHHHHHCCCEEEEECCCCCHHCCCCCCCCEEECCCCEEHHHHHHHHHHH
NDLWFSEYVVAYTNAATIINENFRDTEDLGGLFSGFDPETGQYDTSSWAYEEEDDGRSGG
CCHHHHHEEHEEECHHEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
EIESPGGGHTHGATATHSAAGDEHGSGGPPLAHARVRRDETLQHPRTVFQILKRHYARYT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEMVKDVCGISREDFDYLARSIVENSGRERTTCFAYAVGWTQHTLGAQFIRTATILQLLM
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHH
GNVGRPGSGIMALRGHATIQGSTDIPTLFNLLPGYLPMPKAGVHDTLADYLAAVGSKKQK
CCCCCCCCCEEEEECCEEEECCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
GFWANADAYTVSLLKAWWGEAATADNDWAYDYLPRLTGPHGTYQTVMGMLADEVEGYFLL
CEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEE
GQNPAVGSAHGRMQRLGMSHLKWLVVRDFNLIESATWWKDGPEIASGELKTEEIETEVFF
CCCCCCCCHHHHHHHHHHHHHEEEEEECCHHHHCCCCCCCCCCCCCCCCCHHEECEEEEE
LPAATHVEKAGSFTQTQRLVQWRHQAVEPPGQCQSELQFFYELGKRIRQRLAGSTDERDR
ECCHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PLLDLTWDYPTDEHGDPDGEAVLAEINGYRVGEPADPLASYTELRADGSTAAGCWIYTGV
CEEEEEECCCCCCCCCCCCCEEEEEECCEECCCCCCHHHHHHHHHCCCCCCCCHHEEHHH
YANAVNQAARRVPNGGASPSQSEWGWAWPADRRVLYNRASADPDGKPWSERKRYIWWDPD
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCHHHCCCEEEECCC
QRRWVGYDVPDFVVDRAPGARPDPELGGPDALAGDDPFIMQADGKGWLFAPKGVVDGPLP
CCCEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCC
THYEPQESPVANALYPQQRNPARITFARKDNLSAPSAGEPGSDVYPYVFTTYRLTEHHTA
CCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCC
GGMSRWLPYLSELQPEMFCEVSPELAAERGLQPYGWATIISPRAAIEARVLVTKRVAPLV
CCHHHHHHHHHHCCHHHHHCCCHHHHHHCCCCCCCCEEEECCHHHHHEEEEEECCCCCEE
INGHTVHQIGLPYHWGVGGDAVVSGDAANDLLGVTLDPNVQIQESKAGSCDIRPGRRPRG
ECCCEEEEECCCEEECCCCCEEECCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCH
EELLRLIADYQSRSGVTAETGNVRVDDAVWERGS
HHHHHHHHHHHHCCCCEECCCCEEECHHHHCCCC
>Mature Secondary Structure 
AECHPVGFQWVEEARARGARVIHVDPRFTRTSAVSDRHIPIRAGSDVVLLGALINHVLT
CCCCCCCHHHHHHHHHCCCEEEEECCCCCHHCCCCCCCCEEECCCCEEHHHHHHHHHHH
NDLWFSEYVVAYTNAATIINENFRDTEDLGGLFSGFDPETGQYDTSSWAYEEEDDGRSGG
CCHHHHHEEHEEECHHEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
EIESPGGGHTHGATATHSAAGDEHGSGGPPLAHARVRRDETLQHPRTVFQILKRHYARYT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEMVKDVCGISREDFDYLARSIVENSGRERTTCFAYAVGWTQHTLGAQFIRTATILQLLM
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHH
GNVGRPGSGIMALRGHATIQGSTDIPTLFNLLPGYLPMPKAGVHDTLADYLAAVGSKKQK
CCCCCCCCCEEEEECCEEEECCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
GFWANADAYTVSLLKAWWGEAATADNDWAYDYLPRLTGPHGTYQTVMGMLADEVEGYFLL
CEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEE
GQNPAVGSAHGRMQRLGMSHLKWLVVRDFNLIESATWWKDGPEIASGELKTEEIETEVFF
CCCCCCCCHHHHHHHHHHHHHEEEEEECCHHHHCCCCCCCCCCCCCCCCCHHEECEEEEE
LPAATHVEKAGSFTQTQRLVQWRHQAVEPPGQCQSELQFFYELGKRIRQRLAGSTDERDR
ECCHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PLLDLTWDYPTDEHGDPDGEAVLAEINGYRVGEPADPLASYTELRADGSTAAGCWIYTGV
CEEEEEECCCCCCCCCCCCCEEEEEECCEECCCCCCHHHHHHHHHCCCCCCCCHHEEHHH
YANAVNQAARRVPNGGASPSQSEWGWAWPADRRVLYNRASADPDGKPWSERKRYIWWDPD
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCHHHCCCEEEECCC
QRRWVGYDVPDFVVDRAPGARPDPELGGPDALAGDDPFIMQADGKGWLFAPKGVVDGPLP
CCCEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCC
THYEPQESPVANALYPQQRNPARITFARKDNLSAPSAGEPGSDVYPYVFTTYRLTEHHTA
CCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCC
GGMSRWLPYLSELQPEMFCEVSPELAAERGLQPYGWATIISPRAAIEARVLVTKRVAPLV
CCHHHHHHHHHHCCHHHHHCCCHHHHHHCCCCCCCCEEEECCHHHHHEEEEEECCCCCEE
INGHTVHQIGLPYHWGVGGDAVVSGDAANDLLGVTLDPNVQIQESKAGSCDIRPGRRPRG
ECCCEEEEECCCEEECCCCCEEECCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCH
EELLRLIADYQSRSGVTAETGNVRVDDAVWERGS
HHHHHHHHHHHHCCCCEECCCCEEECHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA