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The map label for this gene is fdhA [H]

Identifier: 41406465

GI number: 41406465

Start: 392279

End: 392860

Strand: Direct

Name: fdhA [H]

Synonym: MAP0367

Alternate gene names: 41406465

Gene position: 392279-392860 (Clockwise)

Preceding gene: 41406464

Following gene: 41406466

Centisome position: 8.12

GC content: 67.53

Gene sequence:

>582_bases
ATGGCCCCGAAAAAAGCCCTGAGCAAGGTGTTTCTGGAATGGCCCGTGCTGCGCCAGGTGCGCTCGACGGACAAACTCGG
CCGCGGCTCGGCGGTGACCTCCAAACACACCCGCGCGCTGGCGCCGCGCACCGCCACCGCCGACCGGGTGGTGCAGAGCG
TGTGCCCGTACTGCGCCGTCGGCTGCGGCCAGCGGGTGTACGTCAAGGACGAGCGGGTCGTGGCGATCGAGGGCGACCCC
GATTCGCCGATCTCGCGAGGACGCTTGTGCCCCAAGGGATCTGCGAGCGAGCAGTTGGTGAACTCGCCGGGGCGGCAGCT
GCAGGTGCTCTACCGCGCGCCGCGCGCCACCGAATGGCAGCCGCTGCAGCTGGACACCGCGATCGACATGATCGCCGACC
GCTTCGTGGAATCGCGCCGCAACAGCTGGCAGGACATCGACAAGAAGGGCAACCTGCTGCGCCGCACCATGGGCATCGCC
GCGCTGGGCGGCGCGACCCTGGACAACGAAGAGAACTACCTCATCAAGAAGCTCTTCACCGCCGCGGGCGCCATTCAGAT
CGAGAACCAAGCCCGTATTTGA

Upstream 100 bases:

>100_bases
CGGCGAGCACACCATCGTGGTGCGCTGAGCGGGCCGATAACAGATGGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCG
ATCGCCATTAGGGTGAGGGG

Downstream 100 bases:

>100_bases
CACAGTGCCACGGTTCCCGGTCTGGGAGCCTCCTTCGGGCGCGGCGGCGCCACCCAATCACTGCAAGACATGGCCAATGC
CGACTGCATCGTCATCCAGG

Product: hypothetical protein

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MAPKKALSKVFLEWPVLRQVRSTDKLGRGSAVTSKHTRALAPRTATADRVVQSVCPYCAVGCGQRVYVKDERVVAIEGDP
DSPISRGRLCPKGSASEQLVNSPGRQLQVLYRAPRATEWQPLQLDTAIDMIADRFVESRRNSWQDIDKKGNLLRRTMGIA
ALGGATLDNEENYLIKKLFTAAGAIQIENQARI

Sequences:

>Translated_193_residues
MAPKKALSKVFLEWPVLRQVRSTDKLGRGSAVTSKHTRALAPRTATADRVVQSVCPYCAVGCGQRVYVKDERVVAIEGDP
DSPISRGRLCPKGSASEQLVNSPGRQLQVLYRAPRATEWQPLQLDTAIDMIADRFVESRRNSWQDIDKKGNLLRRTMGIA
ALGGATLDNEENYLIKKLFTAAGAIQIENQARI
>Mature_192_residues
APKKALSKVFLEWPVLRQVRSTDKLGRGSAVTSKHTRALAPRTATADRVVQSVCPYCAVGCGQRVYVKDERVVAIEGDPD
SPISRGRLCPKGSASEQLVNSPGRQLQVLYRAPRATEWQPLQLDTAIDMIADRFVESRRNSWQDIDKKGNLLRRTMGIAA
LGGATLDNEENYLIKKLFTAAGAIQIENQARI

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868720, Length=181, Percent_Identity=32.5966850828729, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI3868719, Length=181, Percent_Identity=32.0441988950276, Blast_Score=96, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 21318; Mature: 21187

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPKKALSKVFLEWPVLRQVRSTDKLGRGSAVTSKHTRALAPRTATADRVVQSVCPYCAV
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
GCGQRVYVKDERVVAIEGDPDSPISRGRLCPKGSASEQLVNSPGRQLQVLYRAPRATEWQ
CCCCEEEEECCEEEEEECCCCCCHHCCCCCCCCCCHHHHHHCCCCEEEHEEECCCCCCCC
PLQLDTAIDMIADRFVESRRNSWQDIDKKGNLLRRTMGIAALGGATLDNEENYLIKKLFT
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AAGAIQIENQARI
HHCCEEECCCCCC
>Mature Secondary Structure 
APKKALSKVFLEWPVLRQVRSTDKLGRGSAVTSKHTRALAPRTATADRVVQSVCPYCAV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
GCGQRVYVKDERVVAIEGDPDSPISRGRLCPKGSASEQLVNSPGRQLQVLYRAPRATEWQ
CCCCEEEEECCEEEEEECCCCCCHHCCCCCCCCCCHHHHHHCCCCEEEHEEECCCCCCCC
PLQLDTAIDMIADRFVESRRNSWQDIDKKGNLLRRTMGIAALGGATLDNEENYLIKKLFT
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AAGAIQIENQARI
HHCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA