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The map label for this gene is crp [H]

Identifier: 41406180

GI number: 41406180

Start: 92165

End: 92842

Strand: Direct

Name: crp [H]

Synonym: MAP0082

Alternate gene names: 41406180

Gene position: 92165-92842 (Clockwise)

Preceding gene: 41406179

Following gene: 41406184

Centisome position: 1.91

GC content: 66.37

Gene sequence:

>678_bases
GTGGACGACATTTTGGCCCAGGCCACCATCTTCCAGGGAATCGACCCGGAGGCGGTCGCCGCGTTGTCGCGGCACCTGCA
ACACGTGTCCTTCCCGCGCCGGCGCACCGTCTTCGTCGAAGGCGAGCCGGGCGACGACCTCTACGTCATCGTGTCGGGCG
CGGTGAAGATTCGCCATCAGACGGCGGACGGCCGCGAAACCGTCTTCGCGGTGTTAGGCCCCGGCGACGTGTTCGGTGAG
CTCGCGCTCTTCGACCCGGGCCCTCGAACCTCGACGGTGATCACCCTGACCGAGGTGGAAGCCCTCCGGATGGACCGCAA
TGCCCTGCGGACGTGGATCATCGAACGGCCCGAAATCGCCGAGCAACTGCTGCGGGTGCTCGCGCGCCGGCTCCGGCACA
CGAACAACACCTTGTGCGACTTGATCTTCACCGACGTTCCTGCCCGGGTTGCGAAGCAAATCCTGGACCTGGCAATGCGA
TTCGGCACCGACAGCGGCGGCCCGGTGCGCGTCGAGCATCATCTCACCCAAAAAGAGCTCGCCCAACTGGTCGGCTCCTC
GCGGGAAACGGTCAACAAGGCGCTGGCGGACTTCGCCCAGCGGGGGTGGATCCGCCAGCAGGGCAAGGCCCTGATCATCG
ACCAGCCCGCGAAACTGGCTCGGCGCGCTAGAGCCTAA

Upstream 100 bases:

>100_bases
TGCTACTCGTGTAAAGTCGAGGACTGCGAGCCAAGACGCCCCCTTCGGAGCAGCGCCTAGTGCGCGCAAACGCCGTGCGG
AACGCGTTGAAAGGGGCGGC

Downstream 100 bases:

>100_bases
GCTGTCGGCGCCGGTAACGGCACCGGTCTCGGCATGAGCACGATCGTCCACCCGTCCGGGTCCAAGAAGGCGTCCGCTCC
GTTGCGCCGCCACCACGGGT

Product: hypothetical protein

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MDDILAQATIFQGIDPEAVAALSRHLQHVSFPRRRTVFVEGEPGDDLYVIVSGAVKIRHQTADGRETVFAVLGPGDVFGE
LALFDPGPRTSTVITLTEVEALRMDRNALRTWIIERPEIAEQLLRVLARRLRHTNNTLCDLIFTDVPARVAKQILDLAMR
FGTDSGGPVRVEHHLTQKELAQLVGSSRETVNKALADFAQRGWIRQQGKALIIDQPAKLARRARA

Sequences:

>Translated_225_residues
MDDILAQATIFQGIDPEAVAALSRHLQHVSFPRRRTVFVEGEPGDDLYVIVSGAVKIRHQTADGRETVFAVLGPGDVFGE
LALFDPGPRTSTVITLTEVEALRMDRNALRTWIIERPEIAEQLLRVLARRLRHTNNTLCDLIFTDVPARVAKQILDLAMR
FGTDSGGPVRVEHHLTQKELAQLVGSSRETVNKALADFAQRGWIRQQGKALIIDQPAKLARRARA
>Mature_225_residues
MDDILAQATIFQGIDPEAVAALSRHLQHVSFPRRRTVFVEGEPGDDLYVIVSGAVKIRHQTADGRETVFAVLGPGDVFGE
LALFDPGPRTSTVITLTEVEALRMDRNALRTWIIERPEIAEQLLRVLARRLRHTNNTLCDLIFTDVPARVAKQILDLAMR
FGTDSGGPVRVEHHLTQKELAQLVGSSRETVNKALADFAQRGWIRQQGKALIIDQPAKLARRARA

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI47132583, Length=107, Percent_Identity=28.9719626168224, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI47132581, Length=107, Percent_Identity=28.9719626168224, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI4506063, Length=107, Percent_Identity=28.9719626168224, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1789756, Length=202, Percent_Identity=31.1881188118812, Blast_Score=100, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 25028; Mature: 25028

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDILAQATIFQGIDPEAVAALSRHLQHVSFPRRRTVFVEGEPGDDLYVIVSGAVKIRHQ
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECEEEEEEE
TADGRETVFAVLGPGDVFGELALFDPGPRTSTVITLTEVEALRMDRNALRTWIIERPEIA
CCCCCEEEEEEECCCHHHCCEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHH
EQLLRVLARRLRHTNNTLCDLIFTDVPARVAKQILDLAMRFGTDSGGPVRVEHHLTQKEL
HHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCHHHH
AQLVGSSRETVNKALADFAQRGWIRQQGKALIIDQPAKLARRARA
HHHHCCCHHHHHHHHHHHHHCCCHHHCCCEEEEECCHHHHHHCCC
>Mature Secondary Structure
MDDILAQATIFQGIDPEAVAALSRHLQHVSFPRRRTVFVEGEPGDDLYVIVSGAVKIRHQ
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECEEEEEEE
TADGRETVFAVLGPGDVFGELALFDPGPRTSTVITLTEVEALRMDRNALRTWIIERPEIA
CCCCCEEEEEEECCCHHHCCEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHH
EQLLRVLARRLRHTNNTLCDLIFTDVPARVAKQILDLAMRFGTDSGGPVRVEHHLTQKEL
HHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCHHHH
AQLVGSSRETVNKALADFAQRGWIRQQGKALIIDQPAKLARRARA
HHHHCCCHHHHHHHHHHHHHCCCHHHCCCEEEEECCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800 [H]