Click here to switch to the map view.

The map label for this gene is atpA2

Identifier: 52843177

GI number: 52843177

Start: 3377587

End: 3379140

Strand: Reverse

Name: atpA2

Synonym: lpg2984

Alternate gene names: 52843177

Gene position: 3379140-3377587 (Counterclockwise)

Preceding gene: 52843178

Following gene: 52843176

Centisome position: 99.45

GC content: 43.18

Gene sequence:

>1554_bases
ATGTCAGAACAAGTAGCGTTAAATCCTTCTGAAATCAGTGAATTAATCAGAAAGAAAATAGATCAATTTAGTGTGGTTTC
TGAAGCACGAAATGAAGGTACTATCGTTAGTTTGAAAGACGGTATTGTACGACTGCATGGTCTTGCCGATGTTATGGCAG
GTGAAATGATAGAGTTTCCAGGAGGGGTCTACGGATTGGCTCTTAACCTGGAGAGAGATTCTGTTGGTGCTGTAATATTA
GGCGACTCATCCACATTAGCTGAAGGGCAAAAAGGTAAATGTACAGGTCGTATTCTGGAAGTCCCAGTTGGAAAAGGTCT
TTTGGGACGTGTCGTTGATGCTTTAGGAAATCCTATAGACGGGAAAGGCCCGATAGAGTCATCAGGTATGTCTCCAATAG
AAAAAGTCGCTCCTGGTGTAATTACACGTAAATCAGTAGATCAACCTGTTCAGACAGGATTAAAAGCAATCGATGCGATG
ATCCCCGTTGGAAGAGGTCAGCGAGAGCTTATTATTGGTGACCGCCAAACTGGTAAAACTGCCATTGCTATTGATGCGAT
TATCAATCAAAAAGGTACCGGCGTTAAATGCGTATATGTAGCCATTGGTCAAAAGGCTTCATCCGTTGCATCGATTGTTA
GAAAATTGGAAGAGCATGGCGCTCTTGAGCATACTATTGTTGTGGTAGCGGGAGCCTCTGATTCAGCAGCACTCCAATAT
ATAGCACCTTACTCAGGTTGTACCATGGGTGAGTATTTCATGGAGCGTGGGGAAGATGCATTGATTGTTTACGATGATTT
AACTAAACAAGCATGGGCATATAGGCAGATCTCCTTGTTATTACGTCGGCCACCAGGTCGCGAAGCTTATCCTGGTGATA
TTTTCTATTTGCATTCTCGCTTGTTGGAAAGAGCCGCAAGAATTAATGCCGATGAAGTAGAAAAATTAACTAATGGAGAA
GTGAAGGGTAAAACAGGATCACTGACTGCATTGCCGATTATCGAAACACAAGCGGGAGATGTGTCAGCCTTCGTACCAAC
AAACGTAATCTCTATTACCGATGGGCAAATATTCCTTGATGTTGACTTATTTAACTCAGGTGTTAGACCAGCAATCAATT
CCGGACTGTCCGTTTCACGGGTTGGTGGTGCTGCACAAACGAAAATCATGAAAAAGCTTGGTGGTGGTACTCGGCTTGCT
CTGGCACAATTCCGTGAGTTAGAAGCATTCTCCCAATTTGCATCTGATCTTGATGATGCAACACGTAAGCAGCTGGAGCG
TGGACAACGCATTACAGAGCTGATGAAACAAAAGCAATACTCCCCACTTACAGTGGCTGAAATGGGGGTAAGCTTGTTTG
TGGTAGAAAAGGGATACTTGGACGATGTACCTGTAAATGAAATCAGCTCGTTTGAAGCTTCCTTGCACGATTACATGCGC
AGTACCCATGCCGCTTTATTACATGCAATTAATGAAGCCGGTGCTTATGATAATGAAATCGAAGCAAAACTGAAAAAAGC
AGTAGAAGAGTTCAAGAACACAGGCAGTTGGTAA

Upstream 100 bases:

>100_bases
CGCTAATTCGAGCAGGCGATTTAGTTATCGATGGTTCAGTTCGGGGCAAGCTTAATATGCTTGGCACCAGCTTGGCCGCT
TAATTTAGAGGATAGTTTCC

Downstream 100 bases:

>100_bases
GGTATGGCCTCAAAGAGCTAACTCTTTGAGGCACAAAGGCCATTATTTGAAAGTAATGGCCTCTAAAACTAATTAAGGCG
AATTGAAAGATGGCTGGAGC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha 2; F-ATPase subunit alpha 2

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MSEQVALNPSEISELIRKKIDQFSVVSEARNEGTIVSLKDGIVRLHGLADVMAGEMIEFPGGVYGLALNLERDSVGAVIL
GDSSTLAEGQKGKCTGRILEVPVGKGLLGRVVDALGNPIDGKGPIESSGMSPIEKVAPGVITRKSVDQPVQTGLKAIDAM
IPVGRGQRELIIGDRQTGKTAIAIDAIINQKGTGVKCVYVAIGQKASSVASIVRKLEEHGALEHTIVVVAGASDSAALQY
IAPYSGCTMGEYFMERGEDALIVYDDLTKQAWAYRQISLLLRRPPGREAYPGDIFYLHSRLLERAARINADEVEKLTNGE
VKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLDVDLFNSGVRPAINSGLSVSRVGGAAQTKIMKKLGGGTRLA
LAQFRELEAFSQFASDLDDATRKQLERGQRITELMKQKQYSPLTVAEMGVSLFVVEKGYLDDVPVNEISSFEASLHDYMR
STHAALLHAINEAGAYDNEIEAKLKKAVEEFKNTGSW

Sequences:

>Translated_517_residues
MSEQVALNPSEISELIRKKIDQFSVVSEARNEGTIVSLKDGIVRLHGLADVMAGEMIEFPGGVYGLALNLERDSVGAVIL
GDSSTLAEGQKGKCTGRILEVPVGKGLLGRVVDALGNPIDGKGPIESSGMSPIEKVAPGVITRKSVDQPVQTGLKAIDAM
IPVGRGQRELIIGDRQTGKTAIAIDAIINQKGTGVKCVYVAIGQKASSVASIVRKLEEHGALEHTIVVVAGASDSAALQY
IAPYSGCTMGEYFMERGEDALIVYDDLTKQAWAYRQISLLLRRPPGREAYPGDIFYLHSRLLERAARINADEVEKLTNGE
VKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLDVDLFNSGVRPAINSGLSVSRVGGAAQTKIMKKLGGGTRLA
LAQFRELEAFSQFASDLDDATRKQLERGQRITELMKQKQYSPLTVAEMGVSLFVVEKGYLDDVPVNEISSFEASLHDYMR
STHAALLHAINEAGAYDNEIEAKLKKAVEEFKNTGSW
>Mature_516_residues
SEQVALNPSEISELIRKKIDQFSVVSEARNEGTIVSLKDGIVRLHGLADVMAGEMIEFPGGVYGLALNLERDSVGAVILG
DSSTLAEGQKGKCTGRILEVPVGKGLLGRVVDALGNPIDGKGPIESSGMSPIEKVAPGVITRKSVDQPVQTGLKAIDAMI
PVGRGQRELIIGDRQTGKTAIAIDAIINQKGTGVKCVYVAIGQKASSVASIVRKLEEHGALEHTIVVVAGASDSAALQYI
APYSGCTMGEYFMERGEDALIVYDDLTKQAWAYRQISLLLRRPPGREAYPGDIFYLHSRLLERAARINADEVEKLTNGEV
KGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLDVDLFNSGVRPAINSGLSVSRVGGAAQTKIMKKLGGGTRLAL
AQFRELEAFSQFASDLDDATRKQLERGQRITELMKQKQYSPLTVAEMGVSLFVVEKGYLDDVPVNEISSFEASLHDYMRS
THAALLHAINEAGAYDNEIEAKLKKAVEEFKNTGSW

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=510, Percent_Identity=56.2745098039216, Blast_Score=563, Evalue=1e-160,
Organism=Homo sapiens, GI4757810, Length=510, Percent_Identity=56.2745098039216, Blast_Score=563, Evalue=1e-160,
Organism=Homo sapiens, GI19913428, Length=335, Percent_Identity=27.1641791044776, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI19913426, Length=379, Percent_Identity=25.5936675461741, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI32189394, Length=457, Percent_Identity=23.1947483588621, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI19913424, Length=263, Percent_Identity=26.2357414448669, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1790172, Length=511, Percent_Identity=72.9941291585127, Blast_Score=791, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=310, Percent_Identity=25.1612903225806, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788251, Length=295, Percent_Identity=27.4576271186441, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71988063, Length=513, Percent_Identity=56.3352826510721, Blast_Score=567, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71988080, Length=513, Percent_Identity=56.3352826510721, Blast_Score=566, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71988074, Length=513, Percent_Identity=52.4366471734893, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17510931, Length=377, Percent_Identity=26.2599469496021, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17570191, Length=368, Percent_Identity=27.445652173913, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25144756, Length=395, Percent_Identity=22.7848101265823, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=56, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565854, Length=258, Percent_Identity=25.968992248062, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319370, Length=515, Percent_Identity=54.1747572815534, Blast_Score=568, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319603, Length=409, Percent_Identity=27.3838630806846, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322581, Length=433, Percent_Identity=24.7113163972286, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24658560, Length=513, Percent_Identity=54.1910331384016, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI281361666, Length=364, Percent_Identity=26.6483516483516, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24646341, Length=364, Percent_Identity=26.6483516483516, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17136796, Length=364, Percent_Identity=26.6483516483516, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24638766, Length=331, Percent_Identity=25.0755287009063, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574560, Length=323, Percent_Identity=25.3869969040248, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24583988, Length=263, Percent_Identity=26.615969581749, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24583986, Length=263, Percent_Identity=26.615969581749, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24583984, Length=263, Percent_Identity=26.615969581749, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24583992, Length=263, Percent_Identity=26.615969581749, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA2_LEGPA (Q5X0P1)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_125357.1
- ProteinModelPortal:   Q5X0P1
- SMR:   Q5X0P1
- STRING:   Q5X0P1
- GeneID:   3117604
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp3055
- LegioList:   lpp3055
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- ProtClustDB:   PRK09281
- BioCyc:   LPNE297246:LPP3055-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55529; Mature: 55398

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00152 ATPASE_ALPHA_BETA; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQVALNPSEISELIRKKIDQFSVVSEARNEGTIVSLKDGIVRLHGLADVMAGEMIEFP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCHHCCC
GGVYGLALNLERDSVGAVILGDSSTLAEGQKGKCTGRILEVPVGKGLLGRVVDALGNPID
CCEEEEEEEECCCCCCEEEECCCHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCC
GKGPIESSGMSPIEKVAPGVITRKSVDQPVQTGLKAIDAMIPVGRGQRELIIGDRQTGKT
CCCCCCCCCCCHHHHHCCCCEEHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCE
AIAIDAIINQKGTGVKCVYVAIGQKASSVASIVRKLEEHGALEHTIVVVAGASDSAALQY
EEEEEEHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEE
IAPYSGCTMGEYFMERGEDALIVYDDLTKQAWAYRQISLLLRRPPGREAYPGDIFYLHSR
ECCCCCCCHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LLERAARINADEVEKLTNGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLD
HHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEE
VDLFNSGVRPAINSGLSVSRVGGAAQTKIMKKLGGGTRLALAQFRELEAFSQFASDLDDA
EECCCCCCCHHHHCCCEEHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
TRKQLERGQRITELMKQKQYSPLTVAEMGVSLFVVEKGYLDDVPVNEISSFEASLHDYMR
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
STHAALLHAINEAGAYDNEIEAKLKKAVEEFKNTGSW
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEQVALNPSEISELIRKKIDQFSVVSEARNEGTIVSLKDGIVRLHGLADVMAGEMIEFP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCHHCCC
GGVYGLALNLERDSVGAVILGDSSTLAEGQKGKCTGRILEVPVGKGLLGRVVDALGNPID
CCEEEEEEEECCCCCCEEEECCCHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCC
GKGPIESSGMSPIEKVAPGVITRKSVDQPVQTGLKAIDAMIPVGRGQRELIIGDRQTGKT
CCCCCCCCCCCHHHHHCCCCEEHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCE
AIAIDAIINQKGTGVKCVYVAIGQKASSVASIVRKLEEHGALEHTIVVVAGASDSAALQY
EEEEEEHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEE
IAPYSGCTMGEYFMERGEDALIVYDDLTKQAWAYRQISLLLRRPPGREAYPGDIFYLHSR
ECCCCCCCHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LLERAARINADEVEKLTNGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLD
HHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEE
VDLFNSGVRPAINSGLSVSRVGGAAQTKIMKKLGGGTRLALAQFRELEAFSQFASDLDDA
EECCCCCCCHHHHCCCEEHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
TRKQLERGQRITELMKQKQYSPLTVAEMGVSLFVVEKGYLDDVPVNEISSFEASLHDYMR
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
STHAALLHAINEAGAYDNEIEAKLKKAVEEFKNTGSW
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA