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The map label for this gene is maeA

Identifier: 52843165

GI number: 52843165

Start: 3360082

End: 3361752

Strand: Direct

Name: maeA

Synonym: lpg2971

Alternate gene names: 52843165

Gene position: 3360082-3361752 (Clockwise)

Preceding gene: 52843162

Following gene: 52843166

Centisome position: 98.89

GC content: 40.63

Gene sequence:

>1671_bases
ATGGCAATCAAAGTAACAAAAAGGGGAATGGACATACTAAGAGACCCCATACTAAATAAAGGTACCGCATTTAGCCTCCA
GGAAAGAGATGAATTTGCCTTGCATGGTTTAATACCAACAACAGTGGAAACCCTTGAACAACAAGTAGTTCGCTGCCTTG
ACGCTTATAGTGCCAAAGAGGACCCTTTGGAGAAACACATTTACTTACGTGCCTTGCAGGACCGAAATGAAGTACTTTTT
TATCGTTTTATAATTGATAATCTGGTTCATATTTTGCCCATTATATACACACCGGTTGTCGGCCAAGCCTGTGAAATGTT
TTCCCACATTTATCGGCAACCAAGAGGAGTATTTCTAAGTTATCCAGAGCGAGACAAACTGGACAGCATCATACAAAACA
TTGCGTCGACTCGTTCAACCAAAGTAATTGTTGTCACTGATGGCGAACGGATCTTGGGGTTGGGAGATCAAGGAGCAGGT
GGATTGGGAATTCCTATAGGCAAATTGTCTCTTTATACCAGTTGCGGTGGTATACATCCTTCTAACACTTTACCTATTAT
TCTGGATGTAGGAACCAATAATAAGGAGCGTCTGGACGATCCGGAATATATTGGGTGGAGACACGCTCGGATTTCAGGCA
AAGAGTATGATGATTTTGTTGATCAATTTGTGCAAAGTATAAAACGCCATATGCCTCATGTGCTATTACAATTCGAAGAT
TTTGCACAACAACATGCCTATCCTTTATTGGAGCGATATAAAAATCAACTTTGTACTTTTAATGATGATATTCAAGGAAC
TGCTTCTGTTGCTGTAGCCGCCATACTAGCAGCAACTCGTGTTACTAATACTCCTTTAAAGGAACATCGAGTTGCTTTAT
TAGGTGCAGGATCAGCGGGTTGTGGGATCAGTGAGCAGCTGGTGCATGCCATGATGAACCAGGGACTTTCTGAAGAAGAA
GCCAGATCACGTTTTTATTTAGTTGACAGGTATGGACTTTTACATGATGAGATGACAGATCTATTGCCATTTCAAAAAGG
ATTTGTCCGTTCTTCTACCAGTCTCCAAAATTGGAAATTAGAAAAAAAAGGAGAAATCACGTTAACAGACGTTATTAACA
ATGCCCAACCGACTATACTCCTGGGGGTGTCTGGCCAACCTAACCAATTCAAGGAAGCAATGATCAAGACCATGCTAAGC
TATTGTGAACGCCCCATAATTTTTCCTTTATCAAATCCTACGTCTCGCGCAGAAGCAATCCCGCAAGATCTGTTAAATTG
GACAGCTGGTAAAGCTTTAATTGCAACAGGCAGTCCCTTTGAGCCAGTTGTAATTAATGGTCATAAAATTGAGATAGCTC
AATGCAATAATTCTTACATTTTCCCGGGAGTTGGTCTTGGAGTAGTTGCAGGACAAGCCAAAAGAGTGACTGATTTAATG
ATGATGGCAGCAGCAGTTGCATTAAGTGAGCTAGCACCTGCAATCAGAACCGGAGAAGGACGCTTACTCCCAGAATTAAA
TTCCATTAGAGAAGTCAGTCAACATATAGCGAGAGCGGTAATTTTACAGGGTATAAAAGAGGGTCATATAGAGCCAATGA
ACAATAATAAAATCGATGATTCTATAAAAAGAACGATGTGGACTCCACAATATGAACCATATGTTCTATAA

Upstream 100 bases:

>100_bases
TGTAAATAACTTCCATCTTAAAATCAATGAGTTGAATTGAAGTTATTTAGAAGTCCTGATTTAAATTTCTCGGTTACAAA
TATTCACAAGGAGTGTTCTA

Downstream 100 bases:

>100_bases
TAAACCGATGTAGAAATTGCTGGAATTTAAGTTTTAATTTTTTAGAAAGACTAAAATTTATTAGTTTATCGCAATAGAAT
TTACAGCATAGGGTTGAGGG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MAIKVTKRGMDILRDPILNKGTAFSLQERDEFALHGLIPTTVETLEQQVVRCLDAYSAKEDPLEKHIYLRALQDRNEVLF
YRFIIDNLVHILPIIYTPVVGQACEMFSHIYRQPRGVFLSYPERDKLDSIIQNIASTRSTKVIVVTDGERILGLGDQGAG
GLGIPIGKLSLYTSCGGIHPSNTLPIILDVGTNNKERLDDPEYIGWRHARISGKEYDDFVDQFVQSIKRHMPHVLLQFED
FAQQHAYPLLERYKNQLCTFNDDIQGTASVAVAAILAATRVTNTPLKEHRVALLGAGSAGCGISEQLVHAMMNQGLSEEE
ARSRFYLVDRYGLLHDEMTDLLPFQKGFVRSSTSLQNWKLEKKGEITLTDVINNAQPTILLGVSGQPNQFKEAMIKTMLS
YCERPIIFPLSNPTSRAEAIPQDLLNWTAGKALIATGSPFEPVVINGHKIEIAQCNNSYIFPGVGLGVVAGQAKRVTDLM
MMAAAVALSELAPAIRTGEGRLLPELNSIREVSQHIARAVILQGIKEGHIEPMNNNKIDDSIKRTMWTPQYEPYVL

Sequences:

>Translated_556_residues
MAIKVTKRGMDILRDPILNKGTAFSLQERDEFALHGLIPTTVETLEQQVVRCLDAYSAKEDPLEKHIYLRALQDRNEVLF
YRFIIDNLVHILPIIYTPVVGQACEMFSHIYRQPRGVFLSYPERDKLDSIIQNIASTRSTKVIVVTDGERILGLGDQGAG
GLGIPIGKLSLYTSCGGIHPSNTLPIILDVGTNNKERLDDPEYIGWRHARISGKEYDDFVDQFVQSIKRHMPHVLLQFED
FAQQHAYPLLERYKNQLCTFNDDIQGTASVAVAAILAATRVTNTPLKEHRVALLGAGSAGCGISEQLVHAMMNQGLSEEE
ARSRFYLVDRYGLLHDEMTDLLPFQKGFVRSSTSLQNWKLEKKGEITLTDVINNAQPTILLGVSGQPNQFKEAMIKTMLS
YCERPIIFPLSNPTSRAEAIPQDLLNWTAGKALIATGSPFEPVVINGHKIEIAQCNNSYIFPGVGLGVVAGQAKRVTDLM
MMAAAVALSELAPAIRTGEGRLLPELNSIREVSQHIARAVILQGIKEGHIEPMNNNKIDDSIKRTMWTPQYEPYVL
>Mature_555_residues
AIKVTKRGMDILRDPILNKGTAFSLQERDEFALHGLIPTTVETLEQQVVRCLDAYSAKEDPLEKHIYLRALQDRNEVLFY
RFIIDNLVHILPIIYTPVVGQACEMFSHIYRQPRGVFLSYPERDKLDSIIQNIASTRSTKVIVVTDGERILGLGDQGAGG
LGIPIGKLSLYTSCGGIHPSNTLPIILDVGTNNKERLDDPEYIGWRHARISGKEYDDFVDQFVQSIKRHMPHVLLQFEDF
AQQHAYPLLERYKNQLCTFNDDIQGTASVAVAAILAATRVTNTPLKEHRVALLGAGSAGCGISEQLVHAMMNQGLSEEEA
RSRFYLVDRYGLLHDEMTDLLPFQKGFVRSSTSLQNWKLEKKGEITLTDVINNAQPTILLGVSGQPNQFKEAMIKTMLSY
CERPIIFPLSNPTSRAEAIPQDLLNWTAGKALIATGSPFEPVVINGHKIEIAQCNNSYIFPGVGLGVVAGQAKRVTDLMM
MAAAVALSELAPAIRTGEGRLLPELNSIREVSQHIARAVILQGIKEGHIEPMNNNKIDDSIKRTMWTPQYEPYVL

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=552, Percent_Identity=42.0289855072464, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI62420882, Length=557, Percent_Identity=41.113105924596, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI62420880, Length=557, Percent_Identity=41.113105924596, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI239049447, Length=557, Percent_Identity=41.113105924596, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI4505145, Length=556, Percent_Identity=40.6474820143885, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI270265879, Length=465, Percent_Identity=42.7956989247312, Blast_Score=384, Evalue=1e-106,
Organism=Escherichia coli, GI87081919, Length=543, Percent_Identity=52.670349907919, Blast_Score=589, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17537199, Length=518, Percent_Identity=45.7528957528958, Blast_Score=426, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6322823, Length=574, Percent_Identity=41.4634146341463, Blast_Score=446, Evalue=1e-126,
Organism=Drosophila melanogaster, GI281362674, Length=539, Percent_Identity=42.1150278293135, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI281362672, Length=539, Percent_Identity=42.1150278293135, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI21356279, Length=539, Percent_Identity=42.1150278293135, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24646386, Length=546, Percent_Identity=40.2930402930403, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24646388, Length=546, Percent_Identity=40.2930402930403, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI78707242, Length=556, Percent_Identity=36.8705035971223, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707238, Length=556, Percent_Identity=36.8705035971223, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707240, Length=529, Percent_Identity=37.9962192816635, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI78707232, Length=528, Percent_Identity=34.6590909090909, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI281363505, Length=551, Percent_Identity=33.7568058076225, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI78707236, Length=551, Percent_Identity=33.7568058076225, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI281363503, Length=534, Percent_Identity=34.2696629213483, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI19922384, Length=552, Percent_Identity=27.7173913043478, Blast_Score=238, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 61926; Mature: 61795

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKVTKRGMDILRDPILNKGTAFSLQERDEFALHGLIPTTVETLEQQVVRCLDAYSAKE
CEEEEEHHHHHHHHCCCCCCCCEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
DPLEKHIYLRALQDRNEVLFYRFIIDNLVHILPIIYTPVVGQACEMFSHIYRQPRGVFLS
CCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
YPERDKLDSIIQNIASTRSTKVIVVTDGERILGLGDQGAGGLGIPIGKLSLYTSCGGIHP
CCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHEEEHHCCCCCC
SNTLPIILDVGTNNKERLDDPEYIGWRHARISGKEYDDFVDQFVQSIKRHMPHVLLQFED
CCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHH
FAQQHAYPLLERYKNQLCTFNDDIQGTASVAVAAILAATRVTNTPLKEHRVALLGAGSAG
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCEEEEECCCCC
CGISEQLVHAMMNQGLSEEEARSRFYLVDRYGLLHDEMTDLLPFQKGFVRSSTSLQNWKL
CCHHHHHHHHHHHCCCCHHHHHCEEEEEEHHCCHHHHHHHHHHHHHHHHCCCCCHHCCEE
EKKGEITLTDVINNAQPTILLGVSGQPNQFKEAMIKTMLSYCERPIIFPLSNPTSRAEAI
CCCCCEEEEEHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHH
PQDLLNWTAGKALIATGSPFEPVVINGHKIEIAQCNNSYIFPGVGLGVVAGQAKRVTDLM
HHHHHHHCCCCEEEECCCCCCCEEECCCEEEEEECCCCEECCCCCHHHHCCCHHHHHHHH
MMAAAVALSELAPAIRTGEGRLLPELNSIREVSQHIARAVILQGIKEGHIEPMNNNKIDD
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
SIKRTMWTPQYEPYVL
HHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AIKVTKRGMDILRDPILNKGTAFSLQERDEFALHGLIPTTVETLEQQVVRCLDAYSAKE
EEEEEHHHHHHHHCCCCCCCCEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
DPLEKHIYLRALQDRNEVLFYRFIIDNLVHILPIIYTPVVGQACEMFSHIYRQPRGVFLS
CCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
YPERDKLDSIIQNIASTRSTKVIVVTDGERILGLGDQGAGGLGIPIGKLSLYTSCGGIHP
CCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHEEEHHCCCCCC
SNTLPIILDVGTNNKERLDDPEYIGWRHARISGKEYDDFVDQFVQSIKRHMPHVLLQFED
CCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHH
FAQQHAYPLLERYKNQLCTFNDDIQGTASVAVAAILAATRVTNTPLKEHRVALLGAGSAG
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCEEEEECCCCC
CGISEQLVHAMMNQGLSEEEARSRFYLVDRYGLLHDEMTDLLPFQKGFVRSSTSLQNWKL
CCHHHHHHHHHHHCCCCHHHHHCEEEEEEHHCCHHHHHHHHHHHHHHHHCCCCCHHCCEE
EKKGEITLTDVINNAQPTILLGVSGQPNQFKEAMIKTMLSYCERPIIFPLSNPTSRAEAI
CCCCCEEEEEHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHH
PQDLLNWTAGKALIATGSPFEPVVINGHKIEIAQCNNSYIFPGVGLGVVAGQAKRVTDLM
HHHHHHHCCCCEEEECCCCCCCEEECCCEEEEEECCCCEECCCCCHHHHCCCHHHHHHHH
MMAAAVALSELAPAIRTGEGRLLPELNSIREVSQHIARAVILQGIKEGHIEPMNNNKIDD
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
SIKRTMWTPQYEPYVL
HHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA