Click here to switch to the map view.

The map label for this gene is argD

Identifier: 52843162

GI number: 52843162

Start: 3356827

End: 3357996

Strand: Direct

Name: argD

Synonym: lpg2968

Alternate gene names: 52843162

Gene position: 3356827-3357996 (Clockwise)

Preceding gene: 52843161

Following gene: 52843165

Centisome position: 98.8

GC content: 42.22

Gene sequence:

>1170_bases
ATGAGTTTAATTACAAGTTACAGCCCAATGCCTGTAACCTTCACGCACGGAGAAGGCGTGTGGTTGTATGATGAGCAGGG
GAAAAAATACCTCGATGGCTTAAGCGGGATAGCAGTTTGTGGATTAGGTCATGCACACCCTGATGTCACCCGTACCATAC
AGGAGCAGGCAGCCAGGCTAATACATACTTCTAATGTCTTTCATATTAAAGAACAAGAATTATTAGCCGCCAAACTCACT
TCAATGGCACGAATGGAGCAGGTTTTTTTTGCTAATTCTGGAGCAGAAGCTAATGAAGCAGCCATTAAACTTACTCGTCT
GTTTGGTCATAAAAAGGGAATTGAAACGCCTTCTATTATTGTAATGGAAAAAGCATTTCATGGTCGCACTATGGCCACCT
TAACTGCATCAGGCAGTCGTAAAGTTCAAGCTGGTTTTGAACCCTTGGTCCCTGGGTTTATTCGTGCTCCCTTCAATGAT
CTTGATGCCATTCATACTATTGCGGCCAACAGAGAGGATGTGGTTGCAGTTATGGTAGAACCGATTCAGGGCGAGGGGGG
AATTTATCCCGCAGAGGAAGGTTATCTGCGTGCATTGGCTAACCTTTGCGAGCAGAATGACTGGATGTTAATTTTGGATG
AAATACAAACAGGAAATGGCAGAACAGGTAAGCTTTATTCTTGTATGCATTACGACATACAACCTGACATTCTTACTACG
GCAAAAGGACTTGGAAACGGTATGCCAATTGGGGCTTGTTTAATGAGCAAGCGAGCTAAAGATTTATTTAAACCTGGAAA
TCATGGCTCGACTTTTGGTGGCAACCCTTTAGCTTGTGCAACGGCTTTGACTGTTCTGGAGGTCATTGAACGAGATAAGC
TATGTGAGCGCGTCACTAAAAACAGTGCTTTGTTAATGGATAAATTAATTAGCAACCTGGGAGAGCATCCCCATGTAAAA
GCTATACGTGGTAAAGGTTATATGATAGGAATAGAGTTGGACAGACCTGCAAATGACATGCGCGTCCTGGGTTTGGAAAA
CCAAGTTTTGTTCAATATTACAGCTGAAACAGTAGTAAGATTATTACCTCCACTTATTATCAGTGAAGATGAAATTGATG
AATTGGTCAATCGAATAACTCGTACTATTAACCAGTTCACCAATCAGTAG

Upstream 100 bases:

>100_bases
CATTAGTTAATTGGGATTTTGCGAGCAGTAATCTGAAATAAAATAACAAGCTGGATTTGTTGCAATCCCTACCGGATAAT
TTTATGTTTATGGAGACATC

Downstream 100 bases:

>100_bases
TGAGAAGACAACTTTCTCTCAATTGAATAGAAATTGTTTTCTCCCTGGCTGTCTCGCAGTATGCTAAATTAATCTGGTAT
CTGACAACATGCTCCCTGGA

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSLITSYSPMPVTFTHGEGVWLYDEQGKKYLDGLSGIAVCGLGHAHPDVTRTIQEQAARLIHTSNVFHIKEQELLAAKLT
SMARMEQVFFANSGAEANEAAIKLTRLFGHKKGIETPSIIVMEKAFHGRTMATLTASGSRKVQAGFEPLVPGFIRAPFND
LDAIHTIAANREDVVAVMVEPIQGEGGIYPAEEGYLRALANLCEQNDWMLILDEIQTGNGRTGKLYSCMHYDIQPDILTT
AKGLGNGMPIGACLMSKRAKDLFKPGNHGSTFGGNPLACATALTVLEVIERDKLCERVTKNSALLMDKLISNLGEHPHVK
AIRGKGYMIGIELDRPANDMRVLGLENQVLFNITAETVVRLLPPLIISEDEIDELVNRITRTINQFTNQ

Sequences:

>Translated_389_residues
MSLITSYSPMPVTFTHGEGVWLYDEQGKKYLDGLSGIAVCGLGHAHPDVTRTIQEQAARLIHTSNVFHIKEQELLAAKLT
SMARMEQVFFANSGAEANEAAIKLTRLFGHKKGIETPSIIVMEKAFHGRTMATLTASGSRKVQAGFEPLVPGFIRAPFND
LDAIHTIAANREDVVAVMVEPIQGEGGIYPAEEGYLRALANLCEQNDWMLILDEIQTGNGRTGKLYSCMHYDIQPDILTT
AKGLGNGMPIGACLMSKRAKDLFKPGNHGSTFGGNPLACATALTVLEVIERDKLCERVTKNSALLMDKLISNLGEHPHVK
AIRGKGYMIGIELDRPANDMRVLGLENQVLFNITAETVVRLLPPLIISEDEIDELVNRITRTINQFTNQ
>Mature_388_residues
SLITSYSPMPVTFTHGEGVWLYDEQGKKYLDGLSGIAVCGLGHAHPDVTRTIQEQAARLIHTSNVFHIKEQELLAAKLTS
MARMEQVFFANSGAEANEAAIKLTRLFGHKKGIETPSIIVMEKAFHGRTMATLTASGSRKVQAGFEPLVPGFIRAPFNDL
DAIHTIAANREDVVAVMVEPIQGEGGIYPAEEGYLRALANLCEQNDWMLILDEIQTGNGRTGKLYSCMHYDIQPDILTTA
KGLGNGMPIGACLMSKRAKDLFKPGNHGSTFGGNPLACATALTVLEVIERDKLCERVTKNSALLMDKLISNLGEHPHVKA
IRGKGYMIGIELDRPANDMRVLGLENQVLFNITAETVVRLLPPLIISEDEIDELVNRITRTINQFTNQ

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=389, Percent_Identity=35.73264781491, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI284507298, Length=303, Percent_Identity=37.6237623762376, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI13994255, Length=439, Percent_Identity=31.6628701594533, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI24119277, Length=410, Percent_Identity=27.8048780487805, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI37574042, Length=419, Percent_Identity=26.9689737470167, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=26.1282660332542, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI226442709, Length=384, Percent_Identity=27.34375, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI188536080, Length=433, Percent_Identity=22.1709006928406, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI38679950, Length=433, Percent_Identity=22.1709006928406, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI38679946, Length=433, Percent_Identity=22.1709006928406, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1788044, Length=392, Percent_Identity=39.030612244898, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1789759, Length=387, Percent_Identity=38.7596899224806, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI145693181, Length=386, Percent_Identity=34.9740932642487, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1789016, Length=410, Percent_Identity=30.2439024390244, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1787560, Length=385, Percent_Identity=31.4285714285714, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI1786991, Length=407, Percent_Identity=28.2555282555283, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786349, Length=335, Percent_Identity=27.1641791044776, Blast_Score=111, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=392, Percent_Identity=36.9897959183673, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI25144274, Length=276, Percent_Identity=38.0434782608696, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=31.7351598173516, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71992977, Length=426, Percent_Identity=29.1079812206573, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71981843, Length=169, Percent_Identity=34.9112426035503, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17541228, Length=434, Percent_Identity=23.2718894009217, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324432, Length=394, Percent_Identity=36.5482233502538, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6323470, Length=406, Percent_Identity=34.2364532019704, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6321456, Length=421, Percent_Identity=24.2280285035629, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324386, Length=323, Percent_Identity=25.077399380805, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21357415, Length=384, Percent_Identity=36.71875, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI28574759, Length=365, Percent_Identity=30.1369863013699, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI161085790, Length=369, Percent_Identity=30.6233062330623, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21356575, Length=416, Percent_Identity=28.8461538461538, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI281366494, Length=426, Percent_Identity=24.6478873239437, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24667139, Length=426, Percent_Identity=24.6478873239437, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24667143, Length=426, Percent_Identity=24.6478873239437, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 42651; Mature: 42520

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLITSYSPMPVTFTHGEGVWLYDEQGKKYLDGLSGIAVCGLGHAHPDVTRTIQEQAARL
CCCCCCCCCCCEEEECCCEEEEECCCCHHHHHCCCCHHEECCCCCCCHHHHHHHHHHHHH
IHTSNVFHIKEQELLAAKLTSMARMEQVFFANSGAEANEAAIKLTRLFGHKKGIETPSII
HHCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEE
VMEKAFHGRTMATLTASGSRKVQAGFEPLVPGFIRAPFNDLDAIHTIAANREDVVAVMVE
EEECCCCCCEEEEEECCCCCEEECCCCCCCCHHHHCCCHHHHHHHHHHCCCCCEEEEEEE
PIQGEGGIYPAEEGYLRALANLCEQNDWMLILDEIQTGNGRTGKLYSCMHYDIQPDILTT
EECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCHHHH
AKGLGNGMPIGACLMSKRAKDLFKPGNHGSTFGGNPLACATALTVLEVIERDKLCERVTK
HHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NSALLMDKLISNLGEHPHVKAIRGKGYMIGIELDRPANDMRVLGLENQVLFNITAETVVR
CHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCCCEEEEECCCEEEEEEHHHHHHH
LLPPLIISEDEIDELVNRITRTINQFTNQ
HHCCHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLITSYSPMPVTFTHGEGVWLYDEQGKKYLDGLSGIAVCGLGHAHPDVTRTIQEQAARL
CCCCCCCCCCEEEECCCEEEEECCCCHHHHHCCCCHHEECCCCCCCHHHHHHHHHHHHH
IHTSNVFHIKEQELLAAKLTSMARMEQVFFANSGAEANEAAIKLTRLFGHKKGIETPSII
HHCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEE
VMEKAFHGRTMATLTASGSRKVQAGFEPLVPGFIRAPFNDLDAIHTIAANREDVVAVMVE
EEECCCCCCEEEEEECCCCCEEECCCCCCCCHHHHCCCHHHHHHHHHHCCCCCEEEEEEE
PIQGEGGIYPAEEGYLRALANLCEQNDWMLILDEIQTGNGRTGKLYSCMHYDIQPDILTT
EECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCHHHH
AKGLGNGMPIGACLMSKRAKDLFKPGNHGSTFGGNPLACATALTVLEVIERDKLCERVTK
HHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NSALLMDKLISNLGEHPHVKAIRGKGYMIGIELDRPANDMRVLGLENQVLFNITAETVVR
CHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCCCEEEEECCCEEEEEEHHHHHHH
LLPPLIISEDEIDELVNRITRTINQFTNQ
HHCCHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]