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The map label for this gene is glmU

Identifier: 52843070

GI number: 52843070

Start: 3253169

End: 3254554

Strand: Direct

Name: glmU

Synonym: lpg2875

Alternate gene names: 52843070

Gene position: 3253169-3254554 (Clockwise)

Preceding gene: 52843068

Following gene: 52843071

Centisome position: 95.74

GC content: 42.86

Gene sequence:

>1386_bases
ATGAATTTACAAATTATTATTTTAGCTGCAGGGCAAGGTAAAAGAATGTATTCGGACACGCCCAAAGTTCTTCACCACCT
AGCTGGCAAACCGCTGTTAACCCACGTCGTGGAAACCGCTCAGCAACTAAATCCCAATGCAATTCATGTCATTTATGGTC
ATGGTGGTGAACAAATTAAAAGTTCACTCCCCAACTTACCTGTTCATTGGGTGCATCAGGCAGAGCAACTAGGGACTGGC
CATGCTGTTTTGCAAGCCATGCCCCATATCCCTGACGATGCATACGTTCTGGTTTTATCTGCCGATGTTCCCCTGATACA
AGTGGAAACTCTTCAATCATTAATTGAATGCAGCCAACGTCAAAATCCAGATCATTCTGTTTTAGCACTCCTGGTTGCAG
AACTGGAAAATCCAAGCGGTCTTGGGCGTATTATCAGAAACAACCAAGGTGAAATTTATAGCATTGTAGAAGAAAAGGAT
GCAAATGAGCAAGTAAAGAATATAAAAGAAATTTATTCCGGGGTGTGTTGTACTTTGGCAAATAATCTGAAGAAATGGTT
GCCTCAACTAAGTAATAGTAACGCACAAGGCGAATATTATTTAACTGAAATTATCTCATTGGCTGTACAAAATAAAACAC
CCATTACGTCATTAACCGCCAAGAACAGCTTTGAGGTACAGGGCATTAATAATCGCCAACAACTTCAGCAACTCGAACGC
ATCTGGCAGCAAAGAGCAGCCAATCAACTCATGGAAAAAGGCGCGACCCTGGCTGATGCCAACCGCTTTGATTTGAGAGG
AGAATTATATTGTGGCAAAGACGTCTATATCGACATTAACTGCATTTTTACAGGCAAGGTAGTTTTAGGTAATGGCTGTA
AAATTGGCCCAAACTGCAGTCTGACTAATGTGACATTAGGCGATGGGTGCGAAGTTTACGCTAATAGCGTACTGGAAGGC
TGCCACATTGCAAACGACTGCCACATCGGTCCTTTTGCCCGCTTGCGCTCAGGGACGCAATTAGCTTCCCATTGTAAAAT
CGGCAATTTTGTTGAAACTAAAAAAGCGATTTTTGATGAAGGCACGAAAGCCAGTCATCTCAGTTACTTAGGGGACGTCC
TGTTAGGAAAAAATGTAAACGTTGGCGCTGGAACCATTACTTGTAATTACGATGGGGTTAATAAGCATCAAACAATTATC
GAAGATGGTGTTTTTATTGGGTCAGATACTCAATTAATTGCTCCAGTTACCGTGGGCGCTAACGCAACAATAGGAGCAGG
GAGCACCATACGCCGGAATGTGCCGCCCGATGAGTTAACATTAACCGAATCACGACAAAAAACCATCTACGGCTGGAAAA
GGCCGGTAAAAAGAGAGAGGGATTAA

Upstream 100 bases:

>100_bases
ACTTATTTATCATATAGCTCTTTACATCATTCATAACATTGGGGCAGACTGTTTAAATCAGCACCGATTATGATATTTAA
CTTAGGAAAACACAAATCTC

Downstream 100 bases:

>100_bases
ATAAAAGAGGACAGAAATGCCTTCTGCTGTCATCATTCTTCTGATTATTCTTATTGCAATTGCTTTACGGCAGGTTGTCA
GAGTTATCATTCCAATTTGG

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MNLQIIILAAGQGKRMYSDTPKVLHHLAGKPLLTHVVETAQQLNPNAIHVIYGHGGEQIKSSLPNLPVHWVHQAEQLGTG
HAVLQAMPHIPDDAYVLVLSADVPLIQVETLQSLIECSQRQNPDHSVLALLVAELENPSGLGRIIRNNQGEIYSIVEEKD
ANEQVKNIKEIYSGVCCTLANNLKKWLPQLSNSNAQGEYYLTEIISLAVQNKTPITSLTAKNSFEVQGINNRQQLQQLER
IWQQRAANQLMEKGATLADANRFDLRGELYCGKDVYIDINCIFTGKVVLGNGCKIGPNCSLTNVTLGDGCEVYANSVLEG
CHIANDCHIGPFARLRSGTQLASHCKIGNFVETKKAIFDEGTKASHLSYLGDVLLGKNVNVGAGTITCNYDGVNKHQTII
EDGVFIGSDTQLIAPVTVGANATIGAGSTIRRNVPPDELTLTESRQKTIYGWKRPVKRERD

Sequences:

>Translated_461_residues
MNLQIIILAAGQGKRMYSDTPKVLHHLAGKPLLTHVVETAQQLNPNAIHVIYGHGGEQIKSSLPNLPVHWVHQAEQLGTG
HAVLQAMPHIPDDAYVLVLSADVPLIQVETLQSLIECSQRQNPDHSVLALLVAELENPSGLGRIIRNNQGEIYSIVEEKD
ANEQVKNIKEIYSGVCCTLANNLKKWLPQLSNSNAQGEYYLTEIISLAVQNKTPITSLTAKNSFEVQGINNRQQLQQLER
IWQQRAANQLMEKGATLADANRFDLRGELYCGKDVYIDINCIFTGKVVLGNGCKIGPNCSLTNVTLGDGCEVYANSVLEG
CHIANDCHIGPFARLRSGTQLASHCKIGNFVETKKAIFDEGTKASHLSYLGDVLLGKNVNVGAGTITCNYDGVNKHQTII
EDGVFIGSDTQLIAPVTVGANATIGAGSTIRRNVPPDELTLTESRQKTIYGWKRPVKRERD
>Mature_461_residues
MNLQIIILAAGQGKRMYSDTPKVLHHLAGKPLLTHVVETAQQLNPNAIHVIYGHGGEQIKSSLPNLPVHWVHQAEQLGTG
HAVLQAMPHIPDDAYVLVLSADVPLIQVETLQSLIECSQRQNPDHSVLALLVAELENPSGLGRIIRNNQGEIYSIVEEKD
ANEQVKNIKEIYSGVCCTLANNLKKWLPQLSNSNAQGEYYLTEIISLAVQNKTPITSLTAKNSFEVQGINNRQQLQQLER
IWQQRAANQLMEKGATLADANRFDLRGELYCGKDVYIDINCIFTGKVVLGNGCKIGPNCSLTNVTLGDGCEVYANSVLEG
CHIANDCHIGPFARLRSGTQLASHCKIGNFVETKKAIFDEGTKASHLSYLGDVLLGKNVNVGAGTITCNYDGVNKHQTII
EDGVFIGSDTQLIAPVTVGANATIGAGSTIRRNVPPDELTLTESRQKTIYGWKRPVKRERD

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=457, Percent_Identity=50.328227571116, Blast_Score=468, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 50392; Mature: 50392

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQIIILAAGQGKRMYSDTPKVLHHLAGKPLLTHVVETAQQLNPNAIHVIYGHGGEQIK
CCEEEEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHH
SSLPNLPVHWVHQAEQLGTGHAVLQAMPHIPDDAYVLVLSADVPLIQVETLQSLIECSQR
HHCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHC
QNPDHSVLALLVAELENPSGLGRIIRNNQGEIYSIVEEKDANEQVKNIKEIYSGVCCTLA
CCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
NNLKKWLPQLSNSNAQGEYYLTEIISLAVQNKTPITSLTAKNSFEVQGINNRQQLQQLER
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCHHHHHHHHH
IWQQRAANQLMEKGATLADANRFDLRGELYCGKDVYIDINCIFTGKVVLGNGCKIGPNCS
HHHHHHHHHHHHCCCCEECCCCCCCCEEEEECCEEEEEEEEEEEEEEEECCCCEECCCCC
LTNVTLGDGCEVYANSVLEGCHIANDCHIGPFARLRSGTQLASHCKIGNFVETKKAIFDE
EEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHCCCCCHHHHHHHHHCC
GTKASHLSYLGDVLLGKNVNVGAGTITCNYDGVNKHQTIIEDGVFIGSDTQLIAPVTVGA
CCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHCCEEECCCCEEEEEEEECC
NATIGAGSTIRRNVPPDELTLTESRQKTIYGWKRPVKRERD
CCEECCCCCEECCCCCCCEEECCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNLQIIILAAGQGKRMYSDTPKVLHHLAGKPLLTHVVETAQQLNPNAIHVIYGHGGEQIK
CCEEEEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHH
SSLPNLPVHWVHQAEQLGTGHAVLQAMPHIPDDAYVLVLSADVPLIQVETLQSLIECSQR
HHCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHC
QNPDHSVLALLVAELENPSGLGRIIRNNQGEIYSIVEEKDANEQVKNIKEIYSGVCCTLA
CCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
NNLKKWLPQLSNSNAQGEYYLTEIISLAVQNKTPITSLTAKNSFEVQGINNRQQLQQLER
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCHHHHHHHHH
IWQQRAANQLMEKGATLADANRFDLRGELYCGKDVYIDINCIFTGKVVLGNGCKIGPNCS
HHHHHHHHHHHHCCCCEECCCCCCCCEEEEECCEEEEEEEEEEEEEEEECCCCEECCCCC
LTNVTLGDGCEVYANSVLEGCHIANDCHIGPFARLRSGTQLASHCKIGNFVETKKAIFDE
EEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHCCCCCHHHHHHHHHCC
GTKASHLSYLGDVLLGKNVNVGAGTITCNYDGVNKHQTIIEDGVFIGSDTQLIAPVTVGA
CCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHCCEEECCCCEEEEEEEECC
NATIGAGSTIRRNVPPDELTLTESRQKTIYGWKRPVKRERD
CCEECCCCCEECCCCCCCEEECCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA