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The map label for this gene is 52843033

Identifier: 52843033

GI number: 52843033

Start: 3211378

End: 3212679

Strand: Reverse

Name: 52843033

Synonym: lpg2837

Alternate gene names: NA

Gene position: 3212679-3211378 (Counterclockwise)

Preceding gene: 52843040

Following gene: 52843032

Centisome position: 94.55

GC content: 39.55

Gene sequence:

>1302_bases
ATGATCCAAAACAACAGGATTTGTCGCTGGCTCTTCATTGTATTGTTGTCTCTCCCTTTGGTTGGTTTTACGTCTATTCC
AGTGAAATCAATAGTGGTGTTTGGAGACAGCTTGTCTGATAACGGTAATACTACCCATTTACTTAAAAGCCTGCGTCAGG
AAGAGGATCCTGCGTTTTTAGTGGCTCCTTTCAAAATTTTTGTTATCAACAAAATGATAGAGTTTGCTAACGATTATTAT
GTTCCACAGATCGTGCTTGATGCAGGAATATCAGCAGTTACAGATTTTTTTGATCATGATTTGGCTCCCTATCTTGCCAA
TTTGGTGGGTAAAGTAAAACAGGTCCCGGTGCTGCCTGGCAAACCTTATTGGAAAAATCGCTTTTCTAATGGTCGTGTCT
GGATTGAGTATTTGGCAGAAATGTTATCGATACAAAAAAGTGATGAAGAAGTCTACCTAAATAAAGCATTTGGAGGTAGC
TGGTCTGCCACTTATGATTATCAATTAACAGTTTGGAACTTGATACGGCATCCATTGGGAACAATCAAGAACCTGATAGT
AGGAAAATTAATTCCTCCGAGTCTTGGTCTGATAGTGCAAGCTTATCTGCTGGAACACGAGCAGTTAAGTGATGAAACGC
TGTATTTTATTTATTCAGGAAGTAATGATTACATTAATGTTCTGTTTTTTGAAGACAATTACAATACTGAAGTAATGAGC
ACCTATATTGACAATGTGTTGGATGGTTTGAGTTCTGCAGTTCTGAAACTGGCTAATGCGGGAGCGAGACGTTTTGTTAT
TATGGGAATACCACATGTGGGGGATACTCCCAAGTTTGTGAAAACTACTGATCGTGACGTGTTAAATGCAGCGGTAGACC
TTCATAATGAGCGCCTTGCAAAACGGATTGACGCATGGAAAGAGCGGTATCCAACAGCTGACTTCTTGTTTGTAAATACA
GAGCAATACCTGAAAAAAGCGTTTGAAGATCCGGAGAAATATGGTTTTTATAATGTGAAAGATGCCTGTATCGATGTGAA
GTTCCCCATGTTCAATGCATTCATTCACTCTCCATTTGCTCGTAACTACGTATTGCAATACACACAGGTTCTTCAATATC
GAGATAAGCAATTTGCTCCAGGTGAAAATAACTATCACATGTGTAGTGAACCAGAAGACTATTTATTCTGGGATGAAATT
CATCCAACCACGAGAGCACATAACTATCTTGCTTATGAGGTTTGTATGGCTTTGGAGGAACATGGCTACGAGGTAACTTG
CAAAATGCCAGAGTCCGCCTAA

Upstream 100 bases:

>100_bases
TTAAGTATAAAGAATCGTTGACAATAATTAAATTCTGATCATACTCTAAGGGTTAAGCTGCTATCTTTTGTTTCGCTGGC
TTTGATATAAGGAGATTTTT

Downstream 100 bases:

>100_bases
TACAATTAGGTATCATCACTTGAACCACATTAACAGTGGTTCAGGTGATTTCATGATGAAGTTGTCTAAATTGATCCTCA
TTTAAGTAAATCCAGAGCGG

Product: phospholipase/lecithinase/hemolysin, lysophospholipase A, glycerophospholipid-cholesterol acyltransferase

Products: NA

Alternate protein names: Glycerophospholipid-cholesterol acyltransferase; GCAT [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MIQNNRICRWLFIVLLSLPLVGFTSIPVKSIVVFGDSLSDNGNTTHLLKSLRQEEDPAFLVAPFKIFVINKMIEFANDYY
VPQIVLDAGISAVTDFFDHDLAPYLANLVGKVKQVPVLPGKPYWKNRFSNGRVWIEYLAEMLSIQKSDEEVYLNKAFGGS
WSATYDYQLTVWNLIRHPLGTIKNLIVGKLIPPSLGLIVQAYLLEHEQLSDETLYFIYSGSNDYINVLFFEDNYNTEVMS
TYIDNVLDGLSSAVLKLANAGARRFVIMGIPHVGDTPKFVKTTDRDVLNAAVDLHNERLAKRIDAWKERYPTADFLFVNT
EQYLKKAFEDPEKYGFYNVKDACIDVKFPMFNAFIHSPFARNYVLQYTQVLQYRDKQFAPGENNYHMCSEPEDYLFWDEI
HPTTRAHNYLAYEVCMALEEHGYEVTCKMPESA

Sequences:

>Translated_433_residues
MIQNNRICRWLFIVLLSLPLVGFTSIPVKSIVVFGDSLSDNGNTTHLLKSLRQEEDPAFLVAPFKIFVINKMIEFANDYY
VPQIVLDAGISAVTDFFDHDLAPYLANLVGKVKQVPVLPGKPYWKNRFSNGRVWIEYLAEMLSIQKSDEEVYLNKAFGGS
WSATYDYQLTVWNLIRHPLGTIKNLIVGKLIPPSLGLIVQAYLLEHEQLSDETLYFIYSGSNDYINVLFFEDNYNTEVMS
TYIDNVLDGLSSAVLKLANAGARRFVIMGIPHVGDTPKFVKTTDRDVLNAAVDLHNERLAKRIDAWKERYPTADFLFVNT
EQYLKKAFEDPEKYGFYNVKDACIDVKFPMFNAFIHSPFARNYVLQYTQVLQYRDKQFAPGENNYHMCSEPEDYLFWDEI
HPTTRAHNYLAYEVCMALEEHGYEVTCKMPESA
>Mature_433_residues
MIQNNRICRWLFIVLLSLPLVGFTSIPVKSIVVFGDSLSDNGNTTHLLKSLRQEEDPAFLVAPFKIFVINKMIEFANDYY
VPQIVLDAGISAVTDFFDHDLAPYLANLVGKVKQVPVLPGKPYWKNRFSNGRVWIEYLAEMLSIQKSDEEVYLNKAFGGS
WSATYDYQLTVWNLIRHPLGTIKNLIVGKLIPPSLGLIVQAYLLEHEQLSDETLYFIYSGSNDYINVLFFEDNYNTEVMS
TYIDNVLDGLSSAVLKLANAGARRFVIMGIPHVGDTPKFVKTTDRDVLNAAVDLHNERLAKRIDAWKERYPTADFLFVNT
EQYLKKAFEDPEKYGFYNVKDACIDVKFPMFNAFIHSPFARNYVLQYTQVLQYRDKQFAPGENNYHMCSEPEDYLFWDEI
HPTTRAHNYLAYEVCMALEEHGYEVTCKMPESA

Specific function: Fatty acid transfer between phosphatidylcholine and cholesterol [H]

COG id: COG3240

COG function: function code IR; Phospholipase/lecithinase/hemolysin

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDSL' lipolytic enzyme family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013830
- InterPro:   IPR013831
- InterPro:   IPR001087
- InterPro:   IPR008265 [H]

Pfam domain/function: PF00657 Lipase_GDSL [H]

EC number: =2.3.1.43 [H]

Molecular weight: Translated: 49792; Mature: 49792

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQNNRICRWLFIVLLSLPLVGFTSIPVKSIVVFGDSLSDNGNTTHLLKSLRQEEDPAFL
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEE
VAPFKIFVINKMIEFANDYYVPQIVLDAGISAVTDFFDHDLAPYLANLVGKVKQVPVLPG
EECHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
KPYWKNRFSNGRVWIEYLAEMLSIQKSDEEVYLNKAFGGSWSATYDYQLTVWNLIRHPLG
CCHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEHHHHHHHHHHH
TIKNLIVGKLIPPSLGLIVQAYLLEHEQLSDETLYFIYSGSNDYINVLFFEDNYNTEVMS
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHH
TYIDNVLDGLSSAVLKLANAGARRFVIMGIPHVGDTPKFVKTTDRDVLNAAVDLHNERLA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHCCCCHHHHHHHHHHHHHHHH
KRIDAWKERYPTADFLFVNTEQYLKKAFEDPEKYGFYNVKDACIDVKFPMFNAFIHSPFA
HHHHHHHHHCCCCEEEEECHHHHHHHHHCCHHHCCCCCCCHHEEEEECHHHHHHHCCCHH
RNYVLQYTQVLQYRDKQFAPGENNYHMCSEPEDYLFWDEIHPTTRAHNYLAYEVCMALEE
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHCCHHHHHHHHHHHH
HGYEVTCKMPESA
CCCEEEEECCCCC
>Mature Secondary Structure
MIQNNRICRWLFIVLLSLPLVGFTSIPVKSIVVFGDSLSDNGNTTHLLKSLRQEEDPAFL
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEE
VAPFKIFVINKMIEFANDYYVPQIVLDAGISAVTDFFDHDLAPYLANLVGKVKQVPVLPG
EECHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
KPYWKNRFSNGRVWIEYLAEMLSIQKSDEEVYLNKAFGGSWSATYDYQLTVWNLIRHPLG
CCHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEHHHHHHHHHHH
TIKNLIVGKLIPPSLGLIVQAYLLEHEQLSDETLYFIYSGSNDYINVLFFEDNYNTEVMS
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHH
TYIDNVLDGLSSAVLKLANAGARRFVIMGIPHVGDTPKFVKTTDRDVLNAAVDLHNERLA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHCCCCHHHHHHHHHHHHHHHH
KRIDAWKERYPTADFLFVNTEQYLKKAFEDPEKYGFYNVKDACIDVKFPMFNAFIHSPFA
HHHHHHHHHCCCCEEEEECHHHHHHHHHCCHHHCCCCCCCHHEEEEECHHHHHHHCCCHH
RNYVLQYTQVLQYRDKQFAPGENNYHMCSEPEDYLFWDEIHPTTRAHNYLAYEVCMALEE
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHCCHHHHHHHHHHHH
HGYEVTCKMPESA
CCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2271578; 3280033; 1985976; 8294469 [H]