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The map label for this gene is tpm

Identifier: 52843031

GI number: 52843031

Start: 3208538

End: 3209203

Strand: Reverse

Name: tpm

Synonym: lpg2835

Alternate gene names: 52843031

Gene position: 3209203-3208538 (Counterclockwise)

Preceding gene: 52843032

Following gene: 52843030

Centisome position: 94.45

GC content: 38.89

Gene sequence:

>666_bases
GTGAACAAAGGTCAATATTTTTGGAATGAGTTATGGTGCGAGGGACGTATTTCTTTTCATAAAGAAGAAGTAAATCCGGA
TTTGATAGCCTATATCTCTTCCTTAAATATACCTGCCAAGGGAAGGGTTCTGGTTCCTTTGTGTGGAAAAAGTGTCGATA
TGCTTTGGTTAGTTCGCCAAGGGTATCATGTGGTTGGTATCGAACTGGTTGAAAAGGCTATTCTTCAGTTTGTTCAGGAG
CACCAAATCACTGTTCGGGAGAATACGACAGGTCAGGCAAAACAATATTTTACAGATAATTTGAATTTATGGATTACCGA
TATTTTTGCTTTAAACGCGGCTTTAATAGAACCAGTTGATGCTATCTATGACAGAGCGGCTTTGGTTGCTTTGCCAAAAA
AATTGCGACCAGCGTATGTAGATATTTGCCTCAAGTGGCTTAAGCCTGGGGGAAGTATTCTGTTAAAGACTTTACAATAT
AATCAAGAGAAAGTGCAGGGTCCTCCGTATAGTGTTTCCCCAGAAGAAATCGCTTTATCGTATCAGCAATGTGCCAAAAT
AGAGTTGTTGAAATCGCAAAAACGAATTCGGGAGCCTAATGATCATTTATTTAATCTTGGTATTAGTGAAGTGAATGATT
ATGTTTGGCGTATTAGGAAGGGGTAA

Upstream 100 bases:

>100_bases
TTTACACTATTCCTTTGCAATTGCTGGCCTATCATGTTGCTGTAGCTAAAGGGACTGATGTGGATCAACCTAGAAACCTT
GCAAAATCGGTGACTGTAGA

Downstream 100 bases:

>100_bases
AACGTAGTACAGTGTTACGCATAAGGACATTTTGTATGGATATTAGCTTAATTTCTATATCGCATTATAGTATGTGATGA
GTATATAATGAGACGATTTT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MNKGQYFWNELWCEGRISFHKEEVNPDLIAYISSLNIPAKGRVLVPLCGKSVDMLWLVRQGYHVVGIELVEKAILQFVQE
HQITVRENTTGQAKQYFTDNLNLWITDIFALNAALIEPVDAIYDRAALVALPKKLRPAYVDICLKWLKPGGSILLKTLQY
NQEKVQGPPYSVSPEEIALSYQQCAKIELLKSQKRIREPNDHLFNLGISEVNDYVWRIRKG

Sequences:

>Translated_221_residues
MNKGQYFWNELWCEGRISFHKEEVNPDLIAYISSLNIPAKGRVLVPLCGKSVDMLWLVRQGYHVVGIELVEKAILQFVQE
HQITVRENTTGQAKQYFTDNLNLWITDIFALNAALIEPVDAIYDRAALVALPKKLRPAYVDICLKWLKPGGSILLKTLQY
NQEKVQGPPYSVSPEEIALSYQQCAKIELLKSQKRIREPNDHLFNLGISEVNDYVWRIRKG
>Mature_221_residues
MNKGQYFWNELWCEGRISFHKEEVNPDLIAYISSLNIPAKGRVLVPLCGKSVDMLWLVRQGYHVVGIELVEKAILQFVQE
HQITVRENTTGQAKQYFTDNLNLWITDIFALNAALIEPVDAIYDRAALVALPKKLRPAYVDICLKWLKPGGSILLKTLQY
NQEKVQGPPYSVSPEEIALSYQQCAKIELLKSQKRIREPNDHLFNLGISEVNDYVWRIRKG

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

Organism=Homo sapiens, GI4507653, Length=197, Percent_Identity=31.4720812182741, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 25384; Mature: 25384

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKGQYFWNELWCEGRISFHKEEVNPDLIAYISSLNIPAKGRVLVPLCGKSVDMLWLVRQ
CCCCHHHHHHHEECCCCEEEHHHCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHC
GYHVVGIELVEKAILQFVQEHQITVRENTTGQAKQYFTDNLNLWITDIFALNAALIEPVD
CCEEEHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHH
AIYDRAALVALPKKLRPAYVDICLKWLKPGGSILLKTLQYNQEKVQGPPYSVSPEEIALS
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHCCHHHCCCCCCCCCHHHHHHH
YQQCAKIELLKSQKRIREPNDHLFNLGISEVNDYVWRIRKG
HHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHEECCC
>Mature Secondary Structure
MNKGQYFWNELWCEGRISFHKEEVNPDLIAYISSLNIPAKGRVLVPLCGKSVDMLWLVRQ
CCCCHHHHHHHEECCCCEEEHHHCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHC
GYHVVGIELVEKAILQFVQEHQITVRENTTGQAKQYFTDNLNLWITDIFALNAALIEPVD
CCEEEHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHH
AIYDRAALVALPKKLRPAYVDICLKWLKPGGSILLKTLQYNQEKVQGPPYSVSPEEIALS
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHCCHHHCCCCCCCCCHHHHHHH
YQQCAKIELLKSQKRIREPNDHLFNLGISEVNDYVWRIRKG
HHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA