Click here to switch to the map view.

The map label for this gene is nuoI

Identifier: 52842979

GI number: 52842979

Start: 3132777

End: 3133277

Strand: Reverse

Name: nuoI

Synonym: lpg2781

Alternate gene names: 52842979

Gene position: 3133277-3132777 (Counterclockwise)

Preceding gene: 52842980

Following gene: 52842978

Centisome position: 92.22

GC content: 38.72

Gene sequence:

>501_bases
ATGAAAAAAGTATATCATTATATAATTCACTATGTTCGTACCTACTTACTGTTAGAGCTATTAGCCGGTTTATGGTTAAC
AGTAAAGTATTTTTTCAGGAAAAAAATAACAGTTCAGTTTCCTGAAGAACAAACGCCACTTTCTCCAAGATTCAGGGGGC
TTTTGGCATTACGTCGTTATCCCAATGGTGAGGAGCGCTGCATTGCATGTAAATTGTGTGAAGCCGTTTGCCCTGCATTA
GCTATTACTATTGAATCAGAGCAAAGAGACGATGGATCACGCCGTACTACTCGGTATGATATTGATATGTTTAAATGCAT
TAATTGTGGATTATGTGAAGAATCTTGCCCTGTTGATTCGATCGTTGTCACTCCAATTCATCACTACCATATCAGCGAAC
GTGGTCAAAATATTATGACAAAAGAGAAGCTTTTAGCAGTAGGCGATTTGATGGAATCACAACTCGCAGCAGACAGAGCT
GCTGATGAAAAATACCGTTGA

Upstream 100 bases:

>100_bases
GAAGGTACTTATCCCTGTTACTATAGTTTGGTTAATAGTAACCGCCCTTATGGTGGTTGCTCATGTCAAGCCATGGTTTT
GACGGTTAGAAGAGAAGCCG

Downstream 100 bases:

>100_bases
TGGGGTGATTTATGCATGAATGGGTAATCCAAGCAATTTTTTATGTCTTTGCATTATTGACCGTACTGTCGGCAGTAATG
GTAATAAGCCAAAACAATCC

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MKKVYHYIIHYVRTYLLLELLAGLWLTVKYFFRKKITVQFPEEQTPLSPRFRGLLALRRYPNGEERCIACKLCEAVCPAL
AITIESEQRDDGSRRTTRYDIDMFKCINCGLCEESCPVDSIVVTPIHHYHISERGQNIMTKEKLLAVGDLMESQLAADRA
ADEKYR

Sequences:

>Translated_166_residues
MKKVYHYIIHYVRTYLLLELLAGLWLTVKYFFRKKITVQFPEEQTPLSPRFRGLLALRRYPNGEERCIACKLCEAVCPAL
AITIESEQRDDGSRRTTRYDIDMFKCINCGLCEESCPVDSIVVTPIHHYHISERGQNIMTKEKLLAVGDLMESQLAADRA
ADEKYR
>Mature_166_residues
MKKVYHYIIHYVRTYLLLELLAGLWLTVKYFFRKKITVQFPEEQTPLSPRFRGLLALRRYPNGEERCIACKLCEAVCPAL
AITIESEQRDDGSRRTTRYDIDMFKCINCGLCEESCPVDSIVVTPIHHYHISERGQNIMTKEKLLAVGDLMESQLAADRA
ADEKYR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=155, Percent_Identity=59.3548387096774, Blast_Score=189, Evalue=1e-48,
Organism=Escherichia coli, GI1788617, Length=139, Percent_Identity=38.8489208633094, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17555194, Length=161, Percent_Identity=54.6583850931677, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI17864306, Length=153, Percent_Identity=57.516339869281, Blast_Score=184, Evalue=2e-47,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 19292; Mature: 19292

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVYHYIIHYVRTYLLLELLAGLWLTVKYFFRKKITVQFPEEQTPLSPRFRGLLALRRY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHCC
PNGEERCIACKLCEAVCPALAITIESEQRDDGSRRTTRYDIDMFKCINCGLCEESCPVDS
CCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEECHHHHHHHCCCCCCCCCCCCC
IVVTPIHHYHISERGQNIMTKEKLLAVGDLMESQLAADRAADEKYR
EEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKVYHYIIHYVRTYLLLELLAGLWLTVKYFFRKKITVQFPEEQTPLSPRFRGLLALRRY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHCC
PNGEERCIACKLCEAVCPALAITIESEQRDDGSRRTTRYDIDMFKCINCGLCEESCPVDS
CCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEECHHHHHHHCCCCCCCCCCCCC
IVVTPIHHYHISERGQNIMTKEKLLAVGDLMESQLAADRAADEKYR
EEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA