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The map label for this gene is hemX [H]

Identifier: 52842941

GI number: 52842941

Start: 3087363

End: 3088487

Strand: Direct

Name: hemX [H]

Synonym: lpg2737

Alternate gene names: 52842941

Gene position: 3087363-3088487 (Clockwise)

Preceding gene: 52842940

Following gene: 52842942

Centisome position: 90.86

GC content: 36.62

Gene sequence:

>1125_bases
ATGGCCAATAGCAATGAAGAACAGAAAAAAACAATTCAACCGCAACAACCATCTAAAGTTGAGCCCGACATCAACCAACA
AATGAAAGCCTCTTTCTTCGGTAGTAAATACCTATCCTTAATAATCAGCTTGACATCGCTTTTGGCGTTCCTTGCTATCA
TCGTCTCTATTTATTCCATTCAATTGGAGAAACAATTTCAAAACCATCAGCTTGTTGAAAACAAAAATTTAACTGATGAA
TTGGAAAGAATAAAAGTAGAGCAAAATACAGTCCAAAAGCTCCTGGATAACAATGCCAATCATCTTCAGCAAATTCAGAG
TGATTTAACAAGCAAAATGGATAGCTTAAATAAAGAATTACAAACAGCTATGAAGCAAAAATTGTATCAAAATAATGATT
GGCTTCTTTTAAAGGCACGTTATTATCTTGAATTAGCGCAAATCAATGTTCATTGGAGTGATAATTTTAATACCTCTGTC
GCCCTTTTACAGCAAGCTGATGCGCTACTGAAAGGTATGAATATCCCCAAAATATTTACCATTCGCCAGACAATCGCCAA
AGAAATTGCCCAATTAAAGTCAATTTCTGTTGTTGATATCACAGGGATATTAAGTCAATTGGATGCGGCCCAAGCGGCTA
TCAATAATCTTTCTATTCAATCCGTAGTAGATCAACAGGAAGTGCTAAACCATATCACCAAGTCTGAAGAGTCTGGCAAA
ACTGGATGGCGAAATCGGTTGCAAGACAGTGTGAATTTTCTGGAGAAATTGGTTGTTATTCGTCGCCACAATGAAAATAT
TCAACCACTTATATCCCCTCTATATGAATCTGCAATAAAAGAGAATATCCGCCTTAACCTTCAGGAAGCGCAGTGGGCTA
TTTTAAATAATAACCCCGCAGTCTACCAGTTTGCTTTAAACCAGGCCATTGCAAATCTTAAAAGAGTATTTAATGAATCT
TCCCAAAACACCGACGTTTTGATTAAGCAATTGTCCACTTTGCAAAATGTAAAATTAACTCAGGAAAAACCTGTCGTAGG
ACAAGCCATCCCGCTAATCAATCAAATGATTGACAATAAAGAGTTGCTGGTCGATCAAGCAAACAGCAAGAAAGGAGAAA
ATTAA

Upstream 100 bases:

>100_bases
CCGACTTGCAAAGGTAGCTTCTTTATTTGGAATTAAAAAGATTCTTATTAGCCATCCAGAAAGGATGATAGGTGCGTTAT
TTGACTATAAGGATTAATCC

Downstream 100 bases:

>100_bases
GAATGATACGAGTTCTGTTTGCTTTTATTATTTTACTGCTCTCTGTGTTCCTTGGTATTCAACTCAATAAGGATCCAGGT
TATGTCTTAATAGCTATTAA

Product: uroporphyrinogen III methylase

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MANSNEEQKKTIQPQQPSKVEPDINQQMKASFFGSKYLSLIISLTSLLAFLAIIVSIYSIQLEKQFQNHQLVENKNLTDE
LERIKVEQNTVQKLLDNNANHLQQIQSDLTSKMDSLNKELQTAMKQKLYQNNDWLLLKARYYLELAQINVHWSDNFNTSV
ALLQQADALLKGMNIPKIFTIRQTIAKEIAQLKSISVVDITGILSQLDAAQAAINNLSIQSVVDQQEVLNHITKSEESGK
TGWRNRLQDSVNFLEKLVVIRRHNENIQPLISPLYESAIKENIRLNLQEAQWAILNNNPAVYQFALNQAIANLKRVFNES
SQNTDVLIKQLSTLQNVKLTQEKPVVGQAIPLINQMIDNKELLVDQANSKKGEN

Sequences:

>Translated_374_residues
MANSNEEQKKTIQPQQPSKVEPDINQQMKASFFGSKYLSLIISLTSLLAFLAIIVSIYSIQLEKQFQNHQLVENKNLTDE
LERIKVEQNTVQKLLDNNANHLQQIQSDLTSKMDSLNKELQTAMKQKLYQNNDWLLLKARYYLELAQINVHWSDNFNTSV
ALLQQADALLKGMNIPKIFTIRQTIAKEIAQLKSISVVDITGILSQLDAAQAAINNLSIQSVVDQQEVLNHITKSEESGK
TGWRNRLQDSVNFLEKLVVIRRHNENIQPLISPLYESAIKENIRLNLQEAQWAILNNNPAVYQFALNQAIANLKRVFNES
SQNTDVLIKQLSTLQNVKLTQEKPVVGQAIPLINQMIDNKELLVDQANSKKGEN
>Mature_373_residues
ANSNEEQKKTIQPQQPSKVEPDINQQMKASFFGSKYLSLIISLTSLLAFLAIIVSIYSIQLEKQFQNHQLVENKNLTDEL
ERIKVEQNTVQKLLDNNANHLQQIQSDLTSKMDSLNKELQTAMKQKLYQNNDWLLLKARYYLELAQINVHWSDNFNTSVA
LLQQADALLKGMNIPKIFTIRQTIAKEIAQLKSISVVDITGILSQLDAAQAAINNLSIQSVVDQQEVLNHITKSEESGKT
GWRNRLQDSVNFLEKLVVIRRHNENIQPLISPLYESAIKENIRLNLQEAQWAILNNNPAVYQFALNQAIANLKRVFNESS
QNTDVLIKQLSTLQNVKLTQEKPVVGQAIPLINQMIDNKELLVDQANSKKGEN

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=229, Percent_Identity=27.0742358078603, Blast_Score=92, Evalue=8e-20,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 42534; Mature: 42403

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSNEEQKKTIQPQQPSKVEPDINQQMKASFFGSKYLSLIISLTSLLAFLAIIVSIYSI
CCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLEKQFQNHQLVENKNLTDELERIKVEQNTVQKLLDNNANHLQQIQSDLTSKMDSLNKEL
HHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QTAMKQKLYQNNDWLLLKARYYLELAQINVHWSDNFNTSVALLQQADALLKGMNIPKIFT
HHHHHHHHHCCCCEEEEEHHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHH
IRQTIAKEIAQLKSISVVDITGILSQLDAAQAAINNLSIQSVVDQQEVLNHITKSEESGK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
TGWRNRLQDSVNFLEKLVVIRRHNENIQPLISPLYESAIKENIRLNLQEAQWAILNNNPA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEHHHEEEEECCCCC
VYQFALNQAIANLKRVFNESSQNTDVLIKQLSTLQNVKLTQEKPVVGQAIPLINQMIDNK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCH
ELLVDQANSKKGEN
HHHHCCCCCCCCCC
>Mature Secondary Structure 
ANSNEEQKKTIQPQQPSKVEPDINQQMKASFFGSKYLSLIISLTSLLAFLAIIVSIYSI
CCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLEKQFQNHQLVENKNLTDELERIKVEQNTVQKLLDNNANHLQQIQSDLTSKMDSLNKEL
HHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QTAMKQKLYQNNDWLLLKARYYLELAQINVHWSDNFNTSVALLQQADALLKGMNIPKIFT
HHHHHHHHHCCCCEEEEEHHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHH
IRQTIAKEIAQLKSISVVDITGILSQLDAAQAAINNLSIQSVVDQQEVLNHITKSEESGK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
TGWRNRLQDSVNFLEKLVVIRRHNENIQPLISPLYESAIKENIRLNLQEAQWAILNNNPA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEHHHEEEEECCCCC
VYQFALNQAIANLKRVFNESSQNTDVLIKQLSTLQNVKLTQEKPVVGQAIPLINQMIDNK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCH
ELLVDQANSKKGEN
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]