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The map label for this gene is hemD [H]

Identifier: 52842940

GI number: 52842940

Start: 3086607

End: 3087359

Strand: Direct

Name: hemD [H]

Synonym: lpg2736

Alternate gene names: 52842940

Gene position: 3086607-3087359 (Clockwise)

Preceding gene: 52842939

Following gene: 52842941

Centisome position: 90.84

GC content: 40.11

Gene sequence:

>753_bases
ATGACCAAATCACTTAATGGTCTTCGCATATTAAACACCAGACCCAGGGAGCAAGCACAAGTGCTTAATAAAAAAATTAT
CGAGTCTGGCGGAATACCCATCGACTGCCCCACGATGGAAATAATGGCGTCTGAAACCAATTGGATAAATAATTTGCCTG
ATTTGACCTCAGTAAATCAGGCCATTTTTGTCAGTACAAATGCCGTTCGTTATTTCATGATGGAACTGGCTTCCAAAAAC
ATCAATTGGCCAAATAGCATCCGGGTAACTGCTATAGGTAAAGGCACCTCCAGAGTACTCAATGAATTCAATATCCAGGT
TAGTGATGTCCCCGAATTACCTGACAGCGAGCATTTACTGACTCTCAATTCGTTGCAACAAATAAGAAATCAGACGATTC
TGCTTGTGAAAGGAGAAGGAGGCAGGCAACTGATTGAAGAATATTTAATGCTGAAGGGAGCGAAACTATGTCTTCTGTCA
GTCTATAAACGAGTCATGCCAGCCATCGACCAAGAATTTATTAATTCTCTGTGGCGCGATGACCTGGTGGACATTATACT
GTTAACAAGTGAGCAGTCCATACATAATCTTTTTAAAATGTTTAGCATAGAGGGGCAAATGTGGTTACAAAACAAACCTT
GCCTGGTCATTAGTGACCGACTTGCAAAGGTAGCTTCTTTATTTGGAATTAAAAAGATTCTTATTAGCCATCCAGAAAGG
ATGATAGGTGCGTTATTTGACTATAAGGATTAA

Upstream 100 bases:

>100_bases
AGCAACAAGGGAAAATTGCAGAAGCTGAAGTCATTGCAGACAGGTGTACCGAGTCATTAATGACTAAAGGTGCAATGTCC
TTATTAAGTACGATACCATC

Downstream 100 bases:

>100_bases
TCCATGGCCAATAGCAATGAAGAACAGAAAAAAACAATTCAACCGCAACAACCATCTAAAGTTGAGCCCGACATCAACCA
ACAAATGAAAGCCTCTTTCT

Product: uroporphyrinogen III methylase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTKSLNGLRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASETNWINNLPDLTSVNQAIFVSTNAVRYFMMELASKN
INWPNSIRVTAIGKGTSRVLNEFNIQVSDVPELPDSEHLLTLNSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLS
VYKRVMPAIDQEFINSLWRDDLVDIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILISHPER
MIGALFDYKD

Sequences:

>Translated_250_residues
MTKSLNGLRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASETNWINNLPDLTSVNQAIFVSTNAVRYFMMELASKN
INWPNSIRVTAIGKGTSRVLNEFNIQVSDVPELPDSEHLLTLNSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLS
VYKRVMPAIDQEFINSLWRDDLVDIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILISHPER
MIGALFDYKD
>Mature_249_residues
TKSLNGLRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASETNWINNLPDLTSVNQAIFVSTNAVRYFMMELASKNI
NWPNSIRVTAIGKGTSRVLNEFNIQVSDVPELPDSEHLLTLNSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSV
YKRVMPAIDQEFINSLWRDDLVDIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILISHPERM
IGALFDYKD

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=233, Percent_Identity=26.6094420600858, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28373; Mature: 28241

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSLNGLRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASETNWINNLPDLTSVNQ
CCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHEEECCCCHHCCCCCCCCCCC
AIFVSTNAVRYFMMELASKNINWPNSIRVTAIGKGTSRVLNEFNIQVSDVPELPDSEHLL
EEEEEHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHCCEECCCCCCCCCCCEE
TLNSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSVYKRVMPAIDQEFINSLWRD
EHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLVDIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILISHPER
HHHEEEEEECCHHHHHHHHHHHCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHHCHHH
MIGALFDYKD
HHHHHHCCCC
>Mature Secondary Structure 
TKSLNGLRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASETNWINNLPDLTSVNQ
CCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHEEECCCCHHCCCCCCCCCCC
AIFVSTNAVRYFMMELASKNINWPNSIRVTAIGKGTSRVLNEFNIQVSDVPELPDSEHLL
EEEEEHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHCCEECCCCCCCCCCCEE
TLNSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSVYKRVMPAIDQEFINSLWRD
EHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLVDIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILISHPER
HHHEEEEEECCHHHHHHHHHHHCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHHCHHH
MIGALFDYKD
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]