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The map label for this gene is hemC

Identifier: 52842939

GI number: 52842939

Start: 3085645

End: 3086610

Strand: Direct

Name: hemC

Synonym: lpg2735

Alternate gene names: 52842939

Gene position: 3085645-3086610 (Clockwise)

Preceding gene: 52842937

Following gene: 52842940

Centisome position: 90.81

GC content: 42.03

Gene sequence:

>966_bases
ATGATCTTTACCCAAAGAACATATACCGTCTATTCCATGAGCGCAAAAATTATACGAATCGCAACGAGGCAGAGCCCGCT
TGCACTATGGCAGGCTAATCATGTACGGGAAATGCTTGTAAAGCAATGGCCAAATCTAAGCATTGAATTATTACCCATGA
TAACCTCTGGCGATCGGTTTCTTAAAGATAAATTATTATCCGCAGGAGGGAAAGGGTTATTTGTTAAAGAGTTAGAAGAA
GCATTATTGGATAAAAGAGCGGACTTGGCTGTTCATTCGACTAAAGACATGCCAGCACAACTTCCGGATGGCCTCTTGTT
GACCGCCATTTGCAAAAGAGATAACCCTTTTGACGCTTTAATAAGTCCCCAATTTAAAAGTCTTGCTGCTCTCCCCAAAA
ACGCGATTATTGGTACATCAAGCCTTAGACGTCAATCTCAACTATTGGCTTACAATCCCAATTTGCAAATCAAAACATTA
AGAGGAAACATCCATACAAGACTCAGCAAACTGGAGTCAGGAGAGTATCAAGCCATTATTCTTGCTGCCGCAGGCTTGGA
AAGAATGGGCTTGGCACATCACATCACCCAACTCATACCCGATGACATTATGCTGCCTACTTGTGCTCAGGGCGCTTTAT
GTATTGAGTGCCGAACTGACGATTTGGAAATCCAGGAGCTGGTTCATGGCTTAAATGATCCAATTTCTGCTCTTTGTGTC
CATACTGAGCGACGCGTCAACGCAAAATTAGGAGGCAATTGCCATATACCCTTTGCTGTTTATTGTACCATTACTGAGGA
GAAACTCCTCCTTTTGAGAGCAAAAGTACTTAATATGGATGGTTCTCAAATGATTGATGATGAGCAACAAGGGAAAATTG
CAGAAGCTGAAGTCATTGCAGACAGGTGTACCGAGTCATTAATGACTAAAGGTGCAATGTCCTTATTAAGTACGATACCA
TCATGA

Upstream 100 bases:

>100_bases
TTCTCAAACCGGTAGGAATGCTCATTTATAAATCAATTGCCCGACAAGATTTGCGTACCTATTATCTCAATGGGGTTCTT
TTTAAATTAGAATCAATGTT

Downstream 100 bases:

>100_bases
CCAAATCACTTAATGGTCTTCGCATATTAAACACCAGACCCAGGGAGCAAGCACAAGTGCTTAATAAAAAAATTATCGAG
TCTGGCGGAATACCCATCGA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MIFTQRTYTVYSMSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKGLFVKELEE
ALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALPKNAIIGTSSLRRQSQLLAYNPNLQIKTL
RGNIHTRLSKLESGEYQAIILAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCV
HTERRVNAKLGGNCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGAMSLLSTIP
S

Sequences:

>Translated_321_residues
MIFTQRTYTVYSMSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKGLFVKELEE
ALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALPKNAIIGTSSLRRQSQLLAYNPNLQIKTL
RGNIHTRLSKLESGEYQAIILAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCV
HTERRVNAKLGGNCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGAMSLLSTIP
S
>Mature_321_residues
MIFTQRTYTVYSMSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKGLFVKELEE
ALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALPKNAIIGTSSLRRQSQLLAYNPNLQIKTL
RGNIHTRLSKLESGEYQAIILAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCV
HTERRVNAKLGGNCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGAMSLLSTIP
S

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=282, Percent_Identity=42.1985815602837, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI66933009, Length=282, Percent_Identity=42.1985815602837, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI48994974, Length=307, Percent_Identity=49.8371335504886, Blast_Score=296, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6319996, Length=325, Percent_Identity=38.1538461538462, Blast_Score=206, Evalue=5e-54,
Organism=Drosophila melanogaster, GI20130425, Length=290, Percent_Identity=38.2758620689655, Blast_Score=181, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35479; Mature: 35479

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFTQRTYTVYSMSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRF
CEEECEEEEEEEECEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHH
LKDKLLSAGGKGLFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDAL
HHHHHHHCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEHHHHCCCCCCCHH
ISPQFKSLAALPKNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAII
CCCHHHHHHHCCCCCEECCHHHHHHCCEEEECCCEEEEEECCHHHHHHHHHCCCCEEEEE
LAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCV
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHHHH
HTERRVNAKLGGNCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIA
HHHHHCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCHHCCCHHHHHHHH
DRCTESLMTKGAMSLLSTIPS
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIFTQRTYTVYSMSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRF
CEEECEEEEEEEECEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHH
LKDKLLSAGGKGLFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDAL
HHHHHHHCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEHHHHCCCCCCCHH
ISPQFKSLAALPKNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAII
CCCHHHHHHHCCCCCEECCHHHHHHCCEEEECCCEEEEEECCHHHHHHHHHCCCCEEEEE
LAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCV
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHHHH
HTERRVNAKLGGNCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIA
HHHHHCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCHHCCCHHHHHHHH
DRCTESLMTKGAMSLLSTIPS
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA