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The map label for this gene is yvmA [H]

Identifier: 52842709

GI number: 52842709

Start: 2818415

End: 2819647

Strand: Direct

Name: yvmA [H]

Synonym: lpg2501

Alternate gene names: 52842709

Gene position: 2818415-2819647 (Clockwise)

Preceding gene: 52842708

Following gene: 52842712

Centisome position: 82.95

GC content: 40.55

Gene sequence:

>1233_bases
ATGACTTTTTATATGCCTAAATCACATAATTCCATTATATTTCTTGGTTTGCTTTCTGCGTTTTCTTTGCTTACATTTGA
TCTTTATCAACCATCACTGCCTTTCATAACGAATTATTTTAATATTACCCCAAGTATGGGGCAATTAACCCTAAGTATTT
ATTTGCTAGTTTATGGTATCACGCATCTTCTATGGGGACCACTTATAGACCATTTTGGGCGCCGGCGCCTACTTCCCGGA
AACCTTTTATTAGCCTTAATTGGCAGTTTAATGTGTGCTTTTGCACCGAATATCACCATGCTTATTTGCGGTCGTGCCCT
ACAAGGATTCGCTTTATGCTGCGCCAATCTCATTGCCTATTCCGCAGCACGTGATTTTGAAGACACGATTGTTCGCGCCA
AAGTGCTGTCCTATATTTCCATGACCGTTTCAGTTTCACCGATTATAGCCCCGGTAATTGGTGCTCTTATCTTTCATCAT
TTTGGCTGGCAAGCCAATTTTATAGTCATGGCAATCGTTGCCTGTATTCTATTGATACAAACCAAACTCTCCTTGCTAGA
GTCCCCTTTCTGGACTCCTCCCCAGGAGAGGTTCTCGGTAAAAAAAATACTCCAGGAATATAAGTCCATACTCAATATAC
CCTCTCTATGGTGCGCATCATTTATTTTAATGTTTGGCATTTCTGCTGTCATGCTCACTGTAATTAATTCCTCTTACCTT
ATCATCGAGGTACTGAATTACTCTCCACTTGCCTATGGACTTATTTTTATTCTGAATGGTTTAAATATTATTTTTGGAAA
CTATCTGGGCATTTGGCTTCGTGACCGATTACCCATTATCACCACCATCTATTTGGGGAACTGGTTCATTGTCCTTGGTG
GTACAGCGATGTTGGTTACTTCCAAATTGTTTGGATTTAGTCTGTTAGCATTGTCATTTTCATTAATTGCCAACTTGGGA
ATTAGTGTCAGTGCCGCTCCAACTATCTCCATCGCCCTAACGGATTTTAAGCAAAATGCAGGAATAGTTATGGCTTTTAT
GAATACCATACGTTTAATCGGCCCCTCTCTTTTAACTATTCTAACCGGCTATTTGTTGACAAGGAATCTTGACGCGCTTC
CACTGGGATTAATAGGCTCAGGAATTGGAGCCCTCTTTTTCTCATGGCATTTTAGCCGATTGACCACTGAATCGAGAAAC
TCAGACATGGATAGCGAAGAAGCGTTGACCTAA

Upstream 100 bases:

>100_bases
ATCTGTCCCAGAGTAAAGCATGTTGGCAGTTGCCAACTTGCTTTAATATTTCCTTTCAAATGCAAGCTGAATTTGGTTAC
AATCGCATAATTTTTGGTGA

Downstream 100 bases:

>100_bases
CAGTCTGTTAACTTCCCCATATTGGATATAAAATTTTTTATATAATTCTCCTGAAACACAGAGCCACACATTGGTTCTGT
GAAGGTAAAGCAAAACATGA

Product: multidrug resistance protein D

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTFYMPKSHNSIIFLGLLSAFSLLTFDLYQPSLPFITNYFNITPSMGQLTLSIYLLVYGITHLLWGPLIDHFGRRRLLPG
NLLLALIGSLMCAFAPNITMLICGRALQGFALCCANLIAYSAARDFEDTIVRAKVLSYISMTVSVSPIIAPVIGALIFHH
FGWQANFIVMAIVACILLIQTKLSLLESPFWTPPQERFSVKKILQEYKSILNIPSLWCASFILMFGISAVMLTVINSSYL
IIEVLNYSPLAYGLIFILNGLNIIFGNYLGIWLRDRLPIITTIYLGNWFIVLGGTAMLVTSKLFGFSLLALSFSLIANLG
ISVSAAPTISIALTDFKQNAGIVMAFMNTIRLIGPSLLTILTGYLLTRNLDALPLGLIGSGIGALFFSWHFSRLTTESRN
SDMDSEEALT

Sequences:

>Translated_410_residues
MTFYMPKSHNSIIFLGLLSAFSLLTFDLYQPSLPFITNYFNITPSMGQLTLSIYLLVYGITHLLWGPLIDHFGRRRLLPG
NLLLALIGSLMCAFAPNITMLICGRALQGFALCCANLIAYSAARDFEDTIVRAKVLSYISMTVSVSPIIAPVIGALIFHH
FGWQANFIVMAIVACILLIQTKLSLLESPFWTPPQERFSVKKILQEYKSILNIPSLWCASFILMFGISAVMLTVINSSYL
IIEVLNYSPLAYGLIFILNGLNIIFGNYLGIWLRDRLPIITTIYLGNWFIVLGGTAMLVTSKLFGFSLLALSFSLIANLG
ISVSAAPTISIALTDFKQNAGIVMAFMNTIRLIGPSLLTILTGYLLTRNLDALPLGLIGSGIGALFFSWHFSRLTTESRN
SDMDSEEALT
>Mature_409_residues
TFYMPKSHNSIIFLGLLSAFSLLTFDLYQPSLPFITNYFNITPSMGQLTLSIYLLVYGITHLLWGPLIDHFGRRRLLPGN
LLLALIGSLMCAFAPNITMLICGRALQGFALCCANLIAYSAARDFEDTIVRAKVLSYISMTVSVSPIIAPVIGALIFHHF
GWQANFIVMAIVACILLIQTKLSLLESPFWTPPQERFSVKKILQEYKSILNIPSLWCASFILMFGISAVMLTVINSSYLI
IEVLNYSPLAYGLIFILNGLNIIFGNYLGIWLRDRLPIITTIYLGNWFIVLGGTAMLVTSKLFGFSLLALSFSLIANLGI
SVSAAPTISIALTDFKQNAGIVMAFMNTIRLIGPSLLTILTGYLLTRNLDALPLGLIGSGIGALFFSWHFSRLTTESRNS
DMDSEEALT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790146, Length=341, Percent_Identity=28.7390029325513, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788509, Length=356, Percent_Identity=25.2808988764045, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI48994889, Length=360, Percent_Identity=23.6111111111111, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787065, Length=331, Percent_Identity=23.5649546827795, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082312, Length=250, Percent_Identity=24.8, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790794, Length=190, Percent_Identity=28.4210526315789, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081738, Length=164, Percent_Identity=30.4878048780488, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788068, Length=161, Percent_Identity=27.3291925465839, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319657, Length=160, Percent_Identity=28.75, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45246; Mature: 45114

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFYMPKSHNSIIFLGLLSAFSLLTFDLYQPSLPFITNYFNITPSMGQLTLSIYLLVYGI
CEEECCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCHHHHHHHHHHHHHHH
THLLWGPLIDHFGRRRLLPGNLLLALIGSLMCAFAPNITMLICGRALQGFALCCANLIAY
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHH
SAARDFEDTIVRAKVLSYISMTVSVSPIIAPVIGALIFHHFGWQANFIVMAIVACILLIQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
TKLSLLESPFWTPPQERFSVKKILQEYKSILNIPSLWCASFILMFGISAVMLTVINSSYL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
IIEVLNYSPLAYGLIFILNGLNIIFGNYLGIWLRDRLPIITTIYLGNWFIVLGGTAMLVT
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCHHHHHH
SKLFGFSLLALSFSLIANLGISVSAAPTISIALTDFKQNAGIVMAFMNTIRLIGPSLLTI
HHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
LTGYLLTRNLDALPLGLIGSGIGALFFSWHFSRLTTESRNSDMDSEEALT
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCC
>Mature Secondary Structure 
TFYMPKSHNSIIFLGLLSAFSLLTFDLYQPSLPFITNYFNITPSMGQLTLSIYLLVYGI
EEECCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCHHHHHHHHHHHHHHH
THLLWGPLIDHFGRRRLLPGNLLLALIGSLMCAFAPNITMLICGRALQGFALCCANLIAY
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHH
SAARDFEDTIVRAKVLSYISMTVSVSPIIAPVIGALIFHHFGWQANFIVMAIVACILLIQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
TKLSLLESPFWTPPQERFSVKKILQEYKSILNIPSLWCASFILMFGISAVMLTVINSSYL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
IIEVLNYSPLAYGLIFILNGLNIIFGNYLGIWLRDRLPIITTIYLGNWFIVLGGTAMLVT
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCHHHHHH
SKLFGFSLLALSFSLIANLGISVSAAPTISIALTDFKQNAGIVMAFMNTIRLIGPSLLTI
HHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
LTGYLLTRNLDALPLGLIGSGIGALFFSWHFSRLTTESRNSDMDSEEALT
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]