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The map label for this gene is pla

Identifier: 52842596

GI number: 52842596

Start: 2695048

End: 2695974

Strand: Reverse

Name: pla

Synonym: lpg2387

Alternate gene names: 52842596

Gene position: 2695974-2695048 (Counterclockwise)

Preceding gene: 52842597

Following gene: 52842583

Centisome position: 79.35

GC content: 38.19

Gene sequence:

>927_bases
ATGAAAAATAAAATAGTTTTGTTGGCTCCAGTCTCTTTATCCTTTCTTTTCTCATTCTCTACTTATGCTGCGGATTACGA
ATTTAATGGTTTGTCATTAAGTGCTTCTCTAGGCATTCTGTCAGGTAAAGCTCATGAATATGTTTACCATCCAGAGACAG
ACACTAAGTTAAGCCAGCTGGATTGGCGCATAAAAAATGCTCCGATAATAAAAGGGGAATTAAATTATGATGTCCTGGAT
TGGCTTAGCATGAATGGTCAAGGCTGGACAACTTTGGTAAAAAATAAAGCTGCTATGGATGATTATGATTGGCTCAATCC
TTATCAAGATACCTGGACTCACTGGTCTCATCATGAAGATACGCATCTCAATTATGCAAATGAGTTAGATATGAGCTTAA
GGGCTTGGTTGATGCAAAAACAAAATTACAAGTTAGGCCTGGCTACTGGTTATCAATGGAATTCCTTTGACTGGAAAGCT
ACCGGAGGTTGTTACCAATATAACGGAGGGCTCTATGCCGGTTGTTTTCCAGGAGATCAACCTGGAATAGGATACCAACA
AAAATTTAGAACTCCTTATGTTGGTTTGGCAGGGAGGTATTTTATTAATAATTTTGAGTTTAGTGGTGTTTTAAAATTTA
GTGATTGGGTTTCAGCTCGAGATCATGATGAGCATTATGCCCGTAACTTAACATTCAATGAGCGGGGAAATAGCTCCAGA
TATTATGCGGCAACGATTCATTCTGGCTACTTTTTGAAACCTAATACGAAAATTTTTGTTGAGGCTTCTTACAATCATTA
TCCTAATGGGAGAGCGGATACTGAAATCATTGACAATGACACGGGTGAGCGCAGTTATTTTGGTGATTCAGCAGGGCTAT
CCAATAAACACTATACTGTCGCTCTTGGTTTACAGTATCTTTTTTAA

Upstream 100 bases:

>100_bases
CAATGTTGATCTTGACAAGATCATTTTGGATCACAATAATGCGATTGGTTTTTTAAAGTCACTTTGCTGCAAGGATTGCC
AGCCTTAACTAGGAAAAAAT

Downstream 100 bases:

>100_bases
AAGGCTCAAATTCTCTAATCTCAACTAGCAAGTGGCAACCTTCTTAAGTTCTGGCTTCAAGACGGTTGCTGCATGCGTTC
GTTATTTCAACAATATCTGG

Product: outer membrane protease

Products: NA

Alternate protein names: Plasminogen activator [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKNKIVLLAPVSLSFLFSFSTYAADYEFNGLSLSASLGILSGKAHEYVYHPETDTKLSQLDWRIKNAPIIKGELNYDVLD
WLSMNGQGWTTLVKNKAAMDDYDWLNPYQDTWTHWSHHEDTHLNYANELDMSLRAWLMQKQNYKLGLATGYQWNSFDWKA
TGGCYQYNGGLYAGCFPGDQPGIGYQQKFRTPYVGLAGRYFINNFEFSGVLKFSDWVSARDHDEHYARNLTFNERGNSSR
YYAATIHSGYFLKPNTKIFVEASYNHYPNGRADTEIIDNDTGERSYFGDSAGLSNKHYTVALGLQYLF

Sequences:

>Translated_308_residues
MKNKIVLLAPVSLSFLFSFSTYAADYEFNGLSLSASLGILSGKAHEYVYHPETDTKLSQLDWRIKNAPIIKGELNYDVLD
WLSMNGQGWTTLVKNKAAMDDYDWLNPYQDTWTHWSHHEDTHLNYANELDMSLRAWLMQKQNYKLGLATGYQWNSFDWKA
TGGCYQYNGGLYAGCFPGDQPGIGYQQKFRTPYVGLAGRYFINNFEFSGVLKFSDWVSARDHDEHYARNLTFNERGNSSR
YYAATIHSGYFLKPNTKIFVEASYNHYPNGRADTEIIDNDTGERSYFGDSAGLSNKHYTVALGLQYLF
>Mature_308_residues
MKNKIVLLAPVSLSFLFSFSTYAADYEFNGLSLSASLGILSGKAHEYVYHPETDTKLSQLDWRIKNAPIIKGELNYDVLD
WLSMNGQGWTTLVKNKAAMDDYDWLNPYQDTWTHWSHHEDTHLNYANELDMSLRAWLMQKQNYKLGLATGYQWNSFDWKA
TGGCYQYNGGLYAGCFPGDQPGIGYQQKFRTPYVGLAGRYFINNFEFSGVLKFSDWVSARDHDEHYARNLTFNERGNSSR
YYAATIHSGYFLKPNTKIFVEASYNHYPNGRADTEIIDNDTGERSYFGDSAGLSNKHYTVALGLQYLF

Specific function: Seems to play an essential role in plague transmission by mediating flea blockage in a temperature-dependent fashion. Fibrinolytic activity prevails at 37 degrees Celsius whereas coagulase expression predominates at lower temperatures (<30 degrees Celsius

COG id: COG4571

COG function: function code M; Outer membrane protease

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A26 family [H]

Homologues:

Organism=Escherichia coli, GI1786777, Length=314, Percent_Identity=38.8535031847134, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020080
- InterPro:   IPR000036
- InterPro:   IPR020079 [H]

Pfam domain/function: PF01278 Omptin [H]

EC number: =3.4.23.48 [H]

Molecular weight: Translated: 35342; Mature: 35342

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00037 MYB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKIVLLAPVSLSFLFSFSTYAADYEFNGLSLSASLGILSGKAHEYVYHPETDTKLSQL
CCCCEEEEECCCEEEEEEHHHEECCEEECCEEEEEEEEEECCCCEEEEECCCCCCCHHHH
DWRIKNAPIIKGELNYDVLDWLSMNGQGWTTLVKNKAAMDDYDWLNPYQDTWTHWSHHED
EEEECCCCEEEECCCCCEEEHEECCCCCEEEEEECCCCCCCCCCCCCCHHHCCCCCCCCC
THLNYANELDMSLRAWLMQKQNYKLGLATGYQWNSFDWKATGGCYQYNGGLYAGCFPGDQ
CCCCCHHHCCHHHHHHHHHCCCCEEEEEECCEECCCCEEECCCEEEECCCEEEEECCCCC
PGIGYQQKFRTPYVGLAGRYFINNFEFSGVLKFSDWVSARDHDEHYARNLTFNERGNSSR
CCCCHHHHHCCCEECCCCEEEEECCCEEEEEEEHHHCCCCCCCHHHHHCCEECCCCCCCE
YYAATIHSGYFLKPNTKIFVEASYNHYPNGRADTEIIDNDTGERSYFGDSAGLSNKHYTV
EEEEEECCCEEECCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEE
ALGLQYLF
EEEEEECC
>Mature Secondary Structure
MKNKIVLLAPVSLSFLFSFSTYAADYEFNGLSLSASLGILSGKAHEYVYHPETDTKLSQL
CCCCEEEEECCCEEEEEEHHHEECCEEECCEEEEEEEEEECCCCEEEEECCCCCCCHHHH
DWRIKNAPIIKGELNYDVLDWLSMNGQGWTTLVKNKAAMDDYDWLNPYQDTWTHWSHHED
EEEECCCCEEEECCCCCEEEHEECCCCCEEEEEECCCCCCCCCCCCCCHHHCCCCCCCCC
THLNYANELDMSLRAWLMQKQNYKLGLATGYQWNSFDWKATGGCYQYNGGLYAGCFPGDQ
CCCCCHHHCCHHHHHHHHHCCCCEEEEEECCEECCCCEEECCCEEEECCCEEEEECCCCC
PGIGYQQKFRTPYVGLAGRYFINNFEFSGVLKFSDWVSARDHDEHYARNLTFNERGNSSR
CCCCHHHHHCCCEECCCCEEEEECCCEEEEEEEHHHCCCCCCCHHHHHCCEECCCCCCCE
YYAATIHSGYFLKPNTKIFVEASYNHYPNGRADTEIIDNDTGERSYFGDSAGLSNKHYTV
EEEEEECCCEEECCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEE
ALGLQYLF
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2526282; 2651310; 9748454; 11586360 [H]