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The map label for this gene is hemK [H]

Identifier: 52842547

GI number: 52842547

Start: 2640340

End: 2641203

Strand: Direct

Name: hemK [H]

Synonym: lpg2337

Alternate gene names: 52842547

Gene position: 2640340-2641203 (Clockwise)

Preceding gene: 52842546

Following gene: 52842548

Centisome position: 77.71

GC content: 40.51

Gene sequence:

>864_bases
ATGATTGATATTCGTTCATTACTGGAACAAGCTCTGCAACAATTCAAAGTCAAAAACCAGGAAACCAAGTTAGAGGCAGA
ACTTTTACTCTGCCATGTGTTAAACAAAAACCGGGCCTATCTTTTTGCCCATCCGGATGCTTTGGTTTCTCCTGAACAGA
TAGAAACCTATTTGCAGATGATTAAACAACGTGCTGAAGGTCTACCAATCGCCTACATTACTGGACAGCGGGAATTTTGG
TCTCTTTCGTTAAAAGTAACACCCAATGTTCTCATTCCAAGACATGAAACCGAGCGTCTGGTGGAGCTTGCACTGGAGCT
AATACCTGACAAGGAGAATGTTTCTGTCCTTGATCTGGGAACAGGAAGTGGTGCTATTGCCTTGGCGCTTGCAAAAGAAA
GACCCCTTTGGCATATTGACGCCTGTGATTTCAGCAAAGAGGCATTGGAGTTAGCCCGTTATAACGCTAAAACACTCGGC
TTAAACAATATTAATTTCTGTCATTCCTACTGGTTTAATAATCTCCCCCTAAAACAATACCACGCTATTGTATCTAATCC
GCCCTACATTGCTGAAAATGATCCTCATTTAAAACATGGCGATGTCCGCTTTGAACCAACAAGTGCATTAGTCAGTAGTC
AAGATGGATTAGCTGATCTACAATATATTATTCAGCACAGTTATGAATATCTTTTGCCTGATGGACTGCTCTTGGTTGAA
CATGGTTTTGAACAAAAAAATGAGATAAGCGCTATACTTAATCAATTAGGATATAAAAACATACACTGTTGGCAAGATCT
TCAAGGACATGATAGGGTAAGTGGAGGACAACGTCCAAGCAATCGGAATAACAAACCTTTGTAG

Upstream 100 bases:

>100_bases
ATCTACCAGCTTAGTGACATCATGGAAGGGAATTTATCCCTGGTCATTGACCCGTTAAAACGCGAATACCATGCTGAACT
GCTAGCCGATTTAGGTCGAC

Downstream 100 bases:

>100_bases
TGATTATTTTTTTGTTGATGATACTGACATTTTTTGGTATACGTAGCGATTTTGTATAAAACTCAGTTTCAGATACAGAA
TGAAATATAGGGTCTGGCAT

Product: protein methyltransferase HemK

Products: NA

Alternate protein names: M.VchAHemK2P [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MIDIRSLLEQALQQFKVKNQETKLEAELLLCHVLNKNRAYLFAHPDALVSPEQIETYLQMIKQRAEGLPIAYITGQREFW
SLSLKVTPNVLIPRHETERLVELALELIPDKENVSVLDLGTGSGAIALALAKERPLWHIDACDFSKEALELARYNAKTLG
LNNINFCHSYWFNNLPLKQYHAIVSNPPYIAENDPHLKHGDVRFEPTSALVSSQDGLADLQYIIQHSYEYLLPDGLLLVE
HGFEQKNEISAILNQLGYKNIHCWQDLQGHDRVSGGQRPSNRNNKPL

Sequences:

>Translated_287_residues
MIDIRSLLEQALQQFKVKNQETKLEAELLLCHVLNKNRAYLFAHPDALVSPEQIETYLQMIKQRAEGLPIAYITGQREFW
SLSLKVTPNVLIPRHETERLVELALELIPDKENVSVLDLGTGSGAIALALAKERPLWHIDACDFSKEALELARYNAKTLG
LNNINFCHSYWFNNLPLKQYHAIVSNPPYIAENDPHLKHGDVRFEPTSALVSSQDGLADLQYIIQHSYEYLLPDGLLLVE
HGFEQKNEISAILNQLGYKNIHCWQDLQGHDRVSGGQRPSNRNNKPL
>Mature_287_residues
MIDIRSLLEQALQQFKVKNQETKLEAELLLCHVLNKNRAYLFAHPDALVSPEQIETYLQMIKQRAEGLPIAYITGQREFW
SLSLKVTPNVLIPRHETERLVELALELIPDKENVSVLDLGTGSGAIALALAKERPLWHIDACDFSKEALELARYNAKTLG
LNNINFCHSYWFNNLPLKQYHAIVSNPPYIAENDPHLKHGDVRFEPTSALVSSQDGLADLQYIIQHSYEYLLPDGLLLVE
HGFEQKNEISAILNQLGYKNIHCWQDLQGHDRVSGGQRPSNRNNKPL

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=239, Percent_Identity=28.4518828451883, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787463, Length=270, Percent_Identity=43.3333333333333, Blast_Score=223, Evalue=9e-60,
Organism=Escherichia coli, GI87082085, Length=196, Percent_Identity=34.6938775510204, Blast_Score=105, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24582226, Length=244, Percent_Identity=29.9180327868852, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 32678; Mature: 32678

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDIRSLLEQALQQFKVKNQETKLEAELLLCHVLNKNRAYLFAHPDALVSPEQIETYLQM
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
IKQRAEGLPIAYITGQREFWSLSLKVTPNVLIPRHETERLVELALELIPDKENVSVLDLG
HHHHHCCCCEEEEECCCEEEEEEEEECCCEEECCCHHHHHHHHHHHHCCCCCCEEEEEEC
TGSGAIALALAKERPLWHIDACDFSKEALELARYNAKTLGLNNINFCHSYWFNNLPLKQY
CCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHCCCEECCCCCHHHHHHHCCCCCHHHH
HAIVSNPPYIAENDPHLKHGDVRFEPTSALVSSQDGLADLQYIIQHSYEYLLPDGLLLVE
HHHHCCCCEECCCCCCCCCCCEEECCHHHHHCCCCCHHHHHHHHHHCHHHCCCCCEEEEE
HGFEQKNEISAILNQLGYKNIHCWQDLQGHDRVSGGQRPSNRNNKPL
CCCCCHHHHHHHHHHCCCCCEEHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIDIRSLLEQALQQFKVKNQETKLEAELLLCHVLNKNRAYLFAHPDALVSPEQIETYLQM
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
IKQRAEGLPIAYITGQREFWSLSLKVTPNVLIPRHETERLVELALELIPDKENVSVLDLG
HHHHHCCCCEEEEECCCEEEEEEEEECCCEEECCCHHHHHHHHHHHHCCCCCCEEEEEEC
TGSGAIALALAKERPLWHIDACDFSKEALELARYNAKTLGLNNINFCHSYWFNNLPLKQY
CCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHCCCEECCCCCHHHHHHHCCCCCHHHH
HAIVSNPPYIAENDPHLKHGDVRFEPTSALVSSQDGLADLQYIIQHSYEYLLPDGLLLVE
HHHHCCCCEECCCCCCCCCCCEEECCHHHHHCCCCCHHHHHHHHHHCHHHCCCCCEEEEE
HGFEQKNEISAILNQLGYKNIHCWQDLQGHDRVSGGQRPSNRNNKPL
CCCCCHHHHHHHHHHCCCCCEEHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]