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The map label for this gene is hemA

Identifier: 52842545

GI number: 52842545

Start: 2637893

End: 2639275

Strand: Direct

Name: hemA

Synonym: lpg2335

Alternate gene names: 52842545

Gene position: 2637893-2639275 (Clockwise)

Preceding gene: 52842542

Following gene: 52842546

Centisome position: 77.64

GC content: 40.27

Gene sequence:

>1383_bases
ATGATTGCAAGAAACAGAAATACAAGGAACCTTGTCTTTTTCTCTACAAATTTTACAATGAATCGTTTACAATTCGTTAA
TTCCCTTAAACAAATAAATCAAGATTCTATGGTATTTGTAGCTTGCGGGCTTAATCATAAAACTGCTCCAATTCATGTGC
GTGAAAAAGTCGCACTGCAGCCAGCCATGCAAGATTCTCTATTGAGCAGTCTGCTTGATTTACCTGAAGTCAATGAAGCG
GCTATTTTATCTACATGCAACCGGACTGAAATCTACTGTGATACCAATACCCCTGAGGTTCTTGGAAACTGGTTAGCTCA
TGAACACCAATTATCAGAGGAATTATTATCTCAATTTTTGTATATCCATCAGGGAAAAGAAGGAATCAAACATACCTTGC
GTGTTGCCAGCGGTTTGGATTCCATGATGATAGGCGAACCACAAATCCTTGGCCAAATGAAACAGGCGTATCAACATGCT
TGTCGTCTTGGCACAGTAAAAACACAATTACGGCCTGTGTTTGAATATATTTTCAGAGCGTCCAAACGCATCAGAACTCG
TAGCGGAATTGGGGCTAATCCCGTATCGATTGCCTATGCTGCGGTACAACTGATAGGGCAATTATTTAAAAACTATCATT
CCTTAAGTGTCTTTTTAATTGGTTCCGGAGAAACAGCCTCTCTGGTTGCTAAATACCTGCATCAGCATGGTGTCCATCGT
TTTTTGATAGCGAGCCGCACTCTGGAAAATGCTCAAAAATTAGCTGAAACTTTCGGTGGAAAAACACTGTCCATTGGTGA
TATCCCGCAATATTTACCTCTGGCCGATGTTGTTATTTCTGCCACAGCATGCCCACTCCCATTCATCAATAAAAGCCTGG
TTGAGCATGCCTTAGAGCAAAGAAACCATGCCCCCATGTTTTTATTGGATTTGGCCGTTCCTCGTGATATTGAAGGAAAT
GTCAATGAATTGGAACAAGTTCATCTCTATAATGTAGATGATTTACAATCCATGATAGAAAAAGGGATGGATGAAAGGCG
AAATGCGGCATTACAAGCAGAACAATTGATCGAAAGCGAACTGGATAACTACATTAGATGGCATCGCTCGCTTAGAGCCA
AAGACGTCATTTGCGATTACCGCAATCAAATGCACACTTTGGCTCAACAGGAATTACAACGTGCTTTGAAAAAAATATCC
GCTGGTCAAAATCAGCAAGACGTTTTAAATGAATTCAGTATGCGCTTGGTCAACAAGCTAACTCATAATCCCACCATAGG
TTTAAGACAAATAGCATGGGATAACAGAGAAGACTTACTTGACCTCGCGCGATATCTCTTTGATACAACAGCCAATCAAT
CATTATATGAAGAAATCTCTTGA

Upstream 100 bases:

>100_bases
CCCGTTTGAAGATAGAGAAAGTAAATTGAATCCCTTGCCAGCAAATTTTCCCAAGTGGGACAATCTTGAGGAAGAAGGCG
GGTAAAAAATATACTGTAAA

Downstream 100 bases:

>100_bases
GTTAAAATTACAGCAAATGTTGGAGCGATACGAGGAAGTAGGCCGCTTACTGTCCGAAGCATCCATTATTGCCGATCAAA
ACCAATTTAAGTCTTTATCA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MIARNRNTRNLVFFSTNFTMNRLQFVNSLKQINQDSMVFVACGLNHKTAPIHVREKVALQPAMQDSLLSSLLDLPEVNEA
AILSTCNRTEIYCDTNTPEVLGNWLAHEHQLSEELLSQFLYIHQGKEGIKHTLRVASGLDSMMIGEPQILGQMKQAYQHA
CRLGTVKTQLRPVFEYIFRASKRIRTRSGIGANPVSIAYAAVQLIGQLFKNYHSLSVFLIGSGETASLVAKYLHQHGVHR
FLIASRTLENAQKLAETFGGKTLSIGDIPQYLPLADVVISATACPLPFINKSLVEHALEQRNHAPMFLLDLAVPRDIEGN
VNELEQVHLYNVDDLQSMIEKGMDERRNAALQAEQLIESELDNYIRWHRSLRAKDVICDYRNQMHTLAQQELQRALKKIS
AGQNQQDVLNEFSMRLVNKLTHNPTIGLRQIAWDNREDLLDLARYLFDTTANQSLYEEIS

Sequences:

>Translated_460_residues
MIARNRNTRNLVFFSTNFTMNRLQFVNSLKQINQDSMVFVACGLNHKTAPIHVREKVALQPAMQDSLLSSLLDLPEVNEA
AILSTCNRTEIYCDTNTPEVLGNWLAHEHQLSEELLSQFLYIHQGKEGIKHTLRVASGLDSMMIGEPQILGQMKQAYQHA
CRLGTVKTQLRPVFEYIFRASKRIRTRSGIGANPVSIAYAAVQLIGQLFKNYHSLSVFLIGSGETASLVAKYLHQHGVHR
FLIASRTLENAQKLAETFGGKTLSIGDIPQYLPLADVVISATACPLPFINKSLVEHALEQRNHAPMFLLDLAVPRDIEGN
VNELEQVHLYNVDDLQSMIEKGMDERRNAALQAEQLIESELDNYIRWHRSLRAKDVICDYRNQMHTLAQQELQRALKKIS
AGQNQQDVLNEFSMRLVNKLTHNPTIGLRQIAWDNREDLLDLARYLFDTTANQSLYEEIS
>Mature_460_residues
MIARNRNTRNLVFFSTNFTMNRLQFVNSLKQINQDSMVFVACGLNHKTAPIHVREKVALQPAMQDSLLSSLLDLPEVNEA
AILSTCNRTEIYCDTNTPEVLGNWLAHEHQLSEELLSQFLYIHQGKEGIKHTLRVASGLDSMMIGEPQILGQMKQAYQHA
CRLGTVKTQLRPVFEYIFRASKRIRTRSGIGANPVSIAYAAVQLIGQLFKNYHSLSVFLIGSGETASLVAKYLHQHGVHR
FLIASRTLENAQKLAETFGGKTLSIGDIPQYLPLADVVISATACPLPFINKSLVEHALEQRNHAPMFLLDLAVPRDIEGN
VNELEQVHLYNVDDLQSMIEKGMDERRNAALQAEQLIESELDNYIRWHRSLRAKDVICDYRNQMHTLAQQELQRALKKIS
AGQNQQDVLNEFSMRLVNKLTHNPTIGLRQIAWDNREDLLDLARYLFDTTANQSLYEEIS

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=412, Percent_Identity=41.504854368932, Blast_Score=332, Evalue=3e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 52187; Mature: 52187

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARNRNTRNLVFFSTNFTMNRLQFVNSLKQINQDSMVFVACGLNHKTAPIHVREKVALQ
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEHHHHHHHH
PAMQDSLLSSLLDLPEVNEAAILSTCNRTEIYCDTNTPEVLGNWLAHEHQLSEELLSQFL
HHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
YIHQGKEGIKHTLRVASGLDSMMIGEPQILGQMKQAYQHACRLGTVKTQLRPVFEYIFRA
HHHCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKRIRTRSGIGANPVSIAYAAVQLIGQLFKNYHSLSVFLIGSGETASLVAKYLHQHGVHR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHCCHHH
FLIASRTLENAQKLAETFGGKTLSIGDIPQYLPLADVVISATACPLPFINKSLVEHALEQ
HHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RNHAPMFLLDLAVPRDIEGNVNELEQVHLYNVDDLQSMIEKGMDERRNAALQAEQLIESE
CCCCCEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LDNYIRWHRSLRAKDVICDYRNQMHTLAQQELQRALKKISAGQNQQDVLNEFSMRLVNKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
THNPTIGLRQIAWDNREDLLDLARYLFDTTANQSLYEEIS
HCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure
MIARNRNTRNLVFFSTNFTMNRLQFVNSLKQINQDSMVFVACGLNHKTAPIHVREKVALQ
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEHHHHHHHH
PAMQDSLLSSLLDLPEVNEAAILSTCNRTEIYCDTNTPEVLGNWLAHEHQLSEELLSQFL
HHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
YIHQGKEGIKHTLRVASGLDSMMIGEPQILGQMKQAYQHACRLGTVKTQLRPVFEYIFRA
HHHCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKRIRTRSGIGANPVSIAYAAVQLIGQLFKNYHSLSVFLIGSGETASLVAKYLHQHGVHR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHCCHHH
FLIASRTLENAQKLAETFGGKTLSIGDIPQYLPLADVVISATACPLPFINKSLVEHALEQ
HHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RNHAPMFLLDLAVPRDIEGNVNELEQVHLYNVDDLQSMIEKGMDERRNAALQAEQLIESE
CCCCCEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LDNYIRWHRSLRAKDVICDYRNQMHTLAQQELQRALKKISAGQNQQDVLNEFSMRLVNKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
THNPTIGLRQIAWDNREDLLDLARYLFDTTANQSLYEEIS
HCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA