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The map label for this gene is fabH

Identifier: 52842445

GI number: 52842445

Start: 2524093

End: 2525103

Strand: Direct

Name: fabH

Synonym: lpg2232

Alternate gene names: 52842445

Gene position: 2524093-2525103 (Clockwise)

Preceding gene: 52842444

Following gene: 52842448

Centisome position: 74.29

GC content: 42.93

Gene sequence:

>1011_bases
ATGAATTTTTTCCGTTGTGAAAAACCCATCTATATAAAAGGCCCTTTTGTTGCGCTTCCCGAGAGAATCATGAGCAACCA
AGATGTTCTCAATTGGATGAACAGTACCCAAAATCCAACCGTGATTGGATTTTCAACTGGAATTAAAAACCGGCATTGGG
TAAATGAGGATCAAGCCTGTAGCGATCTGGCTGTGCGAGCGGCAGAACATTTGTTTATGGAAAAAACGAGGGAAAAACAT
AAAGTGAACCAAGTGATCCTGGCCACTATCTCAGGGGATTACCCCTCCCCGCCAAGCAGTCCTCTCGTACAATACAGACT
TGGCCTACAAAACGCAGGGGCTTTTGATATAGGGGCTGCCTGTGCCGGATTTGTTGTCGGTTTGCATACCAGTGCTGCTT
TAGCACAGACCAATGATGGTTCGGTATTGCTCATAGCTAGCGAAATTCGCTCCAAATTCTTAAATAAAAACAATTTTGCA
ACCAGTGTCTTATTCGGTGATGGAGCAGCAGCATGTTGTGTTTCTCAAGATAAAGAAGAAGCTGATTTTCGCTTTATAGC
GTCTGCGTTGTTTGCTGACGGTGAAGTATACGATGCCGTCTCAACTCCGGCAGGAGGTTCCCGCTTGCCCGCCGCGGTTT
GCAATGATCATGAGCAATTTTACATTACCATAAAAGAAAGTACTGCTTTATTTGTAAAAGCAGTGCATGGAATGGCAGAT
AGCGCCAAAGATTTTCTAAAAGAATTAAATCTGACAATCTCTGATATCCAATGGCTTGTTCCTCATCAGGGAAATAAAAA
TCTGGTTTTGTCGGTAGCAAAACAATTAGGTTTTCCTGAAGAAAAAACGATAAAAACTGTTGAAGAAACAGGAAATACTT
CAGGATCCAGTGTAGGCATTGCTTTGGATCGACTGAGGTCGGATGGCAAAATAAAATCTGGAGAAAAGGTACTTTTGGTG
GCAGCAGGTGGAGGAGGAATTGCAGCCTGTTCTTTATTGGAAGTTGTCTGA

Upstream 100 bases:

>100_bases
AAGCCATTGATCCACTTTTGTCAAAAACCTCGTTTATGACGGGATCAGTTGTAACAGTCAGTGGTGGTCTGCCTTTAATG
CGTTCAGAAGGATTGTTGTC

Downstream 100 bases:

>100_bases
TTTGGCTTCAGGAATTGTTTGGGTCGAGACTTGCGAAAAACCCCATGGTCAAGGGAAACGATTAGCAAATTCTAATTTAA
CAAATTCAATTTTATATAAA

Product: 3-oxoacyl-(acyl carrier protein) synthase III FabH

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MNFFRCEKPIYIKGPFVALPERIMSNQDVLNWMNSTQNPTVIGFSTGIKNRHWVNEDQACSDLAVRAAEHLFMEKTREKH
KVNQVILATISGDYPSPPSSPLVQYRLGLQNAGAFDIGAACAGFVVGLHTSAALAQTNDGSVLLIASEIRSKFLNKNNFA
TSVLFGDGAAACCVSQDKEEADFRFIASALFADGEVYDAVSTPAGGSRLPAAVCNDHEQFYITIKESTALFVKAVHGMAD
SAKDFLKELNLTISDIQWLVPHQGNKNLVLSVAKQLGFPEEKTIKTVEETGNTSGSSVGIALDRLRSDGKIKSGEKVLLV
AAGGGGIAACSLLEVV

Sequences:

>Translated_336_residues
MNFFRCEKPIYIKGPFVALPERIMSNQDVLNWMNSTQNPTVIGFSTGIKNRHWVNEDQACSDLAVRAAEHLFMEKTREKH
KVNQVILATISGDYPSPPSSPLVQYRLGLQNAGAFDIGAACAGFVVGLHTSAALAQTNDGSVLLIASEIRSKFLNKNNFA
TSVLFGDGAAACCVSQDKEEADFRFIASALFADGEVYDAVSTPAGGSRLPAAVCNDHEQFYITIKESTALFVKAVHGMAD
SAKDFLKELNLTISDIQWLVPHQGNKNLVLSVAKQLGFPEEKTIKTVEETGNTSGSSVGIALDRLRSDGKIKSGEKVLLV
AAGGGGIAACSLLEVV
>Mature_336_residues
MNFFRCEKPIYIKGPFVALPERIMSNQDVLNWMNSTQNPTVIGFSTGIKNRHWVNEDQACSDLAVRAAEHLFMEKTREKH
KVNQVILATISGDYPSPPSSPLVQYRLGLQNAGAFDIGAACAGFVVGLHTSAALAQTNDGSVLLIASEIRSKFLNKNNFA
TSVLFGDGAAACCVSQDKEEADFRFIASALFADGEVYDAVSTPAGGSRLPAAVCNDHEQFYITIKESTALFVKAVHGMAD
SAKDFLKELNLTISDIQWLVPHQGNKNLVLSVAKQLGFPEEKTIKTVEETGNTSGSSVGIALDRLRSDGKIKSGEKVLLV
AAGGGGIAACSLLEVV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=310, Percent_Identity=31.2903225806452, Blast_Score=144, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.180 [H]

Molecular weight: Translated: 36041; Mature: 36041

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFFRCEKPIYIKGPFVALPERIMSNQDVLNWMNSTQNPTVIGFSTGIKNRHWVNEDQAC
CCCEECCCCEEEECCHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHH
SDLAVRAAEHLFMEKTREKHKVNQVILATISGDYPSPPSSPLVQYRLGLQNAGAFDIGAA
HHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCHHHEEECCCCCCCCCHHHH
CAGFVVGLHTSAALAQTNDGSVLLIASEIRSKFLNKNNFATSVLFGDGAAACCVSQDKEE
HHHHHHHHCCCHHEEECCCCCEEEEHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCH
ADFRFIASALFADGEVYDAVSTPAGGSRLPAAVCNDHEQFYITIKESTALFVKAVHGMAD
HHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHCCCEEEEEEEECCCEEEHHHHHCCHH
SAKDFLKELNLTISDIQWLVPHQGNKNLVLSVAKQLGFPEEKTIKTVEETGNTSGSSVGI
HHHHHHHHCCCCHHHEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHH
ALDRLRSDGKIKSGEKVLLVAAGGGGIAACSLLEVV
HHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MNFFRCEKPIYIKGPFVALPERIMSNQDVLNWMNSTQNPTVIGFSTGIKNRHWVNEDQAC
CCCEECCCCEEEECCHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHH
SDLAVRAAEHLFMEKTREKHKVNQVILATISGDYPSPPSSPLVQYRLGLQNAGAFDIGAA
HHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCHHHEEECCCCCCCCCHHHH
CAGFVVGLHTSAALAQTNDGSVLLIASEIRSKFLNKNNFATSVLFGDGAAACCVSQDKEE
HHHHHHHHCCCHHEEECCCCCEEEEHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCH
ADFRFIASALFADGEVYDAVSTPAGGSRLPAAVCNDHEQFYITIKESTALFVKAVHGMAD
HHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHCCCEEEEEEEECCCEEEHHHHHCCHH
SAKDFLKELNLTISDIQWLVPHQGNKNLVLSVAKQLGFPEEKTIKTVEETGNTSGSSVGI
HHHHHHHHCCCCHHHEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHH
ALDRLRSDGKIKSGEKVLLVAAGGGGIAACSLLEVV
HHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]