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The map label for this gene is erg3 [H]

Identifier: 52842448

GI number: 52842448

Start: 2527060

End: 2528262

Strand: Direct

Name: erg3 [H]

Synonym: lpg2235

Alternate gene names: 52842448

Gene position: 2527060-2528262 (Clockwise)

Preceding gene: 52842445

Following gene: 52842449

Centisome position: 74.37

GC content: 38.24

Gene sequence:

>1203_bases
ATGGATATAAATTTAATGGTTTTTGCCTCACCTCTTTTTTTGATCCTCATAGGAATTGAAACTTGGGTAGCCTATTATAA
AAAATCCGGTGTCTATCAACTGAATGATTCGGTCAACAATTTCAGCAGCGGTATCCTTGAAGAAATTGGCGCACTCCCCA
TCAAGGGCCTGATTATTTATAGTTACTATTATTTATATGAGCATTACGCTATTTTTAATGTGAATACTCAATCGATTTTT
TCCTGGTTACTTTTATGGATCGGGGTTGATTTTTTCTATTACTGGTACCACAGAGTAAGCCACAGAAACAGTTTCTTCTG
GATAGGTCATTCGGTCCATCACCAAAGTGAGCACTTTAACTTATCTGTTGCCTTAAGACAGGGCTATTTCCAGACATTAA
CTTCCTGGGTGTTTTATTTGCCCTTGGCTCTGATTGGTTTTCCAACCTGGATGTTTGTCATTGTCGCCTCTGTCAATACC
ATCTATCAATTCTGGATTCATACTGAATCCATTCGGAAAATGGGTTGGTTTGAAAAAATATTTAATACTCCGTCTCATCA
CAGAGTTCATCATGGCAAAAACCCTCAATACATAGATAAAAATTATGCGGGAAGCCTGATTATCTGGGATAAACTGTTCG
GCACTTTTGAACCAGAAGAAGCGCCGGCTGATTATGGAGTCACCGAACCCCTGGATTCATGGAACCCTTTTTACGCCAAC
ATCAAAGTGGTTAAAGATATCCTGTATTATGGTAAAGGGCTAAAAAGTAAATGGGATGTGTTACGCGCGTTCTTTATGCC
GCCAGAATGGATCATTCATCGCTTGCAACAAGAAAAATCCCCTCTCTCAAAAAAAACAACGATTAAAAAAAATACGACCT
CACCTGGGATTTATATGTTAACCAATACTGCATTTGCAGTGTTATTATATACTTATCTCTCTCTTGTTTTTGATCCCGCC
ATGGTCACATCCTGGCTGATTGGCGCATTAATTTTATTGACACTTTATACCCTTGGCCGAATTGCAGATGGCCATAGCAA
TACTCTTTACCTGGAAATATCGCGCGCAACATTGGTACTTTTAATATTATTGCTATTTAAAAATACTCTGTTATTGTCGC
TCGGTTGCAGTGTTTTGTTTTATGTCATCAATTATGCCTTATGCACTACTTTTCCTTATAAAAGAACCGCATCTTCTTTC
TGA

Upstream 100 bases:

>100_bases
CAAGCAAAACAAAAGTATTAGAAAATAAGGCATTGGCCTCAACGTCTGCAAAATAGAAAATACCTATTGCAAAGCGTCTA
TCACTGTTCAAAGGATATTT

Downstream 100 bases:

>100_bases
GAAGCAGACACTATTCAACAAGGATTAACCCTGTGGGTACTGGAGATGTATGGTTTTCTAAGAGTCAGTTTTGTAGCTAA
CATGAATTGTTTCTTGTAAA

Product: sterol desaturase

Products: NA

Alternate protein names: Sterol-C5-desaturase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MDINLMVFASPLFLILIGIETWVAYYKKSGVYQLNDSVNNFSSGILEEIGALPIKGLIIYSYYYLYEHYAIFNVNTQSIF
SWLLLWIGVDFFYYWYHRVSHRNSFFWIGHSVHHQSEHFNLSVALRQGYFQTLTSWVFYLPLALIGFPTWMFVIVASVNT
IYQFWIHTESIRKMGWFEKIFNTPSHHRVHHGKNPQYIDKNYAGSLIIWDKLFGTFEPEEAPADYGVTEPLDSWNPFYAN
IKVVKDILYYGKGLKSKWDVLRAFFMPPEWIIHRLQQEKSPLSKKTTIKKNTTSPGIYMLTNTAFAVLLYTYLSLVFDPA
MVTSWLIGALILLTLYTLGRIADGHSNTLYLEISRATLVLLILLLFKNTLLLSLGCSVLFYVINYALCTTFPYKRTASSF

Sequences:

>Translated_400_residues
MDINLMVFASPLFLILIGIETWVAYYKKSGVYQLNDSVNNFSSGILEEIGALPIKGLIIYSYYYLYEHYAIFNVNTQSIF
SWLLLWIGVDFFYYWYHRVSHRNSFFWIGHSVHHQSEHFNLSVALRQGYFQTLTSWVFYLPLALIGFPTWMFVIVASVNT
IYQFWIHTESIRKMGWFEKIFNTPSHHRVHHGKNPQYIDKNYAGSLIIWDKLFGTFEPEEAPADYGVTEPLDSWNPFYAN
IKVVKDILYYGKGLKSKWDVLRAFFMPPEWIIHRLQQEKSPLSKKTTIKKNTTSPGIYMLTNTAFAVLLYTYLSLVFDPA
MVTSWLIGALILLTLYTLGRIADGHSNTLYLEISRATLVLLILLLFKNTLLLSLGCSVLFYVINYALCTTFPYKRTASSF
>Mature_400_residues
MDINLMVFASPLFLILIGIETWVAYYKKSGVYQLNDSVNNFSSGILEEIGALPIKGLIIYSYYYLYEHYAIFNVNTQSIF
SWLLLWIGVDFFYYWYHRVSHRNSFFWIGHSVHHQSEHFNLSVALRQGYFQTLTSWVFYLPLALIGFPTWMFVIVASVNT
IYQFWIHTESIRKMGWFEKIFNTPSHHRVHHGKNPQYIDKNYAGSLIIWDKLFGTFEPEEAPADYGVTEPLDSWNPFYAN
IKVVKDILYYGKGLKSKWDVLRAFFMPPEWIIHRLQQEKSPLSKKTTIKKNTTSPGIYMLTNTAFAVLLYTYLSLVFDPA
MVTSWLIGALILLTLYTLGRIADGHSNTLYLEISRATLVLLILLLFKNTLLLSLGCSVLFYVINYALCTTFPYKRTASSF

Specific function: Unknown

COG id: COG3000

COG function: function code I; Sterol desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sterol desaturase family [H]

Homologues:

Organism=Homo sapiens, GI51972212, Length=396, Percent_Identity=36.6161616161616, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI25144659, Length=361, Percent_Identity=28.808864265928, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006694 [H]

Pfam domain/function: PF04116 FA_hydroxylase [H]

EC number: NA

Molecular weight: Translated: 46543; Mature: 46543

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDINLMVFASPLFLILIGIETWVAYYKKSGVYQLNDSVNNFSSGILEEIGALPIKGLIIY
CCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHH
SYYYLYEHYAIFNVNTQSIFSWLLLWIGVDFFYYWYHRVSHRNSFFWIGHSVHHQSEHFN
HHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCCCCE
LSVALRQGYFQTLTSWVFYLPLALIGFPTWMFVIVASVNTIYQFWIHTESIRKMGWFEKI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNTPSHHRVHHGKNPQYIDKNYAGSLIIWDKLFGTFEPEEAPADYGVTEPLDSWNPFYAN
HCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHH
IKVVKDILYYGKGLKSKWDVLRAFFMPPEWIIHRLQQEKSPLSKKTTIKKNTTSPGIYML
HHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHCEECCCCCCCCEEEE
TNTAFAVLLYTYLSLVFDPAMVTSWLIGALILLTLYTLGRIADGHSNTLYLEISRATLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHH
LILLLFKNTLLLSLGCSVLFYVINYALCTTFPYKRTASSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDINLMVFASPLFLILIGIETWVAYYKKSGVYQLNDSVNNFSSGILEEIGALPIKGLIIY
CCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHH
SYYYLYEHYAIFNVNTQSIFSWLLLWIGVDFFYYWYHRVSHRNSFFWIGHSVHHQSEHFN
HHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCCCCE
LSVALRQGYFQTLTSWVFYLPLALIGFPTWMFVIVASVNTIYQFWIHTESIRKMGWFEKI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNTPSHHRVHHGKNPQYIDKNYAGSLIIWDKLFGTFEPEEAPADYGVTEPLDSWNPFYAN
HCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHH
IKVVKDILYYGKGLKSKWDVLRAFFMPPEWIIHRLQQEKSPLSKKTTIKKNTTSPGIYML
HHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHCEECCCCCCCCEEEE
TNTAFAVLLYTYLSLVFDPAMVTSWLIGALILLTLYTLGRIADGHSNTLYLEISRATLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHH
LILLLFKNTLLLSLGCSVLFYVINYALCTTFPYKRTASSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]