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The map label for this gene is msrAB [H]

Identifier: 52842313

GI number: 52842313

Start: 2347541

End: 2348062

Strand: Direct

Name: msrAB [H]

Synonym: lpg2099

Alternate gene names: 52842313

Gene position: 2347541-2348062 (Clockwise)

Preceding gene: 52842312

Following gene: 52842318

Centisome position: 69.09

GC content: 38.12

Gene sequence:

>522_bases
ATGCTCGTATCAAGGAGTTATGGGATGAAAAGTCTAGTTAGTTTTATTGTAAGCGTATTTATGCTAAATACTGCCCTGGC
TTACACGCCTGAATTTAACAAATCCGAAAAACTAAAACAGCTTACGCCTCTACAATACCAAGTGACTCAAAAGGCTGCTA
CAGAAAAACCTTTTGATAATCCCTATTGGAATAATGAACAAGCCGGAATTTATGTGGACATAGTTTCAGGAGAGCCTCTG
TTTAGTTCTCTGGATAAATACGACTCAGGAACCGGTTGGCCTAGTTTTACAAAACCCATAAATACCGCAAATGTTATTTT
AAAACCCGCGAGACACTATTTGTTTTTTGTGCAAACTGAAGTGCTTTCTAAAAATGCGCAATCTCATTTAGGGCATGTAT
TTAATGACGGCCCAAAACCCACCGGTGAACGATATTGCATGAATTCGGCGGCATTGCGATTTATCCCAAAAGATCAAATG
AGCAAAGAAGGCTATGAAGAGTATTTAACTCTTTTTAAATAG

Upstream 100 bases:

>100_bases
ATTCCCTCTACAACGTTTTATCCTGCAGAAGAATATCATCAAGATTATTATCAAAAAAATCCAATTCGTTACAAATATTA
CCGTTACAATTGTGGTCGTG

Downstream 100 bases:

>100_bases
ATTGCTTATGAAATTCATAAAGCCTGTGCATCGCTGTCCCTATCACTAACAAAGAAAAGATCATTGCTAAACTTAGGAAG
TGGTTTGGCCAAAGCATCAT

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MLVSRSYGMKSLVSFIVSVFMLNTALAYTPEFNKSEKLKQLTPLQYQVTQKAATEKPFDNPYWNNEQAGIYVDIVSGEPL
FSSLDKYDSGTGWPSFTKPINTANVILKPARHYLFFVQTEVLSKNAQSHLGHVFNDGPKPTGERYCMNSAALRFIPKDQM
SKEGYEEYLTLFK

Sequences:

>Translated_173_residues
MLVSRSYGMKSLVSFIVSVFMLNTALAYTPEFNKSEKLKQLTPLQYQVTQKAATEKPFDNPYWNNEQAGIYVDIVSGEPL
FSSLDKYDSGTGWPSFTKPINTANVILKPARHYLFFVQTEVLSKNAQSHLGHVFNDGPKPTGERYCMNSAALRFIPKDQM
SKEGYEEYLTLFK
>Mature_173_residues
MLVSRSYGMKSLVSFIVSVFMLNTALAYTPEFNKSEKLKQLTPLQYQVTQKAATEKPFDNPYWNNEQAGIYVDIVSGEPL
FSSLDKYDSGTGWPSFTKPINTANVILKPARHYLFFVQTEVLSKNAQSHLGHVFNDGPKPTGERYCMNSAALRFIPKDQM
SKEGYEEYLTLFK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=127, Percent_Identity=47.244094488189, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI301336162, Length=127, Percent_Identity=47.244094488189, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI73089054, Length=127, Percent_Identity=47.244094488189, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI37620216, Length=127, Percent_Identity=47.244094488189, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI117606353, Length=132, Percent_Identity=46.969696969697, Blast_Score=124, Evalue=3e-29,
Organism=Escherichia coli, GI1788077, Length=122, Percent_Identity=45.9016393442623, Blast_Score=114, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17553450, Length=131, Percent_Identity=37.4045801526718, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI115532676, Length=131, Percent_Identity=37.4045801526718, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319816, Length=143, Percent_Identity=32.1678321678322, Blast_Score=72, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45553335, Length=126, Percent_Identity=47.6190476190476, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21356369, Length=126, Percent_Identity=47.6190476190476, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24645799, Length=126, Percent_Identity=47.6190476190476, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24645804, Length=138, Percent_Identity=44.9275362318841, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24645801, Length=137, Percent_Identity=45.2554744525547, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI221378664, Length=123, Percent_Identity=46.3414634146341, Blast_Score=123, Evalue=8e-29,
Organism=Drosophila melanogaster, GI221378662, Length=130, Percent_Identity=44.6153846153846, Blast_Score=119, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 19670; Mature: 19670

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSRSYGMKSLVSFIVSVFMLNTALAYTPEFNKSEKLKQLTPLQYQVTQKAATEKPFDN
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCC
PYWNNEQAGIYVDIVSGEPLFSSLDKYDSGTGWPSFTKPINTANVILKPARHYLFFVQTE
CCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCHHHEEECCHHHHHHHHHH
VLSKNAQSHLGHVFNDGPKPTGERYCMNSAALRFIPKDQMSKEGYEEYLTLFK
HHHCCHHHHHHHHHCCCCCCCCHHHHHCCHHHEECCHHHHCHHHHHHHHHHCC
>Mature Secondary Structure
MLVSRSYGMKSLVSFIVSVFMLNTALAYTPEFNKSEKLKQLTPLQYQVTQKAATEKPFDN
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCC
PYWNNEQAGIYVDIVSGEPLFSSLDKYDSGTGWPSFTKPINTANVILKPARHYLFFVQTE
CCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCHHHEEECCHHHHHHHHHH
VLSKNAQSHLGHVFNDGPKPTGERYCMNSAALRFIPKDQMSKEGYEEYLTLFK
HHHCCHHHHHHHHHCCCCCCCCHHHHHCCHHHEECCHHHHCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]