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The map label for this gene is msrAB [H]

Identifier: 52842312

GI number: 52842312

Start: 2347009

End: 2347581

Strand: Direct

Name: msrAB [H]

Synonym: lpg2098

Alternate gene names: 52842312

Gene position: 2347009-2347581 (Clockwise)

Preceding gene: 52842311

Following gene: 52842313

Centisome position: 69.08

GC content: 37.87

Gene sequence:

>573_bases
ATGCGCTACCTCTTTATTTTGATAGCTCTTCTATCCCAACCACTTTTTGCTAAACCATCCGAAGCCATCTTTGCTGGTGG
TTGTTTTTGGTGTGTTGAAGCCGATTTTGATAAAGTTCCTGGGGTTTTAGAGACTATTTCAGGCTATGATGGTGGTACTG
AGCCTAGGCCTGGTTATGCATTGGTCTCATCGGGTAAAACTGCTTATGTAGAGGTTGTGCGTGTTGTCTTTGATAGCGAT
AAAGTGACCTATCAAGAATTACTAGATTTTTATTGGCGTCATATCGACCCAACAGTACAAAACCAGCAATTTTGCGATGT
TGGTAAGCAATATCGCAGCGTCATTTTCTATTTAAATGACGATCAAAAAAAGGCAGCTTTAGCTAGTATTGATGAAATAA
AAAAACGATTTCCTAAGGTATATACAGAGGTAATTCCCTCTACAACGTTTTATCCTGCAGAAGAATATCATCAAGATTAT
TATCAAAAAAATCCAATTCGTTACAAATATTACCGTTACAATTGTGGTCGTGATGCTCGTATCAAGGAGTTATGGGATGA
AAAGTCTAGTTAG

Upstream 100 bases:

>100_bases
GCTGCTTAAAATTGATCGTGGGTAACATGAGTATTTGAGCTAAAACCTTAAAGTAATTTTCTGCTACACTTAAAATACAA
ACTGTCTTCCAAGGTTAGGT

Downstream 100 bases:

>100_bases
TTTTATTGTAAGCGTATTTATGCTAAATACTGCCCTGGCTTACACGCCTGAATTTAACAAATCCGAAAAACTAAAACAGC
TTACGCCTCTACAATACCAA

Product: MsrA3 - peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MRYLFILIALLSQPLFAKPSEAIFAGGCFWCVEADFDKVPGVLETISGYDGGTEPRPGYALVSSGKTAYVEVVRVVFDSD
KVTYQELLDFYWRHIDPTVQNQQFCDVGKQYRSVIFYLNDDQKKAALASIDEIKKRFPKVYTEVIPSTTFYPAEEYHQDY
YQKNPIRYKYYRYNCGRDARIKELWDEKSS

Sequences:

>Translated_190_residues
MRYLFILIALLSQPLFAKPSEAIFAGGCFWCVEADFDKVPGVLETISGYDGGTEPRPGYALVSSGKTAYVEVVRVVFDSD
KVTYQELLDFYWRHIDPTVQNQQFCDVGKQYRSVIFYLNDDQKKAALASIDEIKKRFPKVYTEVIPSTTFYPAEEYHQDY
YQKNPIRYKYYRYNCGRDARIKELWDEKSS
>Mature_190_residues
MRYLFILIALLSQPLFAKPSEAIFAGGCFWCVEADFDKVPGVLETISGYDGGTEPRPGYALVSSGKTAYVEVVRVVFDSD
KVTYQELLDFYWRHIDPTVQNQQFCDVGKQYRSVIFYLNDDQKKAALASIDEIKKRFPKVYTEVIPSTTFYPAEEYHQDY
YQKNPIRYKYYRYNCGRDARIKELWDEKSS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=152, Percent_Identity=40.7894736842105, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI208609995, Length=161, Percent_Identity=39.1304347826087, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI208609993, Length=121, Percent_Identity=39.6694214876033, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1790665, Length=150, Percent_Identity=42.6666666666667, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17533973, Length=140, Percent_Identity=35.7142857142857, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=178, Percent_Identity=33.7078651685393, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=34.7517730496454, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=34.5588235294118, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=34.7517730496454, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 22165; Mature: 22165

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLFILIALLSQPLFAKPSEAIFAGGCFWCVEADFDKVPGVLETISGYDGGTEPRPGYA
CHHHHHHHHHHCCCCCCCCCCCEEECCEEEEEECCHHHCCHHHHHHCCCCCCCCCCCCEE
LVSSGKTAYVEVVRVVFDSDKVTYQELLDFYWRHIDPTVQNQQFCDVGKQYRSVIFYLND
EEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEECC
DQKKAALASIDEIKKRFPKVYTEVIPSTTFYPAEEYHQDYYQKNPIRYKYYRYNCGRDAR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCH
IKELWDEKSS
HHHHHCCCCC
>Mature Secondary Structure
MRYLFILIALLSQPLFAKPSEAIFAGGCFWCVEADFDKVPGVLETISGYDGGTEPRPGYA
CHHHHHHHHHHCCCCCCCCCCCEEECCEEEEEECCHHHCCHHHHHHCCCCCCCCCCCCEE
LVSSGKTAYVEVVRVVFDSDKVTYQELLDFYWRHIDPTVQNQQFCDVGKQYRSVIFYLND
EEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEECC
DQKKAALASIDEIKKRFPKVYTEVIPSTTFYPAEEYHQDYYQKNPIRYKYYRYNCGRDAR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCH
IKELWDEKSS
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]