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The map label for this gene is hisC2

Identifier: 52842215

GI number: 52842215

Start: 2237572

End: 2238699

Strand: Direct

Name: hisC2

Synonym: lpg1998

Alternate gene names: 52842215

Gene position: 2237572-2238699 (Clockwise)

Preceding gene: 52842210

Following gene: 52842216

Centisome position: 65.85

GC content: 36.17

Gene sequence:

>1128_bases
CTGTCTAGGAATAGAGTTATGTCTATTGATTTTCAACAATTACCCCATGCCGGAATACGTTCTTTAATTCCTTATGTACC
AGGTAAATCCATCGAAGAATTGGCAAAAGAAAAGGGAATAACTGACATTATAAAGCTGGCTAGTAATGAAAACCCATTGG
GATGCAGCCCATTAGCCCTTTCCGTCATTCAGACTATGTCATCGCATTACATAGCAACCTACCCATCGCCCTGGAACCAT
CCTTTAATGTCCAAACTTGCAAGTTACTTAAAAGTAAAACCTGAGCAATTGTTTCTAAGCAATGGGTCTGATTACCTGTT
TAATATTTTATTAAATTGTTTCGCTCTTCATACCGACAGACATATCCTTACTCATGATTACGCTTTTAGCACTTATGCCA
TCCAAGCCAATTCCCTGCAAATACCAATAAATAGTGTGCCTATTGGCCACAACTGGGAGGTTAATATCACTGATATCGTT
AATGCTTGCAATCAACAAACAGGAATTATTTTTATAGCTAATCCAAATAATCCAACTGGGGTGCTAATCCAACAAGAAGA
AATTAAATATTTATTGGAACAAATTCCGAAAAGTACTTTGTTAGTTTTAGATGAAGCCTATTATGAATTTGCTGCTAGCC
AATTAACTGTCAATAGTTTGGATTGGCTTGAAGAACATCCTAATTTGGTTGTTACTCGTACGTTTTCAAAAATCTATGGT
ATGGCAGGTTTGCGTTTAGGTTATGCTATTGCCAACCCATCCATTATTAATATTTTAAAACGAGTACAATTGCCATTTAT
AGTCAATCAAGTTGCTCTTGCAGCAGCCTATGCTGCCATCGATGACGATGACTTCATCCAGTCTAGCCTCAAAATGAATA
ATGAAGGGATGTTGCAGCTACAGGCGGGCTTTAATGAATTAAACATAAAATACTTACCCTCTTCCTGTAATTTCCTTACT
TTTGACTGCGAAGAGGATAGTATGGCTCTTTATAATTATCTATTGGATAATGGCATAATAGTAAGGCCTCTGCATGCTTA
TAAGATGAATAATTTCATCAGGGTTACTATTGGGACCAAAGAACAAAATTCCAGATTTCTAACAGCACTGAAAAATTTTT
ATTTGTAA

Upstream 100 bases:

>100_bases
CTGTTCGCTTATATAAATTCAATATAACGATTTATAAATTCTAAAAAATAAATTCATTCGTGACAGCTGGCATATGCTTA
GGTAATATAAAAACATTTTT

Downstream 100 bases:

>100_bases
CTCTTTTTAAATTAAAAATAAAATTAAGGAATCAAAATGACTAGTGATTTAAGTAGTAAGCATTGTGAATCTTGCGAGGG
AATTGGCGCTGCGCTCAACT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MSRNRVMSIDFQQLPHAGIRSLIPYVPGKSIEELAKEKGITDIIKLASNENPLGCSPLALSVIQTMSSHYIATYPSPWNH
PLMSKLASYLKVKPEQLFLSNGSDYLFNILLNCFALHTDRHILTHDYAFSTYAIQANSLQIPINSVPIGHNWEVNITDIV
NACNQQTGIIFIANPNNPTGVLIQQEEIKYLLEQIPKSTLLVLDEAYYEFAASQLTVNSLDWLEEHPNLVVTRTFSKIYG
MAGLRLGYAIANPSIINILKRVQLPFIVNQVALAAAYAAIDDDDFIQSSLKMNNEGMLQLQAGFNELNIKYLPSSCNFLT
FDCEEDSMALYNYLLDNGIIVRPLHAYKMNNFIRVTIGTKEQNSRFLTALKNFYL

Sequences:

>Translated_375_residues
MSRNRVMSIDFQQLPHAGIRSLIPYVPGKSIEELAKEKGITDIIKLASNENPLGCSPLALSVIQTMSSHYIATYPSPWNH
PLMSKLASYLKVKPEQLFLSNGSDYLFNILLNCFALHTDRHILTHDYAFSTYAIQANSLQIPINSVPIGHNWEVNITDIV
NACNQQTGIIFIANPNNPTGVLIQQEEIKYLLEQIPKSTLLVLDEAYYEFAASQLTVNSLDWLEEHPNLVVTRTFSKIYG
MAGLRLGYAIANPSIINILKRVQLPFIVNQVALAAAYAAIDDDDFIQSSLKMNNEGMLQLQAGFNELNIKYLPSSCNFLT
FDCEEDSMALYNYLLDNGIIVRPLHAYKMNNFIRVTIGTKEQNSRFLTALKNFYL
>Mature_374_residues
SRNRVMSIDFQQLPHAGIRSLIPYVPGKSIEELAKEKGITDIIKLASNENPLGCSPLALSVIQTMSSHYIATYPSPWNHP
LMSKLASYLKVKPEQLFLSNGSDYLFNILLNCFALHTDRHILTHDYAFSTYAIQANSLQIPINSVPIGHNWEVNITDIVN
ACNQQTGIIFIANPNNPTGVLIQQEEIKYLLEQIPKSTLLVLDEAYYEFAASQLTVNSLDWLEEHPNLVVTRTFSKIYGM
AGLRLGYAIANPSIINILKRVQLPFIVNQVALAAAYAAIDDDDFIQSSLKMNNEGMLQLQAGFNELNIKYLPSSCNFLTF
DCEEDSMALYNYLLDNGIIVRPLHAYKMNNFIRVTIGTKEQNSRFLTALKNFYL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=375, Percent_Identity=27.4666666666667, Blast_Score=148, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6322075, Length=395, Percent_Identity=23.7974683544304, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 42233; Mature: 42102

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRNRVMSIDFQQLPHAGIRSLIPYVPGKSIEELAKEKGITDIIKLASNENPLGCSPLAL
CCCCEEEEECHHHCCHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCHHHH
SVIQTMSSHYIATYPSPWNHPLMSKLASYLKVKPEQLFLSNGSDYLFNILLNCFALHTDR
HHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHCCCC
HILTHDYAFSTYAIQANSLQIPINSVPIGHNWEVNITDIVNACNQQTGIIFIANPNNPTG
EEEEECCEEEEEEEEECCEEEECCCCCCCCCCEEEHHHHHHHCCCCCCEEEEECCCCCCE
VLIQQEEIKYLLEQIPKSTLLVLDEAYYEFAASQLTVNSLDWLEEHPNLVVTRTFSKIYG
EEEEHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHEEEHHHHHHHHCCCEEEEEEHHHHHC
MAGLRLGYAIANPSIINILKRVQLPFIVNQVALAAAYAAIDDDDFIQSSLKMNNEGMLQL
CHHHHEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEE
QAGFNELNIKYLPSSCNFLTFDCEEDSMALYNYLLDNGIIVRPLHAYKMNNFIRVTIGTK
ECCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEEHHEECCCEEEEEECCC
EQNSRFLTALKNFYL
CCCHHHHHHHHHHCC
>Mature Secondary Structure 
SRNRVMSIDFQQLPHAGIRSLIPYVPGKSIEELAKEKGITDIIKLASNENPLGCSPLAL
CCCEEEEECHHHCCHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCHHHH
SVIQTMSSHYIATYPSPWNHPLMSKLASYLKVKPEQLFLSNGSDYLFNILLNCFALHTDR
HHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHCCCC
HILTHDYAFSTYAIQANSLQIPINSVPIGHNWEVNITDIVNACNQQTGIIFIANPNNPTG
EEEEECCEEEEEEEEECCEEEECCCCCCCCCCEEEHHHHHHHCCCCCCEEEEECCCCCCE
VLIQQEEIKYLLEQIPKSTLLVLDEAYYEFAASQLTVNSLDWLEEHPNLVVTRTFSKIYG
EEEEHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHEEEHHHHHHHHCCCEEEEEEHHHHHC
MAGLRLGYAIANPSIINILKRVQLPFIVNQVALAAAYAAIDDDDFIQSSLKMNNEGMLQL
CHHHHEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEE
QAGFNELNIKYLPSSCNFLTFDCEEDSMALYNYLLDNGIIVRPLHAYKMNNFIRVTIGTK
ECCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEEHHEECCCEEEEEECCC
EQNSRFLTALKNFYL
CCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA