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The map label for this gene is pip

Identifier: 52842070

GI number: 52842070

Start: 2066101

End: 2067060

Strand: Direct

Name: pip

Synonym: lpg1843

Alternate gene names: 52842070

Gene position: 2066101-2067060 (Clockwise)

Preceding gene: 52842063

Following gene: 52842071

Centisome position: 60.81

GC content: 41.04

Gene sequence:

>960_bases
ATGCATACCCTCTACCCAGCAATTAAACCTTACACACAACACGAATTGAAGGTTAGTAAACTGCATACACTTTATTTGGA
AGAAACCGGAAATCCTGAAGGCATACCTGTTATTGTATTGCACCATGGCCCAGGTGGAGAAGCTGACCCGCATCTAAGAC
GTTTTTTTGATCCTCAACGATATCGCATTATTCTTTTTGATCAGCGAGGTTGTGGCCGTTCAATTCCACATTTGGAAATA
AGTGAAAATAATACCCAGCTTCTCATGGAGGATATCGACTCCATTAGAGATTTCCTGGGCTTAAGGGAATTTGTGTTATT
TGGGGGTGGATGGGGTTCTCTGTTAGCATTATTGTATGCGCAAAAATTTCCTCAACAGGTGAAAGCATTGCTACTCCACC
AAATTTTTTTAGGTCGACAAAAAGACATCGATTGGTTTTATAAGCATGGAGCCAGTCTGGTTTATCCTGATTACTGGGAA
GAGTTTACGAACACAGTCCCCGAAAACAAACTTGATAATATCCCCCAATATTATGCGGAATGTCTACAAGGCTCTAATGA
GCTAGCGCGAATGGCTGCTGCGAAAAACTGGGCTCTTTGGCAAGCCAGATGCAGTAGTTTACAGCCACACTTATATGTTA
TTGATCAGTATAGCGACCCACATTTCGCATTAGCATTAGCAACTCTGGAATCCTATTACATTATTAATCATTATTTTATT
GAAGAAAATCAGGTTATAGCTAATGCCCATAAAATAAGGCACATTCCTACCTATATTGTTCATGGCCGTTTTGACTTGGT
AAGCCCTTTATCCAGCGCATGGGAACTTCATCAAGCGATCCCCGCTTCCAATCTAAGAATTGTCAGAGATGCCGGTCACT
CTGATAGAGAATCGGGAATTATTGATGCACTTATTTATGCCAGTAAGGACATCTCAAAGCAGGGTCTTGATGCATGTTAA

Upstream 100 bases:

>100_bases
CAAGTATTGCTTTCTGATCAATCAGAGCGCAAAATACTGTTCGTTTAAAGTAGCTACTAGATAGTATTATAATACAATGA
CGTTATCATAAAGGACTAAA

Downstream 100 bases:

>100_bases
CTGTATTACAAAGAGTAAAGGAAGCCAGGGTTGATATTGATGGTCAAACAGTTGGCAAAATAAATCATGGCTTGCTGATA
CTTTGTGGTTTTGAACCTAA

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MHTLYPAIKPYTQHELKVSKLHTLYLEETGNPEGIPVIVLHHGPGGEADPHLRRFFDPQRYRIILFDQRGCGRSIPHLEI
SENNTQLLMEDIDSIRDFLGLREFVLFGGGWGSLLALLYAQKFPQQVKALLLHQIFLGRQKDIDWFYKHGASLVYPDYWE
EFTNTVPENKLDNIPQYYAECLQGSNELARMAAAKNWALWQARCSSLQPHLYVIDQYSDPHFALALATLESYYIINHYFI
EENQVIANAHKIRHIPTYIVHGRFDLVSPLSSAWELHQAIPASNLRIVRDAGHSDRESGIIDALIYASKDISKQGLDAC

Sequences:

>Translated_319_residues
MHTLYPAIKPYTQHELKVSKLHTLYLEETGNPEGIPVIVLHHGPGGEADPHLRRFFDPQRYRIILFDQRGCGRSIPHLEI
SENNTQLLMEDIDSIRDFLGLREFVLFGGGWGSLLALLYAQKFPQQVKALLLHQIFLGRQKDIDWFYKHGASLVYPDYWE
EFTNTVPENKLDNIPQYYAECLQGSNELARMAAAKNWALWQARCSSLQPHLYVIDQYSDPHFALALATLESYYIINHYFI
EENQVIANAHKIRHIPTYIVHGRFDLVSPLSSAWELHQAIPASNLRIVRDAGHSDRESGIIDALIYASKDISKQGLDAC
>Mature_319_residues
MHTLYPAIKPYTQHELKVSKLHTLYLEETGNPEGIPVIVLHHGPGGEADPHLRRFFDPQRYRIILFDQRGCGRSIPHLEI
SENNTQLLMEDIDSIRDFLGLREFVLFGGGWGSLLALLYAQKFPQQVKALLLHQIFLGRQKDIDWFYKHGASLVYPDYWE
EFTNTVPENKLDNIPQYYAECLQGSNELARMAAAKNWALWQARCSSLQPHLYVIDQYSDPHFALALATLESYYIINHYFI
EENQVIANAHKIRHIPTYIVHGRFDLVSPLSSAWELHQAIPASNLRIVRDAGHSDRESGIIDALIYASKDISKQGLDAC

Specific function: May be involved in proline metabolism and sensitivity to ascamycin. Has ascamycin dealanylating activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 36578; Mature: 36578

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTLYPAIKPYTQHELKVSKLHTLYLEETGNPEGIPVIVLHHGPGGEADPHLRRFFDPQR
CCCCCCCCCCCCHHHEEHHHEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCC
YRIILFDQRGCGRSIPHLEISENNTQLLMEDIDSIRDFLGLREFVLFGGGWGSLLALLYA
EEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHH
QKFPQQVKALLLHQIFLGRQKDIDWFYKHGASLVYPDYWEEFTNTVPENKLDNIPQYYAE
HHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEECCHHHHHHHCCCCCCHHCCCHHHHHH
CLQGSNELARMAAAKNWALWQARCSSLQPHLYVIDQYSDPHFALALATLESYYIINHYFI
HHCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEEEEE
EENQVIANAHKIRHIPTYIVHGRFDLVSPLSSAWELHQAIPASNLRIVRDAGHSDRESGI
ECCCEEHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCH
IDALIYASKDISKQGLDAC
HHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MHTLYPAIKPYTQHELKVSKLHTLYLEETGNPEGIPVIVLHHGPGGEADPHLRRFFDPQR
CCCCCCCCCCCCHHHEEHHHEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCC
YRIILFDQRGCGRSIPHLEISENNTQLLMEDIDSIRDFLGLREFVLFGGGWGSLLALLYA
EEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHH
QKFPQQVKALLLHQIFLGRQKDIDWFYKHGASLVYPDYWEEFTNTVPENKLDNIPQYYAE
HHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEECCHHHHHHHCCCCCCHHCCCHHHHHH
CLQGSNELARMAAAKNWALWQARCSSLQPHLYVIDQYSDPHFALALATLESYYIINHYFI
HHCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEEEEE
EENQVIANAHKIRHIPTYIVHGRFDLVSPLSSAWELHQAIPASNLRIVRDAGHSDRESGI
ECCCEEHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCH
IDALIYASKDISKQGLDAC
HHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8885412; 8870654 [H]