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The map label for this gene is mvaB

Identifier: 52842057

GI number: 52842057

Start: 2049785

End: 2050693

Strand: Direct

Name: mvaB

Synonym: lpg1830

Alternate gene names: 52842057

Gene position: 2049785-2050693 (Clockwise)

Preceding gene: 52842056

Following gene: 52842058

Centisome position: 60.33

GC content: 39.27

Gene sequence:

>909_bases
ATGGACTATCCTCAGCATGTGACAATAATCGAAGTAGGTCCTAGAGATGGCTTACAAAATGAGCCATCTTTTCTCCATAG
TGATAAAAAAATTGAATTAATCAATTTACTCAGTCAGACAGGGCTGAAAGAGATAGAAGTCACCAGTTTTGTTTCAGCAA
AAGCAATTCCACAGCTAGCTGATAATGAAGAAGTATTTCAATCTATTAATAAGACTCCCTCCATCAACTACTCTGCCCTG
GTTCCAAACGAACGAGGAATGCTTAAAGCCCTGGAAATGGGAGTACAAAATATTGCAGTATTCACTGCTGCAAGTGAATT
ATTCAATCAACGCAATATTAATTGTTCTATTAAAGAAAGTATAGAACGCTTTAAACCTGTTTTAGCATTAGCAAAAACCA
ATCAAATTAGAGTGAGAGGCTATATCTCCTGCGTATTAGGCTGTCCCTATGAAGGATATATACAACCTAGTCAGGTTGTT
AGTGTCACTAAAATGCTTCTTGATCTAGGCGTACACGAAATTTCGTTGGGAGATACTATTGGCGTGGGAACTCCGAGGCA
AACTCAGTTGCTTCTTGATGCCATACTACCCATACTTCCAATCACACAATTAGCCATGCATTTCCACGATACTTATGGAC
AAGCCGTAGCAAATATTTATGCCTCCCTTGAGTATGGAGTTAACCGCTTTGACAGCTCTGTTGCGGGTCTTGGAGGTTGT
CCATATGCTCGAGGTGCCAGTGGCAATGTTGCAACAGAAGATGTACTTTATTTGATGCATGGATTGGGTATTGATACAGG
TATAGATATATTTAAAATTGTTGCTGCCGGAGATATGATTTGCAAAGCACTAGGGCGAAAAAATCAATCCAAAGTAGCTA
ATGCTATGCTAGCCAATCCATGTAATTAA

Upstream 100 bases:

>100_bases
GATGGTATATTATCAGATATTTTTTATTCTGTAGGTTCCCAAGTGAGTGAGGGAGCAGAACTGTTAGCACTTAGCGAATC
GGATACTTAAGAGAATATTT

Downstream 100 bases:

>100_bases
GAAGCTCCATCATTATTGGCTTTGATAAGTACTAAAAATCGGAAACTTAAAGAGAAGCACCCAGTTTTGTGCTAGCCTAT
ACTTATAAACAAATTACTGA

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MDYPQHVTIIEVGPRDGLQNEPSFLHSDKKIELINLLSQTGLKEIEVTSFVSAKAIPQLADNEEVFQSINKTPSINYSAL
VPNERGMLKALEMGVQNIAVFTAASELFNQRNINCSIKESIERFKPVLALAKTNQIRVRGYISCVLGCPYEGYIQPSQVV
SVTKMLLDLGVHEISLGDTIGVGTPRQTQLLLDAILPILPITQLAMHFHDTYGQAVANIYASLEYGVNRFDSSVAGLGGC
PYARGASGNVATEDVLYLMHGLGIDTGIDIFKIVAAGDMICKALGRKNQSKVANAMLANPCN

Sequences:

>Translated_302_residues
MDYPQHVTIIEVGPRDGLQNEPSFLHSDKKIELINLLSQTGLKEIEVTSFVSAKAIPQLADNEEVFQSINKTPSINYSAL
VPNERGMLKALEMGVQNIAVFTAASELFNQRNINCSIKESIERFKPVLALAKTNQIRVRGYISCVLGCPYEGYIQPSQVV
SVTKMLLDLGVHEISLGDTIGVGTPRQTQLLLDAILPILPITQLAMHFHDTYGQAVANIYASLEYGVNRFDSSVAGLGGC
PYARGASGNVATEDVLYLMHGLGIDTGIDIFKIVAAGDMICKALGRKNQSKVANAMLANPCN
>Mature_302_residues
MDYPQHVTIIEVGPRDGLQNEPSFLHSDKKIELINLLSQTGLKEIEVTSFVSAKAIPQLADNEEVFQSINKTPSINYSAL
VPNERGMLKALEMGVQNIAVFTAASELFNQRNINCSIKESIERFKPVLALAKTNQIRVRGYISCVLGCPYEGYIQPSQVV
SVTKMLLDLGVHEISLGDTIGVGTPRQTQLLLDAILPILPITQLAMHFHDTYGQAVANIYASLEYGVNRFDSSVAGLGGC
PYARGASGNVATEDVLYLMHGLGIDTGIDIFKIVAAGDMICKALGRKNQSKVANAMLANPCN

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=292, Percent_Identity=55.1369863013699, Blast_Score=345, Evalue=3e-95,
Organism=Homo sapiens, GI109150427, Length=292, Percent_Identity=54.4520547945205, Blast_Score=342, Evalue=2e-94,
Organism=Homo sapiens, GI109150422, Length=292, Percent_Identity=54.4520547945205, Blast_Score=342, Evalue=2e-94,
Organism=Homo sapiens, GI260654708, Length=135, Percent_Identity=57.7777777777778, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17510563, Length=291, Percent_Identity=48.1099656357388, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6320019, Length=246, Percent_Identity=26.0162601626016, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320071, Length=240, Percent_Identity=25.4166666666667, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24582381, Length=291, Percent_Identity=57.0446735395189, Blast_Score=359, Evalue=1e-99,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32753; Mature: 32753

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYPQHVTIIEVGPRDGLQNEPSFLHSDKKIELINLLSQTGLKEIEVTSFVSAKAIPQLA
CCCCCEEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
DNEEVFQSINKTPSINYSALVPNERGMLKALEMGVQNIAVFTAASELFNQRNINCSIKES
CCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IERFKPVLALAKTNQIRVRGYISCVLGCPYEGYIQPSQVVSVTKMLLDLGVHEISLGDTI
HHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCEE
GVGTPRQTQLLLDAILPILPITQLAMHFHDTYGQAVANIYASLEYGVNRFDSSVAGLGGC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PYARGASGNVATEDVLYLMHGLGIDTGIDIFKIVAAGDMICKALGRKNQSKVANAMLANP
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
CN
CC
>Mature Secondary Structure
MDYPQHVTIIEVGPRDGLQNEPSFLHSDKKIELINLLSQTGLKEIEVTSFVSAKAIPQLA
CCCCCEEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
DNEEVFQSINKTPSINYSALVPNERGMLKALEMGVQNIAVFTAASELFNQRNINCSIKES
CCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IERFKPVLALAKTNQIRVRGYISCVLGCPYEGYIQPSQVVSVTKMLLDLGVHEISLGDTI
HHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCEE
GVGTPRQTQLLLDAILPILPITQLAMHFHDTYGQAVANIYASLEYGVNRFDSSVAGLGGC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PYARGASGNVATEDVLYLMHGLGIDTGIDIFKIVAAGDMICKALGRKNQSKVANAMLANP
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
CN
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]