Click here to switch to the map view.

The map label for this gene is acsA1 [H]

Identifier: 52842058

GI number: 52842058

Start: 2050790

End: 2052790

Strand: Direct

Name: acsA1 [H]

Synonym: lpg1831

Alternate gene names: 52842058

Gene position: 2050790-2052790 (Clockwise)

Preceding gene: 52842057

Following gene: 52842060

Centisome position: 60.36

GC content: 39.58

Gene sequence:

>2001_bases
CTGATGAAATTTTCCAGTGTAACACCCATCATTCAAAACAGAACTATGAGAGAAATTTTCATGAACGACAAAGTATGGAC
ACCTAAAAACCCTGAACAAACAAGAATGTGGCAATTTATGGACTTTGCCGCAAAAAGGCATTGTCAAGTTTTTGAAAATT
ATCAAGACTTACATACCTGGTCAGTAAAGCATCCTGAATCATTCTGGGAAACTCTTTGCCTTTTCTTTAAATTGAACTTT
GATACACCACCTCACCAAATTCTGAATTATTATTCTGAAATGATTGAAGCACGCTGGTTTTCAGGAGCACGCTTCAATTT
CGCTCAAAAATTATTAACCCGCAGGGATAATCACCCTGCCCTAATAAGCCTTGATGAAAATGACTGCAAAAGTGTCATTA
GCTATGCTGAATTATATGAAAAAGTAGCCCAATGCGCTGCTGGTCTTAAAGCAATTGGTGTCGCCACTGGCGACCGGGTG
GCCGCAGTGATGCCTAATACTTCTTACACAATCATTGCCATGCTGGCAACAACTTCTTTAGGGGCAATCTGGTCATCCTG
CTCACCTGACTTTGGTACCCAGGCTGCACTTGACAGGATAGGACAAATTGAACCTAAAGTACTCTTTATTTGTGATGGTC
ATCAATATCAAGGTAAGAAACACAGCAGCTCTGAAAAGGTCGTACAACTTACTGCTGCGATTACTTCTCTAAGACAGGTA
GTAATTTGCCCAAATATTAATGAGGAAATTAATCTCGAACAACTGCCTAACACATCGTATTGGAATGATTTTATAAAACC
GGTAAAAGAATGTGATTTTATTTCTCTGCCTTTTGATCATCCTGTTTATATTATGTTTTCTTCAGGAACAACAGGTAAAC
CTAAATGTATCGTTCATGGCGCGGGAGGTACTTTAATTCAGCATCTGAAAGAATTAGGTCTTCATTCAGATATTAAATCC
GCAGACAATTTATGTTTTTATACAACGTGTGGCTGGATGATGTGGAACTGGACTGTTTCTGCTTTGGCATTGGGAGCTAC
CATCACTCTATATGAAGGTTCTCCAACCTACCCTACAGATAATAGAATGTTTCGACTGATAGATGAAGAAAAAGTCACTG
TATTTGGAACCAGCGCCAAGTTCATATCCGCGATTGAAAAAGCCGGGGTAAAACCAAAAAGTGAATTTCAATTATCCGAG
TTGCGCTGTATCTTGTCTACCGGCTCCCCTCTTCTACCTAAAAACTATGATTTCGTCTATGAACATATTAAAAAAGATCT
GCAATTAAGCTCTATTTCAGGAGGGACGGATATTATTTCTTGTTTTGCATTGGGAAATCCTATTCTCCCGGTTTATAGGG
GTGAATTACAATGCATTGGATTAGGTATGGAAGTTGCGGTGTATGATGAGCAAGGCCATTCAATCAAACAAAAACGTGGT
GAGTTGGTTTGCACCAAACCCTTCCCTTCCATGCCAGTCTGTTTTTGGAATGATAAGGATAGACAAGCATATAAACATGC
TTATTTTGAGCGCTTCCCAGGGGTGTGGGCACATGGCGATTTCGCTGAAATAACTGCCCACAATGGATTAATTATCCATG
GACGTTCCGACGCTATATTAAATCCGGGAGGAGTTCGTATAGGAACAGCTGAAATTTACAGACAAGTTGAAAAAGTAGAT
GATGTTGTTGATAGTATAGTCATTGGGCAAGATTGGCAGGATGATGTACGAGTTGTTTTATTCGTTAAGTTGCGTGAGGG
GAAAAAACTGGATGATGAATTAATCAATCTGATTAAAACAACCATTAGAAAAAATGCCTCACCACGACATGTGCCAGCTA
AAATACTACAAGTCCCAGACATTCCTAAAACTCTTAGCGGGAAAGTAGTGGAGCTCGCCGTCAGGCAAGTTGTTCATGGT
CAATCAGTAAGTAACTTACAGTCTTTGGCAAACCCTCAAGCATTAGAATATTTTAAAGACAGGAACGAATTGAAAAGCTA
A

Upstream 100 bases:

>100_bases
TTAAGAAGCTCCATCATTATTGGCTTTGATAAGTACTAAAAATCGGAAACTTAAAGAGAAGCACCCAGTTTTGTGCTAGC
CTATACTTATAAACAAATTA

Downstream 100 bases:

>100_bases
AATTGCGTGAAAATAGCTATTTTCAGCACGAATCCACATTAAAATTCATCTCATATCAACCAATAGAAAGGGCAACTGCA
AGAGTTGCCCTTTCATGTAA

Product: acetoacetyl-CoA synthetase

Products: NA

Alternate protein names: Acetoacetate--CoA ligase 1; Acyl-activating enzyme 1 [H]

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MMKFSSVTPIIQNRTMREIFMNDKVWTPKNPEQTRMWQFMDFAAKRHCQVFENYQDLHTWSVKHPESFWETLCLFFKLNF
DTPPHQILNYYSEMIEARWFSGARFNFAQKLLTRRDNHPALISLDENDCKSVISYAELYEKVAQCAAGLKAIGVATGDRV
AAVMPNTSYTIIAMLATTSLGAIWSSCSPDFGTQAALDRIGQIEPKVLFICDGHQYQGKKHSSSEKVVQLTAAITSLRQV
VICPNINEEINLEQLPNTSYWNDFIKPVKECDFISLPFDHPVYIMFSSGTTGKPKCIVHGAGGTLIQHLKELGLHSDIKS
ADNLCFYTTCGWMMWNWTVSALALGATITLYEGSPTYPTDNRMFRLIDEEKVTVFGTSAKFISAIEKAGVKPKSEFQLSE
LRCILSTGSPLLPKNYDFVYEHIKKDLQLSSISGGTDIISCFALGNPILPVYRGELQCIGLGMEVAVYDEQGHSIKQKRG
ELVCTKPFPSMPVCFWNDKDRQAYKHAYFERFPGVWAHGDFAEITAHNGLIIHGRSDAILNPGGVRIGTAEIYRQVEKVD
DVVDSIVIGQDWQDDVRVVLFVKLREGKKLDDELINLIKTTIRKNASPRHVPAKILQVPDIPKTLSGKVVELAVRQVVHG
QSVSNLQSLANPQALEYFKDRNELKS

Sequences:

>Translated_666_residues
MMKFSSVTPIIQNRTMREIFMNDKVWTPKNPEQTRMWQFMDFAAKRHCQVFENYQDLHTWSVKHPESFWETLCLFFKLNF
DTPPHQILNYYSEMIEARWFSGARFNFAQKLLTRRDNHPALISLDENDCKSVISYAELYEKVAQCAAGLKAIGVATGDRV
AAVMPNTSYTIIAMLATTSLGAIWSSCSPDFGTQAALDRIGQIEPKVLFICDGHQYQGKKHSSSEKVVQLTAAITSLRQV
VICPNINEEINLEQLPNTSYWNDFIKPVKECDFISLPFDHPVYIMFSSGTTGKPKCIVHGAGGTLIQHLKELGLHSDIKS
ADNLCFYTTCGWMMWNWTVSALALGATITLYEGSPTYPTDNRMFRLIDEEKVTVFGTSAKFISAIEKAGVKPKSEFQLSE
LRCILSTGSPLLPKNYDFVYEHIKKDLQLSSISGGTDIISCFALGNPILPVYRGELQCIGLGMEVAVYDEQGHSIKQKRG
ELVCTKPFPSMPVCFWNDKDRQAYKHAYFERFPGVWAHGDFAEITAHNGLIIHGRSDAILNPGGVRIGTAEIYRQVEKVD
DVVDSIVIGQDWQDDVRVVLFVKLREGKKLDDELINLIKTTIRKNASPRHVPAKILQVPDIPKTLSGKVVELAVRQVVHG
QSVSNLQSLANPQALEYFKDRNELKS
>Mature_666_residues
MMKFSSVTPIIQNRTMREIFMNDKVWTPKNPEQTRMWQFMDFAAKRHCQVFENYQDLHTWSVKHPESFWETLCLFFKLNF
DTPPHQILNYYSEMIEARWFSGARFNFAQKLLTRRDNHPALISLDENDCKSVISYAELYEKVAQCAAGLKAIGVATGDRV
AAVMPNTSYTIIAMLATTSLGAIWSSCSPDFGTQAALDRIGQIEPKVLFICDGHQYQGKKHSSSEKVVQLTAAITSLRQV
VICPNINEEINLEQLPNTSYWNDFIKPVKECDFISLPFDHPVYIMFSSGTTGKPKCIVHGAGGTLIQHLKELGLHSDIKS
ADNLCFYTTCGWMMWNWTVSALALGATITLYEGSPTYPTDNRMFRLIDEEKVTVFGTSAKFISAIEKAGVKPKSEFQLSE
LRCILSTGSPLLPKNYDFVYEHIKKDLQLSSISGGTDIISCFALGNPILPVYRGELQCIGLGMEVAVYDEQGHSIKQKRG
ELVCTKPFPSMPVCFWNDKDRQAYKHAYFERFPGVWAHGDFAEITAHNGLIIHGRSDAILNPGGVRIGTAEIYRQVEKVD
DVVDSIVIGQDWQDDVRVVLFVKLREGKKLDDELINLIKTTIRKNASPRHVPAKILQVPDIPKTLSGKVVELAVRQVVHG
QSVSNLQSLANPQALEYFKDRNELKS

Specific function: Involved in poly-3-hydroxybutyrate degradation. Activates acetoacetate to acetoacetyl-CoA [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI31982927, Length=667, Percent_Identity=42.2788605697151, Blast_Score=561, Evalue=1e-159,
Organism=Homo sapiens, GI8923896, Length=692, Percent_Identity=24.4219653179191, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI253970489, Length=698, Percent_Identity=24.2120343839542, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI28416953, Length=638, Percent_Identity=26.1755485893417, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI13375727, Length=632, Percent_Identity=23.7341772151899, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI38505220, Length=590, Percent_Identity=21.3559322033898, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI122937307, Length=557, Percent_Identity=22.0825852782765, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI115511026, Length=565, Percent_Identity=20.7079646017699, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790505, Length=636, Percent_Identity=23.8993710691824, Blast_Score=188, Evalue=9e-49,
Organism=Escherichia coli, GI1786529, Length=661, Percent_Identity=23.4493192133132, Blast_Score=135, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17569507, Length=646, Percent_Identity=35.4489164086687, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71982997, Length=636, Percent_Identity=25.6289308176101, Blast_Score=169, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71983001, Length=651, Percent_Identity=25.4992319508449, Blast_Score=169, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6323182, Length=655, Percent_Identity=26.2595419847328, Blast_Score=213, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6319264, Length=672, Percent_Identity=26.9345238095238, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24667955, Length=653, Percent_Identity=28.4839203675345, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI62472339, Length=570, Percent_Identity=28.9473684210526, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=28.4615384615385, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI21355225, Length=627, Percent_Identity=25.1993620414673, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005914
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.16 [H]

Molecular weight: Translated: 75071; Mature: 75071

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKFSSVTPIIQNRTMREIFMNDKVWTPKNPEQTRMWQFMDFAAKRHCQVFENYQDLHTW
CCCCCCCCHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHEE
SVKHPESFWETLCLFFKLNFDTPPHQILNYYSEMIEARWFSGARFNFAQKLLTRRDNHPA
CCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCE
LISLDENDCKSVISYAELYEKVAQCAAGLKAIGVATGDRVAAVMPNTSYTIIAMLATTSL
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEECCCCEEEEEHHHHHHH
GAIWSSCSPDFGTQAALDRIGQIEPKVLFICDGHQYQGKKHSSSEKVVQLTAAITSLRQV
HHHHHCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEE
VICPNINEEINLEQLPNTSYWNDFIKPVKECDFISLPFDHPVYIMFSSGTTGKPKCIVHG
EECCCCCCCCCHHHCCCCHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCCCCCEEEEEC
AGGTLIQHLKELGLHSDIKSADNLCFYTTCGWMMWNWTVSALALGATITLYEGSPTYPTD
CCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCCCC
NRMFRLIDEEKVTVFGTSAKFISAIEKAGVKPKSEFQLSELRCILSTGSPLLPKNYDFVY
CCEEEEECCCEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHH
EHIKKDLQLSSISGGTDIISCFALGNPILPVYRGELQCIGLGMEVAVYDEQGHSIKQKRG
HHHHHHCEEECCCCCHHHHHHHHCCCCCCEEECCCEEEEEECEEEEEECCCCCHHHHCCC
ELVCTKPFPSMPVCFWNDKDRQAYKHAYFERFPGVWAHGDFAEITAHNGLIIHGRSDAIL
CEEEECCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEECCCCCEE
NPGGVRIGTAEIYRQVEKVDDVVDSIVIGQDWQDDVRVVLFVKLREGKKLDDELINLIKT
CCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
TIRKNASPRHVPAKILQVPDIPKTLSGKVVELAVRQVVHGQSVSNLQSLANPQALEYFKD
HHHCCCCCCCCCHHHHCCCCCCCHHCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHH
RNELKS
HHHHCC
>Mature Secondary Structure
MMKFSSVTPIIQNRTMREIFMNDKVWTPKNPEQTRMWQFMDFAAKRHCQVFENYQDLHTW
CCCCCCCCHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHEE
SVKHPESFWETLCLFFKLNFDTPPHQILNYYSEMIEARWFSGARFNFAQKLLTRRDNHPA
CCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCE
LISLDENDCKSVISYAELYEKVAQCAAGLKAIGVATGDRVAAVMPNTSYTIIAMLATTSL
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEECCCCEEEEEHHHHHHH
GAIWSSCSPDFGTQAALDRIGQIEPKVLFICDGHQYQGKKHSSSEKVVQLTAAITSLRQV
HHHHHCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEE
VICPNINEEINLEQLPNTSYWNDFIKPVKECDFISLPFDHPVYIMFSSGTTGKPKCIVHG
EECCCCCCCCCHHHCCCCHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCCCCCEEEEEC
AGGTLIQHLKELGLHSDIKSADNLCFYTTCGWMMWNWTVSALALGATITLYEGSPTYPTD
CCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCCCC
NRMFRLIDEEKVTVFGTSAKFISAIEKAGVKPKSEFQLSELRCILSTGSPLLPKNYDFVY
CCEEEEECCCEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHH
EHIKKDLQLSSISGGTDIISCFALGNPILPVYRGELQCIGLGMEVAVYDEQGHSIKQKRG
HHHHHHCEEECCCCCHHHHHHHHCCCCCCEEECCCEEEEEECEEEEEECCCCCHHHHCCC
ELVCTKPFPSMPVCFWNDKDRQAYKHAYFERFPGVWAHGDFAEITAHNGLIIHGRSDAIL
CEEEECCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEECCCCCEE
NPGGVRIGTAEIYRQVEKVDDVVDSIVIGQDWQDDVRVVLFVKLREGKKLDDELINLIKT
CCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
TIRKNASPRHVPAKILQVPDIPKTLSGKVVELAVRQVVHGQSVSNLQSLANPQALEYFKD
HHHCCCCCCCCCHHHHCCCCCCCHHCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHH
RNELKS
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10735852; 11481430 [H]