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The map label for this gene is yngE [H]

Identifier: 52842054

GI number: 52842054

Start: 2045396

End: 2047003

Strand: Direct

Name: yngE [H]

Synonym: lpg1827

Alternate gene names: 52842054

Gene position: 2045396-2047003 (Clockwise)

Preceding gene: 52842053

Following gene: 52842055

Centisome position: 60.2

GC content: 42.91

Gene sequence:

>1608_bases
ATGGCTAAGTTAACTACTCAAATCAATACCAGCAGTCAGGAATTCAAAAATAATCAGGCGAATATGCAAGCATTGGTTAC
TGATTTAAGAGAAAAAATACATCAAATCTCTCTGGGTGGAGATGAAAAAGCACGTACCAAACATCAACAACAAGGCAAAC
TACTTCCGAGAGAACGCTTACACCAGTTGCTGGATCCAGGTAGTCCTTTTCTTGAGCTATCTCAACTTGCTGCCTACCAA
GTCTATGAAGACACAATACCCGCTGCAGGAATAATCACTGGCATTGGAAGAGTGGCAGGAAACGAATGTGTGATTGTGGT
CAACGATGCCACTGTTAAAGGTGGAACATATTATCCTCTGACCGTAAAAAAACACTTAAGGGCACAAGAAATTGCATTGA
TAAACCATCTTCCATGCATCTATCTGGTGGATTCAGGAGGTGCCTTTCTACCGCTTCAAGATCAGGTCTTTGCCGATAAA
GAACATTTTGGACGTGTTTTTTATAATCAAGCGCAAATGTCAGCATTAAATATTCCTCAAATAGCCGTGGTTATGGGATC
TTGTACGGCGGGAGGAGCCTATGTACCAGCCATGGCTGATGAATCTATTATGGTCAAGAATCAGGCAACCATATTCCTTG
GAGGCCCTCCTCTCGTTAAAGCAGCAACAGGAGAAGTAATCAGTGCGGAAGAATTAGGAGGAGCCGAAGTTCACTGTCGC
CACTCAGGAGTATCTGATCATTATGCGGAAAATGACGCTCACGCGCTTCATTTAGCGCGAGTCGCCATTAGCAATTTAAA
TCGTAAAAAACCAGATTCCATTCATAGAGTGGATACAGTTCCTCCTCTTTATGATAGCGAAGATCTTACCGGAATAATTC
CCACTGACCCTAGAAAGCCTTTTGATATAAGAGAAATTATTGCTCGAGTGGTAGATGGTTCAGAGTTTGATGAATTCAAA
GCACTTTTTGGAACAACCCTGGTTTGCGGTTTTGCTCGCCTATATGGATATCCTATAGGGATTATTGCTAATAATGGCAT
ACTTTTTAGTGAAAGTGCGCAAAAGGGCAGCCATTTCATAGAGCTGTGCTGTCAACGTAAAATACCACTTGTATTCCTGC
AAAATATTACAGGATTTATGGTGGGCTCCAAATACGAAGCATCAGGTATTGCAAAACATGGAGCCAAAATGGTGACAGCA
GTTGCCAATGCTAATGTACCCAAATTTACCATCATTGTTGGTGGAAGTTTTGGAGCAGGTAATTATGCCATGTGTGGCCG
GGCATATGCTCCTCGTTTCCTATGGGCCTGGCCTAATGCACGCATCTCAGTTATGGGTGGTGAACAAGCAGCGAATGTTC
TCGCGCAAATCACCAGAGAGAAATATGCAAAGCAAGGAAAAGAATGGTCACTCGAAGAAGAAGAACAATTTAAAACTCAA
ATGAGAAGTCAGTATGAAACTCAGGGAAATCCTTACTATGCCAGTGCCAGGCTTTGGGATGATGGGGTCATCGCGCCTCA
GGATACACGCAAAATACTCGGACTTGGATTATCTGCAGCCTTAAACGCACCGATTGAGGATACTCGTTTCGGTGTATTTC
GCATGTAA

Upstream 100 bases:

>100_bases
GGCACTCAAAGGAAAAGACATGCCCCATTTTATTGCGATTGTCTGGATAATATGGACCATCATAGTCTTGAGTGATATTT
TGATTCGGTAAGGATAAAAA

Downstream 100 bases:

>100_bases
AAGGAAAGGAACAATAGGCATGAGTGATTTATTATATGAAATTCAAGATAAAGTAGGTTTACTTACTATGAATCGAATTA
GCAAGCATAATGCGTTCGAT

Product: propionyl CoA carboxylase beta subunit

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MAKLTTQINTSSQEFKNNQANMQALVTDLREKIHQISLGGDEKARTKHQQQGKLLPRERLHQLLDPGSPFLELSQLAAYQ
VYEDTIPAAGIITGIGRVAGNECVIVVNDATVKGGTYYPLTVKKHLRAQEIALINHLPCIYLVDSGGAFLPLQDQVFADK
EHFGRVFYNQAQMSALNIPQIAVVMGSCTAGGAYVPAMADESIMVKNQATIFLGGPPLVKAATGEVISAEELGGAEVHCR
HSGVSDHYAENDAHALHLARVAISNLNRKKPDSIHRVDTVPPLYDSEDLTGIIPTDPRKPFDIREIIARVVDGSEFDEFK
ALFGTTLVCGFARLYGYPIGIIANNGILFSESAQKGSHFIELCCQRKIPLVFLQNITGFMVGSKYEASGIAKHGAKMVTA
VANANVPKFTIIVGGSFGAGNYAMCGRAYAPRFLWAWPNARISVMGGEQAANVLAQITREKYAKQGKEWSLEEEEQFKTQ
MRSQYETQGNPYYASARLWDDGVIAPQDTRKILGLGLSAALNAPIEDTRFGVFRM

Sequences:

>Translated_535_residues
MAKLTTQINTSSQEFKNNQANMQALVTDLREKIHQISLGGDEKARTKHQQQGKLLPRERLHQLLDPGSPFLELSQLAAYQ
VYEDTIPAAGIITGIGRVAGNECVIVVNDATVKGGTYYPLTVKKHLRAQEIALINHLPCIYLVDSGGAFLPLQDQVFADK
EHFGRVFYNQAQMSALNIPQIAVVMGSCTAGGAYVPAMADESIMVKNQATIFLGGPPLVKAATGEVISAEELGGAEVHCR
HSGVSDHYAENDAHALHLARVAISNLNRKKPDSIHRVDTVPPLYDSEDLTGIIPTDPRKPFDIREIIARVVDGSEFDEFK
ALFGTTLVCGFARLYGYPIGIIANNGILFSESAQKGSHFIELCCQRKIPLVFLQNITGFMVGSKYEASGIAKHGAKMVTA
VANANVPKFTIIVGGSFGAGNYAMCGRAYAPRFLWAWPNARISVMGGEQAANVLAQITREKYAKQGKEWSLEEEEQFKTQ
MRSQYETQGNPYYASARLWDDGVIAPQDTRKILGLGLSAALNAPIEDTRFGVFRM
>Mature_534_residues
AKLTTQINTSSQEFKNNQANMQALVTDLREKIHQISLGGDEKARTKHQQQGKLLPRERLHQLLDPGSPFLELSQLAAYQV
YEDTIPAAGIITGIGRVAGNECVIVVNDATVKGGTYYPLTVKKHLRAQEIALINHLPCIYLVDSGGAFLPLQDQVFADKE
HFGRVFYNQAQMSALNIPQIAVVMGSCTAGGAYVPAMADESIMVKNQATIFLGGPPLVKAATGEVISAEELGGAEVHCRH
SGVSDHYAENDAHALHLARVAISNLNRKKPDSIHRVDTVPPLYDSEDLTGIIPTDPRKPFDIREIIARVVDGSEFDEFKA
LFGTTLVCGFARLYGYPIGIIANNGILFSESAQKGSHFIELCCQRKIPLVFLQNITGFMVGSKYEASGIAKHGAKMVTAV
ANANVPKFTIIVGGSFGAGNYAMCGRAYAPRFLWAWPNARISVMGGEQAANVLAQITREKYAKQGKEWSLEEEEQFKTQM
RSQYETQGNPYYASARLWDDGVIAPQDTRKILGLGLSAALNAPIEDTRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=536, Percent_Identity=65.1119402985075, Blast_Score=730, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=490, Percent_Identity=31.6326530612245, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI295821216, Length=510, Percent_Identity=30.3921568627451, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI310133460, Length=146, Percent_Identity=60.958904109589, Blast_Score=165, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17552936, Length=535, Percent_Identity=61.4953271028037, Blast_Score=706, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=492, Percent_Identity=31.3008130081301, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25147362, Length=492, Percent_Identity=31.3008130081301, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24586065, Length=549, Percent_Identity=63.5701275045537, Blast_Score=726, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 58461; Mature: 58329

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLTTQINTSSQEFKNNQANMQALVTDLREKIHQISLGGDEKARTKHQQQGKLLPRERL
CCEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHH
HQLLDPGSPFLELSQLAAYQVYEDTIPAAGIITGIGRVAGNECVIVVNDATVKGGTYYPL
HHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCEECCCEEEEE
TVKKHLRAQEIALINHLPCIYLVDSGGAFLPLQDQVFADKEHFGRVFYNQAQMSALNIPQ
EHHHHCCHHHHHHHHCCCEEEEECCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCE
IAVVMGSCTAGGAYVPAMADESIMVKNQATIFLGGPPLVKAATGEVISAEELGGAEVHCR
EEEEEECCCCCCEEECCCCCCEEEEECCEEEEECCCCEEEECCCCEEEHHHCCCCEEEEE
HSGVSDHYAENDAHALHLARVAISNLNRKKPDSIHRVDTVPPLYDSEDLTGIIPTDPRKP
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
FDIREIIARVVDGSEFDEFKALFGTTLVCGFARLYGYPIGIIANNGILFSESAQKGSHFI
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCHHHH
ELCCQRKIPLVFLQNITGFMVGSKYEASGIAKHGAKMVTAVANANVPKFTIIVGGSFGAG
HHHHCCCCCEEEECCCCCEEECCCCCCCCHHHHCHHEEEEECCCCCCEEEEEEECCCCCC
NYAMCGRAYAPRFLWAWPNARISVMGGEQAANVLAQITREKYAKQGKEWSLEEEEQFKTQ
CHHHCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
MRSQYETQGNPYYASARLWDDGVIAPQDTRKILGLGLSAALNAPIEDTRFGVFRM
HHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHCCHHHHCCCCCCCCCCCEECC
>Mature Secondary Structure 
AKLTTQINTSSQEFKNNQANMQALVTDLREKIHQISLGGDEKARTKHQQQGKLLPRERL
CEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHH
HQLLDPGSPFLELSQLAAYQVYEDTIPAAGIITGIGRVAGNECVIVVNDATVKGGTYYPL
HHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCEECCCEEEEE
TVKKHLRAQEIALINHLPCIYLVDSGGAFLPLQDQVFADKEHFGRVFYNQAQMSALNIPQ
EHHHHCCHHHHHHHHCCCEEEEECCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCE
IAVVMGSCTAGGAYVPAMADESIMVKNQATIFLGGPPLVKAATGEVISAEELGGAEVHCR
EEEEEECCCCCCEEECCCCCCEEEEECCEEEEECCCCEEEECCCCEEEHHHCCCCEEEEE
HSGVSDHYAENDAHALHLARVAISNLNRKKPDSIHRVDTVPPLYDSEDLTGIIPTDPRKP
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
FDIREIIARVVDGSEFDEFKALFGTTLVCGFARLYGYPIGIIANNGILFSESAQKGSHFI
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCHHHH
ELCCQRKIPLVFLQNITGFMVGSKYEASGIAKHGAKMVTAVANANVPKFTIIVGGSFGAG
HHHHCCCCCEEEECCCCCEEECCCCCCCCHHHHCHHEEEEECCCCCCEEEEEEECCCCCC
NYAMCGRAYAPRFLWAWPNARISVMGGEQAANVLAQITREKYAKQGKEWSLEEEEQFKTQ
CHHHCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
MRSQYETQGNPYYASARLWDDGVIAPQDTRKILGLGLSAALNAPIEDTRFGVFRM
HHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHCCHHHHCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]