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The map label for this gene is nrdB

Identifier: 52842002

GI number: 52842002

Start: 1983037

End: 1984182

Strand: Direct

Name: nrdB

Synonym: lpg1775

Alternate gene names: 52842002

Gene position: 1983037-1984182 (Clockwise)

Preceding gene: 52842001

Following gene: 52842003

Centisome position: 58.36

GC content: 39.53

Gene sequence:

>1146_bases
CTGATCCAGACTGCGAGGCTTGCCAATAATCAGGAGAAATTTATGAACTACAATGATACTCAAGAAATTATCGTAACTCC
TCTTATGGGCGCGACAGGGCTCGAAACTTTAGAAATGGGGGCTGCACGCATTCATGTTGATGATAAGCAAATCATTAATT
GCCGTGCTGACTTAAATCAATTGGTGCCTTTCAAATACAAATGGGCTTGGGATAAATACTTGACAGCCTGTGCCAATCAT
TGGATGCCCAATGAAATCAGTATGAGTGCCGATGTCGCTTTATGGAAAGATCCTTATGGTCTTACAGAAGATGAGCGTTT
AATCATTAAGCGTAATTTGGGATTTTTCTCAACCGCCGATTCACTCGTTGCGAATAATCTGGTTCTTGCTGTTTACAGAC
ATATTACTAATCCTGAGTGTCGACAATATCTTCTAAGGCAAGCTTTTGAAGAAGCGTTACACACTCATGCTTATCAATAC
ATTATAGAGAGTTTGGGGCTGGATGAAGCTGAAGTATTTAATATGTATAGAGAAATACCTTCTGTATCCAGGAAAGCAGT
TTGGGCATTACCATTTACTCAAAGTTTAGGTGATGAAACCTTCCATACAGGCACTCCAGAAAATGATCAACGCCTGCTAC
GCGATTTAATTGCATTTTATGTCGTGTTTGAGGGTATTTTCTTTTATGTCGGATTTACTCAAATTCTCTCTATGGGACGT
CGTAACAAAATGGTAGGAACATCAGAACAGTTCCAATATATACTGCGCGATGAGTCCATGCATATGAATTTCGGTATTGA
TGTGATTAATCAAATCAAAATCGAAAATCCTCACTTATGGACACCTGAATTTAAGAATGAAATGATCCAACTCATCAGAG
AAGGTGTTGAGCTCGAATACCAATACGCCAGAGACACTATGCCTCATGGCATTCTCGGAATGAACGCCGAGATGTTTGAA
GAATATTTGCACTTTATTGCAAACCGTCGCTTAAATCAAATAGGTCTGCCGGATCAATACCCAGGTGCTGAAAACCCATT
TCCCTGGATGAGTGAAATGCTGGATCTCAAAAAAGAGAAAAACTTTTTTGAAACTCGTGTTATTGAATATCAGGCTGGTG
GTACTTTAAGCTGGGATGATGAATAA

Upstream 100 bases:

>100_bases
CGTAGTTTAGGTGCAAGTAATGCTGAAAAATCCACTGTTACCGACGGGGCACTTAACGCAGTCAAATTAATAGATACCGA
ACCAAAGGCTTGTTCTATTA

Downstream 100 bases:

>100_bases
AGTTTAATGATGTTACCTCTAGCAAAGTAAGGGAGTTCATTTAGAGAAATCCCTTACTTTGTGAAAAATGTCATACCCCT
GTCTTTAACTTAACCAAACT

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MIQTARLANNQEKFMNYNDTQEIIVTPLMGATGLETLEMGAARIHVDDKQIINCRADLNQLVPFKYKWAWDKYLTACANH
WMPNEISMSADVALWKDPYGLTEDERLIIKRNLGFFSTADSLVANNLVLAVYRHITNPECRQYLLRQAFEEALHTHAYQY
IIESLGLDEAEVFNMYREIPSVSRKAVWALPFTQSLGDETFHTGTPENDQRLLRDLIAFYVVFEGIFFYVGFTQILSMGR
RNKMVGTSEQFQYILRDESMHMNFGIDVINQIKIENPHLWTPEFKNEMIQLIREGVELEYQYARDTMPHGILGMNAEMFE
EYLHFIANRRLNQIGLPDQYPGAENPFPWMSEMLDLKKEKNFFETRVIEYQAGGTLSWDDE

Sequences:

>Translated_381_residues
MIQTARLANNQEKFMNYNDTQEIIVTPLMGATGLETLEMGAARIHVDDKQIINCRADLNQLVPFKYKWAWDKYLTACANH
WMPNEISMSADVALWKDPYGLTEDERLIIKRNLGFFSTADSLVANNLVLAVYRHITNPECRQYLLRQAFEEALHTHAYQY
IIESLGLDEAEVFNMYREIPSVSRKAVWALPFTQSLGDETFHTGTPENDQRLLRDLIAFYVVFEGIFFYVGFTQILSMGR
RNKMVGTSEQFQYILRDESMHMNFGIDVINQIKIENPHLWTPEFKNEMIQLIREGVELEYQYARDTMPHGILGMNAEMFE
EYLHFIANRRLNQIGLPDQYPGAENPFPWMSEMLDLKKEKNFFETRVIEYQAGGTLSWDDE
>Mature_381_residues
MIQTARLANNQEKFMNYNDTQEIIVTPLMGATGLETLEMGAARIHVDDKQIINCRADLNQLVPFKYKWAWDKYLTACANH
WMPNEISMSADVALWKDPYGLTEDERLIIKRNLGFFSTADSLVANNLVLAVYRHITNPECRQYLLRQAFEEALHTHAYQY
IIESLGLDEAEVFNMYREIPSVSRKAVWALPFTQSLGDETFHTGTPENDQRLLRDLIAFYVVFEGIFFYVGFTQILSMGR
RNKMVGTSEQFQYILRDESMHMNFGIDVINQIKIENPHLWTPEFKNEMIQLIREGVELEYQYARDTMPHGILGMNAEMFE
EYLHFIANRRLNQIGLPDQYPGAENPFPWMSEMLDLKKEKNFFETRVIEYQAGGTLSWDDE

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI4557845, Length=340, Percent_Identity=29.1176470588235, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI260064013, Length=344, Percent_Identity=29.0697674418605, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI289177074, Length=349, Percent_Identity=27.5071633237822, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI42544136, Length=320, Percent_Identity=29.375, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI289177076, Length=297, Percent_Identity=29.2929292929293, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1788567, Length=296, Percent_Identity=24.3243243243243, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17551968, Length=319, Percent_Identity=28.2131661442006, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193206379, Length=304, Percent_Identity=24.3421052631579, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17567153, Length=227, Percent_Identity=27.7533039647577, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322434, Length=331, Percent_Identity=31.4199395770393, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=23.4375, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=30.625, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 44481; Mature: 44481

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQTARLANNQEKFMNYNDTQEIIVTPLMGATGLETLEMGAARIHVDDKQIINCRADLNQ
CCCCCHHCCCHHHHCCCCCCHHEEEECCCCCCCCHHHHCCCEEEEECHHHHHHHHHHHHH
LVPFKYKWAWDKYLTACANHWMPNEISMSADVALWKDPYGLTEDERLIIKRNLGFFSTAD
CCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHH
SLVANNLVLAVYRHITNPECRQYLLRQAFEEALHTHAYQYIIESLGLDEAEVFNMYREIP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
SVSRKAVWALPFTQSLGDETFHTGTPENDQRLLRDLIAFYVVFEGIFFYVGFTQILSMGR
CHHCCEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RNKMVGTSEQFQYILRDESMHMNFGIDVINQIKIENPHLWTPEFKNEMIQLIREGVELEY
CCCCCCCHHHHHHHHHCCCEEEECCCCCHHHEEECCCCCCCCHHHHHHHHHHHHCCCEEE
QYARDTMPHGILGMNAEMFEEYLHFIANRRLNQIGLPDQYPGAENPFPWMSEMLDLKKEK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHC
NFFETRVIEYQAGGTLSWDDE
CHHHHHEEEEECCCCCCCCCC
>Mature Secondary Structure
MIQTARLANNQEKFMNYNDTQEIIVTPLMGATGLETLEMGAARIHVDDKQIINCRADLNQ
CCCCCHHCCCHHHHCCCCCCHHEEEECCCCCCCCHHHHCCCEEEEECHHHHHHHHHHHHH
LVPFKYKWAWDKYLTACANHWMPNEISMSADVALWKDPYGLTEDERLIIKRNLGFFSTAD
CCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHH
SLVANNLVLAVYRHITNPECRQYLLRQAFEEALHTHAYQYIIESLGLDEAEVFNMYREIP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
SVSRKAVWALPFTQSLGDETFHTGTPENDQRLLRDLIAFYVVFEGIFFYVGFTQILSMGR
CHHCCEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RNKMVGTSEQFQYILRDESMHMNFGIDVINQIKIENPHLWTPEFKNEMIQLIREGVELEY
CCCCCCCHHHHHHHHHCCCEEEECCCCCHHHEEECCCCCCCCHHHHHHHHHHHHCCCEEE
QYARDTMPHGILGMNAEMFEEYLHFIANRRLNQIGLPDQYPGAENPFPWMSEMLDLKKEK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHC
NFFETRVIEYQAGGTLSWDDE
CHHHHHEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]