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The map label for this gene is guaA

Identifier: 52841950

GI number: 52841950

Start: 1919670

End: 1921247

Strand: Reverse

Name: guaA

Synonym: lpg1722

Alternate gene names: 52841950

Gene position: 1921247-1919670 (Counterclockwise)

Preceding gene: 52841951

Following gene: 52841949

Centisome position: 56.54

GC content: 41.57

Gene sequence:

>1578_bases
ATGAATGATTTGAAAAAAAGCCCATTATTAATATTAGATTTTGGTTCTCAATACACCCAATTAATTGCAAGACGCGTTCG
AGAAATGGGGGTTTATTGTGAAATTTATCCTTATCATATTAATCATGAACAATTTAAGAAATTAAATCCCTGCGGTGTGA
TTTTATCAGGGGGTCCTTCGACAGTAACGCATGATGCCAATCCCAGGGCTCCTCAATGGCTATTTGATAGTGGTTTGCCC
TTGCTGGGTATTTGCTACGGGATGCAAACCATGGCTGTACAACTCGGTGGCCAAGTGCATTCATCGGCGTTAAGAGAGTT
TGGGTATGCCGAGTTGCGCTTGCATGGCCATAGTCAATTATTAAATAATATCGAAGATCGCATCCTGGCGGATGGCAGCG
CACTATTGGATGTATGGATGAGCCACGGAGATAAAGTTACCGAGTTACCGCCAGGATTTAAAATTATATGTGAAACACGC
AATGCGCCAATTGCAGGTATGGCTGATGAGAGTCGTCAAATGTATGGTTTGCAATTTCATCCAGAAGTTACTCATACCTT
GCAAGGTTTAAGAATTTTACAACGTTTTGTCGTAGATATTTGTAAAGCATCAACAGACTGGACTCCAGAGCATATTATTG
ATGAAGCCATTAATAAAATCAGAGAACAGGTAGGAACTGAAAAAGTTTTACTGGGCCTATCCGGAGGCGTTGACTCTTCT
GTTGTAGCCGCATTGCTGCATAGAGCCATTGGAGAGCAACTGGTTTGTGTTTTCGTTGATACGGGTTTACTCAGACTTAA
TGAGGCGGAGCAAGTGCTGAGCATGTTCGGTCGGCATATGGGAATACGCATTATTGCAGTCAATGCCGAAGATAAATTTT
TAACTGCTTTGAAGGGAGTAACTTGCCCAGAGGAAAAGAGAAAAATTATTGGGCGTACATTTATTGAAGTCTTTGATGAG
GAAGCACAGAAACTGACTGAGATAAAGTGGCTGGCTCAGGGCACAATCTATCCCGATGTCATCGAGTCTGCAGCAACAAG
TACTAATGATGCGGCTGTGGTCATAAAGTCTCATCATAATGTCGGTGGCTTACCAGATACATTAAATCTTAAACTGCTGG
AACCTATTCGTGAGCTCTTTAAAGATGAAGTACGTCAAGTAGGTCTGGAATTGGGACTCCCACATGATATGGTCTATCGG
CATCCCTTTCCTGGACCTGGATTGGGTGTAAGAATTTTAGCGGAAGTAAAAAAAGAATATGCGGATATATTACGTAAAGC
CGATGCTATTTTTATTGAAGAACTGCATAACGCGCAGCTTTATCATAAAATCAGCCAGGCATTTGCTGTTTTTTTACCAG
TAAAGAGCGTAGGTGTGATGGGGGATGGACGCCGATACGATTACGTAATTTGTTTAAGAGCTGTTGAGACAGTTGATTTT
ATGACAGCACATTGGTCTCAATTGCCCTGGGATTTTTTAGGAAAAGTATCCAATCGAATTATTAATGAAGTAGAGGGAGT
ATCACGTGTCACTTACGATATTTCTGGCAAGCCACCTGCTACCATTGAATGGGAATGA

Upstream 100 bases:

>100_bases
CTGAATTTGTGCAAGTGACTAATGCTGGTATGCGTGAGTCACATGTGCATGATGTGAGTATTACTAAGCAAGCCCCCAAT
TATCAGGTGGATAATTAATA

Downstream 100 bases:

>100_bases
TTGATAAATTTTGGATGCAACTGGCTTACGAGCAAGCGGTTATAGCTCGTAATGAAGGAGAGGTTCCTGTTGGGGCTGTG
TTGGTTAGCAAAGACAATCA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MNDLKKSPLLILDFGSQYTQLIARRVREMGVYCEIYPYHINHEQFKKLNPCGVILSGGPSTVTHDANPRAPQWLFDSGLP
LLGICYGMQTMAVQLGGQVHSSALREFGYAELRLHGHSQLLNNIEDRILADGSALLDVWMSHGDKVTELPPGFKIICETR
NAPIAGMADESRQMYGLQFHPEVTHTLQGLRILQRFVVDICKASTDWTPEHIIDEAINKIREQVGTEKVLLGLSGGVDSS
VVAALLHRAIGEQLVCVFVDTGLLRLNEAEQVLSMFGRHMGIRIIAVNAEDKFLTALKGVTCPEEKRKIIGRTFIEVFDE
EAQKLTEIKWLAQGTIYPDVIESAATSTNDAAVVIKSHHNVGGLPDTLNLKLLEPIRELFKDEVRQVGLELGLPHDMVYR
HPFPGPGLGVRILAEVKKEYADILRKADAIFIEELHNAQLYHKISQAFAVFLPVKSVGVMGDGRRYDYVICLRAVETVDF
MTAHWSQLPWDFLGKVSNRIINEVEGVSRVTYDISGKPPATIEWE

Sequences:

>Translated_525_residues
MNDLKKSPLLILDFGSQYTQLIARRVREMGVYCEIYPYHINHEQFKKLNPCGVILSGGPSTVTHDANPRAPQWLFDSGLP
LLGICYGMQTMAVQLGGQVHSSALREFGYAELRLHGHSQLLNNIEDRILADGSALLDVWMSHGDKVTELPPGFKIICETR
NAPIAGMADESRQMYGLQFHPEVTHTLQGLRILQRFVVDICKASTDWTPEHIIDEAINKIREQVGTEKVLLGLSGGVDSS
VVAALLHRAIGEQLVCVFVDTGLLRLNEAEQVLSMFGRHMGIRIIAVNAEDKFLTALKGVTCPEEKRKIIGRTFIEVFDE
EAQKLTEIKWLAQGTIYPDVIESAATSTNDAAVVIKSHHNVGGLPDTLNLKLLEPIRELFKDEVRQVGLELGLPHDMVYR
HPFPGPGLGVRILAEVKKEYADILRKADAIFIEELHNAQLYHKISQAFAVFLPVKSVGVMGDGRRYDYVICLRAVETVDF
MTAHWSQLPWDFLGKVSNRIINEVEGVSRVTYDISGKPPATIEWE
>Mature_525_residues
MNDLKKSPLLILDFGSQYTQLIARRVREMGVYCEIYPYHINHEQFKKLNPCGVILSGGPSTVTHDANPRAPQWLFDSGLP
LLGICYGMQTMAVQLGGQVHSSALREFGYAELRLHGHSQLLNNIEDRILADGSALLDVWMSHGDKVTELPPGFKIICETR
NAPIAGMADESRQMYGLQFHPEVTHTLQGLRILQRFVVDICKASTDWTPEHIIDEAINKIREQVGTEKVLLGLSGGVDSS
VVAALLHRAIGEQLVCVFVDTGLLRLNEAEQVLSMFGRHMGIRIIAVNAEDKFLTALKGVTCPEEKRKIIGRTFIEVFDE
EAQKLTEIKWLAQGTIYPDVIESAATSTNDAAVVIKSHHNVGGLPDTLNLKLLEPIRELFKDEVRQVGLELGLPHDMVYR
HPFPGPGLGVRILAEVKKEYADILRKADAIFIEELHNAQLYHKISQAFAVFLPVKSVGVMGDGRRYDYVICLRAVETVDF
MTAHWSQLPWDFLGKVSNRIINEVEGVSRVTYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=565, Percent_Identity=36.6371681415929, Blast_Score=309, Evalue=4e-84,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=67.6864244741874, Blast_Score=762, Evalue=0.0,
Organism=Caenorhabditis elegans, GI133901714, Length=574, Percent_Identity=33.2752613240418, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71992710, Length=574, Percent_Identity=33.2752613240418, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71992717, Length=574, Percent_Identity=33.2752613240418, Blast_Score=280, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=526, Percent_Identity=52.4714828897338, Blast_Score=539, Evalue=1e-154,
Organism=Drosophila melanogaster, GI281365319, Length=568, Percent_Identity=35.5633802816901, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58646; Mature: 58646

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLKKSPLLILDFGSQYTQLIARRVREMGVYCEIYPYHINHEQFKKLNPCGVILSGGPS
CCCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHCCCCCEEEECCCCC
TVTHDANPRAPQWLFDSGLPLLGICYGMQTMAVQLGGQVHSSALREFGYAELRLHGHSQL
CEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCHHHH
LNNIEDRILADGSALLDVWMSHGDKVTELPPGFKIICETRNAPIAGMADESRQMYGLQFH
HHHHHHHHHCCCHHHHHHHHHCCCEECCCCCCCEEEEECCCCCEECCCCCCHHEECEEEC
PEVTHTLQGLRILQRFVVDICKASTDWTPEHIIDEAINKIREQVGTEKVLLGLSGGVDSS
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHH
VVAALLHRAIGEQLVCVFVDTGLLRLNEAEQVLSMFGRHMGIRIIAVNAEDKFLTALKGV
HHHHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCC
TCPEEKRKIIGRTFIEVFDEEAQKLTEIKWLAQGTIYPDVIESAATSTNDAAVVIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCC
VGGLPDTLNLKLLEPIRELFKDEVRQVGLELGLPHDMVYRHPFPGPGLGVRILAEVKKEY
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
ADILRKADAIFIEELHNAQLYHKISQAFAVFLPVKSVGVMGDGRRYDYVICLRAVETVDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCCCCCCCEEHEEEHHHHHHHHH
MTAHWSQLPWDFLGKVSNRIINEVEGVSRVTYDISGKPPATIEWE
HHHHHHCCCHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCCEECC
>Mature Secondary Structure
MNDLKKSPLLILDFGSQYTQLIARRVREMGVYCEIYPYHINHEQFKKLNPCGVILSGGPS
CCCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHCCCCCEEEECCCCC
TVTHDANPRAPQWLFDSGLPLLGICYGMQTMAVQLGGQVHSSALREFGYAELRLHGHSQL
CEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCHHHH
LNNIEDRILADGSALLDVWMSHGDKVTELPPGFKIICETRNAPIAGMADESRQMYGLQFH
HHHHHHHHHCCCHHHHHHHHHCCCEECCCCCCCEEEEECCCCCEECCCCCCHHEECEEEC
PEVTHTLQGLRILQRFVVDICKASTDWTPEHIIDEAINKIREQVGTEKVLLGLSGGVDSS
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHH
VVAALLHRAIGEQLVCVFVDTGLLRLNEAEQVLSMFGRHMGIRIIAVNAEDKFLTALKGV
HHHHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCC
TCPEEKRKIIGRTFIEVFDEEAQKLTEIKWLAQGTIYPDVIESAATSTNDAAVVIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCC
VGGLPDTLNLKLLEPIRELFKDEVRQVGLELGLPHDMVYRHPFPGPGLGVRILAEVKKEY
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
ADILRKADAIFIEELHNAQLYHKISQAFAVFLPVKSVGVMGDGRRYDYVICLRAVETVDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCCCCCCCEEHEEEHHHHHHHHH
MTAHWSQLPWDFLGKVSNRIINEVEGVSRVTYDISGKPPATIEWE
HHHHHHCCCHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA