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The map label for this gene is guaB

Identifier: 52841951

GI number: 52841951

Start: 1921250

End: 1922722

Strand: Reverse

Name: guaB

Synonym: lpg1723

Alternate gene names: 52841951

Gene position: 1922722-1921250 (Counterclockwise)

Preceding gene: 52841953

Following gene: 52841950

Centisome position: 56.59

GC content: 42.02

Gene sequence:

>1473_bases
ATGCCTCTATCCATTGTGCAACAGTCATTAACCTTTGACGATGTTTTGCTTGTCCCTGCCCACTCAACTATTTTACCCAA
AGACGTTTCATTGAAAACCAAATTAACCCGTGCAATCCACCTTAATATGCCTTTAATTTCGGCGGCAATGGATACAGTGA
CCGAAGCGAGGTTAGCTATCGCTTTAGCACAGGAAGGTGGTTTGGGGATTATTCATAAGAATATGAGTATCGCTGATCAA
GCAGAGGAAGTCAGAAGAGTAAAAAAATTTGAAAGCGGTATGGTGAAAGATCCTATTTCAGTAACTCCCGACTTGACAGT
TAAAGAATTGCTTGCAGTCATGACAAAATATAATTTTTCAGGGGTGCCTGTGGTTGATGGTAAGCATTTGGTAGGAATAG
TAACCAGTCGAGATATTCGTTTTGAAACCAATATGAATTTGACTGTGGCGCAAGTAATGACTCCCAAAGGGCGTTTAGTT
ACTGTAAAAGAAGGAGCGAGTAGAGAAGAAGTCAGAAGTTTGCTCCATAAGCACCGAATAGAAAAATTATTGGTAGTGAA
TGAGAATTTTGAGTTACGTGGACTCATTACAGTAAAAGACATACAAAAAGCAAAAGACAACCCCTATGCTTGTAAAGACA
GTTTTGAGCAGCTAAGAGTTGGGGCTGCTGTTGGTGTTGGTGAAGGGACTGATGAGCGAGTTGCAGCTCTGGTTGAATCC
GGAGTTGATGTCATAGTAGTGGATACAGCGCATGGTCATTCTCAGGGCGTATTAAATCGCGTGAAATGGATTAAAAAGAA
TTATCCTGATGTACAAGTCATAGGTGGTAATATTGCAACCGCTGCCGCCGCAAGAGATTTATATGAGGCGGGTGCTGATG
CAGTAAAAGTTGGAATTGGGCCAGGATCAATTTGTACCACTCGCATAGTGACCGGTGTTGGTATCCCGCAAATTAGCGCT
ATAGCAAATGTGGCACAAGAACTTAAAGGGATAATTCCTGTGATAGCCGATGGAGGAATACGTTTTTCTGGTGACGTTTG
TAAAGCGTTGGCTGCCGGTGCTGATACTGTAATGCTTGGCAGTATGTTTGCAGGTACGGAAGAATCTCCTGGTGAAATTG
AATTATATCAGGGGCGTACTTATAAAAATTACAGAGGTATGGGATCCATTGGAGCCATGTCATTAGCTCAGGGGTCAAGT
GACCGCTATTTTCAGGATGCTTCTCTTGGTACAGAAAAACTGGTTCCCGAAGGCATTGAAGGAAGAGTACCTTATAAAGG
ACCGGTTCAAACAATTATTCATCAATTATTAGGTGGTTTACGCTCCTGTATGGGCTATACCGGTTGTGCTACTATTGAGG
AATTGCATTCTAAAACTGAATTTGTGCAAGTGACTAATGCTGGTATGCGTGAGTCACATGTGCATGATGTGAGTATTACT
AAGCAAGCCCCCAATTATCAGGTGGATAATTAA

Upstream 100 bases:

>100_bases
AATTAAAAGGTTGTAGTGATATATTTATACAATAAATGTTTAAATTTTTTAAAGTTTGTAGTAAACTATTTGGTTATTTA
ATTACTGGAGTGAGATAAAA

Downstream 100 bases:

>100_bases
TAATGAATGATTTGAAAAAAAGCCCATTATTAATATTAGATTTTGGTTCTCAATACACCCAATTAATTGCAAGACGCGTT
CGAGAAATGGGGGTTTATTG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MPLSIVQQSLTFDDVLLVPAHSTILPKDVSLKTKLTRAIHLNMPLISAAMDTVTEARLAIALAQEGGLGIIHKNMSIADQ
AEEVRRVKKFESGMVKDPISVTPDLTVKELLAVMTKYNFSGVPVVDGKHLVGIVTSRDIRFETNMNLTVAQVMTPKGRLV
TVKEGASREEVRSLLHKHRIEKLLVVNENFELRGLITVKDIQKAKDNPYACKDSFEQLRVGAAVGVGEGTDERVAALVES
GVDVIVVDTAHGHSQGVLNRVKWIKKNYPDVQVIGGNIATAAAARDLYEAGADAVKVGIGPGSICTTRIVTGVGIPQISA
IANVAQELKGIIPVIADGGIRFSGDVCKALAAGADTVMLGSMFAGTEESPGEIELYQGRTYKNYRGMGSIGAMSLAQGSS
DRYFQDASLGTEKLVPEGIEGRVPYKGPVQTIIHQLLGGLRSCMGYTGCATIEELHSKTEFVQVTNAGMRESHVHDVSIT
KQAPNYQVDN

Sequences:

>Translated_490_residues
MPLSIVQQSLTFDDVLLVPAHSTILPKDVSLKTKLTRAIHLNMPLISAAMDTVTEARLAIALAQEGGLGIIHKNMSIADQ
AEEVRRVKKFESGMVKDPISVTPDLTVKELLAVMTKYNFSGVPVVDGKHLVGIVTSRDIRFETNMNLTVAQVMTPKGRLV
TVKEGASREEVRSLLHKHRIEKLLVVNENFELRGLITVKDIQKAKDNPYACKDSFEQLRVGAAVGVGEGTDERVAALVES
GVDVIVVDTAHGHSQGVLNRVKWIKKNYPDVQVIGGNIATAAAARDLYEAGADAVKVGIGPGSICTTRIVTGVGIPQISA
IANVAQELKGIIPVIADGGIRFSGDVCKALAAGADTVMLGSMFAGTEESPGEIELYQGRTYKNYRGMGSIGAMSLAQGSS
DRYFQDASLGTEKLVPEGIEGRVPYKGPVQTIIHQLLGGLRSCMGYTGCATIEELHSKTEFVQVTNAGMRESHVHDVSIT
KQAPNYQVDN
>Mature_489_residues
PLSIVQQSLTFDDVLLVPAHSTILPKDVSLKTKLTRAIHLNMPLISAAMDTVTEARLAIALAQEGGLGIIHKNMSIADQA
EEVRRVKKFESGMVKDPISVTPDLTVKELLAVMTKYNFSGVPVVDGKHLVGIVTSRDIRFETNMNLTVAQVMTPKGRLVT
VKEGASREEVRSLLHKHRIEKLLVVNENFELRGLITVKDIQKAKDNPYACKDSFEQLRVGAAVGVGEGTDERVAALVESG
VDVIVVDTAHGHSQGVLNRVKWIKKNYPDVQVIGGNIATAAAARDLYEAGADAVKVGIGPGSICTTRIVTGVGIPQISAI
ANVAQELKGIIPVIADGGIRFSGDVCKALAAGADTVMLGSMFAGTEESPGEIELYQGRTYKNYRGMGSIGAMSLAQGSSD
RYFQDASLGTEKLVPEGIEGRVPYKGPVQTIIHQLLGGLRSCMGYTGCATIEELHSKTEFVQVTNAGMRESHVHDVSITK
QAPNYQVDN

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=478, Percent_Identity=41.8410041841004, Blast_Score=353, Evalue=3e-97,
Organism=Homo sapiens, GI34328930, Length=478, Percent_Identity=41.8410041841004, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI156616279, Length=478, Percent_Identity=41.8410041841004, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI34328928, Length=478, Percent_Identity=41.8410041841004, Blast_Score=352, Evalue=6e-97,
Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=39.5010395010395, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=41.7721518987342, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI217035148, Length=478, Percent_Identity=41.0041841004184, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI217035150, Length=478, Percent_Identity=39.1213389121339, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI50541956, Length=268, Percent_Identity=41.044776119403, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI50541954, Length=268, Percent_Identity=41.044776119403, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI50541952, Length=268, Percent_Identity=41.044776119403, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI50541948, Length=268, Percent_Identity=41.044776119403, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI156104880, Length=251, Percent_Identity=40.6374501992032, Blast_Score=172, Evalue=9e-43,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=64.9590163934426, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1786293, Length=226, Percent_Identity=39.3805309734513, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=476, Percent_Identity=36.5546218487395, Blast_Score=277, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=39.0476190476191, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=257, Percent_Identity=35.408560311284, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323585, Length=489, Percent_Identity=40.4907975460123, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6322012, Length=489, Percent_Identity=39.8773006134969, Blast_Score=336, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=41.6149068322981, Blast_Score=330, Evalue=4e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=344, Percent_Identity=40.6976744186046, Blast_Score=256, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=114, Percent_Identity=41.2280701754386, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=39.7515527950311, Blast_Score=324, Evalue=8e-89,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=39.7515527950311, Blast_Score=324, Evalue=8e-89,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=40.5895691609977, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52563; Mature: 52432

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSIVQQSLTFDDVLLVPAHSTILPKDVSLKTKLTRAIHLNMPLISAAMDTVTEARLAI
CCHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHEE
ALAQEGGLGIIHKNMSIADQAEEVRRVKKFESGMVKDPISVTPDLTVKELLAVMTKYNFS
EEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
GVPVVDGKHLVGIVTSRDIRFETNMNLTVAQVMTPKGRLVTVKEGASREEVRSLLHKHRI
CCEEECCCEEEEEEECCCEEEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHH
EKLLVVNENFELRGLITVKDIQKAKDNPYACKDSFEQLRVGAAVGVGEGTDERVAALVES
CEEEEECCCCEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHC
GVDVIVVDTAHGHSQGVLNRVKWIKKNYPDVQVIGGNIATAAAARDLYEAGADAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGIPQISAIANVAQELKGIIPVIADGGIRFSGDVCKALAAGADTVMLG
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCEEECHHHHHHHHCCCCCEEEH
SMFAGTEESPGEIELYQGRTYKNYRGMGSIGAMSLAQGSSDRYFQDASLGTEKLVPEGIE
HHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCEEECCCCCHHHCCCCCCC
GRVPYKGPVQTIIHQLLGGLRSCMGYTGCATIEELHSKTEFVQVTNAGMRESHVHDVSIT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHEEEEECCCCCCCCCCEEEEE
KQAPNYQVDN
CCCCCCCCCC
>Mature Secondary Structure 
PLSIVQQSLTFDDVLLVPAHSTILPKDVSLKTKLTRAIHLNMPLISAAMDTVTEARLAI
CHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHEE
ALAQEGGLGIIHKNMSIADQAEEVRRVKKFESGMVKDPISVTPDLTVKELLAVMTKYNFS
EEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
GVPVVDGKHLVGIVTSRDIRFETNMNLTVAQVMTPKGRLVTVKEGASREEVRSLLHKHRI
CCEEECCCEEEEEEECCCEEEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHH
EKLLVVNENFELRGLITVKDIQKAKDNPYACKDSFEQLRVGAAVGVGEGTDERVAALVES
CEEEEECCCCEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHC
GVDVIVVDTAHGHSQGVLNRVKWIKKNYPDVQVIGGNIATAAAARDLYEAGADAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGIPQISAIANVAQELKGIIPVIADGGIRFSGDVCKALAAGADTVMLG
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCEEECHHHHHHHHCCCCCEEEH
SMFAGTEESPGEIELYQGRTYKNYRGMGSIGAMSLAQGSSDRYFQDASLGTEKLVPEGIE
HHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCEEECCCCCHHHCCCCCCC
GRVPYKGPVQTIIHQLLGGLRSCMGYTGCATIEELHSKTEFVQVTNAGMRESHVHDVSIT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHEEEEECCCCCCCCCCEEEEE
KQAPNYQVDN
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA