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The map label for this gene is map

Identifier: 52841947

GI number: 52841947

Start: 1915872

End: 1916636

Strand: Direct

Name: map

Synonym: lpg1719

Alternate gene names: 52841947

Gene position: 1915872-1916636 (Clockwise)

Preceding gene: 52841944

Following gene: 52841948

Centisome position: 56.39

GC content: 40.13

Gene sequence:

>765_bases
ATGGGCGTTACAATTAAAACTCCTGATGAAATTGAAAAAATGCGTGTCGCTGGCAGACTGGCAGCCGAAGTACTTGAGAT
GATTGGTCCTTATGTTCAAGTTGGCATTACAACTGATGAATTAAACACTATTTGTCACGATTATATTGTTAATGTACAAA
AGGCTATTCCCGCCCCTTTAAATTATAACGGTTTCCCCAAATCAATTTGCACCTCAATTAATCATGTGGTATGTCATGGA
ATACCAGGGAAAAAAACTTTAAAAGATGGAGACATCATCAATATTGATGTCACTGTTATAAAAAATGAATACCACGGTGA
TACCAGTAAAATGTTTATTGTAGGCACCCCTTCTGTCAAGGCCAAGCATGTAGTGCAGATAGCACATGAGTGCTTGTATA
TTGGAATTGATATGGTTAAACCCGGTGTCCAGCTAGGCGATATAGGGCATGCCATTCAGCAACATGCAGAAAAAAATCGT
TGCTCTGTGGTGCGCGATTACTGCGGACATGGAATTGGCCGTGTATTTCATGAGGATCCACAAGTGCTTCACTATGGAGT
TCCCGGAACAGGGATGAAATTAGAACCAGGGATGACTTTTACTATAGAGCCGATGGTTAATATAGGGAAACATCATACTC
GGCTATTACCAGATCATTGGACTGTCGTTACCAAAGATCATAGTCTTTCAGCTCAATGGGAGCACACACTTTTGGTAACT
GATACAGGTGTTGAAATTCTGACTTTACGTAATGAAGAACGATAA

Upstream 100 bases:

>100_bases
TACATGTGATTTTCATTGAAAATCTATTATTTTGCTGATTGAAGAGTATTGTTGCCCCTCTTACCCATGTGCTAACATTT
ATGATTTTGGATAAACCATA

Downstream 100 bases:

>100_bases
TCGCATCATAAAAAATACGATTAAACAGTTCAAGGAGAAGCTGTGCAAGGACTTTAGCCAAAAAACTAATATTACCTCCA
TCACACGCAAGCTTGCTGTA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MGVTIKTPDEIEKMRVAGRLAAEVLEMIGPYVQVGITTDELNTICHDYIVNVQKAIPAPLNYNGFPKSICTSINHVVCHG
IPGKKTLKDGDIINIDVTVIKNEYHGDTSKMFIVGTPSVKAKHVVQIAHECLYIGIDMVKPGVQLGDIGHAIQQHAEKNR
CSVVRDYCGHGIGRVFHEDPQVLHYGVPGTGMKLEPGMTFTIEPMVNIGKHHTRLLPDHWTVVTKDHSLSAQWEHTLLVT
DTGVEILTLRNEER

Sequences:

>Translated_254_residues
MGVTIKTPDEIEKMRVAGRLAAEVLEMIGPYVQVGITTDELNTICHDYIVNVQKAIPAPLNYNGFPKSICTSINHVVCHG
IPGKKTLKDGDIINIDVTVIKNEYHGDTSKMFIVGTPSVKAKHVVQIAHECLYIGIDMVKPGVQLGDIGHAIQQHAEKNR
CSVVRDYCGHGIGRVFHEDPQVLHYGVPGTGMKLEPGMTFTIEPMVNIGKHHTRLLPDHWTVVTKDHSLSAQWEHTLLVT
DTGVEILTLRNEER
>Mature_253_residues
GVTIKTPDEIEKMRVAGRLAAEVLEMIGPYVQVGITTDELNTICHDYIVNVQKAIPAPLNYNGFPKSICTSINHVVCHGI
PGKKTLKDGDIINIDVTVIKNEYHGDTSKMFIVGTPSVKAKHVVQIAHECLYIGIDMVKPGVQLGDIGHAIQQHAEKNRC
SVVRDYCGHGIGRVFHEDPQVLHYGVPGTGMKLEPGMTFTIEPMVNIGKHHTRLLPDHWTVVTKDHSLSAQWEHTLLVTD
TGVEILTLRNEER

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=248, Percent_Identity=47.1774193548387, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI40385867, Length=246, Percent_Identity=42.6829268292683, Blast_Score=205, Evalue=3e-53,
Organism=Escherichia coli, GI1786364, Length=254, Percent_Identity=64.1732283464567, Blast_Score=335, Evalue=2e-93,
Organism=Escherichia coli, GI1788728, Length=249, Percent_Identity=25.7028112449799, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=253, Percent_Identity=44.6640316205534, Blast_Score=226, Evalue=9e-60,
Organism=Saccharomyces cerevisiae, GI6323273, Length=252, Percent_Identity=48.015873015873, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21355531, Length=253, Percent_Identity=50.5928853754941, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=46.7479674796748, Blast_Score=234, Evalue=4e-62,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28119; Mature: 27988

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVTIKTPDEIEKMRVAGRLAAEVLEMIGPYVQVGITTDELNTICHDYIVNVQKAIPAPL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCC
NYNGFPKSICTSINHVVCHGIPGKKTLKDGDIINIDVTVIKNEYHGDTSKMFIVGTPSVK
CCCCCCHHHHHHHCCEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCC
AKHVVQIAHECLYIGIDMVKPGVQLGDIGHAIQQHAEKNRCSVVRDYCGHGIGRVFHEDP
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
QVLHYGVPGTGMKLEPGMTFTIEPMVNIGKHHTRLLPDHWTVVTKDHSLSAQWEHTLLVT
CEEEECCCCCCEEECCCCEEEECHHHCCCCCCCEECCCCEEEEEECCCCCCCCCEEEEEE
DTGVEILTLRNEER
ECCEEEEEECCCCC
>Mature Secondary Structure 
GVTIKTPDEIEKMRVAGRLAAEVLEMIGPYVQVGITTDELNTICHDYIVNVQKAIPAPL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCC
NYNGFPKSICTSINHVVCHGIPGKKTLKDGDIINIDVTVIKNEYHGDTSKMFIVGTPSVK
CCCCCCHHHHHHHCCEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCC
AKHVVQIAHECLYIGIDMVKPGVQLGDIGHAIQQHAEKNRCSVVRDYCGHGIGRVFHEDP
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
QVLHYGVPGTGMKLEPGMTFTIEPMVNIGKHHTRLLPDHWTVVTKDHSLSAQWEHTLLVT
CEEEECCCCCCEEECCCCEEEECHHHCCCCCCCEECCCCEEEEEECCCCCCCCCEEEEEE
DTGVEILTLRNEER
ECCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]