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The map label for this gene is 52841885

Identifier: 52841885

GI number: 52841885

Start: 1833166

End: 1833933

Strand: Direct

Name: 52841885

Synonym: lpg1657

Alternate gene names: NA

Gene position: 1833166-1833933 (Clockwise)

Preceding gene: 52841868

Following gene: 52841886

Centisome position: 53.95

GC content: 37.37

Gene sequence:

>768_bases
ATGTTTAAAAATGCTATAGTAAGAACACCATCTTCTACAATGATCAATGGACTAACCACATCGGCTGATTTGGGGAAACC
CAATTATGAGCTTGCATTAATACAGCATCAAAATTATATCAAAGCACTATCAACATGTGGTCTTGAAGTGACAGTGCTTC
CAGATCTAGAACAATTCCCGGATGCTTGTTTTGTAGAAGACGTGTCATTATTAACTGAACAATTTGCTGTCTTGACATGC
CCTGGCGCAGAGTCCAGGCGAGATGAAGTTCAGGAAATTGAACCCAGCATTCAAGCATTCTTTAAAGACAGGATTTTCAG
AATAAGCACGCCTGGCAGACTTGAGGCTGGAGATGTGCTTAGAATAGACAATCATTTTTTTATTGGTCTCTCAGAAAGAA
CTAACAAAGAGGGGGCTGAGCAACTAATTTATTTACTGAATCAGCATGGCTATACAGCCTCAGTAATTCAGCTAAAAAAA
TTTCTGCATCTTAAAACAGGAGTGAGTTACCTGAATAATGATTATGTATTGGTTAGTGGAGAATTAATCAATCATCAAGC
ATTTGGTCATTTAAAACAAATAGTAGTAAGTCATGAAGAAGCGTACGCAGCTAATTGCATTATGATTAATGAGACTGTGT
TATTACCCAAAGGGTGTCCTAAAATAACCCATCGTTTATCCGAACTGGGGTTTTCAATTATTGAATTGGATATGAGCGAA
TTTAGAAAGTTGGATGGTGGTTTAAGCTGCTTGTCGTTGAGATTTTAA

Upstream 100 bases:

>100_bases
AGCTAATTTAATCAAATTAACAATGATTGCATTTTGAAGACTCTTTGTTTAATCTCTGGCTGCGTGTGTATTGGAAATCA
CTTATTTAAGGACATGATGA

Downstream 100 bases:

>100_bases
TGAAAAGCCGCTTATCTGTTTTAAGTCTTGCCTTAATCACTGTTTGCTCGGTTGATAGCATTAGAAATCTTCCAGCAGCC
GCTTTAGCGGGGAACCAGCT

Product: NG,NG-dimethylarginine dimethylaminohydrolase

Products: NA

Alternate protein names: DDAH; Dimethylarginine dimethylaminohydrolase; Dimethylargininase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MFKNAIVRTPSSTMINGLTTSADLGKPNYELALIQHQNYIKALSTCGLEVTVLPDLEQFPDACFVEDVSLLTEQFAVLTC
PGAESRRDEVQEIEPSIQAFFKDRIFRISTPGRLEAGDVLRIDNHFFIGLSERTNKEGAEQLIYLLNQHGYTASVIQLKK
FLHLKTGVSYLNNDYVLVSGELINHQAFGHLKQIVVSHEEAYAANCIMINETVLLPKGCPKITHRLSELGFSIIELDMSE
FRKLDGGLSCLSLRF

Sequences:

>Translated_255_residues
MFKNAIVRTPSSTMINGLTTSADLGKPNYELALIQHQNYIKALSTCGLEVTVLPDLEQFPDACFVEDVSLLTEQFAVLTC
PGAESRRDEVQEIEPSIQAFFKDRIFRISTPGRLEAGDVLRIDNHFFIGLSERTNKEGAEQLIYLLNQHGYTASVIQLKK
FLHLKTGVSYLNNDYVLVSGELINHQAFGHLKQIVVSHEEAYAANCIMINETVLLPKGCPKITHRLSELGFSIIELDMSE
FRKLDGGLSCLSLRF
>Mature_255_residues
MFKNAIVRTPSSTMINGLTTSADLGKPNYELALIQHQNYIKALSTCGLEVTVLPDLEQFPDACFVEDVSLLTEQFAVLTC
PGAESRRDEVQEIEPSIQAFFKDRIFRISTPGRLEAGDVLRIDNHFFIGLSERTNKEGAEQLIYLLNQHGYTASVIQLKK
FLHLKTGVSYLNNDYVLVSGELINHQAFGHLKQIVVSHEEAYAANCIMINETVLLPKGCPKITHRLSELGFSIIELDMSE
FRKLDGGLSCLSLRF

Specific function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS [H]

COG id: COG1834

COG function: function code E; N-Dimethylarginine dimethylaminohydrolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DDAH family [H]

Homologues:

Organism=Homo sapiens, GI6912328, Length=267, Percent_Identity=31.8352059925094, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18859791, Length=242, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003198 [H]

Pfam domain/function: PF02274 Amidinotransf [H]

EC number: =3.5.3.18 [H]

Molecular weight: Translated: 28552; Mature: 28552

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKNAIVRTPSSTMINGLTTSADLGKPNYELALIQHQNYIKALSTCGLEVTVLPDLEQFP
CCCCCEEECCCCHHHCCCCCCCCCCCCCEEEEEEECHHHHHHHHHCCEEEEECCCHHHCC
DACFVEDVSLLTEQFAVLTCPGAESRRDEVQEIEPSIQAFFKDRIFRISTPGRLEAGDVL
CHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEE
RIDNHFFIGLSERTNKEGAEQLIYLLNQHGYTASVIQLKKFLHLKTGVSYLNNDYVLVSG
EECCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEC
ELINHQAFGHLKQIVVSHEEAYAANCIMINETVLLPKGCPKITHRLSELGFSIIELDMSE
HHHCHHHHHHHHHHHHHCCHHHEEEEEEEECEEECCCCCHHHHHHHHHCCCCEEEECHHH
FRKLDGGLSCLSLRF
HHHHCCCCCEEEECC
>Mature Secondary Structure
MFKNAIVRTPSSTMINGLTTSADLGKPNYELALIQHQNYIKALSTCGLEVTVLPDLEQFP
CCCCCEEECCCCHHHCCCCCCCCCCCCCEEEEEEECHHHHHHHHHCCEEEEECCCHHHCC
DACFVEDVSLLTEQFAVLTCPGAESRRDEVQEIEPSIQAFFKDRIFRISTPGRLEAGDVL
CHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEE
RIDNHFFIGLSERTNKEGAEQLIYLLNQHGYTASVIQLKKFLHLKTGVSYLNNDYVLVSG
EECCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEC
ELINHQAFGHLKQIVVSHEEAYAANCIMINETVLLPKGCPKITHRLSELGFSIIELDMSE
HHHCHHHHHHHHHHHHHCCHHHEEEEEEEECEEECCCCCHHHHHHHHHCCCCEEEECHHH
FRKLDGGLSCLSLRF
HHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 11473257 [H]