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The map label for this gene is uup

Identifier: 52841844

GI number: 52841844

Start: 1783428

End: 1784888

Strand: Reverse

Name: uup

Synonym: lpg1616

Alternate gene names: 52841844

Gene position: 1784888-1783428 (Counterclockwise)

Preceding gene: 52841846

Following gene: 52841843

Centisome position: 52.53

GC content: 38.74

Gene sequence:

>1461_bases
ATGAACCATAAACCGATTCAATTTAAAGACCTCAGTCTTATCTATCCGCATAAAACCTGTTTTCAAGACTTTAGTGGTGA
AATCCATTTCGCTGATCGCATTGCACTGATTGGCCGTAATGGCTCAGGAAAATCAACGCTACTCAAGATGCTTTGTGGTC
TTTTTTTAGCCCCTGCGGGCGAAATTAAAATACCCCATGATGTTCGCTTTGGTCATTTACCTCAAGTGCTTGAAAATTGT
CCTGATTTAAGTGGCGGTCAGCGATTAAACCGAGTATTAAGCAAAATACTGTCGTATGAGCCTAATGTATTGTTGTTAGA
TGAGCCCACAAATCATCTGGACAGACGTAATCGTTGTTCTTTAATGCGCATGCTTGAGCATTATCCTGGGACATTGATTA
TAGCCTCTCATGATATAGAACTCATCAATACAGTCACAGATACTCTATGGCATATTGATTTAGGTCAAGTGACTGTATTC
AGAGGAACTTATTTTGATTATCAACAAATTCTTGAAGACAAGAAAGCATCGATTGAACAGGAGTTATCAAGGATTGTACG
ACAGAAAAAAGAATCACATCTTGCTTTGATGAAAGAGCAGGAGCGTAATAAACGTGCGCGTGTTCAGGGTGAAAAGAAGA
TAACCCAACGCAAATGGCCAACGATTCGATCTCATACAAAGCTCGGTTCAGCAATTACAACAGGCAATAAACGATTAAGT
CACATTAACTATAAAAAACAACAATTACTCGAGGAGCTTTCTTCTCTAAACTATCCGGAGGTAATTAAGCCCAAATTTAG
GTTAAAGGGACTTGGGCACCATAAACCCTTAATCAGGATTCAAGACGCTTCTGTTGCCTATGAGGCTGTTGTGATTCTTG
AAAATATTCATTTTCACCTTAGCGGTTGCGAACGAGCGGCATTATATGGCAAGAATGCATCAGGTAAGTCGACCTTTGTC
AAAGCGATTTTGGGGGAAAGTCAAATTAAGAGAACAGGGGAATGGGCTGTGCCTGATTGCAATACAATAGGCTATATCGA
TCAACATTATCAACATTTGAACTTCAATGAAACAGTCCTGGATTTAATGCGCTCCAGTATGCCCCATGCATTTCATACAG
AAATTCGTGCTCATTTAAATGATTTTTTATTTCGCAAAAATGAAGAAGTAGAAATTAAGGTCAAAAATCTTTCTGGTGGT
GAAAAGGCAAGGTTATCGATGGCATTGATTGCTGCAAATCCACCTAAACTACTTATTTTAGATGAGATCACGAACAATGT
AGATTTGGAAACACGCACTCATATCATTCAGGTGCTGCGTGAATTCCAAGGTGCAATGCTGGTTATTTCTCATGACTATG
ACTTTTTAGAATCCATTCACATTGAAACCAGGTATCAGATTCATCAAGGGAAGATACATCATTTCAATGAGAAACAATTA
GAGGTAGTGCATCATGACTAA

Upstream 100 bases:

>100_bases
AATTACATCTTAAGTGCGCCCAACTATAGGGCAAAGTAAACAAAGTCCTTTGTGACTTTTAGTTTTTTACTGTCCTGGCA
GACATGCTTAAGAGTAAATC

Downstream 100 bases:

>100_bases
TCGTTTGCCCAATCACTTGGGCTCTTTTATGTGGCATTTTTTAAAACCATATCGAGGCATAGTGATATTATTTATCCTGT
TTGCTCTATTGGCCGGGTTT

Product: ABC transporter ATP-binding protein Uup, erythromycin resistance

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MNHKPIQFKDLSLIYPHKTCFQDFSGEIHFADRIALIGRNGSGKSTLLKMLCGLFLAPAGEIKIPHDVRFGHLPQVLENC
PDLSGGQRLNRVLSKILSYEPNVLLLDEPTNHLDRRNRCSLMRMLEHYPGTLIIASHDIELINTVTDTLWHIDLGQVTVF
RGTYFDYQQILEDKKASIEQELSRIVRQKKESHLALMKEQERNKRARVQGEKKITQRKWPTIRSHTKLGSAITTGNKRLS
HINYKKQQLLEELSSLNYPEVIKPKFRLKGLGHHKPLIRIQDASVAYEAVVILENIHFHLSGCERAALYGKNASGKSTFV
KAILGESQIKRTGEWAVPDCNTIGYIDQHYQHLNFNETVLDLMRSSMPHAFHTEIRAHLNDFLFRKNEEVEIKVKNLSGG
EKARLSMALIAANPPKLLILDEITNNVDLETRTHIIQVLREFQGAMLVISHDYDFLESIHIETRYQIHQGKIHHFNEKQL
EVVHHD

Sequences:

>Translated_486_residues
MNHKPIQFKDLSLIYPHKTCFQDFSGEIHFADRIALIGRNGSGKSTLLKMLCGLFLAPAGEIKIPHDVRFGHLPQVLENC
PDLSGGQRLNRVLSKILSYEPNVLLLDEPTNHLDRRNRCSLMRMLEHYPGTLIIASHDIELINTVTDTLWHIDLGQVTVF
RGTYFDYQQILEDKKASIEQELSRIVRQKKESHLALMKEQERNKRARVQGEKKITQRKWPTIRSHTKLGSAITTGNKRLS
HINYKKQQLLEELSSLNYPEVIKPKFRLKGLGHHKPLIRIQDASVAYEAVVILENIHFHLSGCERAALYGKNASGKSTFV
KAILGESQIKRTGEWAVPDCNTIGYIDQHYQHLNFNETVLDLMRSSMPHAFHTEIRAHLNDFLFRKNEEVEIKVKNLSGG
EKARLSMALIAANPPKLLILDEITNNVDLETRTHIIQVLREFQGAMLVISHDYDFLESIHIETRYQIHQGKIHHFNEKQL
EVVHHD
>Mature_486_residues
MNHKPIQFKDLSLIYPHKTCFQDFSGEIHFADRIALIGRNGSGKSTLLKMLCGLFLAPAGEIKIPHDVRFGHLPQVLENC
PDLSGGQRLNRVLSKILSYEPNVLLLDEPTNHLDRRNRCSLMRMLEHYPGTLIIASHDIELINTVTDTLWHIDLGQVTVF
RGTYFDYQQILEDKKASIEQELSRIVRQKKESHLALMKEQERNKRARVQGEKKITQRKWPTIRSHTKLGSAITTGNKRLS
HINYKKQQLLEELSSLNYPEVIKPKFRLKGLGHHKPLIRIQDASVAYEAVVILENIHFHLSGCERAALYGKNASGKSTFV
KAILGESQIKRTGEWAVPDCNTIGYIDQHYQHLNFNETVLDLMRSSMPHAFHTEIRAHLNDFLFRKNEEVEIKVKNLSGG
EKARLSMALIAANPPKLLILDEITNNVDLETRTHIIQVLREFQGAMLVISHDYDFLESIHIETRYQIHQGKIHHFNEKQL
EVVHHD

Specific function: Unknown

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI148612853, Length=381, Percent_Identity=25.7217847769029, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI27881506, Length=400, Percent_Identity=26.75, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI10947137, Length=400, Percent_Identity=26.75, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI69354671, Length=381, Percent_Identity=26.509186351706, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI10947135, Length=381, Percent_Identity=26.509186351706, Blast_Score=109, Evalue=6e-24,
Organism=Escherichia coli, GI1789751, Length=399, Percent_Identity=30.0751879699248, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI2367384, Length=416, Percent_Identity=26.6826923076923, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1787182, Length=397, Percent_Identity=28.7153652392947, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1787041, Length=414, Percent_Identity=26.3285024154589, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788165, Length=186, Percent_Identity=30.1075268817204, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17559834, Length=378, Percent_Identity=26.984126984127, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17555318, Length=420, Percent_Identity=27.6190476190476, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17553372, Length=381, Percent_Identity=24.9343832020997, Blast_Score=104, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6321121, Length=396, Percent_Identity=26.7676767676768, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320874, Length=397, Percent_Identity=26.448362720403, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324314, Length=185, Percent_Identity=28.6486486486486, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323278, Length=176, Percent_Identity=28.4090909090909, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641342, Length=379, Percent_Identity=27.7044854881267, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24666836, Length=375, Percent_Identity=27.4666666666667, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24642252, Length=425, Percent_Identity=26.1176470588235, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18859989, Length=425, Percent_Identity=26.1176470588235, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 55907; Mature: 55907

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHKPIQFKDLSLIYPHKTCFQDFSGEIHFADRIALIGRNGSGKSTLLKMLCGLFLAPAG
CCCCCCEEECCEEECCCHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCC
EIKIPHDVRFGHLPQVLENCPDLSGGQRLNRVLSKILSYEPNVLLLDEPTNHLDRRNRCS
CEECCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHCHHHHHH
LMRMLEHYPGTLIIASHDIELINTVTDTLWHIDLGQVTVFRGTYFDYQQILEDKKASIEQ
HHHHHHHCCCEEEEEECCHHHHHHHHHHHEEEECCCEEEEECCCHHHHHHHHHHHHHHHH
ELSRIVRQKKESHLALMKEQERNKRARVQGEKKITQRKWPTIRSHTKLGSAITTGNKRLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHCCCEEECCCCHHH
HINYKKQQLLEELSSLNYPEVIKPKFRLKGLGHHKPLIRIQDASVAYEAVVILENIHFHL
HCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCEEEEECCCHHHHHEEEEECCEEEE
SGCERAALYGKNASGKSTFVKAILGESQIKRTGEWAVPDCNTIGYIDQHYQHLNFNETVL
CCCCCHHHCCCCCCCHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHH
DLMRSSMPHAFHTEIRAHLNDFLFRKNEEVEIKVKNLSGGEKARLSMALIAANPPKLLIL
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCEEEE
DEITNNVDLETRTHIIQVLREFQGAMLVISHDYDFLESIHIETRYQIHQGKIHHFNEKQL
ECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHEEEEEECCCEECCCCCEE
EVVHHD
EEEECC
>Mature Secondary Structure
MNHKPIQFKDLSLIYPHKTCFQDFSGEIHFADRIALIGRNGSGKSTLLKMLCGLFLAPAG
CCCCCCEEECCEEECCCHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCC
EIKIPHDVRFGHLPQVLENCPDLSGGQRLNRVLSKILSYEPNVLLLDEPTNHLDRRNRCS
CEECCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHCHHHHHH
LMRMLEHYPGTLIIASHDIELINTVTDTLWHIDLGQVTVFRGTYFDYQQILEDKKASIEQ
HHHHHHHCCCEEEEEECCHHHHHHHHHHHEEEECCCEEEEECCCHHHHHHHHHHHHHHHH
ELSRIVRQKKESHLALMKEQERNKRARVQGEKKITQRKWPTIRSHTKLGSAITTGNKRLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHCCCEEECCCCHHH
HINYKKQQLLEELSSLNYPEVIKPKFRLKGLGHHKPLIRIQDASVAYEAVVILENIHFHL
HCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCEEEEECCCHHHHHEEEEECCEEEE
SGCERAALYGKNASGKSTFVKAILGESQIKRTGEWAVPDCNTIGYIDQHYQHLNFNETVL
CCCCCHHHCCCCCCCHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHH
DLMRSSMPHAFHTEIRAHLNDFLFRKNEEVEIKVKNLSGGEKARLSMALIAANPPKLLIL
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCEEEE
DEITNNVDLETRTHIIQVLREFQGAMLVISHDYDFLESIHIETRYQIHQGKIHHFNEKQL
ECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHEEEEEECCCEECCCCCEE
EVVHHD
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]