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The map label for this gene is thiO [H]

Identifier: 52841796

GI number: 52841796

Start: 1732217

End: 1733287

Strand: Direct

Name: thiO [H]

Synonym: lpg1566

Alternate gene names: 52841796

Gene position: 1732217-1733287 (Clockwise)

Preceding gene: 52841795

Following gene: 52841797

Centisome position: 50.98

GC content: 40.34

Gene sequence:

>1071_bases
ATGCGAGCAGGCATTGTAGGCTCAGGGATCATGGGGCGTCTGCTGGCTTTTGTATTACATAATGCGGGCTGGCAGGTATC
CCTTTTTGATCGCTCTAATGAAAGCATGAATTGCAGTACTGCTGCTGCAGGTCTATTAACACCGTTTTCTGAATTGGATA
AATCAATTCTATTGATTTCCACCTTGGGTCAAGAATCTATTAAGAACTGTTGGCCACGTATTATTGAGGATTTGCCTGAA
TCTGTTTATTTTCAACAATCGGGTAGTCTGGTGCTATGCCACCCAGGCGATCAGGCGGAATGGATTCACTTTAGTCGGCG
TATTCTGAGTCAACTCAATCCGAGTAATTCTGTTTTTCAAAAATTATCCCATGAAAATCTCATTGCGCTTGAGCCTGAGC
TGACAAAGTTTGAAACTGCTTATTATTTTCCAAATGAAGCGCATATTGATTGCCAAACACTAATGTTGTCTTTAAAAAAT
TATCTCGACTCTGTTTGTATACCTCACATTACCAATACTCCTGTCTTATCGCTTAAACCTGGAGAGATCAATACAAAAGA
ACAAAGATATCATTTTGATGTCGTTTTCGATTGTCGTGGTTTAGGTGCGCAAAATGTATTTTCTGATTTACGAGGTATTA
GAGGTGAACTCATTTGGCTTCATGCGCCAGGAGTTCAACTACATCGCCCTATTCGTCTTCTGCATCCAAGGTACAGTCTA
TATCTTGTACCCAGACCTGGAAATTTTTACCTCATAGGCGCTAGCGAAATTGAGGCAGAAGATTTTAGTCCGGTTTCAGT
ACGTACGGCTTTGGAATTATTGACCGCTGTGTATTATTTACATAGGAACTTTGATGAAGCACGCATTATAAAAACAGTGA
CCCATTGCCGTCCAACCTTAGTAAATCATTTACCACGTATTAAATTTGCCGACGGGCTAATAGCAGTTAACGGTCTTTAT
CGTCATGGTTATTTAATAGCCCCAGCCTTGGCAGAAGAAATTTTACGGGGTGTGACATCCAATTTTCGTCATCTGAATTA
TCCAGAACTTTGGGAGAATTATTGTGATTAA

Upstream 100 bases:

>100_bases
ATGAACATTTTGATATCTCGCAATGCTATACGAATCGTTTTTTGCCAGATACACCTTATTCTGATTTGAAACCAATCGCC
TGTTGTCTTGAAAATTAATT

Downstream 100 bases:

>100_bases
TGTCTATTTCAACGATAAAATTTACAACATCCAACCCTCATTATCATTAAGCGCATTTTTAAAGCAGCTTAATTATACTC
AACAGCATTTTGCTGTCGCT

Product: thiamine biosynthesis oxidoreductase ThiO

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MRAGIVGSGIMGRLLAFVLHNAGWQVSLFDRSNESMNCSTAAAGLLTPFSELDKSILLISTLGQESIKNCWPRIIEDLPE
SVYFQQSGSLVLCHPGDQAEWIHFSRRILSQLNPSNSVFQKLSHENLIALEPELTKFETAYYFPNEAHIDCQTLMLSLKN
YLDSVCIPHITNTPVLSLKPGEINTKEQRYHFDVVFDCRGLGAQNVFSDLRGIRGELIWLHAPGVQLHRPIRLLHPRYSL
YLVPRPGNFYLIGASEIEAEDFSPVSVRTALELLTAVYYLHRNFDEARIIKTVTHCRPTLVNHLPRIKFADGLIAVNGLY
RHGYLIAPALAEEILRGVTSNFRHLNYPELWENYCD

Sequences:

>Translated_356_residues
MRAGIVGSGIMGRLLAFVLHNAGWQVSLFDRSNESMNCSTAAAGLLTPFSELDKSILLISTLGQESIKNCWPRIIEDLPE
SVYFQQSGSLVLCHPGDQAEWIHFSRRILSQLNPSNSVFQKLSHENLIALEPELTKFETAYYFPNEAHIDCQTLMLSLKN
YLDSVCIPHITNTPVLSLKPGEINTKEQRYHFDVVFDCRGLGAQNVFSDLRGIRGELIWLHAPGVQLHRPIRLLHPRYSL
YLVPRPGNFYLIGASEIEAEDFSPVSVRTALELLTAVYYLHRNFDEARIIKTVTHCRPTLVNHLPRIKFADGLIAVNGLY
RHGYLIAPALAEEILRGVTSNFRHLNYPELWENYCD
>Mature_356_residues
MRAGIVGSGIMGRLLAFVLHNAGWQVSLFDRSNESMNCSTAAAGLLTPFSELDKSILLISTLGQESIKNCWPRIIEDLPE
SVYFQQSGSLVLCHPGDQAEWIHFSRRILSQLNPSNSVFQKLSHENLIALEPELTKFETAYYFPNEAHIDCQTLMLSLKN
YLDSVCIPHITNTPVLSLKPGEINTKEQRYHFDVVFDCRGLGAQNVFSDLRGIRGELIWLHAPGVQLHRPIRLLHPRYSL
YLVPRPGNFYLIGASEIEAEDFSPVSVRTALELLTAVYYLHRNFDEARIIKTVTHCRPTLVNHLPRIKFADGLIAVNGLY
RHGYLIAPALAEEILRGVTSNFRHLNYPELWENYCD

Specific function: May have amino acid oxidase activity in the biosynthesis of thiazole when cysteine gives its thiol group to be inserted into the thiazole molecule and the rest of the molecule is deaminated to give pyruvic acid and ammonia [H]

COG id: COG0665

COG function: function code E; Glycine/D-amino acid oxidases (deaminating)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR012727 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: NA

Molecular weight: Translated: 40357; Mature: 40357

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAGIVGSGIMGRLLAFVLHNAGWQVSLFDRSNESMNCSTAAAGLLTPFSELDKSILLIS
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCHHHHCCCEEEEE
TLGQESIKNCWPRIIEDLPESVYFQQSGSLVLCHPGDQAEWIHFSRRILSQLNPSNSVFQ
CCCHHHHHHHHHHHHHHCCHHEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHHH
KLSHENLIALEPELTKFETAYYFPNEAHIDCQTLMLSLKNYLDSVCIPHITNTPVLSLKP
HHCCCCEEEECCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
GEINTKEQRYHFDVVFDCRGLGAQNVFSDLRGIRGELIWLHAPGVQLHRPIRLLHPRYSL
CCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCEEE
YLVPRPGNFYLIGASEIEAEDFSPVSVRTALELLTAVYYLHRNFDEARIIKTVTHCRPTL
EEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VNHLPRIKFADGLIAVNGLYRHGYLIAPALAEEILRGVTSNFRHLNYPELWENYCD
HHHCCCCEECCCEEEECCHHHCCEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MRAGIVGSGIMGRLLAFVLHNAGWQVSLFDRSNESMNCSTAAAGLLTPFSELDKSILLIS
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCHHHHCCCEEEEE
TLGQESIKNCWPRIIEDLPESVYFQQSGSLVLCHPGDQAEWIHFSRRILSQLNPSNSVFQ
CCCHHHHHHHHHHHHHHCCHHEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHHH
KLSHENLIALEPELTKFETAYYFPNEAHIDCQTLMLSLKNYLDSVCIPHITNTPVLSLKP
HHCCCCEEEECCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
GEINTKEQRYHFDVVFDCRGLGAQNVFSDLRGIRGELIWLHAPGVQLHRPIRLLHPRYSL
CCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCEEE
YLVPRPGNFYLIGASEIEAEDFSPVSVRTALELLTAVYYLHRNFDEARIIKTVTHCRPTL
EEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VNHLPRIKFADGLIAVNGLYRHGYLIAPALAEEILRGVTSNFRHLNYPELWENYCD
HHHCCCCEECCCEEEECCHHHCCEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371431 [H]