Click here to switch to the map view.

The map label for this gene is ndk

Identifier: 52841778

GI number: 52841778

Start: 1712448

End: 1712924

Strand: Reverse

Name: ndk

Synonym: lpg1548

Alternate gene names: 52841778

Gene position: 1712924-1712448 (Counterclockwise)

Preceding gene: 52841779

Following gene: 52841777

Centisome position: 50.41

GC content: 37.95

Gene sequence:

>477_bases
ATGAATTCATGTATAATAATGCACTTTAAATTAATCTCATTGGAGTGCATGATGGCAAAAGAATTAACATTATCTATTAT
TAAACCTGATGCTGTAGCAAAGTCTGTGATAGGTGAAATATATACCCGCTTTGAAAAAGCAGGCTTGGATATTGTTGCCG
CTAAAATGACACAACTTTCACGCGAACAAGCCGAGAGCTTTTATGATATTCATCGCGCGCGACCATTCTTTAAGGATCTG
GTGGATTTTATGATTTCTGGTCCTGTAATGATCCAAGTATTAAAAGGTGAAAATGCTGTCGCTAAAAACAGAGAAATTAT
GGGCGCGACAAATCCCAAAGAAGCAGCACCTGGAACTATACGTGCTGATTTTGCTGATAGTATTGATGCAAATGCTGTGC
ATGGTTCTGACAGCCTTGAAAATGCTGCTCGTGAAATAGCATTTTTCTTTGAACAGCATGAGTTGTGCAATAGATAA

Upstream 100 bases:

>100_bases
CGATTGGAGAGCGCTAACGCAAAACCCTATTTTCTCTAAAATCATACTATAACTATTGACTGAATGGTTGAATGCATGAA
TTTTTATTAGCCAGACCACT

Downstream 100 bases:

>100_bases
AGGCAGGCTTGGGAGCGGTAATGGACCAACAAAAAGTGAATCTATTAAATTATAATTACTCACAGCTACGAGAATTATTG
ATAGCGTGGGATGAAAAACC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MNSCIIMHFKLISLECMMAKELTLSIIKPDAVAKSVIGEIYTRFEKAGLDIVAAKMTQLSREQAESFYDIHRARPFFKDL
VDFMISGPVMIQVLKGENAVAKNREIMGATNPKEAAPGTIRADFADSIDANAVHGSDSLENAAREIAFFFEQHELCNR

Sequences:

>Translated_158_residues
MNSCIIMHFKLISLECMMAKELTLSIIKPDAVAKSVIGEIYTRFEKAGLDIVAAKMTQLSREQAESFYDIHRARPFFKDL
VDFMISGPVMIQVLKGENAVAKNREIMGATNPKEAAPGTIRADFADSIDANAVHGSDSLENAAREIAFFFEQHELCNR
>Mature_158_residues
MNSCIIMHFKLISLECMMAKELTLSIIKPDAVAKSVIGEIYTRFEKAGLDIVAAKMTQLSREQAESFYDIHRARPFFKDL
VDFMISGPVMIQVLKGENAVAKNREIMGATNPKEAAPGTIRADFADSIDANAVHGSDSLENAAREIAFFFEQHELCNR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=154, Percent_Identity=43.5064935064935, Blast_Score=136, Evalue=6e-33,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=43.0656934306569, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=43.0656934306569, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=43.0656934306569, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=43.0656934306569, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=43.0656934306569, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=43.0656934306569, Blast_Score=123, Evalue=7e-29,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=43.0656934306569, Blast_Score=123, Evalue=7e-29,
Organism=Homo sapiens, GI4826862, Length=141, Percent_Identity=41.8439716312057, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI37574614, Length=140, Percent_Identity=39.2857142857143, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI7019465, Length=140, Percent_Identity=39.2857142857143, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI5031951, Length=141, Percent_Identity=37.5886524822695, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI148839372, Length=135, Percent_Identity=36.2962962962963, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=34.0740740740741, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=36.2962962962963, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=58.8652482269503, Blast_Score=179, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=139, Percent_Identity=42.4460431654676, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=42.3357664233577, Blast_Score=127, Evalue=6e-31,
Organism=Drosophila melanogaster, GI45549037, Length=157, Percent_Identity=43.312101910828, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=32.5925925925926, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 17586; Mature: 17586

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSCIIMHFKLISLECMMAKELTLSIIKPDAVAKSVIGEIYTRFEKAGLDIVAAKMTQLS
CCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
REQAESFYDIHRARPFFKDLVDFMISGPVMIQVLKGENAVAKNREIMGATNPKEAAPGTI
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCHHCCCCCCCCCCCCCCCCCCE
RADFADSIDANAVHGSDSLENAAREIAFFFEQHELCNR
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSCIIMHFKLISLECMMAKELTLSIIKPDAVAKSVIGEIYTRFEKAGLDIVAAKMTQLS
CCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
REQAESFYDIHRARPFFKDLVDFMISGPVMIQVLKGENAVAKNREIMGATNPKEAAPGTI
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCHHCCCCCCCCCCCCCCCCCCE
RADFADSIDANAVHGSDSLENAAREIAFFFEQHELCNR
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA