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The map label for this gene is hemL

Identifier: 52841764

GI number: 52841764

Start: 1699656

End: 1700957

Strand: Reverse

Name: hemL

Synonym: lpg1534

Alternate gene names: 52841764

Gene position: 1700957-1699656 (Counterclockwise)

Preceding gene: 52841766

Following gene: 52841763

Centisome position: 50.06

GC content: 38.79

Gene sequence:

>1302_bases
TTGGGATTTTCTATGAGCCGTTCTTCAGATTTATTTCATAAAGCACAAACAATCATTCCCGGAGGTGTTAACTCACCAGT
TCGAGCTTTCAAAGGTGTTGGAGGTGAACCTGTTTTTTTCAAATCTGGCAAAGGTGCCTACCTGACGGATGTAGATGATA
AACAATATATTGATTATGTTGGATCATGGGGACCACTTATCCTCGGACACTGCCATCCCAAGGTGATAGAAGCTGTGGAT
AATGTATTACACCGTGGTATGAGCTTTGGCGCTCCAACAGAACTGGAAATACAATTAGCTGAAAAAATTGCTTCCCTGAT
GCCATCAATAGAAAAAATTCGCATGGTGAACTCAGGAACTGAAGCAACTATGACTGCAATTCGGCTGGCGCGCGGATTCA
CCAATAAAAATAAATTTATTAAATTTAACGGCTGTTATCATGGGCATAGCGATAGCCTATTAGTTAAAGCGGGATCTGGT
TTGCTTACTCTCGGAATTCCTTCAACTCCAGGCATTCCACAAAGCATTACCGAACATACTTTAACGGCTGATTTTAATAA
CCTGGAACAAGTTGCTCAACTCTTTGAAAAATATCCAAACGATATCGCTACTGTAATTTTGGAACCTATTCCTGGCAATA
TGGGATTTATCCTACCTAAGATAGAGTTTTTAAAAGGATTACGCGAGCTTTGCGATCAATATAATGCTTTGTTAATTTTT
GATGAAGTAATGACTGGATTTAGAGTTGGTTTACATGGTGCACAGGGCTTGTTTGGGATTAAACCTGATATCACAACACT
TGGAAAAATCATAGGTGGTGGTATGCCTGTAGGTGCTTTAGGTGGTAAACGTGAAATTATGTCCTTTCTGGCGCCTGAAG
GCCCTGTATATCAGGCTGGTACTCTTTCAGGAAATCCATTGGCTATGGCCGCAGGTTTGGCTACTTTAAAAGAGATTGAA
AAAATTAATTTTTTTGAAGATTTAAGCAATACGACTAATAAATTAACCGAGGCATTAGCTGATGCGGCAGAAAACGCAAA
CATTCCATTTTTTGCTGCATCATTGGGCGGAATGTTCGGGTTTTGTTTTACAGATAAAAATAGTGTTGAAAATTATTTGG
ATGTTGCTTCCTCGGATGAAGTTTTATTTAAGAAATTTTTTCATGCTATGCTTGCTCAAGGAGTATATTTTGCGCCATCT
ATGTATGAAGCGGGATTTGTCTCCAGTATGCATGGTGATTTGGAAATACAAAAAACATATGATGCTGCTGAATTGGTACT
GAATCAATTAAAATCTGCCTGA

Upstream 100 bases:

>100_bases
TACCAGTAGAAAAATATTTTAACATTTTTTGTATAATAAATTTCTGAAACATCTTGAATATTAAAAATAATAACTGATAT
TTGTCTAAAGTTTATCATTT

Downstream 100 bases:

>100_bases
TAGCAGAATTGTACCTTATTACCTTAAGTTACTTAAATACAATTTTTAAAATCAGTATTTGGGTAATTAAGTTCAGTAAA
GCGTCTAAATGCGATTGCAG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MGFSMSRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWGPLILGHCHPKVIEAVD
NVLHRGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATMTAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSG
LLTLGIPSTPGIPQSITEHTLTADFNNLEQVAQLFEKYPNDIATVILEPIPGNMGFILPKIEFLKGLRELCDQYNALLIF
DEVMTGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSGNPLAMAAGLATLKEIE
KINFFEDLSNTTNKLTEALADAAENANIPFFAASLGGMFGFCFTDKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPS
MYEAGFVSSMHGDLEIQKTYDAAELVLNQLKSA

Sequences:

>Translated_433_residues
MGFSMSRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWGPLILGHCHPKVIEAVD
NVLHRGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATMTAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSG
LLTLGIPSTPGIPQSITEHTLTADFNNLEQVAQLFEKYPNDIATVILEPIPGNMGFILPKIEFLKGLRELCDQYNALLIF
DEVMTGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSGNPLAMAAGLATLKEIE
KINFFEDLSNTTNKLTEALADAAENANIPFFAASLGGMFGFCFTDKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPS
MYEAGFVSSMHGDLEIQKTYDAAELVLNQLKSA
>Mature_432_residues
GFSMSRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWGPLILGHCHPKVIEAVDN
VLHRGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATMTAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGL
LTLGIPSTPGIPQSITEHTLTADFNNLEQVAQLFEKYPNDIATVILEPIPGNMGFILPKIEFLKGLRELCDQYNALLIFD
EVMTGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSGNPLAMAAGLATLKEIEK
INFFEDLSNTTNKLTEALADAAENANIPFFAASLGGMFGFCFTDKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSM
YEAGFVSSMHGDLEIQKTYDAAELVLNQLKSA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=309, Percent_Identity=32.0388349514563, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI13994255, Length=328, Percent_Identity=29.5731707317073, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI24119277, Length=305, Percent_Identity=27.8688524590164, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI284507298, Length=226, Percent_Identity=31.858407079646, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=58.6854460093897, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1789016, Length=355, Percent_Identity=30.4225352112676, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1787560, Length=381, Percent_Identity=32.0209973753281, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI145693181, Length=296, Percent_Identity=35.1351351351351, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789759, Length=308, Percent_Identity=32.1428571428571, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788044, Length=317, Percent_Identity=32.1766561514196, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786991, Length=336, Percent_Identity=29.1666666666667, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=336, Percent_Identity=28.8690476190476, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=307, Percent_Identity=29.3159609120521, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=293, Percent_Identity=27.3037542662116, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=355, Percent_Identity=27.6056338028169, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=304, Percent_Identity=29.6052631578947, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=329, Percent_Identity=26.1398176291793, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324386, Length=362, Percent_Identity=26.5193370165746, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357415, Length=303, Percent_Identity=28.7128712871287, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46703; Mature: 46572

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFSMSRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYV
CCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECCCCCEEECCCCHHHHHHH
GSWGPLILGHCHPKVIEAVDNVLHRGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGT
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCC
EATMTAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTLGIPSTPGIPQSITEHT
HHHHHHHHHHHCCCCCCCEEEEECEECCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHH
LTADFNNLEQVAQLFEKYPNDIATVILEPIPGNMGFILPKIEFLKGLRELCDQYNALLIF
HHCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEE
DEVMTGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECC
TLSGNPLAMAAGLATLKEIEKINFFEDLSNTTNKLTEALADAAENANIPFFAASLGGMFG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCEE
FCFTDKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEAGFVSSMHGDLEIQKTY
EEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHH
DAAELVLNQLKSA
HHHHHHHHHHHCC
>Mature Secondary Structure 
GFSMSRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYV
CCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECCCCCEEECCCCHHHHHHH
GSWGPLILGHCHPKVIEAVDNVLHRGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGT
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCC
EATMTAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTLGIPSTPGIPQSITEHT
HHHHHHHHHHHCCCCCCCEEEEECEECCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHH
LTADFNNLEQVAQLFEKYPNDIATVILEPIPGNMGFILPKIEFLKGLRELCDQYNALLIF
HHCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEE
DEVMTGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECC
TLSGNPLAMAAGLATLKEIEKINFFEDLSNTTNKLTEALADAAENANIPFFAASLGGMFG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCEE
FCFTDKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEAGFVSSMHGDLEIQKTY
EEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHH
DAAELVLNQLKSA
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA