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The map label for this gene is bioF

Identifier: 52841703

GI number: 52841703

Start: 1627065

End: 1628210

Strand: Direct

Name: bioF

Synonym: lpg1473

Alternate gene names: 52841703

Gene position: 1627065-1628210 (Clockwise)

Preceding gene: 52841702

Following gene: 52841704

Centisome position: 47.89

GC content: 39.18

Gene sequence:

>1146_bases
ATGACTCTTAATATAAAAATTAATGAGTATACAGCACAGCTGCAAGAACAAGGATTATTGCGTACAAGACAAATTTTAGA
AACGGATAAGATAGATTATATTCGATTTGATTCTAATGATTATTTGTCGCTCATAGAAGATAGGCGAATTGCAGAAGCCT
ATCAAAAGGGATATGAGTTGTATCCTTGTGGAAGTGGTGCTTCGATGGTTTTAAGTGGCTACCATAGTAGCCACCAAACC
CTTGAGAGGGCCTTTGCCGAAATGCTGGGAGTAGATGATTGTCTTTTATTTTCCTCTGGGTACTGTGCAAATTTGGCCAT
TACGGCCTTGCTTGGGCGTTTGGGAACACATTGTTTTATAGATAAAAGCGTTCATGCATCAATTTATGATGGATTGGCTT
TGTCACGAGTAACCTACTCTCGTTACATACATAATGACATGAATGCTTTGTCTGCCTTGTTAAAATCTCATTTGGGCGAT
TCTGTTTTGATTACAGAAGGTATTTTTAGTATGAGTGGGCAGATAGCGCCGTTATCAACGATTAATACGTTATGCAAAGA
GAATGGCTCTGAGCTCTTTGTAGATGAAGCGCATGCTTTTGGTGTGATTGGACCGCAAGGAATGGGCTCTGTGCCAGGCC
ATGGGCTGACACAGAATGAAGTTCCCTTGCGAGTTATTCCTTTTGGTAAGGCATTTGCTTCCCAGGGCGCTGTGGTTGGT
GGGCGGAAAGATTGGATAAATGCTTTGTTGCAAACGGCACGTTCTTTTGTTTATTCAACTGCTATTAGTCCTGCTTTATG
CTATGGTTTGCTCAAGACATTGGAGATAATAGCAGCTGCCGACTCCAGAAGAGCAAAATTAAACCAATTAGTTGCTCAAT
TTAAAGAATTAATAAAGTCTTCGCCCTTAAATTGGCTGGATTCAGATACTCCAATTCAGCAATTAAGGTTAGGATGCCCT
CATAAGGCACTGCATTATGCCAGTGAACTGAAAAAAGATGGGATTTATTGCTCTGCTATCAGAGCTCCAACGGTAAATAG
TGCTTCTTCTGGTTTACGGATTATTATTAATTATAAGCATACTATTGAACAAATCATTGAGTTATTTAATAAATTGCACT
TAATACATGAATATTCATCTCGATAA

Upstream 100 bases:

>100_bases
TTCTGTGTTTATTGGCGATAAATTATTGACAGAAGATAATCCCCAGCGCTTCAAAGACAAAACTCTTTTTAACAAACTGG
GTTTGACTGAGATGGTATAA

Downstream 100 bases:

>100_bases
ATATGGGCAAGGTATGCCTTTGGTCCTATTTCATGGCTGGGGATTTGATAGCCAAATCTGGCAACCGATAATTCCTTACC
TTAAGCCTAAATATCAGATT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTLNIKINEYTAQLQEQGLLRTRQILETDKIDYIRFDSNDYLSLIEDRRIAEAYQKGYELYPCGSGASMVLSGYHSSHQT
LERAFAEMLGVDDCLLFSSGYCANLAITALLGRLGTHCFIDKSVHASIYDGLALSRVTYSRYIHNDMNALSALLKSHLGD
SVLITEGIFSMSGQIAPLSTINTLCKENGSELFVDEAHAFGVIGPQGMGSVPGHGLTQNEVPLRVIPFGKAFASQGAVVG
GRKDWINALLQTARSFVYSTAISPALCYGLLKTLEIIAAADSRRAKLNQLVAQFKELIKSSPLNWLDSDTPIQQLRLGCP
HKALHYASELKKDGIYCSAIRAPTVNSASSGLRIIINYKHTIEQIIELFNKLHLIHEYSSR

Sequences:

>Translated_381_residues
MTLNIKINEYTAQLQEQGLLRTRQILETDKIDYIRFDSNDYLSLIEDRRIAEAYQKGYELYPCGSGASMVLSGYHSSHQT
LERAFAEMLGVDDCLLFSSGYCANLAITALLGRLGTHCFIDKSVHASIYDGLALSRVTYSRYIHNDMNALSALLKSHLGD
SVLITEGIFSMSGQIAPLSTINTLCKENGSELFVDEAHAFGVIGPQGMGSVPGHGLTQNEVPLRVIPFGKAFASQGAVVG
GRKDWINALLQTARSFVYSTAISPALCYGLLKTLEIIAAADSRRAKLNQLVAQFKELIKSSPLNWLDSDTPIQQLRLGCP
HKALHYASELKKDGIYCSAIRAPTVNSASSGLRIIINYKHTIEQIIELFNKLHLIHEYSSR
>Mature_380_residues
TLNIKINEYTAQLQEQGLLRTRQILETDKIDYIRFDSNDYLSLIEDRRIAEAYQKGYELYPCGSGASMVLSGYHSSHQTL
ERAFAEMLGVDDCLLFSSGYCANLAITALLGRLGTHCFIDKSVHASIYDGLALSRVTYSRYIHNDMNALSALLKSHLGDS
VLITEGIFSMSGQIAPLSTINTLCKENGSELFVDEAHAFGVIGPQGMGSVPGHGLTQNEVPLRVIPFGKAFASQGAVVGG
RKDWINALLQTARSFVYSTAISPALCYGLLKTLEIIAAADSRRAKLNQLVAQFKELIKSSPLNWLDSDTPIQQLRLGCPH
KALHYASELKKDGIYCSAIRAPTVNSASSGLRIIINYKHTIEQIIELFNKLHLIHEYSSR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI4758668, Length=350, Percent_Identity=28.2857142857143, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI7657118, Length=375, Percent_Identity=26.1333333333333, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI284448556, Length=349, Percent_Identity=27.2206303724928, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI83977442, Length=347, Percent_Identity=27.6657060518732, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI83977444, Length=347, Percent_Identity=27.6657060518732, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI83977440, Length=347, Percent_Identity=27.6657060518732, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4502025, Length=341, Percent_Identity=29.3255131964809, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI40316939, Length=341, Percent_Identity=29.3255131964809, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI119220554, Length=326, Percent_Identity=26.3803680981595, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI5454084, Length=243, Percent_Identity=23.8683127572016, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786993, Length=351, Percent_Identity=37.8917378917379, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1790046, Length=375, Percent_Identity=30.4, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71994529, Length=397, Percent_Identity=28.463476070529, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17560914, Length=323, Percent_Identity=27.5541795665635, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17560912, Length=323, Percent_Identity=27.5541795665635, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32566772, Length=354, Percent_Identity=26.5536723163842, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71982617, Length=274, Percent_Identity=24.4525547445255, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982625, Length=274, Percent_Identity=24.4525547445255, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320438, Length=381, Percent_Identity=26.7716535433071, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323954, Length=292, Percent_Identity=27.0547945205479, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320267, Length=353, Percent_Identity=24.6458923512748, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24662918, Length=339, Percent_Identity=29.2035398230088, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17137420, Length=349, Percent_Identity=28.6532951289398, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17136286, Length=307, Percent_Identity=28.0130293159609, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653280, Length=330, Percent_Identity=24.5454545454545, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24653276, Length=330, Percent_Identity=24.5454545454545, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24653278, Length=330, Percent_Identity=24.5454545454545, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 41994; Mature: 41862

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNIKINEYTAQLQEQGLLRTRQILETDKIDYIRFDSNDYLSLIEDRRIAEAYQKGYEL
CEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEE
YPCGSGASMVLSGYHSSHQTLERAFAEMLGVDDCLLFSSGYCANLAITALLGRLGTHCFI
EECCCCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCCEEE
DKSVHASIYDGLALSRVTYSRYIHNDMNALSALLKSHLGDSVLITEGIFSMSGQIAPLST
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCCHHH
INTLCKENGSELFVDEAHAFGVIGPQGMGSVPGHGLTQNEVPLRVIPFGKAFASQGAVVG
HHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHCCCCEEC
GRKDWINALLQTARSFVYSTAISPALCYGLLKTLEIIAAADSRRAKLNQLVAQFKELIKS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
SPLNWLDSDTPIQQLRLGCPHKALHYASELKKDGIYCSAIRAPTVNSASSGLRIIINYKH
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEECHH
TIEQIIELFNKLHLIHEYSSR
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLNIKINEYTAQLQEQGLLRTRQILETDKIDYIRFDSNDYLSLIEDRRIAEAYQKGYEL
EEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEE
YPCGSGASMVLSGYHSSHQTLERAFAEMLGVDDCLLFSSGYCANLAITALLGRLGTHCFI
EECCCCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCCEEE
DKSVHASIYDGLALSRVTYSRYIHNDMNALSALLKSHLGDSVLITEGIFSMSGQIAPLST
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCCHHH
INTLCKENGSELFVDEAHAFGVIGPQGMGSVPGHGLTQNEVPLRVIPFGKAFASQGAVVG
HHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHCCCCEEC
GRKDWINALLQTARSFVYSTAISPALCYGLLKTLEIIAAADSRRAKLNQLVAQFKELIKS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
SPLNWLDSDTPIQQLRLGCPHKALHYASELKKDGIYCSAIRAPTVNSASSGLRIIINYKH
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEECHH
TIEQIIELFNKLHLIHEYSSR
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA