| Definition | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome. |
|---|---|
| Accession | NC_002942 |
| Length | 3,397,754 |
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The map label for this gene is gyrA
Identifier: 52841647
GI number: 52841647
Start: 1563781
End: 1566396
Strand: Direct
Name: gyrA
Synonym: lpg1417
Alternate gene names: 52841647
Gene position: 1563781-1566396 (Clockwise)
Preceding gene: 52841646
Following gene: 52841648
Centisome position: 46.02
GC content: 41.06
Gene sequence:
>2616_bases CTGTCTAAAGGATACATCCAAATTATGGTATACCTAGCCAAAGAAGTCTTACCAGTCAACATAGAAGACGAATTGAAGCA ATCCTATTTGGATTATGCGATGAGTGTCATTGTGGGTCGAGCATTACCTGATGTACGTGATGGTTTAAAGCCAGTACACA GGCGAGTTCTTTTTGCGATGAGTGAGTTAAGTAATGATTGGAATAAGCCGTATAAAAAATCTGCTCGTGTAGTAGGGGAT GTCATTGGTAAATATCATCCTCATGGGGATACAGCTGTTTATGACACTATTGTTCGTATGGCTCAGCCCTTTTCCATGCG TTATATGCTGATTGATGGGCAGGGTAATTTTGGCTCTGTAGATGGAGATGCTCCAGCTGCCATGCGTTACACTGAAGTAA GAATGTCCAAAGTGGCGCATGCTTTACTGGCTGATTTGGATAAGGAAACCGTTGATTTTAGTCCTAACTATGATGAAACA GAATTTGCTCCAGTGGTATTGCCATCGAGAATTCCCAATTTACTAGTTAATGGCTCTTCCGGTATTGCGGTAGGGATGGC TACTAATATTCCACCACATAATCTTACCGAAGTAATCAATGCATGTATTGCTTTAGTGGATGAACCTGACACGAGTCTTG AAGATTTAATGGAAATTATTCCTGGCCCTGATTTTCCTACAGCCGCAATTATTAATGGTCGTGCTGGAATTATTGAAGGT TATCGTACTGGAAAAGGGCGGGTTGTTATCAGGGCACGCACAGAAATTGAAACGGATGAAAGTTCAGGCCGTCAGTCAAT TATTATTCAGGAATTACCCTATCAGGTGAATAAAGCGCGTTTGATCGAGCGTATTGCTGAATTGGTAAGGGACAAGAAAA TCGAAGGAATTTCCGGCTTGAGAGATGAGTCAGACAAGCAAGGAATGAGAGTAGTCATTGAATTAAAACGCAATGAAGTA GCAGATGTGGTATTGAATAACCTGTTCGCTCATACTCAAATGCAAAATGTATTCGGAATTAATATGGTTGCTCTGGTGGA TGGCCAACCGCGTACTTTGAATTTGAAGCAAATACTGGAATATTTTATAAAACATCGAAGAGAGGTTGTTACCAGACGCA CAATATTTGAATTGAAAAAAGCCAGAAGTCGAGCCCATTTATTGGAGGGCTTGGGAATCGCCTTAGCTAATATCGATGAA ATGATCGCATTAATTAAGCAATCTCCTACTCCTCAAGACGCAAAAAGTGCTTTATTAAGCAAAATATGGCAACCTGGGTT GGTAAAGGCCATGTTGGAAAAGGCTGGCTCAAACGCGTCAAGGCCTGATGATTTAACTGAAGAGTATGGTTTGCATGAGA GCGGATATAAATTATCTGAAGCGCAGGCACAAGCAATACTTGAATTAAGATTACATAGGCTAACAGCTCTTGAACAAGAT AAAATAATTAATGAATTTGAAGAGCTATTGAATTTAATTAAAGAATTACTTGATATATTGGCTTCACCTGAAAGACTTAT GCAAGTTATTCGTGATGAATTGATAGAGATTAAATCCCAATTTGGTGATGAGAGACGAACGGAAATAACAGCCTCACAAG AAGATTTGACTATTGAAGATTTGATTACCGAAGAAGATGTTGTGGTCACTTTATCTCATCAAGGTTATGTAAAATATCAG CCCATTACAGCCTATCAGGCTCAGCGCCGAGGTGGCAAAGGCAAATCGGCAACTCATGTCAAGGATGAGGATTTTGTTGA GCGTTTGGTTATTGCGAGTACTCATGACACCTTATTATGTTTCTCCAATCATGGCAAATTATATTGGCTAAAAGCATATC AATTGCCTCAAGCAAGCCGCGCTTCGAGAGGAAGGCCTATAATCAATATTCTTCCTTTGGCAGAAGGCGAAGAGATTAAT GCTATGCTCCCTGTTCGTGAGTATAAAGACGGCAGCTACGTGTTTATGGCAACCAAGAAGGGAACAGTTAAAAAAGTGCC TTTAAACGCATTTAGCAGGCCGCGTTCCAATGGTATTATTGCTGTGGACCTGGAAGAAGATGACAGTCTCGTTGGAGTTG ATATTACTGATGGTGCTCGCGATATTATGTTGTTTACTGATGCAGGCAAAGTAATCCGCTTTGATGAAAGTAAAGTGCGA CCTATGGGGCGCACGGCTCGAGGAGTTCGTGGAATTAGGGTAGAAAAGGATCAAGCCGTTAAATCTCTTGTGGTAGTCGA TCCAAGTGGAGGCACCATTTTGACGGCAACTGAAAACGGCTACGGCAAGAGAACTCATATTGATGAATATCGAGTGTCAG GACGGGGCGGGCAAGGTGTTATTTCCATTCAGGTTACTGAACGAAATGGTAAAGTGGTCCGCTCCTTGCAGGTTACCGAT AATGACGAAGCCATGTTAATTACAGATAAAGGGACTTTGGTTCGTTTTAAAGTTAATGAATTATCTGTGATAGGCCGAAA TACACAAGGAGTTCGTCTGATTAACGTCAGTTCTGGTGAGGCAGTTGTTGGAATGCAAAAAATTGTAGATCTTGGAGAAG AATTAGAAGAGGCAGAAGATTCATCCCTTAATGCTGAAGACAGCAGTGATGAATAG
Upstream 100 bases:
>100_bases TCGCGAACATTAAAAATATCCTTGAGCTATCCGAAGCTTAAGGTGATTTAATTAAGACGCCCAGTGTGGTATCCTTTTGC ATTAAATTAATCTTAATTTA
Downstream 100 bases:
>100_bases CAGGGTTTTCAATTTTGGAGCTGGCCCTGCCATGCTGCCTGAGGAGATATTAAAAGAGGCTCAAGAGGAATTTCTTAATT GGCGTAATACCGGCATGTCT
Product: DNA gyrase, subunit A, type II topoisomerase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 871; Mature: 870
Protein sequence:
>871_residues MSKGYIQIMVYLAKEVLPVNIEDELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSELSNDWNKPYKKSARVVGD VIGKYHPHGDTAVYDTIVRMAQPFSMRYMLIDGQGNFGSVDGDAPAAMRYTEVRMSKVAHALLADLDKETVDFSPNYDET EFAPVVLPSRIPNLLVNGSSGIAVGMATNIPPHNLTEVINACIALVDEPDTSLEDLMEIIPGPDFPTAAIINGRAGIIEG YRTGKGRVVIRARTEIETDESSGRQSIIIQELPYQVNKARLIERIAELVRDKKIEGISGLRDESDKQGMRVVIELKRNEV ADVVLNNLFAHTQMQNVFGINMVALVDGQPRTLNLKQILEYFIKHRREVVTRRTIFELKKARSRAHLLEGLGIALANIDE MIALIKQSPTPQDAKSALLSKIWQPGLVKAMLEKAGSNASRPDDLTEEYGLHESGYKLSEAQAQAILELRLHRLTALEQD KIINEFEELLNLIKELLDILASPERLMQVIRDELIEIKSQFGDERRTEITASQEDLTIEDLITEEDVVVTLSHQGYVKYQ PITAYQAQRRGGKGKSATHVKDEDFVERLVIASTHDTLLCFSNHGKLYWLKAYQLPQASRASRGRPIINILPLAEGEEIN AMLPVREYKDGSYVFMATKKGTVKKVPLNAFSRPRSNGIIAVDLEEDDSLVGVDITDGARDIMLFTDAGKVIRFDESKVR PMGRTARGVRGIRVEKDQAVKSLVVVDPSGGTILTATENGYGKRTHIDEYRVSGRGGQGVISIQVTERNGKVVRSLQVTD NDEAMLITDKGTLVRFKVNELSVIGRNTQGVRLINVSSGEAVVGMQKIVDLGEELEEAEDSSLNAEDSSDE
Sequences:
>Translated_871_residues MSKGYIQIMVYLAKEVLPVNIEDELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSELSNDWNKPYKKSARVVGD VIGKYHPHGDTAVYDTIVRMAQPFSMRYMLIDGQGNFGSVDGDAPAAMRYTEVRMSKVAHALLADLDKETVDFSPNYDET EFAPVVLPSRIPNLLVNGSSGIAVGMATNIPPHNLTEVINACIALVDEPDTSLEDLMEIIPGPDFPTAAIINGRAGIIEG YRTGKGRVVIRARTEIETDESSGRQSIIIQELPYQVNKARLIERIAELVRDKKIEGISGLRDESDKQGMRVVIELKRNEV ADVVLNNLFAHTQMQNVFGINMVALVDGQPRTLNLKQILEYFIKHRREVVTRRTIFELKKARSRAHLLEGLGIALANIDE MIALIKQSPTPQDAKSALLSKIWQPGLVKAMLEKAGSNASRPDDLTEEYGLHESGYKLSEAQAQAILELRLHRLTALEQD KIINEFEELLNLIKELLDILASPERLMQVIRDELIEIKSQFGDERRTEITASQEDLTIEDLITEEDVVVTLSHQGYVKYQ PITAYQAQRRGGKGKSATHVKDEDFVERLVIASTHDTLLCFSNHGKLYWLKAYQLPQASRASRGRPIINILPLAEGEEIN AMLPVREYKDGSYVFMATKKGTVKKVPLNAFSRPRSNGIIAVDLEEDDSLVGVDITDGARDIMLFTDAGKVIRFDESKVR PMGRTARGVRGIRVEKDQAVKSLVVVDPSGGTILTATENGYGKRTHIDEYRVSGRGGQGVISIQVTERNGKVVRSLQVTD NDEAMLITDKGTLVRFKVNELSVIGRNTQGVRLINVSSGEAVVGMQKIVDLGEELEEAEDSSLNAEDSSDE >Mature_870_residues SKGYIQIMVYLAKEVLPVNIEDELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSELSNDWNKPYKKSARVVGDV IGKYHPHGDTAVYDTIVRMAQPFSMRYMLIDGQGNFGSVDGDAPAAMRYTEVRMSKVAHALLADLDKETVDFSPNYDETE FAPVVLPSRIPNLLVNGSSGIAVGMATNIPPHNLTEVINACIALVDEPDTSLEDLMEIIPGPDFPTAAIINGRAGIIEGY RTGKGRVVIRARTEIETDESSGRQSIIIQELPYQVNKARLIERIAELVRDKKIEGISGLRDESDKQGMRVVIELKRNEVA DVVLNNLFAHTQMQNVFGINMVALVDGQPRTLNLKQILEYFIKHRREVVTRRTIFELKKARSRAHLLEGLGIALANIDEM IALIKQSPTPQDAKSALLSKIWQPGLVKAMLEKAGSNASRPDDLTEEYGLHESGYKLSEAQAQAILELRLHRLTALEQDK IINEFEELLNLIKELLDILASPERLMQVIRDELIEIKSQFGDERRTEITASQEDLTIEDLITEEDVVVTLSHQGYVKYQP ITAYQAQRRGGKGKSATHVKDEDFVERLVIASTHDTLLCFSNHGKLYWLKAYQLPQASRASRGRPIINILPLAEGEEINA MLPVREYKDGSYVFMATKKGTVKKVPLNAFSRPRSNGIIAVDLEEDDSLVGVDITDGARDIMLFTDAGKVIRFDESKVRP MGRTARGVRGIRVEKDQAVKSLVVVDPSGGTILTATENGYGKRTHIDEYRVSGRGGQGVISIQVTERNGKVVRSLQVTDN DEAMLITDKGTLVRFKVNELSVIGRNTQGVRLINVSSGEAVVGMQKIVDLGEELEEAEDSSLNAEDSSDE
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=319, Percent_Identity=26.9592476489028, Blast_Score=76, Evalue=1e-13, Organism=Homo sapiens, GI19913406, Length=322, Percent_Identity=27.0186335403727, Blast_Score=76, Evalue=1e-13, Organism=Escherichia coli, GI1788562, Length=843, Percent_Identity=65.361803084223, Blast_Score=1155, Evalue=0.0, Organism=Escherichia coli, GI1789396, Length=728, Percent_Identity=37.2252747252747, Blast_Score=425, Evalue=1e-120, Organism=Caenorhabditis elegans, GI17535065, Length=182, Percent_Identity=34.0659340659341, Blast_Score=76, Evalue=6e-14, Organism=Caenorhabditis elegans, GI212645657, Length=280, Percent_Identity=29.2857142857143, Blast_Score=75, Evalue=1e-13, Organism=Caenorhabditis elegans, GI212645845, Length=366, Percent_Identity=23.7704918032787, Blast_Score=68, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6324241, Length=348, Percent_Identity=26.1494252873563, Blast_Score=74, Evalue=9e-14, Organism=Drosophila melanogaster, GI17136538, Length=352, Percent_Identity=25.8522727272727, Blast_Score=72, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 96792; Mature: 96661
Theoretical pI: Translated: 5.34; Mature: 5.34
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSKGYIQIMVYLAKEVLPVNIEDELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAM CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH SELSNDWNKPYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSMRYMLIDGQGNFGSV HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCC DGDAPAAMRYTEVRMSKVAHALLADLDKETVDFSPNYDETEFAPVVLPSRIPNLLVNGSS CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCC GIAVGMATNIPPHNLTEVINACIALVDEPDTSLEDLMEIIPGPDFPTAAIINGRAGIIEG CEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEECCCCCEEEC YRTGKGRVVIRARTEIETDESSGRQSIIIQELPYQVNKARLIERIAELVRDKKIEGISGL EECCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCC RDESDKQGMRVVIELKRNEVADVVLNNLFAHTQMQNVFGINMVALVDGQPRTLNLKQILE CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHH YFIKHRREVVTRRTIFELKKARSRAHLLEGLGIALANIDEMIALIKQSPTPQDAKSALLS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH KIWQPGLVKAMLEKAGSNASRPDDLTEEYGLHESGYKLSEAQAQAILELRLHRLTALEQD HHCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH KIINEFEELLNLIKELLDILASPERLMQVIRDELIEIKSQFGDERRTEITASQEDLTIED HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCHHH LITEEDVVVTLSHQGYVKYQPITAYQAQRRGGKGKSATHVKDEDFVERLVIASTHDTLLC HCCCCCEEEEEECCCEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEE FSNHGKLYWLKAYQLPQASRASRGRPIINILPLAEGEEINAMLPVREYKDGSYVFMATKK EECCCCEEEEEEECCCCCHHHCCCCCEEEEEECCCCCCCCEEECHHCCCCCCEEEEEECC GTVKKVPLNAFSRPRSNGIIAVDLEEDDSLVGVDITDGARDIMLFTDAGKVIRFDESKVR CCEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCEEEECCHHCC PMGRTARGVRGIRVEKDQAVKSLVVVDPSGGTILTATENGYGKRTHIDEYRVSGRGGQGV CCCCHHCCCCCEEECHHHHCEEEEEECCCCCEEEEECCCCCCCCCCCHHHEECCCCCCEE ISIQVTERNGKVVRSLQVTDNDEAMLITDKGTLVRFKVNELSVIGRNTQGVRLINVSSGE EEEEEECCCCCEEEEEEECCCCCEEEEECCCEEEEEEECEEEEEECCCCCEEEEEECCCC AVVGMQKIVDLGEELEEAEDSSLNAEDSSDE HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC >Mature Secondary Structure SKGYIQIMVYLAKEVLPVNIEDELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAM CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH SELSNDWNKPYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSMRYMLIDGQGNFGSV HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCC DGDAPAAMRYTEVRMSKVAHALLADLDKETVDFSPNYDETEFAPVVLPSRIPNLLVNGSS CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCC GIAVGMATNIPPHNLTEVINACIALVDEPDTSLEDLMEIIPGPDFPTAAIINGRAGIIEG CEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEECCCCCEEEC YRTGKGRVVIRARTEIETDESSGRQSIIIQELPYQVNKARLIERIAELVRDKKIEGISGL EECCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCC RDESDKQGMRVVIELKRNEVADVVLNNLFAHTQMQNVFGINMVALVDGQPRTLNLKQILE CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHH YFIKHRREVVTRRTIFELKKARSRAHLLEGLGIALANIDEMIALIKQSPTPQDAKSALLS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH KIWQPGLVKAMLEKAGSNASRPDDLTEEYGLHESGYKLSEAQAQAILELRLHRLTALEQD HHCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH KIINEFEELLNLIKELLDILASPERLMQVIRDELIEIKSQFGDERRTEITASQEDLTIED HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCHHH LITEEDVVVTLSHQGYVKYQPITAYQAQRRGGKGKSATHVKDEDFVERLVIASTHDTLLC HCCCCCEEEEEECCCEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEE FSNHGKLYWLKAYQLPQASRASRGRPIINILPLAEGEEINAMLPVREYKDGSYVFMATKK EECCCCEEEEEEECCCCCHHHCCCCCEEEEEECCCCCCCCEEECHHCCCCCCEEEEEECC GTVKKVPLNAFSRPRSNGIIAVDLEEDDSLVGVDITDGARDIMLFTDAGKVIRFDESKVR CCEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCEEEECCHHCC PMGRTARGVRGIRVEKDQAVKSLVVVDPSGGTILTATENGYGKRTHIDEYRVSGRGGQGV CCCCHHCCCCCEEECHHHHCEEEEEECCCCCEEEEECCCCCCCCCCCHHHEECCCCCCEE ISIQVTERNGKVVRSLQVTDNDEAMLITDKGTLVRFKVNELSVIGRNTQGVRLINVSSGE EEEEEECCCCCEEEEEEECCCCCEEEEECCCEEEEEEECEEEEEECCCCCEEEEEECCCC AVVGMQKIVDLGEELEEAEDSSLNAEDSSDE HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11677609; 8849216 [H]