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The map label for this gene is serC

Identifier: 52841648

GI number: 52841648

Start: 1566371

End: 1567477

Strand: Direct

Name: serC

Synonym: lpg1418

Alternate gene names: 52841648

Gene position: 1566371-1567477 (Clockwise)

Preceding gene: 52841647

Following gene: 52841649

Centisome position: 46.1

GC content: 38.3

Gene sequence:

>1107_bases
ATGCTGAAGACAGCAGTGATGAATAGCAGGGTTTTCAATTTTGGAGCTGGCCCTGCCATGCTGCCTGAGGAGATATTAAA
AGAGGCTCAAGAGGAATTTCTTAATTGGCGTAATACCGGCATGTCTATACTTGAAATAGGGCATAGAACACCGGAAATCA
TTAGTCTTTTAAGTACTGCAGAGCAATCGTTAAGAGAGCTGTTAAATATCCCAAAAAATTATCATGTATTATTTTTGGGG
GGGGCAGCTCGGGCACAATTTGCCATGATTCCTATGAATTTATTACGGCCAGGAGATGATGCGGCTTATTTTATTACGGG
AATCTGGTCTAAGATGGCTTATCATGAAGCGAATCTTCTAAAAAAAGCATATTACCTTAGCAGTGAAGAGAAAGAAGGAT
TTGTATCAATTCCTGACTATCAAAAGTGGGAGTTAAAAAGTAATACAGCCTATGTCTATTATACCCCAAATGAAACAATT
AATGGAGTCAGATTTCCTTATGTTCCTAAAACAGAAGGTGTTCCTCTAGTTGCGGATATGACTTCTTGCTTGCTGAGCGA
GCCGATAAATATTAGGCAATATGGTTTGATTTTTGCTGGTGCGCAGAAGAACATTGCCAATGCAGGTTTAACTGTAGTTA
TCATTCATGAGGAATTACTACAAAATCAACCTGAGCCAGTGATTCCTACCATGTTGAATTATAAAAATCATGCTGATCAT
CGCTCCTTATATGCTACACCCCCAGTATTTAATTGTTATTTGGCAAGTAAAATGTTCGAATGGATAAAAAAACAAGGGGG
TATAGAAGAATTATTTCAGAGGAATTGTTTGAAAGCTGCGAAGCTGTATCAATATCTCGATTCAACTGATTTTTATTTAA
CTCCAGTATCTAAAGAAGCTCGCTCTATAATGAATGTTTGCTTTTCCCTGTACTATCCGGATTTGGAACAAAAATTTCTC
GATATGGCTAATGAGCGTGGGTTAAAGGCTTTAAAAGGCCATCGTTTCACTGGAGGATTGCGCGCCAGTTTGTACAATGC
CATGCCTATGGCTGGAGTTGATGCTCTCATTGAGTTTATGTCTGAATTTGCAAAAGAAAATGGTTAA

Upstream 100 bases:

>100_bases
GTTCGTCTGATTAACGTCAGTTCTGGTGAGGCAGTTGTTGGAATGCAAAAAATTGTAGATCTTGGAGAAGAATTAGAAGA
GGCAGAAGATTCATCCCTTA

Downstream 100 bases:

>100_bases
TAAGCATGTTGAATTTTATAAGTAAACCAGTAGGCTGCCTTAAGGGCGAAATCACAGTACCTGGAGATAAATCCATTTCT
CATCGTTCTATTATTTTTGG

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MLKTAVMNSRVFNFGAGPAMLPEEILKEAQEEFLNWRNTGMSILEIGHRTPEIISLLSTAEQSLRELLNIPKNYHVLFLG
GAARAQFAMIPMNLLRPGDDAAYFITGIWSKMAYHEANLLKKAYYLSSEEKEGFVSIPDYQKWELKSNTAYVYYTPNETI
NGVRFPYVPKTEGVPLVADMTSCLLSEPINIRQYGLIFAGAQKNIANAGLTVVIIHEELLQNQPEPVIPTMLNYKNHADH
RSLYATPPVFNCYLASKMFEWIKKQGGIEELFQRNCLKAAKLYQYLDSTDFYLTPVSKEARSIMNVCFSLYYPDLEQKFL
DMANERGLKALKGHRFTGGLRASLYNAMPMAGVDALIEFMSEFAKENG

Sequences:

>Translated_368_residues
MLKTAVMNSRVFNFGAGPAMLPEEILKEAQEEFLNWRNTGMSILEIGHRTPEIISLLSTAEQSLRELLNIPKNYHVLFLG
GAARAQFAMIPMNLLRPGDDAAYFITGIWSKMAYHEANLLKKAYYLSSEEKEGFVSIPDYQKWELKSNTAYVYYTPNETI
NGVRFPYVPKTEGVPLVADMTSCLLSEPINIRQYGLIFAGAQKNIANAGLTVVIIHEELLQNQPEPVIPTMLNYKNHADH
RSLYATPPVFNCYLASKMFEWIKKQGGIEELFQRNCLKAAKLYQYLDSTDFYLTPVSKEARSIMNVCFSLYYPDLEQKFL
DMANERGLKALKGHRFTGGLRASLYNAMPMAGVDALIEFMSEFAKENG
>Mature_368_residues
MLKTAVMNSRVFNFGAGPAMLPEEILKEAQEEFLNWRNTGMSILEIGHRTPEIISLLSTAEQSLRELLNIPKNYHVLFLG
GAARAQFAMIPMNLLRPGDDAAYFITGIWSKMAYHEANLLKKAYYLSSEEKEGFVSIPDYQKWELKSNTAYVYYTPNETI
NGVRFPYVPKTEGVPLVADMTSCLLSEPINIRQYGLIFAGAQKNIANAGLTVVIIHEELLQNQPEPVIPTMLNYKNHADH
RSLYATPPVFNCYLASKMFEWIKKQGGIEELFQRNCLKAAKLYQYLDSTDFYLTPVSKEARSIMNVCFSLYYPDLEQKFL
DMANERGLKALKGHRFTGGLRASLYNAMPMAGVDALIEFMSEFAKENG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine [H]

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily [H]

Homologues:

Organism=Homo sapiens, GI17402893, Length=361, Percent_Identity=40.9972299168975, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI10863955, Length=357, Percent_Identity=36.1344537815126, Blast_Score=243, Evalue=2e-64,
Organism=Escherichia coli, GI1787136, Length=362, Percent_Identity=43.0939226519337, Blast_Score=315, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI17506897, Length=366, Percent_Identity=40.9836065573771, Blast_Score=298, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6324758, Length=388, Percent_Identity=36.8556701030928, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21356589, Length=363, Percent_Identity=40.2203856749311, Blast_Score=279, Evalue=2e-75,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.6.1.52 [H]

Molecular weight: Translated: 41698; Mature: 41698

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTAVMNSRVFNFGAGPAMLPEEILKEAQEEFLNWRNTGMSILEIGHRTPEIISLLSTA
CCCHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHH
EQSLRELLNIPKNYHVLFLGGAARAQFAMIPMNLLRPGDDAAYFITGIWSKMAYHEANLL
HHHHHHHHCCCCCEEEEEEECCCHHEEEEECHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
KKAYYLSSEEKEGFVSIPDYQKWELKSNTAYVYYTPNETINGVRFPYVPKTEGVPLVADM
HHHHHCCCCCCCCCEECCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHH
TSCLLSEPINIRQYGLIFAGAQKNIANAGLTVVIIHEELLQNQPEPVIPTMLNYKNHADH
HHHHHHCCCCCEEEEEEEECCCCCCCCCCCEEEEEEHHHHCCCCCCCCHHHHCCCCCCCC
RSLYATPPVFNCYLASKMFEWIKKQGGIEELFQRNCLKAAKLYQYLDSTDFYLTPVSKEA
CCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHH
RSIMNVCFSLYYPDLEQKFLDMANERGLKALKGHRFTGGLRASLYNAMPMAGVDALIEFM
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
SEFAKENG
HHHHHCCC
>Mature Secondary Structure
MLKTAVMNSRVFNFGAGPAMLPEEILKEAQEEFLNWRNTGMSILEIGHRTPEIISLLSTA
CCCHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHH
EQSLRELLNIPKNYHVLFLGGAARAQFAMIPMNLLRPGDDAAYFITGIWSKMAYHEANLL
HHHHHHHHCCCCCEEEEEEECCCHHEEEEECHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
KKAYYLSSEEKEGFVSIPDYQKWELKSNTAYVYYTPNETINGVRFPYVPKTEGVPLVADM
HHHHHCCCCCCCCCEECCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHH
TSCLLSEPINIRQYGLIFAGAQKNIANAGLTVVIIHEELLQNQPEPVIPTMLNYKNHADH
HHHHHHCCCCCEEEEEEEECCCCCCCCCCCEEEEEEHHHHCCCCCCCCHHHHCCCCCCCC
RSLYATPPVFNCYLASKMFEWIKKQGGIEELFQRNCLKAAKLYQYLDSTDFYLTPVSKEA
CCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHH
RSIMNVCFSLYYPDLEQKFLDMANERGLKALKGHRFTGGLRASLYNAMPMAGVDALIEFM
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
SEFAKENG
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA