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The map label for this gene is folC

Identifier: 52841572

GI number: 52841572

Start: 1480839

End: 1482125

Strand: Direct

Name: folC

Synonym: lpg1342

Alternate gene names: 52841572

Gene position: 1480839-1482125 (Clockwise)

Preceding gene: 52841571

Following gene: 52841573

Centisome position: 43.58

GC content: 37.92

Gene sequence:

>1287_bases
TTGCACGCGCCATGGAGTGAATGGGATTTAAATCACTGGTTGACTCATTTGGAAACCAGAAATACCCAGGAAATACAGCT
TGGTTTGACCAGAGTTTTGACTGTAGCGCAGAAATTAAATTTGCAGCGACCAAATTGCAAGGTAATAACAGTTGCAGGAA
CAAACGGAAAAGGTTCTACAGTCACAGCACTTGAAACCATCTATCACCAGTCAGGTTTTAGAGTTGGTACCTATACGTCA
CCCCATCTTCTTGTGTTTAATGAACGTATTCGAATTAATTTAACACCGATTCAAGATAAAGATTTATGTAAGGCTTTTTC
TGTGATTGAAGAAGCACGTTACCCTACCAATTTAACCTATTTTGAAATGGCAACACTTGCTGCCTTATGGTATTTCAAAC
AGCATGACCTGGATCTGATAATTCTTGAAGTAGGCTTGGGAGGACGGTTGGATGCTACAAACATTGTTGATACTGATTTA
GCGATCATTACTACTATCGACTTTGATCATCAGAGTTTTCTTGGTGACACACTTGAGTTGATAGGGTATGAGAAAGCCGG
AATACTACGAAAAAATAAACCTTTTATCTATGCGGATCTCTCACCACCAAAAAGTATCGTTGAGTTTGCGGTACAACTTG
GAGCATCATCTTATTTATACGGTAAAGACTATTTTTATCAGGAAGAAGCAGACCATTGGGGGGTTACTTGTCAAGGTAAG
CTATTTGAGCAATTGACCAGGCCAAAAATTCAACTTCGTTCTGCGGCAGCAGCTGTAATGGCTTGTTATTTGATGCAAAA
TGATTTGCCTGTATCCTATAAGAATCTAAAGAAAGCGATGGAGCTCATTTATATCCCGGGACGGTTGCAATTACAAAAAG
GAAAGACTGATATTTTGTACGATGTATCTCATAATCTGCAGTCAGTTCGATTACTTGCTGATACAGTAAAAAAAATCAAT
GTAAAAGGGCAAATTCATGCTGTTTTCTCCGCTTTAAAGGATAAAGATCTTTATGGATTGATTATGCCTTTAAGGGATTG
TGTTAATCGATGGTATCCTGCACAATTACATAATAAGCGCGCTGCAAGTCAAGAGGAATTGCTTTCTGTATTCAGGGAAG
CAGAAATTTTTCTAGATGTTTGTTATAATGACCCATTTACAGCTTTTGAAATGGCATTAAAGCAAGCATCAGATGACGAT
TTAATTATTGTTTATGGTTCATTTTTTACGGTTAGTCATGTAATGGCTGCCCAACATAATCTTTTGGAGCAGAAGGAGAA
TCAATGA

Upstream 100 bases:

>100_bases
GAGCATGGACATATTGATATGATAGTTGAACGTAAACATCTTCGAGCAACTATATCCGAATTGGTTTCCAAATTGACTCA
TAAAGGAGCGGAGAGTTTTT

Downstream 100 bases:

>100_bases
AACTGATAATGGATGAGAAAGTTAAACATCGCTTGATAGGTTTGGCCGTTATTATTTCATTGGGGGCAATTTTTGCTCCT
GCACTAATAAAAAAATCAAG

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MHAPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGSTVTALETIYHQSGFRVGTYTS
PHLLVFNERIRINLTPIQDKDLCKAFSVIEEARYPTNLTYFEMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDL
AIITTIDFDHQSFLGDTLELIGYEKAGILRKNKPFIYADLSPPKSIVEFAVQLGASSYLYGKDYFYQEEADHWGVTCQGK
LFEQLTRPKIQLRSAAAAVMACYLMQNDLPVSYKNLKKAMELIYIPGRLQLQKGKTDILYDVSHNLQSVRLLADTVKKIN
VKGQIHAVFSALKDKDLYGLIMPLRDCVNRWYPAQLHNKRAASQEELLSVFREAEIFLDVCYNDPFTAFEMALKQASDDD
LIIVYGSFFTVSHVMAAQHNLLEQKENQ

Sequences:

>Translated_428_residues
MHAPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGSTVTALETIYHQSGFRVGTYTS
PHLLVFNERIRINLTPIQDKDLCKAFSVIEEARYPTNLTYFEMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDL
AIITTIDFDHQSFLGDTLELIGYEKAGILRKNKPFIYADLSPPKSIVEFAVQLGASSYLYGKDYFYQEEADHWGVTCQGK
LFEQLTRPKIQLRSAAAAVMACYLMQNDLPVSYKNLKKAMELIYIPGRLQLQKGKTDILYDVSHNLQSVRLLADTVKKIN
VKGQIHAVFSALKDKDLYGLIMPLRDCVNRWYPAQLHNKRAASQEELLSVFREAEIFLDVCYNDPFTAFEMALKQASDDD
LIIVYGSFFTVSHVMAAQHNLLEQKENQ
>Mature_428_residues
MHAPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGSTVTALETIYHQSGFRVGTYTS
PHLLVFNERIRINLTPIQDKDLCKAFSVIEEARYPTNLTYFEMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDL
AIITTIDFDHQSFLGDTLELIGYEKAGILRKNKPFIYADLSPPKSIVEFAVQLGASSYLYGKDYFYQEEADHWGVTCQGK
LFEQLTRPKIQLRSAAAAVMACYLMQNDLPVSYKNLKKAMELIYIPGRLQLQKGKTDILYDVSHNLQSVRLLADTVKKIN
VKGQIHAVFSALKDKDLYGLIMPLRDCVNRWYPAQLHNKRAASQEELLSVFREAEIFLDVCYNDPFTAFEMALKQASDDD
LIIVYGSFFTVSHVMAAQHNLLEQKENQ

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=155, Percent_Identity=38.7096774193548, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI66932990, Length=155, Percent_Identity=38.7096774193548, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1788654, Length=412, Percent_Identity=38.8349514563107, Blast_Score=282, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17553150, Length=346, Percent_Identity=27.1676300578035, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17553148, Length=346, Percent_Identity=27.1676300578035, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71984923, Length=379, Percent_Identity=26.3852242744063, Blast_Score=114, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6323760, Length=351, Percent_Identity=31.0541310541311, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6324815, Length=178, Percent_Identity=33.7078651685393, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24641571, Length=305, Percent_Identity=29.5081967213115, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24581568, Length=174, Percent_Identity=35.632183908046, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17; =6.3.2.12 [H]

Molecular weight: Translated: 48719; Mature: 48719

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS01012 FOLYLPOLYGLU_SYNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGST
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
VTALETIYHQSGFRVGTYTSPHLLVFNERIRINLTPIQDKDLCKAFSVIEEARYPTNLTY
HHHHHHHHHHCCCEEECCCCCEEEEEECEEEEEEECCCCHHHHHHHHHHHHCCCCCCCHH
FEMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDLAIITTIDFDHQSFLGDTLEL
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEECCCEEEEEEEECCCHHHHHHHHHH
IGYEKAGILRKNKPFIYADLSPPKSIVEFAVQLGASSYLYGKDYFYQEEADHWGVTCQGK
HCCCHHCCEECCCCEEEEECCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCEEECHH
LFEQLTRPKIQLRSAAAAVMACYLMQNDLPVSYKNLKKAMELIYIPGRLQLQKGKTDILY
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCEEEEECCCCEEEE
DVSHNLQSVRLLADTVKKINVKGQIHAVFSALKDKDLYGLIMPLRDCVNRWYPAQLHNKR
ECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHC
AASQEELLSVFREAEIFLDVCYNDPFTAFEMALKQASDDDLIIVYGSFFTVSHVMAAQHN
CCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHH
LLEQKENQ
HHHHCCCC
>Mature Secondary Structure
MHAPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGST
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
VTALETIYHQSGFRVGTYTSPHLLVFNERIRINLTPIQDKDLCKAFSVIEEARYPTNLTY
HHHHHHHHHHCCCEEECCCCCEEEEEECEEEEEEECCCCHHHHHHHHHHHHCCCCCCCHH
FEMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDLAIITTIDFDHQSFLGDTLEL
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEECCCEEEEEEEECCCHHHHHHHHHH
IGYEKAGILRKNKPFIYADLSPPKSIVEFAVQLGASSYLYGKDYFYQEEADHWGVTCQGK
HCCCHHCCEECCCCEEEEECCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCEEECHH
LFEQLTRPKIQLRSAAAAVMACYLMQNDLPVSYKNLKKAMELIYIPGRLQLQKGKTDILY
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCEEEEECCCCEEEE
DVSHNLQSVRLLADTVKKINVKGQIHAVFSALKDKDLYGLIMPLRDCVNRWYPAQLHNKR
ECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHC
AASQEELLSVFREAEIFLDVCYNDPFTAFEMALKQASDDDLIIVYGSFFTVSHVMAAQHN
CCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHH
LLEQKENQ
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]