| Definition | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome. |
|---|---|
| Accession | NC_002942 |
| Length | 3,397,754 |
Click here to switch to the map view.
The map label for this gene is virB4
Identifier: 52841486
GI number: 52841486
Start: 1382136
End: 1384616
Strand: Reverse
Name: virB4
Synonym: lpg1254
Alternate gene names: 52841486
Gene position: 1384616-1382136 (Counterclockwise)
Preceding gene: 52841487
Following gene: 52841485
Centisome position: 40.75
GC content: 43.41
Gene sequence:
>2481_bases ATGAACCTTTCTAAGACATTGAAGCACGTTTATCAGGAAGCAAAAGTGTCAGATTTGTTTCCCGTAACGCATCTTAATAG CCCCAGCATTTTTGAATCGCAATCAGGCTTGGTTGGGTCGGTGATTAAGGTGAATGGTGCGGCTTTTGAAATCGAAGAAG CTGAGACTCTAAATCACCAAAGCTTCTTGCTCCATCAGGCATTAGTGAGTTTGGATTCGCGTTTCATTATTTATGTGACC ACACACCGACAAAAAATATCATGCCCTTTGATTGGGGAATTTAAGCCAGGCTTTGCCAAGGATCTGGATGAGCATTACCA ACAACGCTTTAAAGATAAAAACCTGTATAAAAATACTCTGTACATCACCATTGTCCTTAAAGGAGATGACTCCAGTAAGA CCGGATCTTGGTTGCAGTGGGCAAAAAGCCTCTCGATGAAGGGCAATAGTGAGTTGTCTGAACACCACAGGGAACAAAAC ATCCAAATCTTAAATCGTGTTGTTGAGCAGTTACAAGCAAACCTCAATCCTTTCGGGGCAACGATACTTGGCAAGCAGGA TGAAGCATTAGGTTTTAGCGAGCTGCTTCAGTTCCTTGGGTTGGTGGTGAATGCAGGTCAAACAATTTCATTCAAACATC CTGTGTACAGCCCTCCAATAGCAAACTCGATCCCTCAGTCATTCAGACAGGAAGCCAAATACCCTGAAGGACATCTCGGC CAATATTTAAGTAGTTGTCAGCTTTTATTTGGGGAGTGCATCCAGTTTCAAGGCAATACTCAAAAGGATTGCGTGTTTGG TGCGATGCTGTCACTCAAAAAATATCCCACCAACACCGCCAGCATCCTCTTGGACTCCATGTTATCTCTGGATTGTGAAT TTATTGCCACACATACATTTGCCCCCATTGGGCGAGATAGTGCCTTGAATATGATTTCTAAAAAACGCTCCAAGCTCTTA AGTGCGGAGGACAAGGCATTAAGCCAAACCACGGCATTAAGCGATTTGGAAGATGGAATTGCCAGTGAAACCCTGTTGCT GGGCGCACATCATCACACGGTAATGTTATTGGCACCCAACAAGCCATTATTGGATACAGCCATACTGGAAGCCACCAAAC GCTACGGGGCTTCAGGAATTGTGGTGGTGAAAGAAACGTTAGGACAAGAGCCAGCCTTCTGGAGCCAATTGCCATGCAAC CAGCATTTTATAACACGAGCCTCTCTGATTACCTCTCAAAACTTTGTGGACTTTTGCCCATTACATAACACCCAAACGGG CTTTTCCAATGAGAACTTTTTAGGTGGCGCGGTTACGCTTCTGGAAACCCCATCGAAAACGCCAGTCTATTTCAACTACC ATGCACGAGGCTCTAAAACCAACCCCTCCAAAGGACACGCCGCCATTTTCGGAGGAAACAATGCAGGAAAAACCACACTG GTGAATTTCCTTGATGCACAAATGGGGCGTTTTGGTGGAAGAAGTTTTTTCATTGATAGGGATGAGTCCTCCAAAATTTA TGTTTTAGCTTCCGGTAACAGCTCTTACATCAAAATAGAGCCATCCAATCCAATCGCTATGAATCCTTTGCAACTCCCAG ACACATCAGAAAATCGCTCTTTTCTGAAATTATGGCTTGCAACCTTGGTACAAGAAGAAAGCGAATGTGTTATCCCAAGC CAAATTGCTGAAATCATCAATGACTGTATCGATTACAGCTTTGAACAACTTGCACCGGAGTTCAGAACGCTAAGTCACTT GAGCCAATTTCTACCTGTTGATTTTCCACGTTGGCCACATTTAAAAAGATGGTTAAAGCAGAATGACTCCAGAATTGATG GCGAGTTTCATTGGCTGTTTGATAACCCAAATGATGCCTTAAATCTTGATTTTGACAAGGTGGGATTTGATGTGACCTAC ATGATGGACCAAGTGCACAGCGTTATTGCAACGCCTGTCTATTTGTATTTGCTGCATCGTATGCGCCAATGCCTCGATGG TCGGTTAACTTCTTTTATTATCGCCGAAGCATGGCAGCTCTTTGCATCTCCTTTTTGGGAAAAAGCACTTCGGGAATGGC TGCCTACGATTCGAAAGAAAAACGGGCATTTTATTTTTGATACCCAATCCCCAAAAACGATTACTGATTCCCCCATTAAA CACATTGTTCTGGATAACCTGGCCACCTTGATTGCCTTTCCTAATCCGCTTGCAGATAAAGAAACTTACATGGAGCATTT AAAGCTGACCGAAGCTCAATTTGAGGCGATTAAAGAGAACACGCCAGAATCACGCATTTTTCTTTATAAACAAGACCACA AAGCCTTTTTGTGCAAACTCGATTTAAGCGGTCTAAGCCAATACATCAGGGTGCTTTCTGCCAATACTCAATCGGTTAAA TTGCTGGATGACATCATGCAAGAGGTCGGTCATGACCCAGAACTTTGGCTTCCTGTCTTTTATGAAAGGAGCAAAAAATG A
Upstream 100 bases:
>100_bases TGGCTAGTGTGTCGATACGACACCCATTTTTTTACCATCTGCGCAAAGCGTTTCTTATTGCCAGAAGCTCCCAATACATC ACTATGGAGGGTTCGCGCTT
Downstream 100 bases:
>100_bases AAAGAGCAGCCTGTTTCTTAATTGCAGCAATGGGTATCAGCAGCGCCAGTCATGCGGATATTTTAGGGGTCGAAGATGCG CAGTTGATTGTATTAGCGAT
Product: LvhB4
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 826; Mature: 826
Protein sequence:
>826_residues MNLSKTLKHVYQEAKVSDLFPVTHLNSPSIFESQSGLVGSVIKVNGAAFEIEEAETLNHQSFLLHQALVSLDSRFIIYVT THRQKISCPLIGEFKPGFAKDLDEHYQQRFKDKNLYKNTLYITIVLKGDDSSKTGSWLQWAKSLSMKGNSELSEHHREQN IQILNRVVEQLQANLNPFGATILGKQDEALGFSELLQFLGLVVNAGQTISFKHPVYSPPIANSIPQSFRQEAKYPEGHLG QYLSSCQLLFGECIQFQGNTQKDCVFGAMLSLKKYPTNTASILLDSMLSLDCEFIATHTFAPIGRDSALNMISKKRSKLL SAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPNKPLLDTAILEATKRYGASGIVVVKETLGQEPAFWSQLPCN QHFITRASLITSQNFVDFCPLHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTL VNFLDAQMGRFGGRSFFIDRDESSKIYVLASGNSSYIKIEPSNPIAMNPLQLPDTSENRSFLKLWLATLVQEESECVIPS QIAEIINDCIDYSFEQLAPEFRTLSHLSQFLPVDFPRWPHLKRWLKQNDSRIDGEFHWLFDNPNDALNLDFDKVGFDVTY MMDQVHSVIATPVYLYLLHRMRQCLDGRLTSFIIAEAWQLFASPFWEKALREWLPTIRKKNGHFIFDTQSPKTITDSPIK HIVLDNLATLIAFPNPLADKETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHKAFLCKLDLSGLSQYIRVLSANTQSVK LLDDIMQEVGHDPELWLPVFYERSKK
Sequences:
>Translated_826_residues MNLSKTLKHVYQEAKVSDLFPVTHLNSPSIFESQSGLVGSVIKVNGAAFEIEEAETLNHQSFLLHQALVSLDSRFIIYVT THRQKISCPLIGEFKPGFAKDLDEHYQQRFKDKNLYKNTLYITIVLKGDDSSKTGSWLQWAKSLSMKGNSELSEHHREQN IQILNRVVEQLQANLNPFGATILGKQDEALGFSELLQFLGLVVNAGQTISFKHPVYSPPIANSIPQSFRQEAKYPEGHLG QYLSSCQLLFGECIQFQGNTQKDCVFGAMLSLKKYPTNTASILLDSMLSLDCEFIATHTFAPIGRDSALNMISKKRSKLL SAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPNKPLLDTAILEATKRYGASGIVVVKETLGQEPAFWSQLPCN QHFITRASLITSQNFVDFCPLHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTL VNFLDAQMGRFGGRSFFIDRDESSKIYVLASGNSSYIKIEPSNPIAMNPLQLPDTSENRSFLKLWLATLVQEESECVIPS QIAEIINDCIDYSFEQLAPEFRTLSHLSQFLPVDFPRWPHLKRWLKQNDSRIDGEFHWLFDNPNDALNLDFDKVGFDVTY MMDQVHSVIATPVYLYLLHRMRQCLDGRLTSFIIAEAWQLFASPFWEKALREWLPTIRKKNGHFIFDTQSPKTITDSPIK HIVLDNLATLIAFPNPLADKETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHKAFLCKLDLSGLSQYIRVLSANTQSVK LLDDIMQEVGHDPELWLPVFYERSKK >Mature_826_residues MNLSKTLKHVYQEAKVSDLFPVTHLNSPSIFESQSGLVGSVIKVNGAAFEIEEAETLNHQSFLLHQALVSLDSRFIIYVT THRQKISCPLIGEFKPGFAKDLDEHYQQRFKDKNLYKNTLYITIVLKGDDSSKTGSWLQWAKSLSMKGNSELSEHHREQN IQILNRVVEQLQANLNPFGATILGKQDEALGFSELLQFLGLVVNAGQTISFKHPVYSPPIANSIPQSFRQEAKYPEGHLG QYLSSCQLLFGECIQFQGNTQKDCVFGAMLSLKKYPTNTASILLDSMLSLDCEFIATHTFAPIGRDSALNMISKKRSKLL SAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPNKPLLDTAILEATKRYGASGIVVVKETLGQEPAFWSQLPCN QHFITRASLITSQNFVDFCPLHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTL VNFLDAQMGRFGGRSFFIDRDESSKIYVLASGNSSYIKIEPSNPIAMNPLQLPDTSENRSFLKLWLATLVQEESECVIPS QIAEIINDCIDYSFEQLAPEFRTLSHLSQFLPVDFPRWPHLKRWLKQNDSRIDGEFHWLFDNPNDALNLDFDKVGFDVTY MMDQVHSVIATPVYLYLLHRMRQCLDGRLTSFIIAEAWQLFASPFWEKALREWLPTIRKKNGHFIFDTQSPKTITDSPIK HIVLDNLATLIAFPNPLADKETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHKAFLCKLDLSGLSQYIRVLSANTQSVK LLDDIMQEVGHDPELWLPVFYERSKK
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 93187; Mature: 93187
Theoretical pI: Translated: 6.63; Mature: 6.63
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNLSKTLKHVYQEAKVSDLFPVTHLNSPSIFESQSGLVGSVIKVNGAAFEIEEAETLNHQ CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEHHHHHCCHH SFLLHQALVSLDSRFIIYVTTHRQKISCPLIGEFKPGFAKDLDEHYQQRFKDKNLYKNTL HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEE YITIVLKGDDSSKTGSWLQWAKSLSMKGNSELSEHHREQNIQILNRVVEQLQANLNPFGA EEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE TILGKQDEALGFSELLQFLGLVVNAGQTISFKHPVYSPPIANSIPQSFRQEAKYPEGHLG EEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHH QYLSSCQLLFGECIQFQGNTQKDCVFGAMLSLKKYPTNTASILLDSMLSLDCEFIATHTF HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCC APIGRDSALNMISKKRSKLLSAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPN CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCC KPLLDTAILEATKRYGASGIVVVKETLGQEPAFWSQLPCNQHFITRASLITSQNFVDFCP CCCHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCHHCCCCCCHHHHHHHHHHCCCCCEECC LHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTL CCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCHHHH VNFLDAQMGRFGGRSFFIDRDESSKIYVLASGNSSYIKIEPSNPIAMNPLQLPDTSENRS HHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCEEEEECCCCEEECCCCCCCCCCCHH FLKLWLATLVQEESECVIPSQIAEIINDCIDYSFEQLAPEFRTLSHLSQFLPVDFPRWPH HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHCCCCCCCCHH LKRWLKQNDSRIDGEFHWLFDNPNDALNLDFDKVGFDVTYMMDQVHSVIATPVYLYLLHR HHHHHHCCCCCCCCEEEEEECCCCCCEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH MRQCLDGRLTSFIIAEAWQLFASPFWEKALREWLPTIRKKNGHFIFDTQSPKTITDSPIK HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHH HIVLDNLATLIAFPNPLADKETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHKAFLCKL HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEE DLSGLSQYIRVLSANTQSVKLLDDIMQEVGHDPELWLPVFYERSKK CHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHHCCCCC >Mature Secondary Structure MNLSKTLKHVYQEAKVSDLFPVTHLNSPSIFESQSGLVGSVIKVNGAAFEIEEAETLNHQ CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEHHHHHCCHH SFLLHQALVSLDSRFIIYVTTHRQKISCPLIGEFKPGFAKDLDEHYQQRFKDKNLYKNTL HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEE YITIVLKGDDSSKTGSWLQWAKSLSMKGNSELSEHHREQNIQILNRVVEQLQANLNPFGA EEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE TILGKQDEALGFSELLQFLGLVVNAGQTISFKHPVYSPPIANSIPQSFRQEAKYPEGHLG EEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHH QYLSSCQLLFGECIQFQGNTQKDCVFGAMLSLKKYPTNTASILLDSMLSLDCEFIATHTF HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCC APIGRDSALNMISKKRSKLLSAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPN CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCC KPLLDTAILEATKRYGASGIVVVKETLGQEPAFWSQLPCNQHFITRASLITSQNFVDFCP CCCHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCHHCCCCCCHHHHHHHHHHCCCCCEECC LHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTL CCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCHHHH VNFLDAQMGRFGGRSFFIDRDESSKIYVLASGNSSYIKIEPSNPIAMNPLQLPDTSENRS HHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCEEEEECCCCEEECCCCCCCCCCCHH FLKLWLATLVQEESECVIPSQIAEIINDCIDYSFEQLAPEFRTLSHLSQFLPVDFPRWPH HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHCCCCCCCCHH LKRWLKQNDSRIDGEFHWLFDNPNDALNLDFDKVGFDVTYMMDQVHSVIATPVYLYLLHR HHHHHHCCCCCCCCEEEEEECCCCCCEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH MRQCLDGRLTSFIIAEAWQLFASPFWEKALREWLPTIRKKNGHFIFDTQSPKTITDSPIK HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHH HIVLDNLATLIAFPNPLADKETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHKAFLCKL HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEE DLSGLSQYIRVLSANTQSVKLLDDIMQEVGHDPELWLPVFYERSKK CHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]