Click here to switch to the map view.

The map label for this gene is 52841255

Identifier: 52841255

GI number: 52841255

Start: 1117741

End: 1119102

Strand: Direct

Name: 52841255

Synonym: lpg1021

Alternate gene names: NA

Gene position: 1117741-1119102 (Clockwise)

Preceding gene: 52841254

Following gene: 52841256

Centisome position: 32.9

GC content: 43.32

Gene sequence:

>1362_bases
ATGAAATTAACTTTTTTAGGAGCAACTGAGACGGTTACTGGTTCTAAATATCTTTTGACCATTGGTTCTAAAAAAATCCT
GATTGATTGCGGTCTTTTTCAAGGCTACAAAGAATTACGATTACGTAACTGGGCTCCCTTGCCAATTGATCCCCATGATA
TTGATGCGGTGATTATCACTCATGCGCATATTGACCATTCAGGCTATCTTCCCTTGCTCGTCAAAAACGGATTCCAAGGC
AAAATTTATACAACACCGGGTACCAAAGCACTGTGTTCCATTTTGTTACCCGACAGTGGTCATCTGCAGGAAGAAGAAGC
CCGCTTGGCCAATAAATATGGTTTTTCAAAACATAAGCCTGCTCTCCCTCTTTATACTGAAAAAGAAGCTCAGACGGCAT
TAAATTATTTTGAAACGATCGATTTTGATACTCCGCATCAATTGTTTCACGATTTCAGTTTTGAGTATCATCGTGCTGGT
CACATTGTGGGTGCGGCCATGGTCAAAATAAAAACCCAAAAGGGTTCCATTGTGTTTACTGGAGACATTGGCCGTCCTTA
TGATCCCGTTATGAAAGCCCCTGCCTTCATTCAAGAAACGGATTATCTGGTGATGGAGTCCACCTATGGTGACCGATTGC
ATGATGCCACAGATCCTTTGCCTCAAATGGCTCAGGTGATTAATCAAACCGTTAAACGAGGGGGCTCGGTCATTATTCCT
GCTTTTGCAGTAGGACGTGCTCAAAGTCTTCTTTATTTTATTTACGAATTGAAACGACAAGGGGCTATACCCAAAAACAT
TCCGGTTTTTTTAGATAGCCCTATGGCCATTGACGCGACTCATTTGCTCTGCACCTATAAAGAAGACCATCATTTAACGG
CAGAGCAATGTCAGGGATTATGCCGTATCGCTACTTATGTGAATACACCTGAGGAATCCAAGGAGATTGACCGCCATCAC
ATGCCGCAAATCATCATAGCGGCTAGTGGCATGGCGCAAGGAGGTCGCATTCTCCATCATTTGAAAGTGTTTGCGCCCGA
TCCCAAAAGCACTTTGTTATTTACTGGCTTTCAGGCGGGTGGCACTCGTGGTGCTCGAATTGTGAATGGGGAGAGACAAG
TCAAAATTCATGGGAGTCTTATTCCGATACGAGCCCAGGTGGTAGTTATGAGCAGTACGTCGGCTCATGCGGATTATCAA
GAACTGTTAGGATGGCTTAAGCACTTTGCTAGGCCGCCTAAAAAAGTCTTTATTACTCATGGTGAACCCCACTCTGCTCA
ATCATTAAAAGAAAAGATTGAAAAGCAATTCGGTTTTTCTTGCACGATTCCTTCTTATCTGCAAACGGAGGATTTGTTGT
GA

Upstream 100 bases:

>100_bases
TTTCTGCCCTTTTATTGACCTTAATTGTGATTCCTGTGGTTTATGTGATGTGGCGGGGCCAAATGGATTTGAAAAAAACA
GCAGACTTAACGGAGGCAAG

Downstream 100 bases:

>100_bases
GTAAGAAAACCCCTCATGGGCTTCGTTTAAAGCATTTAGGGATTAAAACCTATCATGAAGCCATTATTTACATGCGCGAG
GATTGCCATGTCTGTCACTC

Product: metallo-beta lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKLTFLGATETVTGSKYLLTIGSKKILIDCGLFQGYKELRLRNWAPLPIDPHDIDAVIITHAHIDHSGYLPLLVKNGFQG
KIYTTPGTKALCSILLPDSGHLQEEEARLANKYGFSKHKPALPLYTEKEAQTALNYFETIDFDTPHQLFHDFSFEYHRAG
HIVGAAMVKIKTQKGSIVFTGDIGRPYDPVMKAPAFIQETDYLVMESTYGDRLHDATDPLPQMAQVINQTVKRGGSVIIP
AFAVGRAQSLLYFIYELKRQGAIPKNIPVFLDSPMAIDATHLLCTYKEDHHLTAEQCQGLCRIATYVNTPEESKEIDRHH
MPQIIIAASGMAQGGRILHHLKVFAPDPKSTLLFTGFQAGGTRGARIVNGERQVKIHGSLIPIRAQVVVMSSTSAHADYQ
ELLGWLKHFARPPKKVFITHGEPHSAQSLKEKIEKQFGFSCTIPSYLQTEDLL

Sequences:

>Translated_453_residues
MKLTFLGATETVTGSKYLLTIGSKKILIDCGLFQGYKELRLRNWAPLPIDPHDIDAVIITHAHIDHSGYLPLLVKNGFQG
KIYTTPGTKALCSILLPDSGHLQEEEARLANKYGFSKHKPALPLYTEKEAQTALNYFETIDFDTPHQLFHDFSFEYHRAG
HIVGAAMVKIKTQKGSIVFTGDIGRPYDPVMKAPAFIQETDYLVMESTYGDRLHDATDPLPQMAQVINQTVKRGGSVIIP
AFAVGRAQSLLYFIYELKRQGAIPKNIPVFLDSPMAIDATHLLCTYKEDHHLTAEQCQGLCRIATYVNTPEESKEIDRHH
MPQIIIAASGMAQGGRILHHLKVFAPDPKSTLLFTGFQAGGTRGARIVNGERQVKIHGSLIPIRAQVVVMSSTSAHADYQ
ELLGWLKHFARPPKKVFITHGEPHSAQSLKEKIEKQFGFSCTIPSYLQTEDLL
>Mature_453_residues
MKLTFLGATETVTGSKYLLTIGSKKILIDCGLFQGYKELRLRNWAPLPIDPHDIDAVIITHAHIDHSGYLPLLVKNGFQG
KIYTTPGTKALCSILLPDSGHLQEEEARLANKYGFSKHKPALPLYTEKEAQTALNYFETIDFDTPHQLFHDFSFEYHRAG
HIVGAAMVKIKTQKGSIVFTGDIGRPYDPVMKAPAFIQETDYLVMESTYGDRLHDATDPLPQMAQVINQTVKRGGSVIIP
AFAVGRAQSLLYFIYELKRQGAIPKNIPVFLDSPMAIDATHLLCTYKEDHHLTAEQCQGLCRIATYVNTPEESKEIDRHH
MPQIIIAASGMAQGGRILHHLKVFAPDPKSTLLFTGFQAGGTRGARIVNGERQVKIHGSLIPIRAQVVVMSSTSAHADYQ
ELLGWLKHFARPPKKVFITHGEPHSAQSLKEKIEKQFGFSCTIPSYLQTEDLL

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=469, Percent_Identity=27.7185501066098, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI7706427, Length=444, Percent_Identity=28.3783783783784, Blast_Score=164, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI32564696, Length=466, Percent_Identity=28.3261802575107, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI32566029, Length=445, Percent_Identity=30.7865168539326, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6323307, Length=457, Percent_Identity=26.4770240700219, Blast_Score=143, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24648013, Length=444, Percent_Identity=28.8288288288288, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21358523, Length=462, Percent_Identity=28.1385281385281, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 50464; Mature: 50464

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTFLGATETVTGSKYLLTIGSKKILIDCGLFQGYKELRLRNWAPLPIDPHDIDAVIIT
CEEEEECCCCEECCCEEEEEECCCEEEEEECHHHCHHHHHHCCCCCCCCCCCCCCEEEEE
HAHIDHSGYLPLLVKNGFQGKIYTTPGTKALCSILLPDSGHLQEEEARLANKYGFSKHKP
EEEECCCCCEEEEEECCCCCEEEECCCHHHHHEEECCCCCCCCHHHHHHHHHCCCCCCCC
ALPLYTEKEAQTALNYFETIDFDTPHQLFHDFSFEYHRAGHIVGAAMVKIKTQKGSIVFT
CCCCEECHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHCCCEEEEEEEEEEECCCCEEEE
GDIGRPYDPVMKAPAFIQETDYLVMESTYGDRLHDATDPLPQMAQVINQTVKRGGSVIIP
CCCCCCCCHHHHCCCCEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
AFAVGRAQSLLYFIYELKRQGAIPKNIPVFLDSPMAIDATHLLCTYKEDHHLTAEQCQGL
EHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEECEEEEEEECCCCCCCHHHHCCC
CRIATYVNTPEESKEIDRHHMPQIIIAASGMAQGGRILHHLKVFAPDPKSTLLFTGFQAG
EEHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEEECCC
GTRGARIVNGERQVKIHGSLIPIRAQVVVMSSTSAHADYQELLGWLKHFARPPKKVFITH
CCCCCEEECCCEEEEEECCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEC
GEPHSAQSLKEKIEKQFGFSCTIPSYLQTEDLL
CCCCCHHHHHHHHHHHCCCEECCCCHHHHCCCC
>Mature Secondary Structure
MKLTFLGATETVTGSKYLLTIGSKKILIDCGLFQGYKELRLRNWAPLPIDPHDIDAVIIT
CEEEEECCCCEECCCEEEEEECCCEEEEEECHHHCHHHHHHCCCCCCCCCCCCCCEEEEE
HAHIDHSGYLPLLVKNGFQGKIYTTPGTKALCSILLPDSGHLQEEEARLANKYGFSKHKP
EEEECCCCCEEEEEECCCCCEEEECCCHHHHHEEECCCCCCCCHHHHHHHHHCCCCCCCC
ALPLYTEKEAQTALNYFETIDFDTPHQLFHDFSFEYHRAGHIVGAAMVKIKTQKGSIVFT
CCCCEECHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHCCCEEEEEEEEEEECCCCEEEE
GDIGRPYDPVMKAPAFIQETDYLVMESTYGDRLHDATDPLPQMAQVINQTVKRGGSVIIP
CCCCCCCCHHHHCCCCEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
AFAVGRAQSLLYFIYELKRQGAIPKNIPVFLDSPMAIDATHLLCTYKEDHHLTAEQCQGL
EHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEECEEEEEEECCCCCCCHHHHCCC
CRIATYVNTPEESKEIDRHHMPQIIIAASGMAQGGRILHHLKVFAPDPKSTLLFTGFQAG
EEHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEEECCC
GTRGARIVNGERQVKIHGSLIPIRAQVVVMSSTSAHADYQELLGWLKHFARPPKKVFITH
CCCCCEEECCCEEEEEECCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEC
GEPHSAQSLKEKIEKQFGFSCTIPSYLQTEDLL
CCCCCHHHHHHHHHHHCCCEECCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA