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The map label for this gene is deoA

Identifier: 52841256

GI number: 52841256

Start: 1119060

End: 1120613

Strand: Direct

Name: deoA

Synonym: lpg1022

Alternate gene names: 52841256

Gene position: 1119060-1120613 (Clockwise)

Preceding gene: 52841255

Following gene: 52841257

Centisome position: 32.94

GC content: 46.72

Gene sequence:

>1554_bases
TTGCACGATTCCTTCTTATCTGCAAACGGAGGATTTGTTGTGAGTAAGAAAACCCCTCATGGGCTTCGTTTAAAGCATTT
AGGGATTAAAACCTATCATGAAGCCATTATTTACATGCGCGAGGATTGCCATGTCTGTCACTCGGAAGGATTTGAAGTAC
AGACCCGTATCCAAGTGACTTTAGGTAGCCGCTCCATTATAGCCACCCTCAATGTGGTGACCTCAGAGCTACTTCAGCCT
GGTGAGGCTGGTTTGTCGGATTACGCCTGGGAGTCTTTACATGCCAAAGAAGGTGATGAAATTCAGGTCTCTCATCCAAA
ACCCTTGGAATCCTTAAGCTATGTGCATGCCAAGATTTATGGCAATGAACTGTCTTTTGAGCAAATGAAAGTGATTATTG
ATGATGTGTTAAGCGGTCGACTTTCTGATGTACAAATTTCCGCTTTTCTAGCGGCAAGTGGCGCAGGACGTCTAACCCGT
ACGGAAGTGATGAAGCTCACCAAAGCTATGATTGATAGTGGCGATCGTTTATCTTGGCCTTCGCCTCTGGTCGTTGATAA
ACATTGCGTGGGGGGATTACCGGGAAATCGCACGACTCTGATTGTAGTTCCCATTGTGGCTTCATTTGGATTGATGATTC
CAAAAACATCATCGCGTGCTATTACATCCCCTGCGGGAACTGCAGATACCATGGAGACTTTAGCTCCAGTCCACTTAAGT
CCCCAAAAGATGCGCCAAGTGGTTGAACAAGAAAATGGCTGTATTGTCTGGGGTGGGGCTGTGAGTTTAAGTCCTGCTGA
TGACGTGCTTATTCGTGTGGAACGAGCCATAGATTTAGATAGTGAAGGGCAATTAGTGGCTTCCATTCTTTCTAAAAAAA
TTGCAACAGGGGCCACACACGCGGTTATTGATATCCCCGTAGGACCTACTGCCAAAGTCAGGAATCAGTCTATGGCGCTC
CTTCTGAAACAATCACTTGAGGAGGTAGGTAACGAGTTAGGGCTTGTTGTCCGTGCGTTATTTACGGATGGGTCGCAGCC
GGTAGGCCATGGCATTGGTCCATCGTTAGAAGCTCGCGATGTATTGGCAGTATTACAAGGGTTGCCTGATGCGCCCAATG
ATTTGCGTGAACGAGCGTTGACGCTTGCAGGTGCTGCGTTAGAGTGTTCTTCGAAAGTACCACCGGGTTTAGGTAAATCC
ATTGCGACGCAATTATTGGAGAGTGGGCAAGCGTTTAAGAAATTTCAGGCCATTTGTGAGGCTCAGGGTGGGATGAGGGA
ATTGACCAAGGCACGTTTTACTTATCCTGTTGTGGCTGCAAAGGAAGGAAAAGTCTCCCTCATTGACAATCGAAAGCTTG
CAAAAATAGCTAAGCTTGCTGGTGCGCCAAAATCGAAATCGGCGGGTATTGACCTCCATGCCCATGTCGGCGAATCCGTT
GAACAAGGCGAGCCTTTGTTTACAATTCATTCGGAGTCTTTAGGGGAGCTCCATTACGCCTGTGATTTACTTCGCGATAA
ACAAGACATCATTATTTTAGGAGAAAACCCTTGA

Upstream 100 bases:

>100_bases
AGCACTTTGCTAGGCCGCCTAAAAAAGTCTTTATTACTCATGGTGAACCCCACTCTGCTCAATCATTAAAAGAAAAGATT
GAAAAGCAATTCGGTTTTTC

Downstream 100 bases:

>100_bases
AGCCCTTGTTATTTTCATTATTTGATTCTTCAGAAATCGCTGGGCGATTACAAGAAAGCCTGCAAGTGGAGGTGGGGGAT
GTGACTTTTCATCGCTTTCC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MHDSFLSANGGFVVSKKTPHGLRLKHLGIKTYHEAIIYMREDCHVCHSEGFEVQTRIQVTLGSRSIIATLNVVTSELLQP
GEAGLSDYAWESLHAKEGDEIQVSHPKPLESLSYVHAKIYGNELSFEQMKVIIDDVLSGRLSDVQISAFLAASGAGRLTR
TEVMKLTKAMIDSGDRLSWPSPLVVDKHCVGGLPGNRTTLIVVPIVASFGLMIPKTSSRAITSPAGTADTMETLAPVHLS
PQKMRQVVEQENGCIVWGGAVSLSPADDVLIRVERAIDLDSEGQLVASILSKKIATGATHAVIDIPVGPTAKVRNQSMAL
LLKQSLEEVGNELGLVVRALFTDGSQPVGHGIGPSLEARDVLAVLQGLPDAPNDLRERALTLAGAALECSSKVPPGLGKS
IATQLLESGQAFKKFQAICEAQGGMRELTKARFTYPVVAAKEGKVSLIDNRKLAKIAKLAGAPKSKSAGIDLHAHVGESV
EQGEPLFTIHSESLGELHYACDLLRDKQDIIILGENP

Sequences:

>Translated_517_residues
MHDSFLSANGGFVVSKKTPHGLRLKHLGIKTYHEAIIYMREDCHVCHSEGFEVQTRIQVTLGSRSIIATLNVVTSELLQP
GEAGLSDYAWESLHAKEGDEIQVSHPKPLESLSYVHAKIYGNELSFEQMKVIIDDVLSGRLSDVQISAFLAASGAGRLTR
TEVMKLTKAMIDSGDRLSWPSPLVVDKHCVGGLPGNRTTLIVVPIVASFGLMIPKTSSRAITSPAGTADTMETLAPVHLS
PQKMRQVVEQENGCIVWGGAVSLSPADDVLIRVERAIDLDSEGQLVASILSKKIATGATHAVIDIPVGPTAKVRNQSMAL
LLKQSLEEVGNELGLVVRALFTDGSQPVGHGIGPSLEARDVLAVLQGLPDAPNDLRERALTLAGAALECSSKVPPGLGKS
IATQLLESGQAFKKFQAICEAQGGMRELTKARFTYPVVAAKEGKVSLIDNRKLAKIAKLAGAPKSKSAGIDLHAHVGESV
EQGEPLFTIHSESLGELHYACDLLRDKQDIIILGENP
>Mature_517_residues
MHDSFLSANGGFVVSKKTPHGLRLKHLGIKTYHEAIIYMREDCHVCHSEGFEVQTRIQVTLGSRSIIATLNVVTSELLQP
GEAGLSDYAWESLHAKEGDEIQVSHPKPLESLSYVHAKIYGNELSFEQMKVIIDDVLSGRLSDVQISAFLAASGAGRLTR
TEVMKLTKAMIDSGDRLSWPSPLVVDKHCVGGLPGNRTTLIVVPIVASFGLMIPKTSSRAITSPAGTADTMETLAPVHLS
PQKMRQVVEQENGCIVWGGAVSLSPADDVLIRVERAIDLDSEGQLVASILSKKIATGATHAVIDIPVGPTAKVRNQSMAL
LLKQSLEEVGNELGLVVRALFTDGSQPVGHGIGPSLEARDVLAVLQGLPDAPNDLRERALTLAGAALECSSKVPPGLGKS
IATQLLESGQAFKKFQAICEAQGGMRELTKARFTYPVVAAKEGKVSLIDNRKLAKIAKLAGAPKSKSAGIDLHAHVGESV
EQGEPLFTIHSESLGELHYACDLLRDKQDIIILGENP

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=417, Percent_Identity=29.9760191846523, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI4503445, Length=417, Percent_Identity=29.9760191846523, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI166158922, Length=417, Percent_Identity=29.9760191846523, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI1790842, Length=407, Percent_Identity=29.2383292383292, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 55296; Mature: 55296

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDSFLSANGGFVVSKKTPHGLRLKHLGIKTYHEAIIYMREDCHVCHSEGFEVQTRIQVT
CCCCEEECCCCEEEECCCCCCCEEEECCHHHHHHHHHEECCCHHHHHCCCCEEEEEEEEE
LGSRSIIATLNVVTSELLQPGEAGLSDYAWESLHAKEGDEIQVSHPKPLESLSYVHAKIY
ECCCEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHEEEEEE
GNELSFEQMKVIIDDVLSGRLSDVQISAFLAASGAGRLTRTEVMKLTKAMIDSGDRLSWP
CCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCC
SPLVVDKHCVGGLPGNRTTLIVVPIVASFGLMIPKTSSRAITSPAGTADTMETLAPVHLS
CCCEECHHHCCCCCCCCEEEEEEEHHHHCCEECCCCCCCCCCCCCCCHHHHHHHCCCCCC
PQKMRQVVEQENGCIVWGGAVSLSPADDVLIRVERAIDLDSEGQLVASILSKKIATGATH
HHHHHHHHHCCCCEEEECCCEECCCCHHHHEEEHHHCCCCCCCHHHHHHHHHHHHCCCCE
AVIDIPVGPTAKVRNQSMALLLKQSLEEVGNELGLVVRALFTDGSQPVGHGIGPSLEARD
EEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
VLAVLQGLPDAPNDLRERALTLAGAALECSSKVPPGLGKSIATQLLESGQAFKKFQAICE
HHHHHHCCCCCCHHHHHHHHHHHCHHEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
AQGGMRELTKARFTYPVVAAKEGKVSLIDNRKLAKIAKLAGAPKSKSAGIDLHAHVGESV
HCCCHHHHHHHHCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCCHH
EQGEPLFTIHSESLGELHYACDLLRDKQDIIILGENP
HCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEECCCC
>Mature Secondary Structure
MHDSFLSANGGFVVSKKTPHGLRLKHLGIKTYHEAIIYMREDCHVCHSEGFEVQTRIQVT
CCCCEEECCCCEEEECCCCCCCEEEECCHHHHHHHHHEECCCHHHHHCCCCEEEEEEEEE
LGSRSIIATLNVVTSELLQPGEAGLSDYAWESLHAKEGDEIQVSHPKPLESLSYVHAKIY
ECCCEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHEEEEEE
GNELSFEQMKVIIDDVLSGRLSDVQISAFLAASGAGRLTRTEVMKLTKAMIDSGDRLSWP
CCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCC
SPLVVDKHCVGGLPGNRTTLIVVPIVASFGLMIPKTSSRAITSPAGTADTMETLAPVHLS
CCCEECHHHCCCCCCCCEEEEEEEHHHHCCEECCCCCCCCCCCCCCCHHHHHHHCCCCCC
PQKMRQVVEQENGCIVWGGAVSLSPADDVLIRVERAIDLDSEGQLVASILSKKIATGATH
HHHHHHHHHCCCCEEEECCCEECCCCHHHHEEEHHHCCCCCCCHHHHHHHHHHHHCCCCE
AVIDIPVGPTAKVRNQSMALLLKQSLEEVGNELGLVVRALFTDGSQPVGHGIGPSLEARD
EEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
VLAVLQGLPDAPNDLRERALTLAGAALECSSKVPPGLGKSIATQLLESGQAFKKFQAICE
HHHHHHCCCCCCHHHHHHHHHHHCHHEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
AQGGMRELTKARFTYPVVAAKEGKVSLIDNRKLAKIAKLAGAPKSKSAGIDLHAHVGESV
HCCCHHHHHHHHCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCCHH
EQGEPLFTIHSESLGELHYACDLLRDKQDIIILGENP
HCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA